Journal of the American Society of Cytopathology最新文献

{"title":"Identification of Infectious Disease in Thoracic Small Biopsies and Fine-Needle Aspirations","authors":"Luisa Ricaurte Archila MD , Annie Elizabeth Abraham MBBS, MD , Adebowale Adeniran MD , Varsha Manucha MD , Karleen Meiklejohn MD , Valentina Robila MD, PhD , Vanda Torous MD , Christopher VandenBussche MD, PhD , Jennifer Sauter MD , Dianna Ng MD","doi":"10.1016/j.jasc.2025.07.046","DOIUrl":"10.1016/j.jasc.2025.07.046","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages S30-S31"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Hormonal Receptors’ Expression in Fine-Needle Aspiration Biopsy Samples of Breast Adenocarcinoma and correlation with Histology Results","authors":"Simona Miceska PhD, MSc, Anamarija Kuhar MSc, Veronika Kloboves Prevodnik MD, PhD","doi":"10.1016/j.jasc.2025.07.023","DOIUrl":"10.1016/j.jasc.2025.07.023","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Page S19"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Pap Smear Results in Women with Postmenopausal Bleeding and Endometrial Carcinoma: A Retrospective Study","authors":"Syed Abbas MD, Akhila Aravind MBBS, MD, Agha Wajdan Baqir MD, Varsha Manucha MD","doi":"10.1016/j.jasc.2025.07.069","DOIUrl":"10.1016/j.jasc.2025.07.069","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Page S42"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immunoexpression of GATA3 in Renal Neoplasms","authors":"Xiaoqi Lin MD, PhD, Ximing Yang MD, PhD","doi":"10.1016/j.jasc.2025.07.058","DOIUrl":"10.1016/j.jasc.2025.07.058","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Page S37"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NKX3.1 in the Airways: A Diagnostic Trap in Transbronchial FNAs","authors":"Joseph Gillam MD, Güliz Barkan MD, FIAC, FCAP, Phillip McMullen MD, PhD","doi":"10.1016/j.jasc.2025.07.044","DOIUrl":"10.1016/j.jasc.2025.07.044","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages S29-S30"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Retrospective Analysis of Rare Gene Fusions and Mutations Identified by Afirma and Thyroseq Testing, in Thyroid Cytology","authors":"Olabisi Afolayan-Oloye MD, MPH, Maria Gonzalez MD, Israh Akhtar MD, FIAC","doi":"10.1016/j.jasc.2025.07.032","DOIUrl":"10.1016/j.jasc.2025.07.032","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages S23-S24"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Subset of HSIL Paps with Negative Molecular High-Risk HPV Test are Positive for High-Risk HPV by HPV mRNA in Situ Hybridization: A Quality Control Study","authors":"Eleanor Dyer MD, Megan Dibbern MD, Brannan Griffin MD, Michelle Reid MD, Michael Hoskins CT(ASCP), Krisztina Hanley MD","doi":"10.1016/j.jasc.2025.07.112","DOIUrl":"10.1016/j.jasc.2025.07.112","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Page S1"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145100271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal utilization of paucicellular vitreous sample for diagnosis of primary vitreoretinal lymphoma","authors":"Armughan S. Khan MBBS,&nbsp;Anam Khan MD,&nbsp;Zarrin Hossein-Zadeh MD,&nbsp;Lawra Murray CT, MS (ASCP),&nbsp;Karen Chau MBA, CT(ASCP),&nbsp;Atif Khan MD,&nbsp;Xinmin Zhang MD,&nbsp;Rubina S. Cocker MD","doi":"10.1016/j.jasc.2025.05.006","DOIUrl":"10.1016/j.jasc.2025.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Primary vitreoretinal lymphoma (PVRL) is a rare, aggressive, and intraocular non-Hodgkin lymphoma, typically manifesting as diffuse large B-cell lymphoma (95%). Vitreous fluid cytology is the gold standard for diagnosis; however, its utility is limited by poor preservation and low cellularity. Recent studies indicate that myeloid differentation primary response protein 88 (MYD88) mutation analysis is more sensitive and accurate on low-cellularity or poorly preserved samples. The incidence of PVRL has reportedly tripled with an annual average of ∼50 cases in the United States. Delayed diagnosis can lead to mortality within 2 years, underscoring the need for improved diagnostic methods.</div></div><div><h3>Materials and methods</h3><div>We conducted a 5-year retrospective study of vitreous samples from 3 tertiary centers. A cytopathologist and a hematopathologist reviewed the samples and classified them as “negative,” “atypical,” or “positive.” Whole slide imaging (WSI) was incorporated to quantify atypical lymphocytes using an arbitrary cutoff (≥25% considered positive; &lt;25% considered atypical) and to document necrosis and apoptosis<span>. Ancillary tests included flow cytometry, immunohistochemistry (IHC), and MYD88 mutation analysis.</span></div></div><div><h3>Results</h3><div>Of the 226 samples, 214 were diagnosed as negative, 6 as atypical, and 6 as positive. WSI enhanced the diagnosis by precisely quantifying atypical lymphocytes. Flow cytometry was conclusive in 2 of 8 cases, IHC in 7 of 8, and MYD88 analysis in 4 of 5 cases.</div></div><div><h3>Conclusions</h3><div>While cytology remains the gold standard, a combination of WSI, targeted IHC, and MYD88 analysis enhances diagnostic precision in paucicellular samples. Flow cytometry should be reserved for cases with high cellularity and strong clinical suspicion.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages 317-326"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144498275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimizing cytology and small biopsy specimen processing for ancillary studies: recommendations from the American Society of Cytopathology taskforce","authors":"Sinchita Roy-Chowdhuri MD, PhD ,&nbsp;Christine N. Booth MD ,&nbsp;Jonas J. Heymann MD ,&nbsp;Elizabeth Jenkins MS ,&nbsp;Joshua R. Menke MD ,&nbsp;Sara E. Monaco MD ,&nbsp;Ritu Nayar MD ,&nbsp;Michiya Nishino MD, PhD ,&nbsp;Roberto Ruiz-Cordero MD ,&nbsp;Donna K. Russell MEd, CT (ASCP) ,&nbsp;Anjali Saqi MD, MBA ,&nbsp;Kaitlin E. Sundling MD, PhD ,&nbsp;Michael J. Thrall MD ,&nbsp;Vanda F. Torous MD ,&nbsp;Christopher J. VandenBussche MD, PhD ,&nbsp;M. Lisa Zhang MD ,&nbsp;Momin T. Siddiqui MD ,&nbsp;Paul A. VanderLaan MD, PhD","doi":"10.1016/j.jasc.2025.06.002","DOIUrl":"10.1016/j.jasc.2025.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Clinically acquired cytopathology and small biopsy specimens provide essential diagnostic and predictive biomarker information that underlies precision medicine and patient care decisions. Biomarker testing using immunochemistry, in situ hybridization, and molecular analysis is routinely used to inform therapeutic decisions and monitor therapy. Cytopathology and small biopsy specimen collection, handling, and processing vary across different practices and are frequently determined by individual laboratory preference. Thus, clinical specimens are subject to different preanalytical variables that can impact downstream nucleic acid quality and protein antigenicity, compromising the reliability of the ancillary testing results.</div></div><div><h3>Materials and methods</h3><div>Based on a recent survey by the American Society of Cytopathology there is wide variation in current practices for specimen collection and processing, reflecting a lack of consensus and standardization among cytopathology laboratories. To address this need, the American Society of Cytopathology established a special task force comprising 18 members with expertise and/or interest in ancillary studies in cytopathology and small biopsy specimens.</div></div><div><h3>Results</h3><div>The task force conducted a survey of existing practices in cytopathology laboratories. A scoping review was performed to identify published literature for relevant evidence focusing on specific areas of interest. The existing literature on preanalytical variables in small specimens and their impact on ancillary studies were reviewed and data were compiled to draft best practice recommendations.</div></div><div><h3>Conclusions</h3><div>The task force has developed these evidence-based best practice recommendations for optimizing and standardizing preanalytical variables in small specimens to ensure quality and reliability of ancillary studies.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages 285-308"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144776418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Paris Study: Multicenter Retrospective Analysis of Artificial Intelligence-Quantified Nuclear-to-Cytoplasmic Ratios and Nuclear Areas in Confirmed Bladder Cancer Urine Cytology Specimens","authors":"Lisa Zhang MD ,&nbsp;Jen-Fan Hang MD ,&nbsp;Poonam Vohra MD ,&nbsp;Derek Allison MD ,&nbsp;Madelyn Lew MD ,&nbsp;Cheng-Hung Yeh MS ,&nbsp;Shih-Wen Hsu MS ,&nbsp;Yi-Siou Liu MS ,&nbsp;Guowei Shao MS ,&nbsp;Wei-Lei Yang PhD ,&nbsp;Tien-Jen Liu MD ,&nbsp;Barbara Crothers DO ,&nbsp;Christopher VandenBussche MD, PhD","doi":"10.1016/j.jasc.2025.07.123","DOIUrl":"10.1016/j.jasc.2025.07.123","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"14 5","pages":"Pages S7-S8"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}