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The EuPA Bioinformatics Community (EuBIC) initiative EuPA生物信息学共同体(EuBIC)倡议
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.009
Marc Vaudel
{"title":"The EuPA Bioinformatics Community (EuBIC) initiative","authors":"Marc Vaudel","doi":"10.1016/j.euprot.2016.03.009","DOIUrl":"10.1016/j.euprot.2016.03.009","url":null,"abstract":"","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Page 34"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54257709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Creation of the EuPA Young Proteomics Investigators Club, YPIC EuPA青年蛋白质组学研究俱乐部(YPIC)成立
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.008
Odile Burlet-Schiltz (coordinator of the YPIC initiative), Fernando Corrales (coordinator of the Communication and Conference Committee), Andrea Urbani (President of EuPA)
{"title":"Creation of the EuPA Young Proteomics Investigators Club, YPIC","authors":"Odile Burlet-Schiltz (coordinator of the YPIC initiative), Fernando Corrales (coordinator of the Communication and Conference Committee), Andrea Urbani (President of EuPA)","doi":"10.1016/j.euprot.2016.03.008","DOIUrl":"10.1016/j.euprot.2016.03.008","url":null,"abstract":"","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Page 33"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54257691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bioscope Group Hands-on Courses on Nano-based Proteomics Bioscope集团纳米蛋白质组学实践课程
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.014
H.M. Santos, C. Lodeiro, E. Oliveira, J.L. Capelo
{"title":"Bioscope Group Hands-on Courses on Nano-based Proteomics","authors":"H.M. Santos, C. Lodeiro, E. Oliveira, J.L. Capelo","doi":"10.1016/j.euprot.2016.03.014","DOIUrl":"10.1016/j.euprot.2016.03.014","url":null,"abstract":"","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Page 41"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.014","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54257767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Message from the President 总统寄语
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.005
Andrea Urbani (President European Proteomics Association, President, IT), The EuPA Executive Committee (EC), Andrea Urbani (President, IT), Emøke Bendixen (Vice-President, DK), Karl Mechtler (Education Committee, AU), Albert Sickmann (Funding, DE), Andy Pitt (Journals, UK), Andrey Lisitsa (EuPA Initiatives, RU), Fernando Corrales (Communication and Conferences, ES)
{"title":"Message from the President","authors":"Andrea Urbani (President European Proteomics Association, President, IT), The EuPA Executive Committee (EC), Andrea Urbani (President, IT), Emøke Bendixen (Vice-President, DK), Karl Mechtler (Education Committee, AU), Albert Sickmann (Funding, DE), Andy Pitt (Journals, UK), Andrey Lisitsa (EuPA Initiatives, RU), Fernando Corrales (Communication and Conferences, ES)","doi":"10.1016/j.euprot.2016.03.005","DOIUrl":"https://doi.org/10.1016/j.euprot.2016.03.005","url":null,"abstract":"","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Pages 28-29"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136522061","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The EuPA2015 Congress. Proteomics: Back to the Future 2015年欧盟大会。蛋白质组学:回到未来
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.011
Paola Roncada , Andrea Urbani , Concha Gil
{"title":"The EuPA2015 Congress. Proteomics: Back to the Future","authors":"Paola Roncada , Andrea Urbani , Concha Gil","doi":"10.1016/j.euprot.2016.03.011","DOIUrl":"10.1016/j.euprot.2016.03.011","url":null,"abstract":"","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Page 36"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.011","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"54257732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages 蛋白转化酶1/3抑制巨噬细胞:一种基于无人机巨噬细胞的新型治疗方法
EuPA Open Proteomics Pub Date : 2016-06-01 DOI: 10.1016/j.euprot.2016.03.003
Marie Duhamel , Franck Rodet , Adriana Murgoci , Maxence Wisztorski , Robert Day , Isabelle Fournier , Michel Salzet
{"title":"Proprotein convertase 1/3 inhibited macrophages: A novel therapeutic based on drone macrophages","authors":"Marie Duhamel ,&nbsp;Franck Rodet ,&nbsp;Adriana Murgoci ,&nbsp;Maxence Wisztorski ,&nbsp;Robert Day ,&nbsp;Isabelle Fournier ,&nbsp;Michel Salzet","doi":"10.1016/j.euprot.2016.03.003","DOIUrl":"10.1016/j.euprot.2016.03.003","url":null,"abstract":"<div><p>We demonstrated here thanks to proteomic, that proprotein convertase 1/3 knockdown macrophages present all the characteristic of activated pro-inflammatory macrophages. TLR4 and TLR9 signaling pathways can be enhanced leading to the secretion of pro-inflammatory factors and antitumor factors. We can control their activation by controlling one enzyme, PC1/3. In a tumor context, PC1/3 inhibition in macrophages may reactivate them and lead to a cytokine storm after stimulation “at distance” with a TLR ligand. Therefore, we name these proprotein convertase inhibited macrophages the “drone macrophages”. They constitute an innovative cell therapy to treat efficiently tumors.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"11 ","pages":"Pages 20-22"},"PeriodicalIF":0.0,"publicationDate":"2016-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.03.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36220634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics 将上皮间充质转化标记转化为临床:蛋白质组学的新见解
EuPA Open Proteomics Pub Date : 2016-03-01 DOI: 10.1016/j.euprot.2016.01.003
Daniele Vergara , Pasquale Simeone , Julien Franck , Marco Trerotola , Anna Giudetti , Loredana Capobianco , Andrea Tinelli , Claudia Bellomo , Isabelle Fournier , Antonio Gaballo , Saverio Alberti , Michel Salzet , Michele Maffia
{"title":"Translating epithelial mesenchymal transition markers into the clinic: Novel insights from proteomics","authors":"Daniele Vergara ,&nbsp;Pasquale Simeone ,&nbsp;Julien Franck ,&nbsp;Marco Trerotola ,&nbsp;Anna Giudetti ,&nbsp;Loredana Capobianco ,&nbsp;Andrea Tinelli ,&nbsp;Claudia Bellomo ,&nbsp;Isabelle Fournier ,&nbsp;Antonio Gaballo ,&nbsp;Saverio Alberti ,&nbsp;Michel Salzet ,&nbsp;Michele Maffia","doi":"10.1016/j.euprot.2016.01.003","DOIUrl":"10.1016/j.euprot.2016.01.003","url":null,"abstract":"<div><p>The growing understanding of the molecular mechanisms underlying epithelial-to-mesenchymal transition (EMT) may represent a potential source of clinical markers. Despite EMT drivers have not yet emerged as candidate markers in the clinical setting, their association with established clinical markers may improve their specificity and sensitivity. Mass spectrometry-based platforms allow analyzing multiple samples for the expression of EMT candidate markers, and may help to diagnose diseases or monitor treatment efficiently. This review highlights proteomic approaches applied to elucidate the differences between epithelial and mesenchymal tumors and describes how these can be used for target discovery and validation.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"10 ","pages":"Pages 31-41"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.01.003","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36221186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 45
The identification of FERM domain protein in serum infected with Plasmodium berghei 伯氏疟原虫感染血清中FERM结构域蛋白的鉴定
EuPA Open Proteomics Pub Date : 2016-03-01 DOI: 10.1016/j.euprot.2016.01.008
Vathsala P.G., Krishna Murthy P.
{"title":"The identification of FERM domain protein in serum infected with Plasmodium berghei","authors":"Vathsala P.G.,&nbsp;Krishna Murthy P.","doi":"10.1016/j.euprot.2016.01.008","DOIUrl":"10.1016/j.euprot.2016.01.008","url":null,"abstract":"<div><p>Malaria continues to affect 500 million people worldwide every year. In this study, we compared the protein profile of uninfected and <em>Plasmodium berghei</em>-infected serum samples by one dimensional SDS-PAGE analysis, MALDI-TOF/TOF mass spectrometry and confirmed by semi-quantitative RT-PCR. Also the protein interacting networks were established using STRING protein⿿protein interaction analysis. We observed for the first time the upregulation of FERM domain during <em>P. berghei</em> infection. We predict that FRMD5 along with the other protein partners (identified by STRING analysis) are involved in the merozoites entry or protein trafficking where cell to cell interaction happens with the host erythrocyte; hence, upregulation.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"10 ","pages":"Pages 59-62"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.01.008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36220628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)9 cell-penetrating peptide EWS-FLI1表达细胞EF与NIH-3T3的蛋白质组学比较及(R/W)9细胞穿透肽的肌动蛋白重塑作用
EuPA Open Proteomics Pub Date : 2016-03-01 DOI: 10.1016/j.euprot.2015.10.002
Séverine Clavier , Françoise Illien , Sandrine Sagan , Gérard Bolbach , Emmanuelle Sachon
{"title":"Proteomic comparison of the EWS-FLI1 expressing cells EF with NIH-3T3 and actin remodeling effect of (R/W)9 cell-penetrating peptide","authors":"Séverine Clavier ,&nbsp;Françoise Illien ,&nbsp;Sandrine Sagan ,&nbsp;Gérard Bolbach ,&nbsp;Emmanuelle Sachon","doi":"10.1016/j.euprot.2015.10.002","DOIUrl":"10.1016/j.euprot.2015.10.002","url":null,"abstract":"<div><p>EWS-FLI1 expression in NIH-3T3 fibroblasts has a profound impact on the phenotype, resulting in the cytoskeleton and adhesive capacity disorganization (EF cells). Besides this, (R/W)<sub>9</sub>, a cell-penetrating peptide (CPP), has an intrinsic actin remodeling activity in EF cells. To evaluate the impact of the oncogenic protein EWS-FLI1 on proteins expression levels, a quantitative comparison of tumoral EF and non-tumoral 3T3 proteomes was performed. Then to see if we could link the EWS-FLI1 oncogenic transformation to the phenotype reversion induced by (R/W)<sub>9</sub>, (R/W)<sub>9</sub> influence on EF cells proteome was assessed. To our knowledge no such ⿿CPPomic⿿ study has been performed before.</p></div><div><h3>Biological significance</h3><p>Up to now very few global quantitative proteomic studies have been published to help understand the oncogenic transformation induced by EWS-FLI1 fusion protein and leading to Ewing sarcoma development and dissemination. The comparison we did in this study between a model tumoral cell line EF and its non-tumoral counterpart (3T3) allowed us to highlight several features either common to most tumor types or specific to Ewing sarcoma. Particularly, lack of actin cytoskeleton organization could very likely be explained by the down-regulation of many important actin binding proteins. These results are in accordance with the hypothesis of a passive/stochastic mode of dissemination conferring Ewing sarcoma tumoral cell a high metastatic potential.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"10 ","pages":"Pages 1-8"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2015.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36221292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Lysine acetylation of major Chlamydia trachomatis antigens 沙眼衣原体主要抗原赖氨酸乙酰化
EuPA Open Proteomics Pub Date : 2016-03-01 DOI: 10.1016/j.euprot.2016.01.007
Jelena Mihailovic , Aleksandra Inic-Kanada , Katarina Smiljanic , Elisabeth Stein , Talin Barisani-Asenbauer , Tanja Cirkovic Velickovic
{"title":"Lysine acetylation of major Chlamydia trachomatis antigens","authors":"Jelena Mihailovic ,&nbsp;Aleksandra Inic-Kanada ,&nbsp;Katarina Smiljanic ,&nbsp;Elisabeth Stein ,&nbsp;Talin Barisani-Asenbauer ,&nbsp;Tanja Cirkovic Velickovic","doi":"10.1016/j.euprot.2016.01.007","DOIUrl":"10.1016/j.euprot.2016.01.007","url":null,"abstract":"<div><p><em>Chlamydia trachomatis</em> (Ct) is a human pathogen causing trachoma and infertility. We investigated acetylation at lysine residues of chlamydial antigenic proteins: major outer membrane protein (MOMP), 60<!--> <!-->kDa chaperonin (chlamydial Hsp60), elongation factor G (EF-G), enolase and the polymorphic membrane proteins PmpB, PmpE and PmpF. 60<!--> <!-->kDa chaperonin, EF-G and PmpB showed the highest degree of acetylation.</p><p>Our data show that important Ct antigens could be post-translationally modified by acetylation of lysine residues at multiple sites. Further studies are needed to investigate total acetylome of Ct and the impact PTMs might have on Ct biology and pathogenicity.</p></div>","PeriodicalId":38260,"journal":{"name":"EuPA Open Proteomics","volume":"10 ","pages":"Pages 63-69"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.euprot.2016.01.007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36220629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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