ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.262
I Balan, R Calcaterra, D Lauritano, E Grecchi, F Carinci
{"title":"A new spiral dental implant: a tool for oral rehabilitation of difficult cases.","authors":"I Balan, R Calcaterra, D Lauritano, E Grecchi, F Carinci","doi":"10.11138/orl/2017.10.3.262","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.262","url":null,"abstract":"<p><p>Spiral dental implant (SDI) is an implant with a conical internal helix that confers the characteristic of self-drilling, self-tapping, and self-bone condensing. These proprieties offer better control during insertion of SDI giving a high primary stabilization, even in poor quality bone. A shorter diameter of SDI results in reduced drilling during insertion and consequently less trauma and minimal bone loss. To address the research purpose, the investigators designed a retrospective cohort study. The study population was composed of 25 patients, 11 males and 14 females that have been treated by Dr. Balan with 187 SDI positioned in mandible and into maxilla bone. The implants were placed during the years 2013 to 2014 in Dr. Balan clinic. All patients underwent the same surgical protocol. Several variables are investigated: demographic (age and gender), anatomic (upper/lower jaws and tooth site), implant (length and diameter and type) variables, edentulism (partial or total), and comorbid status of health (i.e.: hypothyroidism, parodontitis, hypertension, diabetes, presence of cancer, heart disease, hepatitis and rheumatologic disease). Pearson Chi-Square test was used to investigate variables and p < 0.05 was considered statistically significant. Statistically it has been shown that females have a higher possibility of unsuccessful respect of male, with a \"p value\" of 0.014. Another important impact factor for success of implant insertion has been represented by concomitants pathologies: cancer represents the most negative high factor risk with a percentage of unsuccessful of 50%, followed by heart disease (15%), and diabetes (3.7%). SDIs are reliable tools for difficult cases of oral rehabilitation. They have a higher success and survival rate, which means stable results over time. No differences were detected among SDI lengths, implant/crown ratio. In addition, the insertion of SDIs in banked bone can be performed without adverse effects. Finally, flapless and computer tomography-planned surgery does not significantly increase the clinical outcome of SDIs in complex rehabilitation. Cancer represents the most important variable to consider when a patient wants to do oral rehabilitation because of its high risk of unsuccessful.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"262-269"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.262","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35695013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.270
L Ottria, F Luciani, P Piva, A M Alagna, C Arcuri, F N Bartuli
{"title":"The flap recovery on the impacted lower third molar surgery comparing 3 different flap designs: a clinical study.","authors":"L Ottria, F Luciani, P Piva, A M Alagna, C Arcuri, F N Bartuli","doi":"10.11138/orl/2017.10.3.270","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.270","url":null,"abstract":"<p><strong>Aim: </strong>The purpose of the study was to analyze the healing of the deep and superficial lower first and second molars periodontium, after the surgical extraction of the contiguous impacted third molar, comparing 3 mucoperiosteal flap designs.</p><p><strong>Materials and methods: </strong>150 patients which had to undergo a impacted lower third molar surgery were enrolled in this study. They were checked from day 0 to day 90, in order to focus on the recovery quality of the soft tissues around the lower second molar, comparing 3 different flap designs.</p><p><strong>Results: </strong>No intraoperatory incident happened. The complete recovery of the periodontium around the second molar has been shown in each patient after 90 days from surgery and each adverse reaction happened within the sixth week after surgery. Only 2 slight gengival recessions 0,5 mm have been find out.</p><p><strong>Conclusions: </strong>The impacted third molar surgery is an operation that, if rightly programmed and performed, is relatively safe. Besides, the correct handling and management of periodontium around the second molar and the choice of the flap type to be used support a correct recovery on the second molar periodontium, avoiding any long-term damage.</p><p><strong>Clinical significance: </strong>This study wanted to analyze the healing of the deep and superficial lower second molar periodontium, after the impacted lower third molar surgery. In order to improve the surgical technique used for lower third molar germectomies, we wanted to compare 3 different kind of flap designs.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"270-275"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.270","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35695014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.276
G Gastaldi, L Palumbo, C Moreschi, E F Gherlone, P Capparé
{"title":"Prosthetic management of patients with oro-maxillo-facial defects: a long-term follow-up retrospective study.","authors":"G Gastaldi, L Palumbo, C Moreschi, E F Gherlone, P Capparé","doi":"10.11138/orl/2017.10.3.276","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.276","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to determine the outcome of maxillofacial prosthetic rehabilitation after oncological resections, including both intra- and extra-oral prosthetic devices.</p><p><strong>Methods: </strong>In this study were included 72 patients, who have undergone an intra or extra-oral maxillofacial prosthetic rehabilitation after an oncologic resection. Tumors on the head and neck were analyzed and the defects of these resections have been divided in two different groups: intra and extra-oral defects.</p><p><strong>Results: </strong>72 participants were treated with maxillofacial prosthesis, 3 of which with post-traumatic wounds and 69 with resections of tumors on the head and neck. Of the 69 treated for neoplastic disease, 43 received an intraoral prosthesis (palatal obturator) and 29 with an extraoral epithesis (18 with nasal prostheses, 8 with orbital implants and 3 with ear implants). The group included patients with different types of tumors. All the patients were evaluated in terms of aesthetic appearance after the construction of the prostheses and the results were satisfactory.</p><p><strong>Conclusion: </strong>Within the limitations of this study, after the use of maxillofacial protheses patients feel more confident and self-assured. Maxillofacial protheses are a good solution in order to improve the life's quality in patients with tumors resections: prostheses are easy to handle and provide a satisfying social interaction for the patients.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"276-282"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.276","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35694440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.335
P Ghensi, W Stablum, E Bettio, M C Soldini, T R Tripi, C Soldini
{"title":"Management of the exposure of a dense PTFE (d-PTFE) membrane in guided bone regeneration (GBR): a case report.","authors":"P Ghensi, W Stablum, E Bettio, M C Soldini, T R Tripi, C Soldini","doi":"10.11138/orl/2017.10.3.335","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.335","url":null,"abstract":"<p><p>Guided bone regeneration (GBR) is a well-established and generally predictable method for repairing alveolar ridge defects and preparing edentulous sites for implant placement. Standard GBR involves filling the space underneath a membrane with autogenous bone or a mixture composed of autogenous bone particles and allogeneic bone tissue or heterologous biomaterials. The use of a barrier membrane for GBR has sometimes been associated with complications, however - reportedly involving exposure, infection, and collapse - and the non-resorbable types of membrane seem to be involved more often than the resorbable solutions. Such complications may be severe enough to defeat the object of the GBR procedure. A non-resorbable high-density polytetrafluoroethylene (d-PTFE) membrane has recently been designed specifically for use in bone-augmentation procedures that seems to assure a good bone regeneration process even when the membrane is exposed to the oral cavity. This case report describes an exposure of a d-PTFE membrane occurring after a maxillary GBR procedure and how it was overcome successfully, enabling implants insertion.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"335-342"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.335","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35694890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.241
M DI Girolamo, L Baggi, P Pirelli, L Pappalardo, G Massei, F Iaculli, G Iezzi, A Piattelli, R Calcaterra
{"title":"3D X-ray microscopic analysys on a prosthetically loaded implant with platform-switching and conical connection: a case report.","authors":"M DI Girolamo, L Baggi, P Pirelli, L Pappalardo, G Massei, F Iaculli, G Iezzi, A Piattelli, R Calcaterra","doi":"10.11138/orl/2017.10.3.241","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.241","url":null,"abstract":"<p><p>The histological and histomorphometrical examination were the gold standard in the qualitative and quantitative analyses of the peri-implant tissue around the implant. In recent years, the field of microscopy has witnessed a considerable enhancement of the performance of microscopes that have very high resolution performance and allowing very sophisticated analysis even larger than traditional preparations. The possibility to have an affordable analyses of whole implant with the surrounding different tissues (soft and hard tissues) without the traditional pre-treatment necessary for the histological analysis may represent a goal to describe material properties and behaviors or simply to visualize structural details. The aim of the present study were to evaluate a 3D X-ray microscopic analysis of peri-implant tissue compared to a traditional histological and histomorphometrical analysis of the peri-implant tissues around an implant with a conical connection associated with platform-switching in order to assess the validity of the new analysis technique.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"241-246"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735390/pdf/241-246.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35695012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.311
G Ierardo, M Bossù, G D'Angeli, M Celli, G Sfasciotti
{"title":"Bisphosphonates therapy in children with Osteogenesis imperfecta: clinical experience in oral surgery.","authors":"G Ierardo, M Bossù, G D'Angeli, M Celli, G Sfasciotti","doi":"10.11138/orl/2017.10.3.311","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.311","url":null,"abstract":"<p><strong>Objectives: </strong>To define the possible complications of oral surgery in childhood in patients affected by type 1 Osteogenesis imperfecta (OI) and treated with bisphosphonates (BP).</p><p><strong>Methods: </strong>The study was conducted among 20 patients in childhood with an age range 8-14 (12 ♂ e 8 ♀) affected by OI. Patients were initially evaluated at the Policlinico Umberto I, University Hospital of Rome, Rare Disease Center Skeletal Dysplasia-Bone Metabolic Pathologies and after at the Policlinico Umberto I, University Hospital of Rome, Head and Neck Department, UOC Pediatric Dentistry.</p><p><strong>Results: </strong>From this experience, we showed that a proper patient management from the medical and dental point of view can protect these patients from the risk of post-operative problems, such as onj, soft tissue flogos, intraoral and extraoral fistulas, failure to heal the post-extractive alveolus, infections, post-operative pain and pathological fractures. The follow-up, ranging from a minimum of 2 years to a maximum of 5 years, have not demonstrated the presence of particular complications or healing defects.</p><p><strong>Conclusions: </strong>The clinical experiences observed in these patients are encouraging because no postoperative complications have been observed compared to patients non-affected by OI.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"311-316"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.311","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35694441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-11-30eCollection Date: 2017-07-01DOI: 10.11138/orl/2017.10.3.247
Fed Germano, Fra Germano, M Piro, C Arcuri, L Ottria
{"title":"Clinical protocol with digital cad/cam chairside workflow for the rehabilitation of severely worn dentition patients.","authors":"Fed Germano, Fra Germano, M Piro, C Arcuri, L Ottria","doi":"10.11138/orl/2017.10.3.247","DOIUrl":"https://doi.org/10.11138/orl/2017.10.3.247","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this paper is to investigate the effectiveness and to describe a clinical protocol with digital CAD CAM chairside workflow for the rehabilitation of severely compromised and worn dentitions.</p><p><strong>Methods: </strong>This article reports 4 consecutive cases, where a clinical digital chairside workflow is used for the rehabilitation of severely compromised and worn dentitions. Advantages and limitations of this method compared with the traditional prosthetic protocol are also described and discussed.</p><p><strong>Results: </strong>With all four patients treated with this protocol, we obtained a good aesthetic and functional result, improvement in chewing function, loss of cold sensitivity, better preservation of most of the left hard tissue and a good level of satisfaction. In a two-year follow-up, all patients also maintained the condition obtained with prosthetic chairside rehabilitation, resulting in almost 100% cumulative survival rate.</p><p><strong>Conclusion: </strong>Within the limitations of this study, we can assert that the aforementioned restorative treatment with digital CAD/CAM chairside workflow represents a valid alternative to rehabilitate this kind of patients, because it is a safe, predictable and personalized procedure but also it seems easier, faster and cheaper than traditional protocols.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 3","pages":"247-261"},"PeriodicalIF":0.0,"publicationDate":"2017-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.3.247","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35694437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-09-27eCollection Date: 2017-04-01DOI: 10.11138/orl/2017.10.2.087
P Bollero, L Arcuri, M Miranda, L Ottria, R Franco, A Barlattani
{"title":"Marfan Syndrome: oral implication and management.","authors":"P Bollero, L Arcuri, M Miranda, L Ottria, R Franco, A Barlattani","doi":"10.11138/orl/2017.10.2.087","DOIUrl":"https://doi.org/10.11138/orl/2017.10.2.087","url":null,"abstract":"<p><p>Marfan's Syndrome is a multisistemic pathology of connective tissues, a dominant autosomal transmission, first discovered by a French pediatrician, Antoine Bernard-Jean Marfan, who first found in some of his patients a disproportionate alteration of inferior infertility. This alteration was caused by the mutation of the FBN1 gene, located on the long arm of the chromosome 15, which encodes for an extracellular matrix protein, fibrin-1. Later it was discovered that the disease could occasionally be due also to the mutation of the TGFBR2 gene, which encodes for a TGF-beta receptor 1. The estimated incidence of the disease is 2-3 subjects affected every 10,000, in the absence of predilection ratial, ethnic, geographic and gender. It is believed that some 15,000 people in Italy suffer from Marfan Syndrome. The disease is characterized by a wide range of clinical manifestations that affect different organs. The study evaluates through a literature review the manifestations in the oral cavity of the marfan syndrome and the correct management of the patient during dental maneuvers.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 2","pages":"87-96"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5965063/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36200385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-09-27eCollection Date: 2017-04-01DOI: 10.11138/orl/2017.10.2.197
F Grecchi, A E Bianchi, S Siervo, E Grecchi, D Lauritano, F Carinci
{"title":"A new surgical and technical approach in zygomatic implantology.","authors":"F Grecchi, A E Bianchi, S Siervo, E Grecchi, D Lauritano, F Carinci","doi":"10.11138/orl/2017.10.2.197","DOIUrl":"https://doi.org/10.11138/orl/2017.10.2.197","url":null,"abstract":"<p><strong>Purpose: </strong>Different surgical approaches for zygomatic implantology using new designed implants are reported.</p><p><strong>Material and methods: </strong>The surgical technique is described and two cases reported. The zygomatic fixture has a complete extrasinus path in order to preserve the sinus membrane and to avoid any post-surgical sinus sequelae.</p><p><strong>Results: </strong>The surgical procedure allows an optimal position of the implant and consequently an ideal emergence of the fixture on the alveolar crest.</p><p><strong>Conclusion: </strong>The surgical procedures and the zygomatic implant design reduce remarkably the serious post-operative sequelae due to the intrasinus path of the zygomatic fixtures.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 2","pages":"197-208"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.2.197","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36199779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ORAL and ImplantologyPub Date : 2017-09-27eCollection Date: 2017-04-01DOI: 10.11138/orl/2017.10.2.162
P Bollero, C Danesi, M R Ricchiuti, A Milazzo, G Mampieri, C Agrestini, M Mucedero
{"title":"Long-term periodontal status of palatally and buccally impacted canines after closed surgical-orthodontic approach.","authors":"P Bollero, C Danesi, M R Ricchiuti, A Milazzo, G Mampieri, C Agrestini, M Mucedero","doi":"10.11138/orl/2017.10.2.162","DOIUrl":"https://doi.org/10.11138/orl/2017.10.2.162","url":null,"abstract":"<p><strong>Introduction: </strong>The aim of this study is to evaluate the periodontal status of palatally and buccally impacted canines exposed with closed technique, and to compare them with the controlateral canines that served as control teeth as well as to compare them each other.</p><p><strong>Methods: </strong>28 patients, 14 with unilateral palatally impacted canines and 14 with unilateral buccally impacted canines comprised the subjects of the study. Mean recall observational period was 2 years 4 months ± 1 year 1 month. Closed eruption technique without the tunnel was performed to expose both the palatally and the buccally impacted canines. Six periodontal variables were considered: probing pocket depth (PPD); width of keratinized tissue (KT); gingival thickness (GT); plaque index (PI); gingival bleeding index (GBI); gingival recession (REC).</p><p><strong>Results: </strong>Palatally impacted canines exhibited significant greater PPD on the mesiolingual site compared to their controlaterals (P<0.05). Buccally impacted canines had significant increased KT compared to their contralaterals (P<0.05). Palatally impacted canines had significant greater PPD on the midbuccal site and on all the palatal sites when compared to the buccally impacted canines (P<0.05).</p><p><strong>Conclusion: </strong>The changes observed in the periodontal status of impacted canines, although statistically significant, did not reach clinical significance.</p>","PeriodicalId":38303,"journal":{"name":"ORAL and Implantology","volume":"10 2","pages":"162-171"},"PeriodicalIF":0.0,"publicationDate":"2017-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.11138/orl/2017.10.2.162","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36200284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}