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Robust response to pembrolizumab plus lenvatinib in a patient with renal cell carcinoma with rhabdoid features: A case report 派姆单抗联合lenvatinib治疗肾细胞癌伴横纹肌样特征的患者疗效显著：1例报告
IF 0.5
Urology Case Reports Pub Date : 2025-07-23 DOI: 10.1016/j.eucr.2025.103140
Shinkuro Yamamoto , Satoshi Fukata , Takashi Karashima , Atsushi Kurabayashi , Rie Yoshimura , Kaoru Furihata , Yuhei Shiba , Tomoya Nao , Hirofumi Satake , Keiji Inoue
{"title":"Robust response to pembrolizumab plus lenvatinib in a patient with renal cell carcinoma with rhabdoid features: A case report","authors":"Shinkuro Yamamoto ,&nbsp;Satoshi Fukata ,&nbsp;Takashi Karashima ,&nbsp;Atsushi Kurabayashi ,&nbsp;Rie Yoshimura ,&nbsp;Kaoru Furihata ,&nbsp;Yuhei Shiba ,&nbsp;Tomoya Nao ,&nbsp;Hirofumi Satake ,&nbsp;Keiji Inoue","doi":"10.1016/j.eucr.2025.103140","DOIUrl":"10.1016/j.eucr.2025.103140","url":null,"abstract":"<div><div>Renal cell carcinoma (RCC) with rhabdoid features is a rare and highly aggressive condition with no established treatment for early recurrence. We herein report a case involving a 58-year-old man who underwent nephrectomy for clear-cell RCC with rhabdoid features and developed rapid metastases within 3 months. Treatment with pembrolizumab plus lenvatinib achieved a sustained partial response, except for vertebral metastasis. Thereafter, radiotherapy was added, and systemic therapy resumed, which maintained disease control for 2 years. Immunohistochemistry revealed partial PD-L1 expression in rhabdoid areas. This case highlights the potential efficacy of pembrolizumab plus lenvatinib in RCC with rhabdoid features.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103140"},"PeriodicalIF":0.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Difficulties in diagnosing genitourinary tuberculosis: A case of delayed diagnosis resulting in nephrectomy 泌尿生殖系统结核的诊断困难：诊断延误致肾切除1例
IF 0.5
Urology Case Reports Pub Date : 2025-07-23 DOI: 10.1016/j.eucr.2025.103136
Ferhat Çoban, Mustafa Kemal Koç
{"title":"Difficulties in diagnosing genitourinary tuberculosis: A case of delayed diagnosis resulting in nephrectomy","authors":"Ferhat Çoban,&nbsp;Mustafa Kemal Koç","doi":"10.1016/j.eucr.2025.103136","DOIUrl":"10.1016/j.eucr.2025.103136","url":null,"abstract":"<div><div>Genitourinary tuberculosis (GUTB) is a rare infectious disease, yet delays in diagnosis can lead to serious complications. This study presents a case of GUTB in which diagnosis was delayed due to negative conventional laboratory tests, ultimately necessitating nephrectomy at an advanced stage. Initially, the symptoms mimicked a urinary tract infection, which resulted in progressive renal damage. The diagnostic challenges and treatment approaches are discussed in light of the current literature through this case.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103136"},"PeriodicalIF":0.5,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144704776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Primary malignant melanoma of the female urethra: A rare case report 女性尿道原发性恶性黑色素瘤1例报告
IF 0.5
Urology Case Reports Pub Date : 2025-07-22 DOI: 10.1016/j.eucr.2025.103133
Anahita Ansari Djafari , Mohammad Seifi Poor , Sina Samenezhad , Reza Nicknama , Azadeh Rakhshan
{"title":"Primary malignant melanoma of the female urethra: A rare case report","authors":"Anahita Ansari Djafari ,&nbsp;Mohammad Seifi Poor ,&nbsp;Sina Samenezhad ,&nbsp;Reza Nicknama ,&nbsp;Azadeh Rakhshan","doi":"10.1016/j.eucr.2025.103133","DOIUrl":"10.1016/j.eucr.2025.103133","url":null,"abstract":"<div><div>A 61y/o woman who presented with a dark, bleeding mass at the urethral meatus, accompanied by dysuria and significant weight loss. Initial diagnosis by a GP suggested a urethral caruncle. Imaging revealed a urethral mass, which was surgically excised. Histopathological examination confirmed the diagnosis of malignant melanoma. Despite complete surgical resection, follow-up imaging 6 months later revealed widespread metastases. She was referred for systemic and immunotherapy. This case underscores the importance of considering urethral melanoma in the differential diagnosis of urethral masses, especially when the presentation mimics benign conditions. Early recognition, thorough staging and prompt intervention are crucial for improving outcomes.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103133"},"PeriodicalIF":0.5,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Staged repair of Effmann type IIA2Y urethral duplication using composite tissue tubularization: A case report 复合组织管化分阶段修复Effmann IIA2Y型尿道重复1例
IF 0.5
Urology Case Reports Pub Date : 2025-07-21 DOI: 10.1016/j.eucr.2025.103137
P.R. Saju, H. Balabhaskar, Sunil Ashok, S.J. Aquil Faris, Maradana Prudhvi Vasanth, Sharoo Shaneej, Jinesh Jayadevan
{"title":"Staged repair of Effmann type IIA2Y urethral duplication using composite tissue tubularization: A case report","authors":"P.R. Saju,&nbsp;H. Balabhaskar,&nbsp;Sunil Ashok,&nbsp;S.J. Aquil Faris,&nbsp;Maradana Prudhvi Vasanth,&nbsp;Sharoo Shaneej,&nbsp;Jinesh Jayadevan","doi":"10.1016/j.eucr.2025.103137","DOIUrl":"10.1016/j.eucr.2025.103137","url":null,"abstract":"<div><div>Effmann type IIA2Y urethral duplication is a rare congenital anomaly requiring individualized surgical management. We report a pediatric case managed with initial buccal mucosa grafting and perineal urethrostomy, followed by a 9-year loss to follow-up. On return, the graft remained viable, and definitive repair was performed using composite tissue tubularization with buccal mucosa, perineal, and scrotal skin. The patient achieved continent, complication-free voiding. This case highlights the durability of multi-tissue grafts and demonstrates the feasibility of delayed reconstruction in complex urethral anomalies.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103137"},"PeriodicalIF":0.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Massive congenital bladder diverticulum in a teenager: Navigating an uncommon clinical entity through an exceptional therapeutic challenge – A case report 一个青少年的巨大先天性膀胱憩室：通过一个特殊的治疗挑战来导航一个不寻常的临床实体-一个病例报告
IF 0.5
Urology Case Reports Pub Date : 2025-07-21 DOI: 10.1016/j.eucr.2025.103139
W. Salama , M. Tetou , M. Mrabti , M.A. Sobhi , A. Elbahri , M. Alami , A. Ameur
{"title":"Massive congenital bladder diverticulum in a teenager: Navigating an uncommon clinical entity through an exceptional therapeutic challenge – A case report","authors":"W. Salama ,&nbsp;M. Tetou ,&nbsp;M. Mrabti ,&nbsp;M.A. Sobhi ,&nbsp;A. Elbahri ,&nbsp;M. Alami ,&nbsp;A. Ameur","doi":"10.1016/j.eucr.2025.103139","DOIUrl":"10.1016/j.eucr.2025.103139","url":null,"abstract":"<div><div>Primary congenital bladder diverticula, rare in pediatric populations and particularly in females, often justify surgery for symptomatic cases. We report a 15-year-old girl with a giant bladder diverticulum, significant post-void residual urine, and preserved renal function without vesicoureteral reflux. Conservative care included antibiotic prophylaxis, surveillance imaging, and lifestyle modifications was adopted due to family refusal of surgery. Clinical stability (reduced infections, no complications) and anatomical stability were observed, supporting the hypothesis of residual muscular fibers as a stabilizing factor, suggesting potential nosological reclassification. This case underscores individualized therapeutic decisions integrating family preferences and rigorous monitoring.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103139"},"PeriodicalIF":0.5,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant adrenal calcification: rare case report and literature review 巨大肾上腺钙化：罕见病例报告及文献复习
IF 0.5
Urology Case Reports Pub Date : 2025-07-19 DOI: 10.1016/j.eucr.2025.103131
Zaiqing Jiang , Yunfeng Li , Kai Zhao , Xinbao Yin , Ke Wang , Zongliang Zhang
{"title":"Giant adrenal calcification: rare case report and literature review","authors":"Zaiqing Jiang ,&nbsp;Yunfeng Li ,&nbsp;Kai Zhao ,&nbsp;Xinbao Yin ,&nbsp;Ke Wang ,&nbsp;Zongliang Zhang","doi":"10.1016/j.eucr.2025.103131","DOIUrl":"10.1016/j.eucr.2025.103131","url":null,"abstract":"<div><div>We report the largest documented case of idiopathic giant adrenal calcification in a middle-aged woman, incidentally detected during imaging. Preoperative CT revealed an 8.5 × 7.0 × 5.0 cm left adrenal mass. Retroperitoneal laparoscopic adrenalectomy was successfully performed, with no recurrence at 18-month follow-up. This rare condition lacks evidence-based guidelines, necessitating multicenter studies to refine diagnosis and management.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103131"},"PeriodicalIF":0.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunotherapy-related cystitis induced by nivolumab: A case report and review of the literature 纳武单抗诱导的免疫治疗相关性膀胱炎：1例报告和文献回顾
IF 0.5
Urology Case Reports Pub Date : 2025-07-19 DOI: 10.1016/j.eucr.2025.103132
Yingying Yuan , Lianqing Lou , Siheng Zhu , Dong Yan
{"title":"Immunotherapy-related cystitis induced by nivolumab: A case report and review of the literature","authors":"Yingying Yuan ,&nbsp;Lianqing Lou ,&nbsp;Siheng Zhu ,&nbsp;Dong Yan","doi":"10.1016/j.eucr.2025.103132","DOIUrl":"10.1016/j.eucr.2025.103132","url":null,"abstract":"<div><div>Immune checkpoint inhibitors (ICIs) like nivolumab have revolutionized cancer treatment but can cause immune-related adverse events (irAEs), including rare cystitis. This case report describes a gastric cancer patient who developed urinary symptoms, such as hematuria and frequent urination, after nivolumab treatment. Despite initial antibiotics, symptoms worsened, leading to a diagnosis of immune-related cystitis. Intravenous methylprednisolone provided rapid relief and restored renal function. Early recognition and corticosteroid treatment are crucial for managing ICI-induced cystitis and preventing unnecessary antibiotics.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103132"},"PeriodicalIF":0.5,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cough-associated detrusor overactivity resolved after intravesical onabotulinumtoxin A injection: A case report 膀胱内注射肉毒杆菌毒素A后，咳嗽相关逼尿肌过度活动得以缓解：1例报告
IF 0.5
Urology Case Reports Pub Date : 2025-07-18 DOI: 10.1016/j.eucr.2025.103129
Rie Yoshimura , Nobutaka Shimizu , Mio Togo , Shinkuro Yamamoto , Tomoya Nao , Tsutomu Shimamoto , Hideo Fukuhara , Satoshi Fukata , Shingo Ashida , Takashi Karashima , Motoaki Saito , Keiji Inoue
{"title":"Cough-associated detrusor overactivity resolved after intravesical onabotulinumtoxin A injection: A case report","authors":"Rie Yoshimura ,&nbsp;Nobutaka Shimizu ,&nbsp;Mio Togo ,&nbsp;Shinkuro Yamamoto ,&nbsp;Tomoya Nao ,&nbsp;Tsutomu Shimamoto ,&nbsp;Hideo Fukuhara ,&nbsp;Satoshi Fukata ,&nbsp;Shingo Ashida ,&nbsp;Takashi Karashima ,&nbsp;Motoaki Saito ,&nbsp;Keiji Inoue","doi":"10.1016/j.eucr.2025.103129","DOIUrl":"10.1016/j.eucr.2025.103129","url":null,"abstract":"<div><div>A 68-year-old woman developed urgency urinary incontinence (UUI) one month after tension-free vaginal tape (TVT) surgery for stress urinary incontinence. Pharmacological treatment was ineffective. Pressure-flow study revealed cough-associated detrusor overactivity (CADO). An intravesical injection of 100 U botulinum toxin resolved symptoms and normalized bladder sensation. Six months later, CADO recurred and was successfully treated with a second injection. No adverse events occurred. CADO is often misdiagnosed as stress incontinence, and accurate diagnosis requires urodynamic evaluation. This case highlights the potential of intravesical botulinum toxin for managing CADO, including recurrence. Further studies should establish optimal diagnostic strategies and long-term efficacy.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103129"},"PeriodicalIF":0.5,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144665665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Late-presenting congenital anterior urethral diverticulum causing renal impairment in a male child 迟发性先天性前尿道憩室导致男童肾功能损害
IF 0.5
Urology Case Reports Pub Date : 2025-07-17 DOI: 10.1016/j.eucr.2025.103127
Yasmine Houas , Arije Zouaoui , Riadh Jouini
{"title":"Late-presenting congenital anterior urethral diverticulum causing renal impairment in a male child","authors":"Yasmine Houas ,&nbsp;Arije Zouaoui ,&nbsp;Riadh Jouini","doi":"10.1016/j.eucr.2025.103127","DOIUrl":"10.1016/j.eucr.2025.103127","url":null,"abstract":"<div><div>We report the case of a 6-year-old boy who presented with lower urinary tract obstruction and chronic renal impairment due to a delayed diagnosis of isolated CAUD. The diagnosis was eventually made by voiding cystourethrography, which revealed a large anterior diverticulum. This case illustrates a rare late presentation of CAUD with significant renal dysfunction, highlighting a crucial diagnostic pitfall. Clinicians should actively consider and investigate for anterior urethral diverticulum in any male child presenting with unexplained renal insufficiency or voiding symptoms, as early detection is essential to prevent irreversible upper urinary tract damage.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103127"},"PeriodicalIF":0.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A case of mid-segment ureteral duplication: Uncovering a rare developmental anomaly 输尿管中段重复1例：揭示罕见的发育异常
IF 0.5
Urology Case Reports Pub Date : 2025-07-17 DOI: 10.1016/j.eucr.2025.103128
Yazan Dibas , Jana Dibas , Motaz Daraghma , Zaid Sawaftah
{"title":"A case of mid-segment ureteral duplication: Uncovering a rare developmental anomaly","authors":"Yazan Dibas ,&nbsp;Jana Dibas ,&nbsp;Motaz Daraghma ,&nbsp;Zaid Sawaftah","doi":"10.1016/j.eucr.2025.103128","DOIUrl":"10.1016/j.eucr.2025.103128","url":null,"abstract":"<div><div>Ureteral duplication is a congenital anomaly often associated with urinary complications. We report a case of a 54-year-old female presenting with recurrent urinary tract infections and right flank pain. Imaging revealed a rare mid-segment ureteral duplication, where the ureter bifurcates and rejoins before entering the bladder. The anomaly was complicated by ESBL-producing <em>Escherichia coli</em> infection. Conservative management with antibiotics was chosen after the patient declined surgery. This case underscores the diagnostic challenges of mid-segment duplications and highlights the importance of advanced imaging in adults with unexplained recurrent urinary tract infections.</div></div>","PeriodicalId":38188,"journal":{"name":"Urology Case Reports","volume":"62 ","pages":"Article 103128"},"PeriodicalIF":0.5,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144679671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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