Biomolecular Concepts最新文献_第9页

Doxorubicin loaded magnetism nanoparticles based on cyclodextrin dendritic-graphene oxide inhibited MCF-7 cell proliferation. 基于环糊精树突氧化石墨烯负载磁性纳米颗粒的多柔比星抑制MCF-7细胞增殖。

Biomolecular Concepts Pub Date : 2021-04-20 DOI: 10.1515/bmc-2021-0002

Ainaz Mihanfar, Niloufar Targhazeh, Shirin Sadighparvar, Saber Ghazizadeh Darband, Maryam Majidinia, Bahman Yousefi

{"title":"Doxorubicin loaded magnetism nanoparticles based on cyclodextrin dendritic-graphene oxide inhibited MCF-7 cell proliferation.","authors":"Ainaz Mihanfar, Niloufar Targhazeh, Shirin Sadighparvar, Saber Ghazizadeh Darband, Maryam Majidinia, Bahman Yousefi","doi":"10.1515/bmc-2021-0002","DOIUrl":"https://doi.org/10.1515/bmc-2021-0002","url":null,"abstract":"Doxorubicin (DOX) is an effective chemotherapeutic agent used for the treatment of various types of cancer. However, its poor solubility, undesirable side effects, and short half-life have remained a challenge. We used a formulation based on graphene oxide as an anticancer drug delivery system for DOX in MCF-7 breast cancer cells, to address these issues. In vitro release studies confirmed that the synthesized formulation has an improved release profile in acidic conditions (similar to the tumor microenvironment). Further in vitro studies, including MTT, uptake, and apoptosis assays were performed. The toxic effects of the nanocarrier on the kidney, heart and liver of healthy rats were also evaluated. We observed that the DOX-loaded carrier improved the cytotoxic effect of DOX on the breast cell line compared to free DOX. In summary, our results introduce the DOX-loaded carrier as a potential platform for in vitro targeting of cancer cells and suggest further studies are necessary to investigate its in vivo anti-cancer potential.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2021-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2021-0002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"38891530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

In Our Image: The Ethics of CRISPR Genome Editing. 在我们的图像:CRISPR基因组编辑的伦理。

Biomolecular Concepts Pub Date : 2021-01-29 DOI: 10.1515/bmc-2021-0001

Joel C Eissenberg

引用次数: 5

Dysregulation of epigenetic related genes in Diabetic Trigger finger Patients; preliminary analysis of Patient-Derived Samples. 糖尿病扳机指患者表观遗传相关基因失调的研究病人来源样本的初步分析。

Biomolecular Concepts Pub Date : 2020-12-31 DOI: 10.1515/bmc-2020-0020

Michael Cain, Mohamed E Awad, Ravindra Kolhe, Ashis K Mondal, Umar Ghilzai, Carlos Isales, Mark Fulcher, Sadanand Fulzele

{"title":"Dysregulation of epigenetic related genes in Diabetic Trigger finger Patients; preliminary analysis of Patient-Derived Samples.","authors":"Michael Cain, Mohamed E Awad, Ravindra Kolhe, Ashis K Mondal, Umar Ghilzai, Carlos Isales, Mark Fulcher, Sadanand Fulzele","doi":"10.1515/bmc-2020-0020","DOIUrl":"https://doi.org/10.1515/bmc-2020-0020","url":null,"abstract":"Background: Trigger finger (TF), a painful condition involving a finger flexor tendon, is a common problem with a prevalence of ~2-3% in the general population. However, the TF prevalence is higher among diabetic patients-ranges from 6.7% to 10%. We have analyzed the expression of the extracellular matrix, inflammation, and epigenetic related genes in diabetic and non-diabetes TF. We hypothesized that Diabetes condition induces alter the expression of epigenetic modification genes in diabetic patients and one of the underlying determinants for more prevalence of TF in diabetic patients.Method: Tissues from the fingers of patients with symptomatic trigger fingers were collected. We had three groups: carpal tunnel syndrome (as a control), trigger finger, and diabetic trigger finger. A quantitative real-time polymerase chain reaction was performed. The gene expression of Extracellular matrix (ECM) components [COL-I, COL-II, COL-X, Aggrecan], DNA methyltransferases enzymes (DNMT1, DNMT3), growth factors (TGF-b, IGF), and Histone deacetylase enzymes (HDAC1, HDAC2) were evaluated in all groups.Results: The mRNA expression of COL-I, COL-II, Aggrecan was significantly higher in the pully A1 of diabetic patients (p= 0.0164, p=0.0351, p=0.0399, respectively) as compared to non-diabetic TF patients. Diabetes was associated with a significant increase in the DNMT3 expression compared to non-diabetic TF patients (p=0.0485). HDAC1 and HDAC2 gene expression were up-regulated in diabetic TF than non-diabetic TF.Conclusion: The chronic state of hyperglycemia induces epigenetic modification of gene expressions in trigger fingers. This seems to have a significant impact on the development, recurrence, and progression of trigger finger in diabetic patients.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"221-229"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0020","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Graphene Oxide: A Promising Material for Regenerative Medicine and Tissue Engineering. 氧化石墨烯:再生医学和组织工程的一种有前途的材料。

Biomolecular Concepts Pub Date : 2020-12-31 DOI: 10.1515/bmc-2020-0017

Masomeh Maleki, Reza Zarezadeh, Mohammad Nouri, Aydin Raei Sadigh, Farhad Pouremamali, Zatollah Asemi, Hossein Samadi Kafil, Forough Alemi, Bahman Yousefi

{"title":"Graphene Oxide: A Promising Material for Regenerative Medicine and Tissue Engineering.","authors":"Masomeh Maleki, Reza Zarezadeh, Mohammad Nouri, Aydin Raei Sadigh, Farhad Pouremamali, Zatollah Asemi, Hossein Samadi Kafil, Forough Alemi, Bahman Yousefi","doi":"10.1515/bmc-2020-0017","DOIUrl":"https://doi.org/10.1515/bmc-2020-0017","url":null,"abstract":"Regenerative medicine and tissue engineering have been considered pioneer fields in the life sciences, with an ultimate goal of restoring or switching lost or impaired body parts. Graphene oxide (GO) is the product of graphene oxidation and presents a great opportunity to make substantial progress in the field of regenerative medicine; for example, it supports the possibility of creating a cellular niche for stem cells on a nanoparticle surface. GO creates a fascinating structure for regulating stem cell behavior, as it can potentially applied to the noninvasive chase of stem cells in vivo, the liberation of active biological factors from stem cell-containing delivery systems, and the intracellular delivery of factors such as growth factors, DNA, or synthetic proteins in order to modulate stem cell differentiation and proliferation. Due to the interesting physicochemical properties of GO and its possible usage in tissue engineering approaches, the present review aims to elaborate on the ways in which GO can improve current regenerative strategies. In this respect, the applicability of GO to the repair and regeneration of various tissues and organs, including cardiac muscle, skeletal muscle, and nervous, bone, cartilage, adipose, and skin tissues, is discussed.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"182-200"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0017","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 28

Calcium Dynamics Regulate Protective Responses and Growth of Staphylococcus aureus in Macrophages. 钙动力学调节巨噬细胞的保护反应和金黄色葡萄球菌的生长。

Biomolecular Concepts Pub Date : 2020-12-31 DOI: 10.1515/bmc-2020-0021

Chaitenya Verma, Kumar Rana Ankush, Vandana Anang, Brijendra K Tiwari, Aayushi Singh, Shakuntala Surender Kumar Saraswati, Malini Shariff, Krishnamurthy Natarajan

{"title":"Calcium Dynamics Regulate Protective Responses and Growth of Staphylococcus aureus in Macrophages.","authors":"Chaitenya Verma, Kumar Rana Ankush, Vandana Anang, Brijendra K Tiwari, Aayushi Singh, Shakuntala Surender Kumar Saraswati, Malini Shariff, Krishnamurthy Natarajan","doi":"10.1515/bmc-2020-0021","DOIUrl":"https://doi.org/10.1515/bmc-2020-0021","url":null,"abstract":"Staphylococcus aureus (S. aureus) is a gram-positive bacteria, which causes various fatal respiratory infections including pneumonia. The emergence of Methicillin-Resistance Staphylococcus aureus (MRSA) demands a thorough understanding of host-pathogen interactions. Here we report the role of calcium in regulating defence responses of S. aureus in macrophages. Regulating calcium fluxes in cells by different routes differentially governs the expression of T cell costimulatory molecule CD80 and Th1 promoting IL-12 receptor. Inhibiting calcium influx from extracellular medium increased expression of IFN-γ and IL-10 while blocking calcium release from the intracellular stores inhibited TGF-β levels. Blocking voltage-gated calcium channels (VGCC) inhibited the expression of multiple cytokines. While VGCC regulated the expression of apoptosis protein Bax, extracellular calcium-regulated the expression of Cytochrome-C. Similarly, VGCC regulated the expression of autophagy initiator Beclin-1. Blocking VGCC or calcium release from intracellular stores promoted phagosome-lysosome fusion, while activating VGCC inhibited phagosomelysosome fusion. Finally, calcium homeostasis regulated intracellular growth of Staphylococcus, although using different mechanisms. While blocking extracellular calcium influx seems to rely on IFN-γ and IL-12Rβ receptor mediated reduction in bacterial survival, blocking either intracellular calcium release or via VGCC route seem to rely on enhanced autophagy mediated reduction of intracellular bacterial survival. These results point to fine-tuning of defence responses by routes of calcium homeostasis.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"230-239"},"PeriodicalIF":0.0,"publicationDate":"2020-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0021","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25494136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Role of phase partitioning in coordinating DNA damage response: focus on the Apurinic Apyrimidinic Endonuclease 1 interactome. 相分配在协调DNA损伤反应中的作用:聚焦于无嘌呤嘧啶内切酶1相互作用组。

Biomolecular Concepts Pub Date : 2020-12-23 DOI: 10.1515/bmc-2020-0019

Damiano Tosolini, Giulia Antoniali, Emiliano Dalla, Gianluca Tell

{"title":"Role of phase partitioning in coordinating DNA damage response: focus on the Apurinic Apyrimidinic Endonuclease 1 interactome.","authors":"Damiano Tosolini, Giulia Antoniali, Emiliano Dalla, Gianluca Tell","doi":"10.1515/bmc-2020-0019","DOIUrl":"https://doi.org/10.1515/bmc-2020-0019","url":null,"abstract":"Liquid-liquid phase separation (LLPS) is a way to concentrate biochemical reactions while excluding noninteracting components. Disordered domains of proteins, as well as interaction with RNA, favor condensation but are not mandatory for modulating this process. Recent insights about phase-separation mechanisms pointed to new fascinating models that could explain how cells could cope with DNA damage responses, conferring both spatial and temporal fine regulation. APE1 is a multifunctional protein belonging to the Base Excision Repair (BER) pathway, bearing additional 'non-canonical' DNA-repair functions associated with processes like RNA metabolism. Recently, it has been highlighted that several DNA repair enzymes, such as 53BP1 and APE1, are endowed with RNA binding abilities. In this work, after reviewing the recent literature supporting a role of LLPS in DDR, we analyze, as a proof of principle, the interactome of APE1 using a bioinformatics approach to look for clues of LLPS in BER. Some of the APE1 interactors are associated with cellular processes in which LLPS has been either proved or proposed and are involved in different pathogenic events. This work might represent a paradigmatical pipeline for evaluating the relevance of LLPS in DDR.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"209-220"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0019","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 10

Alzheimer's disease: exploring nature's 'medicinal chest' for new therapeutic agents. 阿尔茨海默病:探索大自然的“药箱”，寻找新的治疗药物。

Biomolecular Concepts Pub Date : 2020-12-23 DOI: 10.1515/bmc-2020-0018

Anthony Tsarbopoulos

{"title":"Alzheimer's disease: exploring nature's 'medicinal chest' for new therapeutic agents.","authors":"Anthony Tsarbopoulos","doi":"10.1515/bmc-2020-0018","DOIUrl":"https://doi.org/10.1515/bmc-2020-0018","url":null,"abstract":"Natural products have served humanity as a valuable source for the discovery and development of therapeutic agents. In addition, these phytochemicals can function as lead compounds for the development of synthetic analogs aimed at treating human diseases. In our aging society, Alzheimer's disease (AD) is the most common cause of dementia, which is characterized by a significant and progressive loss of memory and other cognitive functions. As society demographics change, the predominance of AD and other age-related dementias is increasing, with concurrent financial and societal costs.AD represents one of the most remarkable scientific challenges for drug discovery as the search for effective disease-modifying agents has been unsuccessful. Medicinal plants have been used for their \"anti-aging\" properties, and cognitive enhancing properties. In the past decades, natural products have been studied for their anti-AD properties, and their potential for developing therapeutic agents against several molecular targets has been evaluated. This insight evaluates the prospects of medicinal plants for providing disease-modifying, as well as disease-preventing, agents for AD.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"201-208"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0018","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Influence of photobiomodulation and vitamin D on osteoblastic differentiation of human periodontal ligament stem cells and bone-like tissue formation through enzymatic activity and gene expression. 光生物调节和维生素D通过酶活性和基因表达对人牙周韧带干细胞成骨分化和骨样组织形成的影响。

Biomolecular Concepts Pub Date : 2020-12-23 DOI: 10.1515/bmc-2020-0016

Latifa Mohamed Abdelgawad, Asmaa Mohamed Abdelaziz, Dina Sabry, Marwa Abdelgwad

{"title":"Influence of photobiomodulation and vitamin D on osteoblastic differentiation of human periodontal ligament stem cells and bone-like tissue formation through enzymatic activity and gene expression.","authors":"Latifa Mohamed Abdelgawad, Asmaa Mohamed Abdelaziz, Dina Sabry, Marwa Abdelgwad","doi":"10.1515/bmc-2020-0016","DOIUrl":"https://doi.org/10.1515/bmc-2020-0016","url":null,"abstract":"Background: (1)Human periodontal ligament stem cells (HPDLSCs) are a unique population of mesenchymal stem cells (MSCs). Recently, the positive effects of photobiomodulation on the regulation of MSCs proliferation and osteogenic differentiation have gained significant attention. This study aimed to assess the effects of photobiomodulation and vitamin D (as an anabolic factor) on HPDLSCs for bone regeneration.Methods: (2)HPDLSCs were collected, isolated, and characterized and then divided into six groups: groups I and II, control and (10-7 Mol) vitamin D, respectively; group III, irradiation at 1 J/cm2 of 808-nm diode laser; group IV, irradiation at 1 J/cm2 and culture with vitamin D; group V, irradiation at 2 J/cm2, and group VI, irradiation at 2 J/cm2 and culture with vitamin D. Cell viability assay was measured through MTT assay and cell growth curve. Alkaline phosphatase (ALP) enzyme activity and mRNA levels of RUNX2, collagen 1 (Col-1), ALP, and osteonectin were also assessed.Results: (3)Photobiomodulation at 1 and 2 J/cm2 combined with vitamin D significantly promoted HPDLSC proliferation (in MTT assay and cell growth curve results) and osteogenic differentiation (through the gene expression of RUNX2, Col-1, ALP, and osteonectin levels (p < 0.05).Conclusion: (4)Laser irradiation at 2 J/cm2 combined with vitamin D3 enhanced osteoblast differentiation and proliferation of cultured HPDLSCs and thus could further substitute bone grafting.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":" ","pages":"172-181"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bmc-2020-0016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39161849","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Mass spectrometry-based glycomic profiling of the total IgG and total proteome N-glycomes isolated from follicular fluid. 基于质谱技术对从卵泡液中分离出的总 IgG 和总蛋白质组 N-糖进行糖谱分析。

Biomolecular Concepts Pub Date : 2020-10-25 DOI: 10.1515/bmc-2020-0015

Marko Klobučar, Sanja Dević Pavlić, Iris Car, Neda Smiljan Severinski, Tamara Tramišak Milaković, Anđelka Radojčić Badovinac, Sandra Kraljević Pavelić

{"title":"Mass spectrometry-based glycomic profiling of the total IgG and total proteome N-glycomes isolated from follicular fluid.","authors":"Marko Klobučar, Sanja Dević Pavlić, Iris Car, Neda Smiljan Severinski, Tamara Tramišak Milaković, Anđelka Radojčić Badovinac, Sandra Kraljević Pavelić","doi":"10.1515/bmc-2020-0015","DOIUrl":"10.1515/bmc-2020-0015","url":null,"abstract":"Couples with infertility issues have been assisted by in vitro fertilization reproduction technologies with high success rates of 50-80%. However, complications associated with ovarian stimulation remain, such as ovarian hyperstimulation. Oocyte quality is a significant factor impacting the outcome of in vitro fertilization procedures, but other processes are also critical for fertilization success. Increasing evidence points to aberrant inflammation as one of these critical processes reflected in molecular changes, including glycosylation of proteins. Here we report results from a MALDI-TOF-MS-based glycomic profiling of the total IgG and total proteome N-glycomes isolated from the follicular fluid obtained from patients undergoing fertilization through either (1) assisted reproduction by modified natural cycle or (2) controlled ovarian stimulation (GnRH antagonist, GnRH Ant) protocols. Significant inflammatory-related differences between analyzed N-glycomes were observed from samples and correlated with the ovarian stimulation protocol used in patients.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":"11 1","pages":"153-171"},"PeriodicalIF":0.0,"publicationDate":"2020-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10390847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Novel Conceptual Model for the Dual Role of FOF1-ATP Synthase in Cell Life and Cell Death. FOF1-ATP 合成酶在细胞生命和细胞死亡中双重作用的新概念模型。

Biomolecular Concepts Pub Date : 2020-08-22 DOI: 10.1515/bmc-2020-0014

Sunil Nath

{"title":"A Novel Conceptual Model for the Dual Role of FOF1-ATP Synthase in Cell Life and Cell Death.","authors":"Sunil Nath","doi":"10.1515/bmc-2020-0014","DOIUrl":"10.1515/bmc-2020-0014","url":null,"abstract":"The mitochondrial permeability transition (MPT) has been one of the longstanding enigmas in biology. Its cause is currently at the center of an extensive scientific debate, and several hypotheses on its molecular nature have been put forward. The present view holds that the transition arises from the opening of a high-conductance channel in the energy-transducing membrane, the permeability transition pore (PTP), also called the mitochondrial megachannel or the multiconductance channel (MMC). Here, the novel hypothesis is proposed that the aqueous access channels at the interface of the c-ring and the a-subunit of FO in the FOF1-ATP synthase are repurposed during induction of apoptosis and constitute the elusive PTP/ MMC. A unifying principle based on regulation by local potentials is advanced to rationalize the action of the myriad structurally and chemically diverse inducers and inhibitors of PTP/MMC. Experimental evidence in favor of the hypothesis and its differences from current models of PTP/MMC are summarized. The hypothesis explains in considerable detail how the binding of Ca2+ to a β-catalytic site (site 3) in the F1 portion of ATP synthase triggers the opening of the PTP/MMC. It is also shown to connect to longstanding proposals within Nath's torsional mechanism of energy transduction and ATP synthesis as to how the binding of MgADP to site 3 does not induce PTP/MMC, but instead catalyzes physiological ATP synthesis in cell life. In the author's knowledge, this is the first model that explains how Ca2+ transforms the FOF1-ATP synthase from an exquisite energy-conserving enzyme in cell life into an energy-dissipating structure that promotes cell death. This has major implications for basic as well as for clinical research, such as for the development of drugs that target the MPT, given the established role of PTP/MMC dysregulation in cancer, ischemia, cardiac hypertrophy, and various neurodegenerative diseases.","PeriodicalId":38392,"journal":{"name":"Biomolecular Concepts","volume":"11 1","pages":"143-152"},"PeriodicalIF":0.0,"publicationDate":"2020-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10071424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0