Human Pathology: Case Reports最新文献_第8页

Anaplastic diffuse leptomeningeal glioneuronal tumor associated with H3 K27M mutation 与H3 K27M突变相关的无定形弥漫性软脑膜胶质神经元肿瘤

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200296

Shoh Sasaki , Takanori Hirose , Sumihito Nobusawa , Tomoya Myojin , Kohei Morita , Tokiko Nakai , Junko Hirato , Chiho Ohbayashi

引用次数: 2

Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature 乳腺恶性肌上皮瘤;一个有趣的病例报告，病理，免疫组织化学结果和文献回顾

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200301

Ola A. Harb , Ahmed A. Obaya , Taha A. Baiomy , Loay M. Gertallah , Sherif Y. Yousif

{"title":"Malignant myoepithelioma of the breast (MMB); An interesting case report with pathological, immunohistochemical findings and review of literature","authors":"Ola A. Harb , Ahmed A. Obaya , Taha A. Baiomy , Loay M. Gertallah , Sherif Y. Yousif","doi":"10.1016/j.hpcr.2019.200301","DOIUrl":"10.1016/j.hpcr.2019.200301","url":null,"abstract":"<div><h3>Background</h3><p>Malignant myoepithelioma (MMB) of the breast is an extremely rare and aggressive malignant tumor. The biological behavior of such malignancy and treatment outcomes of patients has not been clearly determined.</p></div><div><h3>Hypothesis</h3><p>MMB is morphologically difficult to be distinguished from benign spindle cell proliferations. Identification and further research on the genesis of these tumors could help to discover new molecular targets for its management.</p></div><div><h3>Case report</h3><p>We herein describe the pathological and immunohistochemical characteristics of a case of MMB in a 51 year-old woman to add to the previous data about biological behavior and management strategy of such a rare aggressive entity.</p><p>We have confirmed the diagnosis of our case using immunohistochemisrty because malignant cells revealed diffuse expression of P63, SMA and S-100 in addition to high Ki-67 labeling index.</p></div><div><h3>Conclusions</h3><p>MMB is extremely rare entity which showed be suspected during differential diagnosis of any malignant spindle cell tumor of the breast.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200301"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200301","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48788654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Small bowel obstruction exacerbated by barium sulfate administration 硫酸钡加重了小肠梗阻

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200315

Whitney L. Reid DO , Jesse L. Cox MD, PhD , Karen L. Pennington , Philip McCarthy DO , Vishal M. Kothari MD, FACS , Samuel M. Cohen MD, PhD

引用次数: 2

Langerhans Cell Histiocytosis, Non-Langerhans histiocytosis and concurrent Papillary Thyroid Carcinoma with BRAF V600E mutations: A case report and literature review 朗格汉斯细胞组织细胞增多症、非朗格汉斯组织细胞增多症及合并BRAF V600E突变的甲状腺乳头状癌1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200302

Laura Wake MD , Liqiang Xi MD , Mark Raffeld MD , Elaine S. Jaffe MD

引用次数: 3

The diagnostic value of detection of high-risk HPV in differentiating primary bladder cancer versus uterine cervical cancer involving bladder - A case report 高危型人乳头状瘤病毒检测对原发性膀胱癌症与子宫颈癌症合并膀胱的鉴别诊断价值

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200299

Haiying Zhan, Elizabeth Korangy, Ying Huang

引用次数: 0

Adult Langerhans cell histiocytosis arising in colonic polyp: A case report and literature review 结肠息肉并发成人郎格罕细胞组织细胞增多症一例报告及文献复习

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200311

Feras Zaiem MD, Rafic Beydoun MD

引用次数: 3

Unexpected DOG1 expression in gastrointestinal neuroectodermal tumor of the rectum: A diagnostic pitfall 直肠胃肠道神经外胚层肿瘤中DOG1的意外表达：一个诊断缺陷

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200317

Cindy Bossenmeyer , Emilie Duchalais , Anne Moreau , Céline Bossard

引用次数: 1

Multilocular cystic renal neoplasm of low malignant potential extending into the perinephric adipose tissue 低恶性潜能的多室囊性肾肿瘤，向肾周脂肪组织扩散

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200305

Khaled Abdelfattah Murshed, Mohammed Akhtar, Mohamed Ben-Gashir

引用次数: 2

A case of clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) with two EWSR1-ATF1 fusions 2例EWSR1-ATF1融合的胃肠道透明细胞肉瘤样肿瘤1例

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200300

Ai Ito , Masako Kurashige , Hideki Murakami , Tomomi Koide , Ryota Ando , Ayami Kominami-Kiriyama , Masahiko Fujino , Masafumi Ito

{"title":"A case of clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) with two EWSR1-ATF1 fusions","authors":"Ai Ito , Masako Kurashige , Hideki Murakami , Tomomi Koide , Ryota Ando , Ayami Kominami-Kiriyama , Masahiko Fujino , Masafumi Ito","doi":"10.1016/j.hpcr.2019.200300","DOIUrl":"10.1016/j.hpcr.2019.200300","url":null,"abstract":"<div><p>Clear cell sarcoma-like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare mesenchymal tumor arising from the gastrointestinal tract. We report a case of CCSLGT with two fusion transcripts of <em>EWSR1-ATF1</em>. A 60-year-old female received ileectomy because of repeated ileus history. A 30-mm submucosal tumor with mucosal ulceration was detected in the ileum. Histologically, sarcomatous tumor comprised relatively monomorphic tumor cells arranged in sheets or nests and several multinucleated osteoclast-like giant cells. The main tumor cells contain small round nuclei with prominent nucleoli and abundant clear cytoplasm. Immunohistochemistry, the tumor cells expressed S-100 protein diffusely and focally expressed CAM5.2, EMA, and CD56. They did not express HMB-45, c-kit, CD34, desmin, and α-SMA. FISH analysis revealed <em>EWSR1</em> split signal in the tumor cells. Reverse transcription polymerase chain reaction (RT-PCR) revealed 2 types of <em>EWSR1-ATF1</em> transcripts, including <em>EWSR1</em> exon 7-<em>ATF1</em> exon 5 and <em>EWSR1</em> exon 6-<em>ATF1</em> exon 5. <em>EWSR1-CREB1</em> was not detected. We finally diagnosed CCSLGT as well as identified two types of fusion transcript of <em>EWSR1-ATF1</em>.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200300"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200300","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48586279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors 血管炎表现为肾脏、肺部和软组织多处肿块，类似恶性肿瘤

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200312

Shunhua Guo MD , Mary Ann R. Domingo MD , Qin Chang MD, PhD , Jordan K. Swensson MD

{"title":"Vasculitis manifested with multiple mass lesions in kidneys, lungs and soft tissue, mimicking malignant tumors","authors":"Shunhua Guo MD , Mary Ann R. Domingo MD , Qin Chang MD, PhD , Jordan K. Swensson MD","doi":"10.1016/j.ehpc.2019.200312","DOIUrl":"10.1016/j.ehpc.2019.200312","url":null,"abstract":"<div><p>We report a case of granulomatosis with polyangiitis (GPA) (Wegner's granulomatosis) who presented with multiple mass lesions in kidneys and lung lobes, as well as neck soft tissue, mimicking malignancies. This 71-year-old woman initially presented with sudden right foot drop, left calf pain and right eye vision loss. She was treated with corticosteroid for the diagnosis of possible temporal arteritis. Months after steroid was tapered to 2 mg per day, she developed increasing fatigue, weight loss, and shortness of breath. CT scan showed lung mass lesions in left upper lobe (3.8 × 2.4 cm), right mid lung with pleural extension (3.4 × 3.3 cm), and right lower lobe (1.1 × 1.0 cm); right neck (3.3 × 2.6 cm), right kidney (2.3 × 1.8 cm) and left kidney (2.0 × 1.6 cm). Right quadriceps muscle biopsy shows focal granulomatous inflammation. Lung biopsy showed necrotizing and poorly formed granulomatous inflammation. Biopsies of kidney mass lesions showed necrotizing and non-necrotizing granulomatous inflammation. No crescentic or necrotizing glomerular lesions were observed in the total 40 sampled glomeruli. No malignancy was identified in any of the biopsies. Her c-ANCA was found to be positive and PR3-ANCA antibody was 6.88 U/ml (normal 0–0.90 U/ml). She was diagnosed with granulomatosis with polyangiitis and treated with high dose corticosteroid and rituximab. Eight months later, follow-up showed resolved mass lesions by chest X-ray and CT and stable renal function. The case highlights the atypical clinical presentation of vasculitis and the significance of considering this possibility in differential diagnosis when confronting mass lesions present in multiple organ systems. Biopsy is critical for the correct diagnosis to initiate timely and appropriate treatment, and also important to avoid unnecessary surgical resection.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200312"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2019.200312","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46733351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0