Human Pathology: Case Reports最新文献_第8页

Niemann-Pick disease type C with kidney involvement Niemann-Pick病C型伴肾脏受累

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200486

Aanand A. Patel, Anthony Sisk, Jonathan E. Zuckerman

{"title":"Niemann-Pick disease type C with kidney involvement","authors":"Aanand A. Patel, Anthony Sisk, Jonathan E. Zuckerman","doi":"10.1016/j.ehpc.2021.200486","DOIUrl":"10.1016/j.ehpc.2021.200486","url":null,"abstract":"<div><p>Niemann-Pick disease type C is a lysosomal storage disease characterized by defects in lipid trafficking, typically involving the liver, spleen, and central nervous system. Only rare reports of renal involvement of Niemann-Pick disease have been reported and to date have only been described in type A and B forms of the disease. We report for the first time the kidney biopsy findings in a 21-year-old woman with Niemann-Pick disease type C and nephrotic-range proteinuria. Light microscopy demonstrated foamy podocytes, vacuolated tubular epithelial cells and collections of foam cells in the interstitium. Focal segmental glomerulosclerosis as well as diffuse global glomerulosclerosis were present. Electron microscopy showed myelin-like inclusions in podocytes, endothelial cells, tubular and epithelial cells. The inclusions were similar to those found in Fabry’s disease. This case illustrates Niemann-Pick disease as an important differential diagnosis for myeloid bodies. Additionally, this case highlights that glomerular involvement by Niemann Pick disease can result in nephrotic range proteinuria.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200486","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46385250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Granulocytic sarcoma: Extramedullary manifestation of chronic myeloproliferative neoplasm in a young African woman 粒细胞肉瘤：一名年轻非洲妇女的慢性骨髓增生性肿瘤的髓外表现

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200462

Ajayi A. Ibijola , Abiodun I. Okunlola , Abiodun O. Awe

引用次数: 0

Diagnosis of uterine lymphoma on cervical pap smear: Case report and review of literature 宫颈涂片诊断子宫淋巴瘤:1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200466

Preethi Dileep Menon , Hamza Tariq , Cynthia Forker , Alia Nazarullah

引用次数: 1

Giant placental chorangioma: The first case report in Indonesia 巨大胎盘绒毛管瘤：印度尼西亚首例病例报告

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200472

Emilia Theresia , Detty Siti Nurdiati , Irianiwati Widodo

引用次数: 6

Isolated fatty infiltration of the gastrocnemius medial head, a cadaveric case study 腓肠肌内侧头孤立性脂肪浸润的尸体研究

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200480

Karyne N. Rabey , Lalith Satkunam , Christine A. Webber , Jennifer C. Hocking

{"title":"Isolated fatty infiltration of the gastrocnemius medial head, a cadaveric case study","authors":"Karyne N. Rabey , Lalith Satkunam , Christine A. Webber , Jennifer C. Hocking","doi":"10.1016/j.ehpc.2021.200480","DOIUrl":"10.1016/j.ehpc.2021.200480","url":null,"abstract":"<div><p>Gastrocnemius is a superficial calf muscle with two muscular heads that contribute fibres to the Achilles tendon. While gastrocnemius functions during movement of the knee and ankle joints, the muscle is of particular clinical interest as a target for treatments to alleviate lower limb spasticity and pain. Here, we describe abnormal calf musculature discovered incidentally during cadaveric dissection in an anatomy teaching laboratory. In particular, the medial head of the gastrocnemius in the left leg exhibited almost complete replacement by adipose tissue, while the lateral head and soleus muscles were unaffected. On the right side, the medial head again showed fatty infiltration, but only in the distal part of an otherwise substantial muscle belly. While the nerve to the left medial head was intact, a cyst was discovered in the sacral vertebral column. The full, but isolated replacement of a muscle belly by fat is a highly unusual finding. Potentially, muscle degeneration followed by fatty infiltration was secondary to compression of the S1, S2 nerve roots and denervation of the muscle, but other possible causes are reviewed in the discussion.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200480","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42306040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unusual variant of invasive ductal carcinoma suggesting metaplastic melanocytic differentiation 浸润性导管癌的异常变异提示化生黑素细胞分化

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200482

Chen Mayer , Maya Zilker , Nora Balint-Lahat , Rony Weitzen , Aviv Barzilai , Iris Barshack , Jonathan Weidenfeld

{"title":"Unusual variant of invasive ductal carcinoma suggesting metaplastic melanocytic differentiation","authors":"Chen Mayer , Maya Zilker , Nora Balint-Lahat , Rony Weitzen , Aviv Barzilai , Iris Barshack , Jonathan Weidenfeld","doi":"10.1016/j.ehpc.2021.200482","DOIUrl":"10.1016/j.ehpc.2021.200482","url":null,"abstract":"<div><h3>Background</h3><p>Metaplastic carcinoma of the breast is a general definition referring to a heterogeneous group of neoplasms characterized by a mixture of adenocarcinoma with areas of spindled, squamous or mesenchymal differentiation. Metaplastic breast carcinoma comprising of both epithelial and melanocytic elements is rare, with just nine cases reported in medical literature so far. “metaplastic breast carcinoma with melanocytic differentiation” does not exist as a separate entity on the WHO classification.</p></div><div><h3>Case description</h3><p>Patient reported is a woman diagnosed with having invasive ductal carcinoma in 1997, with new skin lesions appearing in 2009 and 2019. These lesions were biopsied and reviewed for histopathology. On microscopic examination, we observed skin involved by a malignant tumor, showing clusters of atypical cells with solid architecture and focal duct differentiation. Immunohistochemistry revealed tumor cells were positive for breast and melanocytic markers. Given the patient’s clinical history, the possibility of metaplastic breast carcinoma with focal melanocytic differentiation was suggested.</p></div><div><h3>Discussion</h3><p>In our case report, we were able to show dermal breast lesions from the same patient during a 10-year span, showing change and evolution of the lesion to its current form. Recurrent biopsies of similar malignant lesions showing evolution have been described scarcely in the medical literature. From immune-histochemical stains performed on blocks obtained from 2009, we were able to show the development of melanocytic markers over time in similar samples resected ten years apart.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200482","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46402110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case of perivascular epithelioid nodules arising in an intramural leiomyoma 血管周围上皮样结节发生于壁内平滑肌瘤1例

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200470

Yoldez Houcine , Karima Mekni , Emna Brahem , Mouna Mlika , Aida Ayadi , Chiraz Fekih , Imene Ridene , Faouzi El Mezni

引用次数: 0

CD34 and CD79a immunopositivity in megakaryocytes 巨核细胞CD34和CD79a免疫阳性

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200467

Pavithra Ayyanar , Rakhee Kar , Biswajit Dubashi , Debdatta Basu

引用次数: 1

Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection: A case report and review of literature 内镜下黏膜下剥离术切除胃丛状纤维黏液瘤1例并文献复习

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200468

XiaoBo Zhao , XinLou Li , Xin Huang , Le Shang , JianZhong Zhang , JiHua Wu

{"title":"Gastric plexiform fibromyxoma resected by endoscopic submucosal dissection: A case report and review of literature","authors":"XiaoBo Zhao , XinLou Li , Xin Huang , Le Shang , JianZhong Zhang , JiHua Wu","doi":"10.1016/j.ehpc.2020.200468","DOIUrl":"10.1016/j.ehpc.2020.200468","url":null,"abstract":"<div><p>Plexiform fibromyxoma (PF), known as plexiform angiomyxoid myofibroblastic tumor firstly, is derived from gastrointestinal mesenchyme cells, being officially adopted as a distinct benign entity in the 2010 WHO Classification of Tumors of the Digestive System. We report a plexiform fibromyxoma case of a 32-year-old Chinese man who presented with slight intermittent acid regurgitation and abdominal discomfort. Endoscopy and imaging studies revealed a muscularis mucosa mass in the gastric antrum with initial suspicion of a GIST. Microscopically, spindle or oval tumor cells arrange in a nodular plexiform pattern, rich and small-sized vasculature and abundant myxoid matrix. Although it has a classical histological feature of PF, immunohistochemically it was negative for fibroblastic or myofibroblastic differentiation marker; endoscopic submucosal dissection (ESD) was performed as diagnostic therapy. Follow-up evaluation was uneventful for 8 months. To summarize the experience of conservative surgical treatment of plexiform fibromyxoma, we reviewed ESD or laparoscopic endoscopic cooperative surgery (LECS) treatment of plexiform fibromyxoma cases in the literature, and no complications and recurrence were reported after treatment. ESD is an candidate choice for plexiform fibromyxoma.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200468","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47768770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Metastatic pulmonary tumor from type 3 gastric neuroendocrine tumor 3型胃神经内分泌肿瘤的转移性肺肿瘤

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200481

Shuta Ohara , Atsushi Yasuda , Shigeki Shimizu , Kenichi Suda , Tetsuya Mitsudomi

引用次数: 0