Adult Langerhans cell histiocytosis arising in colonic polyp: A case report and literature review

Langerhans cell histiocytosis (LCH) is a rare disease characterized by unifocal, or multifocal unisystem, or disseminated/multisystem disease that commonly involves the bone, skin and lung. LCH involvement of the gastrointestinal tract (GI) in adults is uncommon and it rarely involves colon polyps with only few case reports in the literature. In this report, we present a case of an adult female who was found to have a cecal polyp on a routine screening colonoscopy. The histopathological examination and immunohistochemical studies confirmed the diagnosis of LCH. We also review the literature of adults LCH manifested in GI mostly colonic polyps.