Human Pathology: Case Reports最新文献_第7页

EBV positive extranodal NK/T cell lymphoma presenting as intestinal lymphoma- A diagnostic challenge EBV阳性结外NK/T细胞淋巴瘤表现为肠淋巴瘤-诊断挑战

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200304

Nitya Prabhakaran, Katsiaryna Laziuk, Richard D. Hammer

{"title":"EBV positive extranodal NK/T cell lymphoma presenting as intestinal lymphoma- A diagnostic challenge","authors":"Nitya Prabhakaran, Katsiaryna Laziuk, Richard D. Hammer","doi":"10.1016/j.hpcr.2019.200304","DOIUrl":"10.1016/j.hpcr.2019.200304","url":null,"abstract":"<div><p>The World Health Organization (WHO) recognizes aggressive natural killer (NK)-cell leukemia and extranodal NK/T-cell lymphoma, nasal type as Epstein Barr Virus (EBV) associated lymphoproliferative disorders that may have overlapping features and must be distinguished from other T-cell lymphomas. A 35-year-old Hispanic female presented with fever of unknown origin, hemolysis and pancytopenia. Bone marrow biopsy with flow cytometry was negative for malignancy. Jejunal resection was performed due to concern for perforation and demonstrated a high-grade lymphoid neoplasm. Immunohistochemical stains showed that the neoplastic cells are positive for CD3, CD30, CD56 and cytotoxic markers Granzyme and TIA-1. EBV encoded RNA (EBER) was strongly positive in neoplastic cells. The location and immunophenotype first raised consideration of intestinal T-cell lymphoma, not otherwise specified (NOS). However, EBER positivity is characteristic of extranodal NK/T-cell lymphoma, nasal-type involving the small bowel. The patient soon expired and autopsy demonstrated hepatosplenomegaly with scattered nodules of necrosis with neoplastic cells morphologically similar to those in the jejunum and involving the hepatic sinusoids and splenic red pulp. Overlapping morphology and immunophenotype, lack of specific cytogenetic and molecular abnormalities makes the diagnosis of EBV associated extranodal NK/T cell leukemia/lymphomas challenging. EBER studies are mandatory to differentiate from Intestinal T cell lymphoma NOS. Early diagnosis of this aggressive malignancy is crucial in expediting appropriate treatment.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200304"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200304","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49395851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Perineal nuchal-type fibroma originated from perirectal region: A case report 起源于直肠周围的会阴颈型纤维瘤1例

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200318

Masaki Murata , Kohei Inui , Go Hasegawa , Yohei Ikeda , Yuki Nakagawa , Tsutomu Nishiyama , Yoshihiko Tomita

引用次数: 0

Monophasic epithelial synovial sarcoma initially diagnosed as metastatic adenocarcinoma of unknown primary 单相上皮滑膜肉瘤最初诊断为原发不明的转移性腺癌

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200307

Donghwa Baek , Andreia Barbieri , Alberto G. Ayala , Kwang M. Lee , Myoung J. Ju , Jae Y. Ro

{"title":"Monophasic epithelial synovial sarcoma initially diagnosed as metastatic adenocarcinoma of unknown primary","authors":"Donghwa Baek , Andreia Barbieri , Alberto G. Ayala , Kwang M. Lee , Myoung J. Ju , Jae Y. Ro","doi":"10.1016/j.hpcr.2019.200307","DOIUrl":"10.1016/j.hpcr.2019.200307","url":null,"abstract":"<div><p>Monophasic epithelial synovial sarcoma is extremely rare, and its existence has been debated. We report a case of monophasic epithelial synovial sarcoma, which was initially diagnosed as metastatic adenocarcinoma. A 45-year-old woman presented with a tender pelvic mass, whose morphology was consistent with a glandular neoplasm. The mass was misdiagnosed as metastatic adenocarcinoma of unknown primary, and was treated as such. The tumor recurred 12 years later; it showed biphasic morphology including glandular and spindle sarcomatoid components. TLE1 immunoreactivity of the second tumor supported diagnosis of biphasic synovial sarcoma. The original lesion was reexamined and revealed very focal minor spindle tumor foci admixed with an extensive glandular background. The TLE1 immunostain was strongly positive in the initial lesion, thus confirming diagnosis of epithelial-predominant synovial sarcoma. This case emphasizes the importance of generous sampling and the use of TLE1 staining when soft tissue tumors show predominantly epithelial architectures without an apparent primary site.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200307"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200307","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44779912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Metastatic well-differentiated neuroendocrine tumor in the breast: A case report and literature review 乳腺转移性高分化神经内分泌肿瘤1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200319

Dongfang Yu, Yi Zhou

引用次数: 0

Metanephric adenoma with osseous metaplasia and bone marrow elements 伴有骨化生和骨髓成分的后肾腺瘤

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200316

Alessandro Pietro Aldera MBChB , Jeff John MBChB , Dharshnee Chetty MBBCh FCPath , Dhirendra Govender MBChB FRCPath PhD

引用次数: 0

Whole transcriptome analysis identifies upregulated genes and pathways in ductal carcinoma in situ mimicking usual ductal hyperplasia 全转录组分析确定了导管原位癌中表达上调的基因和通路，模拟了通常的导管增生

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200308

Jennifer Zeng MD , Jonathan Serrano , Matija Snuderl MD , Farbod Darvishian MD

引用次数: 0

Primary intestinal NK-cell lymphoma, EBV-negative: A case report and literature review 原发性肠nk细胞淋巴瘤，ebv阴性:1例报告及文献复习

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200303

Matthew Koo , Olga Olevsky , Kathleen Ruchalski , Sophie Song

{"title":"Primary intestinal NK-cell lymphoma, EBV-negative: A case report and literature review","authors":"Matthew Koo , Olga Olevsky , Kathleen Ruchalski , Sophie Song","doi":"10.1016/j.hpcr.2019.200303","DOIUrl":"10.1016/j.hpcr.2019.200303","url":null,"abstract":"<div><p>Primary intestinal NK-cell lymphoma (PINKL) is a rare entity with an overall poor prognosis. It is frequently EBV-positive and is characteristically negative for a T-cell gene rearrangement. Some parameters that may confer a relatively good prognosis include unifocality, the absence of intestinal perforation, and possibly EBV negativity. While exceedingly rare case reports of EBV-negative PINKL are available in the literature, the NK-cell phenotype of these lymphomas is determined solely by negative T-cell gene rearrangement studies. To the best of our knowledge, there has been no report of an EBV-negative PINKL that is defined by both flow cytometric evidence of absent surface CD3 expression as well as a negative T-cell gene rearrangement study. Furthermore, these reports do not include cytogenetic studies and/or next-generation sequencing (NGS) mutational analysis of the lymphoma. Thus, herein, we report a novel case of a stage I EBV-negative PINKL with an NK-cell phenotype confirmed by both flow cytometric immunophenotyping and a negative T-cell clonality study, describe its cytogenetic and next-generation sequencing (NGS) mutational profile, highlight the clinical course of the patient's 26-month follow-up, and review the relevant literature. The distinctive clinicopathologic findings of this case may expand our knowledge in understanding the biology of EBV-negative NK-cell lymphomas, which may differ from their EBV-positive counterparts.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200303"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200303","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49149785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Synovial sarcoma of submandibular gland with aberrant P63 expression a case report of rare event 下颌下腺滑膜肉瘤伴P63异常表达一例罕见病例报告

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200314

Afnan Elsayed , Haneen Al-Maghrabi , Hosam Alardati , Ameen Alherabi , Abdelrazak Meliti

引用次数: 1

Extranodal Rosai-Dorfman disease of the kidney: A case report 结外肾Rosai-Dorfman病1例报告

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.hpcr.2019.200306

Hiroyuki Tanaka M.D., Ph.D. , Shoichiro Mukai M.D. , Toshiyuki Kamoto M.D., Ph.D. , Hiroaki Kataoka M.D., Ph.D.

{"title":"Extranodal Rosai-Dorfman disease of the kidney: A case report","authors":"Hiroyuki Tanaka M.D., Ph.D. , Shoichiro Mukai M.D. , Toshiyuki Kamoto M.D., Ph.D. , Hiroaki Kataoka M.D., Ph.D.","doi":"10.1016/j.hpcr.2019.200306","DOIUrl":"10.1016/j.hpcr.2019.200306","url":null,"abstract":"<div><p>Extranodal Rosai-Dorfman disease (RDD) of the kidney is rare, with unknown etiology. We present a case of extranodal RDD of the kidney. Imaging revealed a nodular lesion in the right renal pelvis, with accompanying pelvic dilation and parenchymal atrophy, reminiscent of immunoglobulin G4 (IgG4)-related disease. With the clinical diagnosis of suspected renal pelvic cancer, laparoscopic right nephrectomy was performed. Macroscopic findings showed a mass with a white-tan cut surface. Histological examination revealed histiocytes with emperipolesis and patchy infiltration of plasma cells, lymphocytes and foamy macrophages in a fibrocollagenous stroma. Immunohistochemically, the histiocytes were positive for S100, CD68 and CD163, but negative for CD1a, p80/ALK and phospho-p44/42 MARK (Thr202/Tyr204). IgG4-positive plasma cells were not evident.</p><p>These findings indicated that the lesion represented extranodal RDD of the kidney. No mutations of the <em>K-</em> and <em>N</em>-<em>RAS</em> genes could be identified in this case. Although rare, extranodal RDD should be included in the differential diagnosis of a renal pelvic mass.</p></div>","PeriodicalId":38075,"journal":{"name":"Human Pathology: Case Reports","volume":"17 ","pages":"Article 200306"},"PeriodicalIF":0.0,"publicationDate":"2019-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.hpcr.2019.200306","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42492373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Blastic transformation of mantle cell lymphoma with B-lymphoblastic features 具有B淋巴细胞特征的套细胞淋巴瘤的芽细胞转化

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI: 10.1016/j.ehpc.2019.200313

David Cantu , Yuridia Alvarado , Joyce Murata-Collins , Dennis D. Weisenburger

引用次数: 4