Human Pathology: Case Reports最新文献_第9页

Testicular Leydig cell tumor in a 64-year old man with cytological high grade features and no metastasis 64岁男性睾丸间质细胞瘤，细胞学特征高，无转移

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2020.200464

Matthew Crabtree , Doris Cheng , Luciano Barajas

引用次数: 1

A case of thymoma with type A and micronodular thymoma with lymphoid stroma elements A型胸腺瘤和淋巴间质成分小结节性胸腺瘤1例

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200487

Clayton E. Kibler , Matthew J. Cecchini , Marie-Christine Aubry , Said F. Yassin , Julie K. Harrington

引用次数: 1

Unexpected death of a middle-aged man with severe pectus excavatum in association with pulmonary emboli 一名患有严重漏斗胸并伴有肺栓塞的中年男子意外死亡

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200483

Mayumi Kataoka , Hidenori Yoshizawa , Kanako Kobayashi , Keita Sakurai , Keiko Matsuno , Yoshiteru Tamura , Satomu Morita , Hideyuki Maeda , Ken-ichi Yoshida

{"title":"Unexpected death of a middle-aged man with severe pectus excavatum in association with pulmonary emboli","authors":"Mayumi Kataoka , Hidenori Yoshizawa , Kanako Kobayashi , Keita Sakurai , Keiko Matsuno , Yoshiteru Tamura , Satomu Morita , Hideyuki Maeda , Ken-ichi Yoshida","doi":"10.1016/j.ehpc.2021.200483","DOIUrl":"10.1016/j.ehpc.2021.200483","url":null,"abstract":"<div><p>On a mid-summer day, a middle-aged man with severe pectus excavatum died unexpectedly in his bed one to two weeks after the onset of dyspnea, which had been followed by bedrest and restricted drinking and eating. Computed tomography (CT) and autopsy demonstrated an eccentrically hypertrophied heart (weight 600 g), which was displaced, rotated, and occupied a large space in the left thoracic cavity due to a deeply depressed sternum. The pulmonary artery was bent and extended across the left thoracic cavity to the right hilum. Anatomical abnormalities in the heart and pulmonary artery obstructed the right ventricular outflow, dilated the right ventricle, and induced restrictive hemodynamics. The left lung was atelectatic due to compression by the heart, while the right lung was enlarged and partly expanded to the left upper thoracic cavity. Histology confirmed pulmonary infarctions at different stages in the upper and middle lobes of the right lung. Restrictive hemodynamics promoted right ventricular dilation, causing spatial limitation of the left thoracic cavity. It is presumed that diastolic right ventricular dysfunction would have rapidly progressed along with pericardial effusion (150 mL), and intra-cardiac thrombi were formed due to stagnation, arrhythmia, bedrest, and dehydration. Consequently, the thrombi would be repetitively embolized in the right lung, thereby aggravating respiratory dysfunction and right-sided heart failure. This is the first autopsy report on the unexpected death of an untreated adult patient of pectus excavatum, with systematic pathophysiological analyses on the basis of the postmortem CT, macroscopic, and microscopic findings.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200483","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47257531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Follicular dendritic cell sarcoma in the differential diagnosis of GATA3 positive tumors: A case report 滤泡树突状细胞肉瘤与GATA3阳性肿瘤的鉴别诊断1例

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200473

Lavinia P. Middleton , Ryan W. Huey , L. Jeffrey Medeiros , Roberto N. Miranda

{"title":"Follicular dendritic cell sarcoma in the differential diagnosis of GATA3 positive tumors: A case report","authors":"Lavinia P. Middleton , Ryan W. Huey , L. Jeffrey Medeiros , Roberto N. Miranda","doi":"10.1016/j.ehpc.2021.200473","DOIUrl":"10.1016/j.ehpc.2021.200473","url":null,"abstract":"<div><p>We describe a novel pathology finding in a 40-year-old woman without a history of breast carcinoma who presented with axillary swelling. The patient underwent core needle biopsy followed by axillary dissection 6 months later. The core biopsy of the axillary mass was initially considered to be a carcinoma of unknown primary, and as the biopsy specimen showed a pleomorphic malignant neoplasm that was GATA3 positive, the working diagnosis became metastatic breast carcinoma. The patient underwent an axillary dissection and was referred to our center for continuation of care. In addition to being positive for GATA3, the neoplasm was positive for CD21, CD23 and CD35, and negative for keratins, EMA, mammaglobin GCDFP-15, CD138, S-100 protein and other markers. The diagnosis of follicular dendritic cell sarcoma was established. We believe it is important to be aware that follicular dendritic cell sarcoma can be positive for GATA3, to avoid misdiagnosis as a metastatic neoplasm and an exhaustive workup for a primary site.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200473","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47336993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Nodular fasciitis adjacent to the left humerus in a 15-year-old boy 15岁男孩左肱骨附近结节性筋膜炎

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200478

Keita Sasa , Yoshiyuki Suehara , Tatsuya Takagi , Kei Sano , Takuo Hayashi , Tsuyoshi Saito

{"title":"Nodular fasciitis adjacent to the left humerus in a 15-year-old boy","authors":"Keita Sasa , Yoshiyuki Suehara , Tatsuya Takagi , Kei Sano , Takuo Hayashi , Tsuyoshi Saito","doi":"10.1016/j.ehpc.2021.200478","DOIUrl":"10.1016/j.ehpc.2021.200478","url":null,"abstract":"<div><p>Nodular fasciitis is often misdiagnosed as its histological mimics, including malignant tumors, due to high levels of cellularity and the presence of occasional mitotic figures. A 15-year-old boy noticed a mass on his left shoulder and was admitted to the hospital. Based on magnetic resonance imaging (MRI) results, the lesion seemed to be located within the muscle, just below the subcutaneous adipose tissue and adjacent to the periosteum of the left humerus. It showed an iso-low signal on T1-weighted images, a heterogeneously high signal on T2-weighted images, and a hyperintense signal on T2 fat-suppression. A fascial tail sign was observed in T2 and T2 fat-suppression sagittal slices. Although the lesion was diagnosed as nodular fasciitis by biopsy, the lesion gradually increased in size up to 3.7 cm during 2 months of follow up after the first admission. The lesion was surgically resected with the marginal margin. Histological analysis showed fascicular proliferation of spindle-shaped cells with inflammatory infiltrates and stromal bleeding. A diagnosis of nodular fasciitis was confirmed by the detection of an <em>MYH-USP6</em> fusion transcript. The identification of this fusion gene helped to avoid an unnecessary surgical procedure. The patient has been followed up for 6 months after surgery without any evidence of recurrence.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2021.200478","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42634596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Post-CAR-T cell therapy presenting as proteinaceous lymphadenopathy car - t细胞治疗后表现为蛋白性淋巴结病

Human Pathology: Case Reports Pub Date : 2021-03-01 DOI: 10.1016/j.ehpc.2021.200475

Mishi Bhushan, Kirthi R. Kumar

引用次数: 0

Death of a middle-aged man from nontraumatic hemorrhage derived from cerebral venous sinuses and infiltrated through bone defects 一名中年男子死于脑静脉窦非创伤性出血并经骨缺损浸润

Human Pathology: Case Reports Pub Date : 2020-11-01 DOI: 10.1016/j.ehpc.2020.200400

Yoshiteru Tamura , Keiko Matsuno , Kanako Kobayashi , Mayumi Kataoka , Kazuhisa Kawai , Hisami Araki , Ikuhisa Kameda , Hideyuki Maeda , Kyoko Ito , Ken-ichi Yoshida

{"title":"Death of a middle-aged man from nontraumatic hemorrhage derived from cerebral venous sinuses and infiltrated through bone defects","authors":"Yoshiteru Tamura , Keiko Matsuno , Kanako Kobayashi , Mayumi Kataoka , Kazuhisa Kawai , Hisami Araki , Ikuhisa Kameda , Hideyuki Maeda , Kyoko Ito , Ken-ichi Yoshida","doi":"10.1016/j.ehpc.2020.200400","DOIUrl":"10.1016/j.ehpc.2020.200400","url":null,"abstract":"<div><h3>Introduction</h3><p>Arachnoid cyst, a congenital extra-axial lesion, has been implicated in osteolytic lesion and subdural hematoma. Cerebral venous thrombosis occasionally induces subdural hematoma.</p></div><div><h3>Case report</h3><p>A man in his mid-forties with congenital bone defects was found dead after recumbency for months. Autopsy disclosed acute subdural hemorrhage and intracranial hemorrhage that infiltrated to the right neck through large occipital bone defects. CT demonstrateda high density area in the supratentorial venous sinuses and an infratentorial low-density mass adjacent to the bone defects, suggesting cerebral venous thrombosis and arachnoid cysts, respectively.</p></div><div><h3>Conclusion</h3><p>This is the first report on death due to nontraumatic extracranial and subdural hemorrhage derived from cerebral venous sinuses and possibly associated with arachnoid cysts and cerebral venous thrombosis.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44773287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infantile fibrosarcoma with a novel RAF1 rearrangement: The contemporary challenge of reconciling classic morphology with novel molecular genetics 具有新型RAF1重排的婴儿纤维肉瘤:调和经典形态学与新型分子遗传学的当代挑战

Human Pathology: Case Reports Pub Date : 2020-11-01 DOI: 10.1016/j.ehpc.2020.200434

Cheryl M. Coffin , Carol Beadling , Tanaya Neff , Christopher L. Corless , Jessica L. Davis

引用次数: 13

Nasopharyngeal mantle cell lymphoma with IGH/CCND1 rearrangement and MALT1 amplification: A case study with literature review 鼻咽部套细胞淋巴瘤伴IGH/CCND1重排和MALT1扩增1例并文献复习

Human Pathology: Case Reports Pub Date : 2020-11-01 DOI: 10.1016/j.ehpc.2020.200424

Ming Xie, Hongwei Ma

{"title":"Nasopharyngeal mantle cell lymphoma with IGH/CCND1 rearrangement and MALT1 amplification: A case study with literature review","authors":"Ming Xie, Hongwei Ma","doi":"10.1016/j.ehpc.2020.200424","DOIUrl":"10.1016/j.ehpc.2020.200424","url":null,"abstract":"<div><p>Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma and characterized by the t(11;14)(q13;q32)/<em>CCND1+. MALT1</em> amplification is the most common genetic event in MALT lymphomas. Identification of <em>CCND1</em> and <em>MALT1</em> gene over expression plays a key role in the diagnosis of MCL and some MALT lymphomas. Several unusual variants of MCL have been described with variable morphological, immunophenotypic and genetic characteristics. Here, we report an unusual nasopharyngeal B cell lymphoma with both <em>CCND1</em> rearrangement and <em>MALT1</em> amplification. The patient was a 60 year old gentleman admitted for further evaluation of “unspecified lymphoma”. PET oncology study revealed intense FDG avidity in the nasopharyngeal region, highly suspicious for malignancy. A biopsy of nasopharyngeal lesion was performed. Histological examination showed focal expansion of mantle zone surrounding residual germinal centers. Flow cytometry demonstrated one population of monoclonal B cells, negative for CD23 with variable CD5 expression. Lymphocytes in mantle zone were positive for CD20, BCL1 and weakly CD5 by immunohistochemistry. Interestingly, FISH studies were positive for standard and variant <em>IGH/CCND1</em> rearrangement (85%) and <em>MALT1</em> gene amplification (60%). Staging evaluations showed minimal bone marrow lymphoma involvement and increased FDG avidity in bilateral tonsillar regions and regional nodes of the neck, indicative of systemic disease. The overall findings were consistent with primary nasopharyngeal mantle cell lymphoma, which harbored both <em>CCND1</em> and <em>MALT1</em>, with systemic involvement. The patient responded well with chemotherapy. To our knowledge, this is the first such case reported in the literature. Recent studies have shown that <em>MALT1</em> gene may involve in the <em>MYC</em> pathway regulation in MCL, which represents a promising target for future therapies in MCL patients.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200424","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47990387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-grade adenosquamous carcinoma of the breast: A case with pathogenic germline mutation in the BRIP1 gene 低级别乳腺腺鳞癌：一例BRIP1基因致病性种系突变

Human Pathology: Case Reports Pub Date : 2020-11-01 DOI: 10.1016/j.ehpc.2020.200444

Gahie Nam , Rochelle Strenger , Marlene Cutitar , Yihong Wang

{"title":"Low-grade adenosquamous carcinoma of the breast: A case with pathogenic germline mutation in the BRIP1 gene","authors":"Gahie Nam , Rochelle Strenger , Marlene Cutitar , Yihong Wang","doi":"10.1016/j.ehpc.2020.200444","DOIUrl":"10.1016/j.ehpc.2020.200444","url":null,"abstract":"<div><p>Low grade adenosquamous carcinoma (LGAC) is an uncommon variant of metaplastic “triple negative” breast cancer with clinical-radiologic characteristics and histopathology which overlaps with other entities such as syringomatous adenoma. We report a case of LGAC in a woman in her 40s who presented with breast pain. An irregular hypoechoic retroareolar mass was identified on mammogram. Biopsy showed nests of cells with squamoid appearance and compressed “tadpole-shaped” glandular structures embedded in dense collagenous stroma with lymphoid aggregates. The tumor cells were highlighted by CK7 and squamous component by CK5/6 and p63 and were ER, PR and HER2 negative. The morphologic and immunophenotypic features were consistent with LGAC. Genetic study found she was heterozygous for the p.R798* pathogenic germline mutation in <em>BRIP1</em> gene. Patient underwent excision and managed with adjuvant radiation alone post operatively. This is the first LGAC reported with <em>BRIP1</em> mutation and we emphasize characteristics in diagnosis, differential diagnosis and management for LGAC in this report.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.ehpc.2020.200444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48045663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0