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A perivascular epithelioid cell neoplasm of the bladder diagnosed after six years: A case report 膀胱血管周围上皮样细胞瘤6年后诊断：1例报告
IF 0.4
Urology Case Reports Pub Date : 2025-10-01 DOI: 10.1016/j.eucr.2025.103228
Ji-yao Yang, Xiao-rong Yang, Wei-xiang Hei, Yi-dao Liu
{"title":"A perivascular epithelioid cell neoplasm of the bladder diagnosed after six years: A case report","authors":"Ji-yao Yang,&nbsp;Xiao-rong Yang,&nbsp;Wei-xiang Hei,&nbsp;Yi-dao Liu","doi":"10.1016/j.eucr.2025.103228","DOIUrl":"10.1016/j.eucr.2025.103228","url":null,"abstract":"<div><div>Perivascular epithelioid cell neoplasm (PEComa) is a rare mesenchymal-derived tumor with specific histological and immunohistochemical manifestations. Given the rarity of bladder PEComa, standardized diagnostic and therapeutic protocols have yet to be established. This article presents a case of bladder PEComa that was ultimately diagnosed after a six-year delay and reviews recent studies to improve clinicians' understanding of this tumor and minimize the risk of misdiagnosis.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103228"},"PeriodicalIF":0.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Benign Leydig cell tumor presenting in a solitary testis with cryptorchidism: A case report 良性睾丸间质细胞肿瘤伴隐睾：1例报告
IF 0.4
Urology Case Reports Pub Date : 2025-10-01 DOI: 10.1016/j.eucr.2025.103232
Farzad Allameh , Sina Samenezhad , Lena Yaghoubpour , Amirhossein ghasemzade
{"title":"Benign Leydig cell tumor presenting in a solitary testis with cryptorchidism: A case report","authors":"Farzad Allameh ,&nbsp;Sina Samenezhad ,&nbsp;Lena Yaghoubpour ,&nbsp;Amirhossein ghasemzade","doi":"10.1016/j.eucr.2025.103232","DOIUrl":"10.1016/j.eucr.2025.103232","url":null,"abstract":"<div><div>Leydig cell tumors (LCTs) are uncommon testicular neoplasms, accounting for 1–3 % of cases. While most are benign, a small subset demonstrates malignant potential, making accurate diagnosis and tailored management essential. We report the case of a 52-year-old man with a history of cryptorchidism and prior orchiectomy who presented with inguinal pain and infertility. Imaging revealed a solitary testis with a small intratesticular lesion. Intraoperative frozen section suggested a Leydig cell tumor, and partial orchiectomy was performed. Final pathology confirmed a benign LCT. The patient remains recurrence-free at follow-up, highlighting the role of testis-sparing surgery in selected cases.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103232"},"PeriodicalIF":0.4,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pembrolizumab-induced myasthenia gravis: A rare immune-related adverse event in a patient treated for bladder cancer pembrolizumab诱导的重症肌无力：膀胱癌患者治疗中一种罕见的免疫相关不良事件
IF 0.4
Urology Case Reports Pub Date : 2025-09-30 DOI: 10.1016/j.eucr.2025.103226
Stacy R. Bedore , Danielle H. Shin , Joshua van der Eerden , Morgan V. Town , Martha K. Terris
{"title":"Pembrolizumab-induced myasthenia gravis: A rare immune-related adverse event in a patient treated for bladder cancer","authors":"Stacy R. Bedore ,&nbsp;Danielle H. Shin ,&nbsp;Joshua van der Eerden ,&nbsp;Morgan V. Town ,&nbsp;Martha K. Terris","doi":"10.1016/j.eucr.2025.103226","DOIUrl":"10.1016/j.eucr.2025.103226","url":null,"abstract":"<div><div>Immune checkpoint inhibitors (ICIs) targeting programmed cell death protein 1, such as pembrolizumab, are widely used for the treatment of various malignancies. These therapies, while typically less toxic than traditional chemotherapy, are associated with immune related adverse events which may affect the gastrointestinal tract, lungs, skin, liver, and less commonly the nervous system. Neurologic irAE are rare but carry high mortality rates. We present a case of seronegative myasthenia gravis in a patient treated with pembrolizumab for refractory bladder cancer. This case highlights the importance of early recognition of neurologic manifestations of irAE in patients receiving therapy with ICIs.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103226"},"PeriodicalIF":0.4,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic considerations and intraoperative surgical decisions in paraurethral leiomyoma: A case report and review of literature 尿道旁平滑肌瘤的诊断及术中手术决定：1例报告及文献回顾
IF 0.4
Urology Case Reports Pub Date : 2025-09-29 DOI: 10.1016/j.eucr.2025.103229
Farzaneh Sharifi Aghdas , Melika Golmohammadi , Nastaran Mahmoudnejad , Peyman M. Torbati , Niloofar Soleimanifard
{"title":"Diagnostic considerations and intraoperative surgical decisions in paraurethral leiomyoma: A case report and review of literature","authors":"Farzaneh Sharifi Aghdas ,&nbsp;Melika Golmohammadi ,&nbsp;Nastaran Mahmoudnejad ,&nbsp;Peyman M. Torbati ,&nbsp;Niloofar Soleimanifard","doi":"10.1016/j.eucr.2025.103229","DOIUrl":"10.1016/j.eucr.2025.103229","url":null,"abstract":"<div><div>Paraurethral leiomyoma is a rare, benign smooth muscle tumor that often presents with urinary and pelvic symptoms, mimicking other periurethral conditions. We report a 41-year-old woman with pelvic pain and lower urinary tract symptoms, diagnosed with paraurethral leiomyoma and confirmed histologically. Although preoperative assessments may suggest an abdomino-vaginal approach, our case highlights that the surgical route is best determined intraoperatively. To better understand this condition, we reviewed published cases over recent decades, summarizing clinical presentations, diagnostic methods, surgical approaches, and postoperative outcomes.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103229"},"PeriodicalIF":0.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late cutaneous metastasis of clear-cell renal cell carcinoma to the lower eyelid five years after radical nephrectomy: A case report 透明细胞肾细胞癌根治性肾切除术后5年晚期皮肤转移至下眼睑1例
IF 0.4
Urology Case Reports Pub Date : 2025-09-29 DOI: 10.1016/j.eucr.2025.103225
Marek Broul , Jan Milota , Miroslav Šuráň , Vít Horák , Aneta Hujová , Michaela Liegertová
{"title":"Late cutaneous metastasis of clear-cell renal cell carcinoma to the lower eyelid five years after radical nephrectomy: A case report","authors":"Marek Broul ,&nbsp;Jan Milota ,&nbsp;Miroslav Šuráň ,&nbsp;Vít Horák ,&nbsp;Aneta Hujová ,&nbsp;Michaela Liegertová","doi":"10.1016/j.eucr.2025.103225","DOIUrl":"10.1016/j.eucr.2025.103225","url":null,"abstract":"<div><div>Clear-cell renal cell carcinoma (ccRCC) metastasises widely, but cutaneous spread is uncommon and eyelid involvement exceptionally rare. We report a 55-year-old man who developed a painless 4-mm lower-eyelid nodule five years after curative left radical nephrectomy for pT1a ccRCC. Excision confirmed metastatic ccRCC (PAX8+, CD10<sup>+</sup>). Staging showed mediastinal nodal and pulmonary disease. First-line avelumab 800 mg IV every two weeks plus axitinib was initiated; in July 2025 axitinib was reduced to 5 mg once daily. After eight cycles, interim CT (August 2025) demonstrated regression with no locoregional recurrence. This case highlights continued vigilance and prompt biopsy of atypical eyelid lesions.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103225"},"PeriodicalIF":0.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Magnetic sentinel node biopsy with Sienna+®/SentiMag® in penile squamous cell carcinoma: Case report Sienna+®/SentiMag®磁前哨淋巴结活检诊断阴茎鳞状细胞癌1例
IF 0.4
Urology Case Reports Pub Date : 2025-09-29 DOI: 10.1016/j.eucr.2025.103227
Diogo Carmali , Eduardo Felício, Sónia Afonso Ramos, António Pinheiro, Alberto Silva, Sara Duarte, Guilherme Bernardo, Filipe Gaboleiro, André Pita, Fernando Ferrito
{"title":"Magnetic sentinel node biopsy with Sienna+®/SentiMag® in penile squamous cell carcinoma: Case report","authors":"Diogo Carmali ,&nbsp;Eduardo Felício,&nbsp;Sónia Afonso Ramos,&nbsp;António Pinheiro,&nbsp;Alberto Silva,&nbsp;Sara Duarte,&nbsp;Guilherme Bernardo,&nbsp;Filipe Gaboleiro,&nbsp;André Pita,&nbsp;Fernando Ferrito","doi":"10.1016/j.eucr.2025.103227","DOIUrl":"10.1016/j.eucr.2025.103227","url":null,"abstract":"<div><div>Penile squamous cell carcinoma (SCC) is a rare malignancy where accurate nodal staging is essential for prognosis and management. Dynamic sentinel lymph node biopsy with radiotracers is the standard approach but requires nuclear medicine facilities and exposes patients to radiation. We report a 62-year-old man with penile SCC who underwent glansectomy with sentinel lymph node biopsy using Sienna+®/SentiMag® and methylene blue. Two sentinel nodes were identified, one exclusively by Sienna+®/SentiMag®. Both were negative for metastasis. This case supports the feasibility of magnetic tracers as a radiation-free alternative in penile cancer staging.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103227"},"PeriodicalIF":0.4,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fused variant of crossed testicular ectopia: A case report and discussion of the literature 交叉睾丸异位融合型1例报告及文献讨论
IF 0.4
Urology Case Reports Pub Date : 2025-09-24 DOI: 10.1016/j.eucr.2025.103220
Aidan S. Weitzner , Victoria Maxon , Jordan S. Levine , Catherine Robey , Tanisha Martheswaran , Tijesunimi Oni , Chad B. Crigger
{"title":"Fused variant of crossed testicular ectopia: A case report and discussion of the literature","authors":"Aidan S. Weitzner ,&nbsp;Victoria Maxon ,&nbsp;Jordan S. Levine ,&nbsp;Catherine Robey ,&nbsp;Tanisha Martheswaran ,&nbsp;Tijesunimi Oni ,&nbsp;Chad B. Crigger","doi":"10.1016/j.eucr.2025.103220","DOIUrl":"10.1016/j.eucr.2025.103220","url":null,"abstract":"<div><h3>Introduction</h3><div>Crossed testicular ectopia (CTE) is a rare genitourinary anomaly in which both testes descend through the same inguinal canal.</div></div><div><h3>Case presentation</h3><div>We describe a 10-month-old boy with proximal penoscrotal hypospadias and nonpalpable right testis. Despite normal ultrasound findings on the left, the right testis was not visualized. Diagnostic laparoscopy revealed a right-to-left crossed fused ectopia through a left inguinal hernia. The fused testes were surgically dissected and bilateral orchiopexy was performed successfully.</div></div><div><h3>Conclusion</h3><div>Fusion variants of CTE are extremely rare. This case provides the first surgical description of infant fused CTE and highlights the importance of laparoscopy in management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103220"},"PeriodicalIF":0.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome 年轻男性Lynch综合征的原发性膀胱印戒细胞腺癌
IF 0.4
Urology Case Reports Pub Date : 2025-09-24 DOI: 10.1016/j.eucr.2025.103223
James Um, Aidan Kennedy, Christopher D. Jaeger, Nikta Rezakahn Khajeh, Paul Alan Horning, Reenal Patel, Kanika Arora, Adam J. Gadzinski
{"title":"Primary bladder signet ring cell adenocarcinoma in a young male with Lynch Syndrome","authors":"James Um,&nbsp;Aidan Kennedy,&nbsp;Christopher D. Jaeger,&nbsp;Nikta Rezakahn Khajeh,&nbsp;Paul Alan Horning,&nbsp;Reenal Patel,&nbsp;Kanika Arora,&nbsp;Adam J. Gadzinski","doi":"10.1016/j.eucr.2025.103223","DOIUrl":"10.1016/j.eucr.2025.103223","url":null,"abstract":"<div><div>A 32-year-old male with Lynch Syndrome and a history of colon cancer status post total proctocolectomy was found to have invasive high-grade carcinoma with signet ring cell morphology on tissue sampling of the bladder neck following transurethral resection of a bladder tumor (TURBT). The patient subsequently underwent an open cystoprostatectomy and completion proctectomy. Final pathology of the prostate, bladder, and bladder augment confirmed the diagnosis of signet ring cell adenocarcinoma (SRCC) of the bladder. Given its rarity, this case illustrates the challenges of managing an aggressive bladder cancer and underscores the importance of considering appropriate screening strategies in high-risk populations.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103223"},"PeriodicalIF":0.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary renal neuroendocrine tumor: A rare case and review of diagnostic and therapeutic challenges 原发性肾神经内分泌肿瘤：一例罕见病例及诊断和治疗挑战的回顾
IF 0.4
Urology Case Reports Pub Date : 2025-09-24 DOI: 10.1016/j.eucr.2025.103218
Kris Kokoneshi , Diego Gonzalez, Eileen Zhang, Fiona Wardrop, Ryan Antar, Sam Kwon, Sean Tafuri, Mohadese Behtaj, Andrew Hall, Michael Whalen
{"title":"Primary renal neuroendocrine tumor: A rare case and review of diagnostic and therapeutic challenges","authors":"Kris Kokoneshi ,&nbsp;Diego Gonzalez,&nbsp;Eileen Zhang,&nbsp;Fiona Wardrop,&nbsp;Ryan Antar,&nbsp;Sam Kwon,&nbsp;Sean Tafuri,&nbsp;Mohadese Behtaj,&nbsp;Andrew Hall,&nbsp;Michael Whalen","doi":"10.1016/j.eucr.2025.103218","DOIUrl":"10.1016/j.eucr.2025.103218","url":null,"abstract":"<div><div>Primary renal neuroendocrine tumors (NETs) are extremely rare and pose both diagnostic and therapeutic challenges due to their nonspecific presentation and overlap with more common renal masses. We report the case of a 49-year-old woman who presented with flank pain and was found to have a large well-differentiated Grade 2 renal NET. Histopathology revealed classic ribbon-like architecture with Ki-67 index of 3–7 %, and immunohistochemistry confirmed strong synaptophysin and CD56 positivity. Surgical resection via radical nephrectomy was curative. This case highlights the importance of histological evaluation and contributes to the limited literature review on renal NET diagnosis and management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103218"},"PeriodicalIF":0.4,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Case report: Fistula formation of a urachal cyst 6 years after prostatectomy 病例报告：前列腺切除术后6年尿管囊肿瘘管形成
IF 0.4
Urology Case Reports Pub Date : 2025-09-22 DOI: 10.1016/j.eucr.2025.103222
Anton M.F. Kalsbeek , Arnout R. Alberts , Lucia L. Rijstenberg , John van der Hoeven , Tahlita C.M. Zuiverloon
{"title":"Case report: Fistula formation of a urachal cyst 6 years after prostatectomy","authors":"Anton M.F. Kalsbeek ,&nbsp;Arnout R. Alberts ,&nbsp;Lucia L. Rijstenberg ,&nbsp;John van der Hoeven ,&nbsp;Tahlita C.M. Zuiverloon","doi":"10.1016/j.eucr.2025.103222","DOIUrl":"10.1016/j.eucr.2025.103222","url":null,"abstract":"<div><div>Urachal cysts can be a diagnostic dilemma, because determining whether the cyst is malignant can be difficult. As a result, the best treatment is not always obvious. Urachal malignancies account for less than 1 % of total bladder cancer cases thus in most cases urachal cysts are benign, and a watchful waiting approach is justified. However, in cases with symptoms or a suspicion of malignancy, there is an indication for surgical resection. Here, we discuss the management of a symptomatic large persistent urachal cyst in a patient that had undergone a radical prostatectomy which was complicated by recto-vesical fistula.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"63 ","pages":"Article 103222"},"PeriodicalIF":0.4,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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