具有B淋巴细胞特征的套细胞淋巴瘤的芽细胞转化

Q4 Medicine

Human Pathology: Case Reports Pub Date : 2019-09-01 DOI:10.1016/j.ehpc.2019.200313

David Cantu , Yuridia Alvarado , Joyce Murata-Collins , Dennis D. Weisenburger

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引用次数: 4

摘要

套细胞淋巴瘤的特征是存在t(11;14)(q13;q32)，在95%以上的病例中发现。我们报告了一例典型表型的套细胞淋巴瘤，其转化为母细胞形态，CD20、CD5和BCL2表达缺失，CD10和TdT表达增加。在表现为母细胞形态的病例中，除了通常的套细胞淋巴瘤标志物外，CD10和TdT的使用是必不可少的，因为具有b淋巴母细胞特征的套细胞淋巴瘤病例可能需要创新的治疗。

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Blastic transformation of mantle cell lymphoma with B-lymphoblastic features

Mantle cell lymphoma is characterized by the presence of the t(11;14)(q13;q32), which is found in more than 95% of cases. We present a case of mantle cell lymphoma with the typical phenotype, which transformed to a blastic morphology with loss of expression of CD20, CD5 and BCL2, and gain of CD10 and TdT. In cases presenting with blastic morphology, the use of CD10 and TdT in addition to the usual mantle cell lymphoma markers is essential since cases of mantle cell lymphoma with B-lymphoblastic features may require innovative treatment.

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来源期刊

Human Pathology: Case Reports Medicine-Pathology and Forensic Medicine

CiteScore

0.50

自引率

0.00%

发文量

审稿时长

16 weeks