Journal of the American Society of Cytopathology最新文献

{"title":"Artificial Intelligence-Assisted Interpretation of Cervical Carcinoma in ThinPrep Pap Tests: A Descriptive Study","authors":"John Grove, Samer Khader MD, FIAC, Esther Elishaev MD, Liron Pantanowitz MD, PhD, MHA, Lakshmi Harinath MD, MPH","doi":"10.1016/j.jasc.2026.08.013","DOIUrl":"10.1016/j.jasc.2026.08.013","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S14"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149011091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In reply: Role of ancillary techniques in the WHO classification of lymph node fine-needle cytology by Maffei et al","authors":"Kajsa Ericson Lindquist MD, PhD, Mats Ehinger MD, PhD","doi":"10.1016/j.jasc.2026.04.008","DOIUrl":"10.1016/j.jasc.2026.04.008","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages 387-388"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of ancillary techniques in the WHO classification of lymph node fine-needle cytology","authors":"Elisabetta Maffei MD, Riccardo Ruotolo MD, Pio Zeppa MD, PhD, Alessandro Caputo MD","doi":"10.1016/j.jasc.2026.04.007","DOIUrl":"10.1016/j.jasc.2026.04.007","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages 385-386"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148057436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Hologic Genius Digital Diagnostics System for clinical use in Papanicolaou test interpretation: a validation study of 1748 cases","authors":"Dawn L. Underwood M.Ed, CT(ASCP), Rema (Rao) Chaari MD, Sydnee Webb CT(ASCP), Christine N. Booth MD, Erika E. Doxtader MD","doi":"10.1016/j.jasc.2026.05.004","DOIUrl":"10.1016/j.jasc.2026.05.004","url":null,"abstract":"<div><ul><li><span>•</span><span><div>Papanicolaou test interpretation using the GDDS is highly concordant with the TIS.</div></span></li><li><span>•</span><span><div>In our study, the concordance rate exceeded the 95% threshold recommended for clinical validation.</div></span></li><li><span>•</span><span><div>Most discordances stemmed from the GDDS quantifying cellularity in borderline adequate cases.</div></span></li></ul></div><div><h3>Introduction</h3><div>The integration of digital whole slide imaging and artificial intelligence is poised to transform cytopathology practice. Our aim was to validate the Hologic Genius Digital Diagnostics System (GDDS) for clinical use in Papanicolaou (Pap) test interpretation by comparing digital interpretations using the GDDS to computer-assisted interpretations using the ThinPrep Imaging System (TIS).</div></div><div>The integration of digital whole slide imaging and artificial intelligence is poised to transform cytopathology practice. Our aim was to validate the Hologic Genius Digital Diagnostics System (GDDS) for clinical use in Papanicolaou (Pap) test interpretation by comparing digital interpretations using the GDDS to computer-assisted interpretations using the ThinPrep Imaging System (TIS).</div><div><h3>Materials and methods</h3><div>The study set consisted of 1748 Pap tests, including 53 unsatisfactory for evaluation cases, 1450 negative for intraepithelial lesion or malignancy (NILM) cases, and 245 atypical squamous cells of undetermined significance or worse cases. Each Pap test was reviewed either retrospectively or prospectively by one of 29 cytologists, and results of review on the GDDS were compared to review on the TIS for concordance. Cases requiring hierarchical review were reviewed by one of 23 pathologists. Concordance was calculated between each method. Diagnostic concordance of 95% was required for validation.</div></div><div>The study set consisted of 1748 Pap tests, including 53 unsatisfactory for evaluation cases, 1450 negative for intraepithelial lesion or malignancy (NILM) cases, and 245 atypical squamous cells of undetermined significance or worse cases. Each Pap test was reviewed either retrospectively or prospectively by one of 29 cytologists, and results of review on the GDDS were compared to review on the TIS for concordance. Cases requiring hierarchical review were reviewed by one of 23 pathologists. Concordance was calculated between each method. Diagnostic concordance of 95% was required for validation.</div><div><h3>Results</h3><div>The GDDS interpretation was concordant with the TIS interpretation in 1722/1748 cases (98.5%). Of the 26 discordant cases, most (20) were discordances between unsatisfactory and NILM, while 5 were attributed to interpretation error, and one was a low-cellularity low-grade squamous intraepithelial lesion containing rare diagnostic cells in the GDDS tiles that was originally interpreted as NILM on the TIS.</div></div><div>The GDDS interpretation","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages 378-384"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148272613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cytologic Characteristics of Pap Smears with Follow-Up Diagnosis of Endocervical Adenocarcinoma and Adenocarcinoma in-situ","authors":"Harsimar Kaur MD, Rita Abi-Raad MD","doi":"10.1016/j.jasc.2026.08.083","DOIUrl":"10.1016/j.jasc.2026.08.083","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S45"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HPV-Negative High-Grade Squamous Intraepithelial Lesion/Neoplasm (CIN2 or Higher): Frequency and Cytologic Features","authors":"Muhammad Moseeb Ali Hashim MD, James Dawson DO, Wedad Alfarkh MD","doi":"10.1016/j.jasc.2026.08.026","DOIUrl":"10.1016/j.jasc.2026.08.026","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Page S7"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of AI-Assisted Screening in Pulmonary ROSE: Impact on Screening Time and Agreement with Pathology Assessment","authors":"Joanna Danczuk CT(ASCP), Guliz Barkan MD, FIAC, FCAP, Victor J. Carlo-Chevere MD, FCAP, ECNU, FIAC, Mark Costaldi MD, MS, Mariam Fouad CT(ASCP), Akshath Hariharan BS, Hariharan Subramanian PhD, MBA, Taylor Dean MS","doi":"10.1016/j.jasc.2026.08.034","DOIUrl":"10.1016/j.jasc.2026.08.034","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S17-S18"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-Definitive Cervical Cytology and Subsequent Surgical Specimens: Diagnostic Challenges and the Use of Immunohistochemistry in the time of CINtec PLUS","authors":"Violet Quann DO, Joanna Chan MD, Allison Goldberg MD","doi":"10.1016/j.jasc.2026.08.086","DOIUrl":"10.1016/j.jasc.2026.08.086","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S46-S47"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discordance Between Cytopathologist ROSE Interpretation and Endoscopist Documentation in Pancreatic EUS-FNA","authors":"Nathalie Andon SCT, Ivan Chebib MD","doi":"10.1016/j.jasc.2026.08.053","DOIUrl":"10.1016/j.jasc.2026.08.053","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S29-S30"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Fine Needle Aspiration in Breast Cancer: A Comparative Analysis of Primary Neoplasms and Synchronous Lymph Node Involvement","authors":"Eduardo Alcaraz-Mateos MD, PhD, MIAC, Carlos Alcolea-Guardiola HT, Fuensanta Caballero-Aleman RN, Lidia Cano-Bermudez HT, Jose Ignacio Gil-Izquierdo MD, Javier Lopez-Robles MD, Nicolas Sanchez-Campoy HT, Andres Nieto-Olivares MD","doi":"10.1016/j.jasc.2026.08.062","DOIUrl":"10.1016/j.jasc.2026.08.062","url":null,"abstract":"","PeriodicalId":38262,"journal":{"name":"Journal of the American Society of Cytopathology","volume":"15 5","pages":"Pages S34-S35"},"PeriodicalIF":2.7,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149010938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}