Journal of the American Society of Cytopathology最新文献_第6页

Erratum regarding missing informed consent disclosure statements in previously published articles 关于以前发表的文章中知情同意披露声明缺失的勘误。

Journal of the American Society of Cytopathology Pub Date : 2024-11-01 DOI: 10.1016/j.jasc.2024.09.002

引用次数: 0

Evolving concepts in thyroid cytology 甲状腺细胞学概念的演变。

Journal of the American Society of Cytopathology Pub Date : 2024-11-01 DOI: 10.1016/j.jasc.2024.08.127

N. Paul Ohori MD

{"title":"Evolving concepts in thyroid cytology","authors":"N. Paul Ohori MD","doi":"10.1016/j.jasc.2024.08.127","DOIUrl":"10.1016/j.jasc.2024.08.127","url":null,"abstract":"<div><div>Concepts in thyroid diagnostics are evolving. As cytopathologists, we benefit from understanding the changes taking place in cytopathology practice as well as intersecting areas that may have implications for us. In this review, we discuss recent changes to 1. Classification systems, 2. Ancillary molecular testing modalities, and 3. Key metrics that affect thyroid cytopathology. The recent World Health Organization, Bethesda Thyroid Cytopathology, and American Joint Committee on Cancer classification systems have aspects that are designed to harmonize the clinical, cytopathologic, histomorphologic, and molecular findings for improved communication and patient management. New terminologies such as thyroid follicular nodular disease and low-risk follicular cell-derived thyroid neoplasms are introduced to reflect the subtle biologic nuances involving benign non-neoplastic and low-grade neoplastic conditions. The Bethesda Thyroid Cytopathology System has simplified its terminology, updated risk of malignancy estimates, and expanded the discussions on molecular testing, clinical and imaging assessments, and pediatric cytopathology. There is now a single term for each of the 6 diagnostic categories. The American Joint Committee on Cancer has refined the staging criteria to provide improved stratification of patient prognostication. Molecular testing using next-generation technology now offers large panels of markers that are sensitive for detecting the wide range of thyroid neoplasms. These panels were developed in North America and whether other regions of the world will choose similar tests remain to be seen. Finally, metrics such as molecular-derived risk of malignancy and molecular risk group may be viewed as surrogates of resection information and used to complement diagnostics, management, and quality assurance.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 389-396"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Telecytology versus conventional rapid on-site evaluation for endobronchial ultrasound-guided fine needle aspiration: a single institution’s experience 支气管内超声引导下细针穿刺的远程细胞学与传统现场快速评估：一家医疗机构的经验。

Journal of the American Society of Cytopathology Pub Date : 2024-11-01 DOI: 10.1016/j.jasc.2024.08.128

Xiaobing Jin MD , Xin Jing MD , Liron Pantanowitz MD, MHA , Brian S. Smola BS , Madelyn Lew MD

{"title":"Telecytology versus conventional rapid on-site evaluation for endobronchial ultrasound-guided fine needle aspiration: a single institution’s experience","authors":"Xiaobing Jin MD , Xin Jing MD , Liron Pantanowitz MD, MHA , Brian S. Smola BS , Madelyn Lew MD","doi":"10.1016/j.jasc.2024.08.128","DOIUrl":"10.1016/j.jasc.2024.08.128","url":null,"abstract":"<div><h3>Introduction</h3><div>Telecytology (TC) has the advantage of allowing cytopathologists to remotely support multiple sites rapid on-site evaluation (ROSE) concurrently and represents a potential solution for an increased clinical demand for ROSE. In this study, we share our comparative experience of using TC versus conventional (in-person) ROSE for endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA).</div></div><div><h3>Materials and methods</h3><div>We evaluated 475 consecutive cases of EBUS-FNA that underwent TC-ROSE from May 2020 to August 2021 along with 475 consecutive cases which had conventional ROSE from November 2019 to August 2021 at the University of Michigan. Concordant rates of preliminary and final diagnoses were calculated and compared between TC and conventional methods.</div></div><div><h3>Results</h3><div>While there was no significant difference in preliminary diagnostic rates of nondiagnostic, benign, atypical, and malignant categories between the TC and conventional cohorts, a significantly lower proportion of TC cases received a preliminary suspicious for malignancy diagnosis (2%) compared to the conventional group (4%) (<em>P</em> = 0.03). The concordance rate of preliminary and final diagnoses in TC and conventional ROSE was 96% and 94%, respectively. The average total number of passes per procedure did not differ significantly between TC and conventional ROSE (4.9 versus 4.7). While a relatively higher number of TC-ROSE cases collected dedicated passes compared with conventional ROSE (49% versus 40%), the difference was not statistically significant.</div></div><div><h3>Conclusions</h3><div>The performance of TC-ROSE for EBUS-FNA is comparable to that of conventional ROSE with similar performance metrics and therefore can be used as a feasible substitute.</div></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 6","pages":"Pages 431-437"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142297547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The present & future of cytopathology practice: A series of articles spanning clinical guidelines, classification schemes, and ancillary tests 细胞病理学实践的现状与未来：涵盖临床指南、分类方案和辅助检验的系列文章。

Journal of the American Society of Cytopathology Pub Date : 2024-11-01 DOI: 10.1016/j.jasc.2024.08.001

Madelyn Lew MD

引用次数: 0

Supernatant fluid from endobronchial ultrasound-guided transbronchial needle aspiration for rapid next-generation sequencing 用于下一代快速测序的支气管内超声引导下经支气管针吸出液上清液

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.04.007

{"title":"Supernatant fluid from endobronchial ultrasound-guided transbronchial needle aspiration for rapid next-generation sequencing","authors":"","doi":"10.1016/j.jasc.2024.04.007","DOIUrl":"10.1016/j.jasc.2024.04.007","url":null,"abstract":"<div><h3>Introduction</h3><p>There is an increasing demand to optimize the workflow and maximize tissue available for next-generation sequencing (NGS) for non-small cell carcinoma. We looked at transbronchial needle endobronchial ultrasound-guided bronchoscopy<span> with transbronchial needle aspiration samples and evaluated the performance of supernatant (SN) fluid processed from a dedicated aspirate collected for NGS testing.</span></p></div><div><h3>Materials and methods</h3><p>Nineteen samples were collected and processed using a new workflow. Five aspirates were collected in formalin. One additional dedicated pass was collected fresh and centrifuged. The resulting cell pellet was added to formalin for cell block (CB) processing. DNA and RNA were extracted from concentrated SN for targeted testing using the Oncomine Precision Assay (Thermo Scientific, Waltham, MA). NGS results from the corresponding CB samples were used as “controls” for comparison.</p></div><div><h3>Results</h3><p>Thirty-one mutations were detected in SN (Table 1). The most frequently mutated genes were <em>TP53</em> (35%), <em>EGFR</em> (23%), <em>KRAS</em> (13%), <em>CTNNB1</em> (6%), and <em>ERBB2</em> (6%). There was 100% concordance between the mutations detected in SN and corresponding CBs with comparable variant allele frequencies. Turnaround time of NGS results was 1 day for SN compared to 4-10 days for CB.</p></div><div><h3>Conclusions</h3><p>We were able to demonstrate the usefulness of SN for reliable rapid molecular results. We successfully incorporated the workflow for tissue handling and processing among our clinical, cytopathology<span>, and molecular teams. Molecular results were available at the same time as the cytologic diagnosis, allowing for timely reporting of a comprehensive diagnosis. This approach is particularly useful in patients with advanced disease requiring urgent management.</span></p></div>","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"13 5","pages":"Pages 340-345"},"PeriodicalIF":0.0,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the Efficacy of an Artificial Intelligence Model for Fungal Screening in Bronchoalveolar Lavage Cytology Specimens 探索人工智能模型在支气管肺泡灌洗液细胞学标本中进行真菌筛查的有效性

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.08.004

Robert Post DO, Alaa S. Hrizat MD, Allison Goldberg MD

引用次数: 0

Thyroid Fine Needle Aspiration Cytology with Histologic Correlation and Risk of Malignancy for Bethesda Categories: An Institutional Retrospective Review 甲状腺细针抽吸细胞学与贝塞斯达分类的组织学相关性和恶性风险：机构回顾性研究

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.08.073

Maria Beeter MD, Renee Eng MD, John Rogers MD, Vijayalakshmi Padmanabhan MBBS, MD, MPH, Michael Thrall MD, Dina Mody MD, Paul Christensen MD, Elizabeth Jacobi MD

引用次数: 0

A Quality Improvement Study to Evaluate Discordance Rates of Low-Grade Squamous Intraepithelial Lesion on Cervical Pap Smears with Histopathologic Correlation 评估宫颈巴氏涂片低度鳞状上皮内病变与组织病理学相关性不一致率的质量改进研究

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.08.058

Abhinav Grover MBBS, MD, MS, Rebecca Czaja MD, MPH, Carl Dernell MD, Tamar Giorgadze MD, PhD, Juan Felix MD, Laila Nomani MD, Bryan Hunt MD

引用次数: 0

Milan System Salivary Gland Neoplasm of Uncertain Malignant Potential: Males and 30–69-year-olds have the Highest Risk of Malignancy 恶性可能性不确定的米兰系统唾液腺肿瘤：男性和 30-69 岁的人患恶性肿瘤的风险最高

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.08.064

Henri Lagerstam BMed , Erkka Tommola MD , David Kalfert MD , Saara Kares MSc , Ivana Kholova MD, PhD, MIAC

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A Novel Technique for the Preparation of Formalin Fixed Paraffin Embedded Surgical and Cell Block Specimens, is Proven to be Effective for HPV Testing 制备福尔马林固定石蜡包埋手术和细胞块标本的新技术已被证明可有效用于人乳头瘤病毒检测

Journal of the American Society of Cytopathology Pub Date : 2024-09-01 DOI: 10.1016/j.jasc.2024.08.066

Jennifer Kernodle-Zimmer SCT(ASCP)CT(IAC), Eirinn Kelley SCT(ASCP), Marcia Carvin CT(ASCP), Jason Tseng CT(ASCP), Melissa Randolph SCT(ASCP)cm

引用次数: 0