Preventive Medicine Reports最新文献

{"title":"Cardiometabolic deaths in black and white men: Tracing the risks from early- to mid-adulthood","authors":"Rebecca Arden Harris ,&nbsp;Sameed Ahmed M. Khatana ,&nbsp;Judith A. Long","doi":"10.1016/j.pmedr.2025.102997","DOIUrl":"10.1016/j.pmedr.2025.102997","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to estimate and compare cardiometabolic disease (CMD) mortality in U.S. Black and White men during the transition from early adulthood to middle age.</div></div><div><h3>Methods</h3><div>Using 2022 National Vital Statistics System data and standard period life table methods, we estimated the risk of CMD death in hypothetical cohorts of Black and White men from age 25 to 45 years. We estimated cumulative risk, excess mortality, years of lost life (YLL), and proportion of deaths due to CMD, stratifying by metabolic and cardiovascular disease.</div></div><div><h3>Results</h3><div>Of the 325,134 Black men aged 25 years in the initial cohort, the cumulative risk of cardiometabolic death before age 45 was one in 63 individuals or 1.58 %. For White men, the risks were markedly lower. Of the 1,185,384 White men aged 25 years in the initial cohort, the cumulative risk of cardiometabolic death before age 45 was one in 158 individuals or 0.63 %. The study also found that of the 5141 expected CMD deaths in the Black cohort, 3090 or 60.10 % were excess deaths relative to the White cohort. Additionally, the proportion of all deaths due to CMD among Black men was 19.15 % rising from 6.02 % at age 25 to 38.00 % at age 45, compared with 11.10 % among White men, increasing from 4.57 % at age 25 to 19.79 % at age 45. The YLL for Black men averaged 6.72 months per person while White men averaged 2.94 months.</div></div><div><h3>Conclusions</h3><div>This investigation shows profound racial disparities in CMD mortality from early to mid-adulthood.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"51 ","pages":"Article 102997"},"PeriodicalIF":2.4,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143350100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating lifestyle behaviors in school education: A proactive approach to preventive medicine","authors":"Mohamad Motevalli ,&nbsp;Fatima Cody Stanford ,&nbsp;Günther Apflauer ,&nbsp;Katharina Christina Wirnitzer","doi":"10.1016/j.pmedr.2025.102999","DOIUrl":"10.1016/j.pmedr.2025.102999","url":null,"abstract":"<div><h3>Objective</h3><div>Individual behavior is regarded as the primary factor influencing health. Despite recent advances in health science, the increasing prevalence of both non-communicable diseases and unhealthy lifestyle behaviors needs to be effectively controlled. The objective of this short communication is to explore the theoretical basis for integrating lifestyle habits into school education and highlight its significance for public health policy.</div></div><div><h3>Methods</h3><div>A conceptual, perspective-driven analysis was conducted, drawing on evidence from existing literature on the role of educational settings in promoting healthy lifestyle behaviors. The study evaluates current physical education (PE) programs and curricula addressing health-related issues while proposing an updated, proactive approach to mitigating existing health concerns.</div></div><div><h3>Results</h3><div>Schools have significant potential to cultivate healthy lifestyle habits through practical, real-life applications. PE is a primary school-based subject capable of promoting an active lifestyle; however, debates persist regarding its adequacy and effectiveness in other facets of health promotion. From a holistic perspective, it is proposed that PE be evolved into lifestyle education (LE), that aims to integrate all lifestyle factors—beyond physical activity—within the school-based educational framework on a global scale.</div></div><div><h3>Conclusions</h3><div>Establishing school-based LE appears crucial for addressing the growing pandemic of chronic health conditions from their earliest origins.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"51 ","pages":"Article 102999"},"PeriodicalIF":2.4,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143277959","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoke-free hospitality environments and cognitive health: A population-based study in the United States","authors":"Lucie Kalousová","doi":"10.1016/j.pmedr.2024.102961","DOIUrl":"10.1016/j.pmedr.2024.102961","url":null,"abstract":"<div><h3>Introduction</h3><div>Cigarette smoking is among the largest risk factors for cognitive decline in later life. This study examines the associations between hospitality smoke-free coverage in the US and the prevalence of self-rated cognitive function decline and disparities therein.</div></div><div><h3>Methods</h3><div>I use the repeated cross-sectional Behavioral Risk Factor Surveillance data collected between 2017 and 2022 from a sample of Americans 45 years and older and estimate logistic regression models predicting self-rated cognitive function decline by calculated smoke-free hospitality coverage in restaurants and bars.</div></div><div><h3>Results</h3><div>Fully adjusted models indicate a marginally statistically significant 0.16 percentage point reduction [CI −0.35 to 0.02] in the probability of self-rated cognitive function decline for a 10 % increase in the smoke-free bar coverage. The effect is statistically significant and larger for women, a 0.29 [CI −0.50 to −0.01] percentage point decrease, and for non-smokers, a 0.35 [CI −0.56 to −0.15] percentage point decrease. I do not find a parallel effect of smoke-free restaurant laws and I find no effect of either law on self-rated cognitive function decline-related limitations in daily life for either hospitality law.</div></div><div><h3>Conclusions</h3><div>The findings suggest that smoke-free bar laws could play a role in preventing cognitive decline among older adults in the United States. Effective public health strategies against cognitive decline should include both targeted and broad-based policy measures.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102961"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11770490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143060840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sleep duration and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysis","authors":"Kasra Pirahesh ,&nbsp;Ali Zarrinnia ,&nbsp;Leila Nikniaz ,&nbsp;Zeinab Nikniaz","doi":"10.1016/j.pmedr.2025.102968","DOIUrl":"10.1016/j.pmedr.2025.102968","url":null,"abstract":"<div><h3>Introduction</h3><div>Considering that both long and short sleep duration may have an association with nonalcoholic fatty liver disease (NAFLD), in this meta-analysis, we analyzed the dose-response association between sleep duration and NAFLD along with meta-analyses of the differences in mean sleep duration between NAFLD patients and healthy controls, and linear meta-analysis of the association between sleep duration and NAFLD.</div></div><div><h3>Methods</h3><div>PubMed (665 articles), Scopus (442 articles), and Web of Sciences (200 articles) were searched from inception until November 2023. Observational studies were included if they assess the association between sleep duration and NAFLD or compare the mean sleep duration between patients with NAFLD and healthy population. All studies done in humans without restriction on sex, age, and language were included. The methological quality of studies was assessed by Joanna Briggs Institute (JBI) tools. The meta-analysis was conducted using STATA.</div></div><div><h3>Results</h3><div>Thirty-one studies that included 836,117 participants were included in this systematic review. The results indicated no significant differences between NAFLD patients and healthy controls regarding mean sleep duration [Mean difference: -7.08, 95 % CI: −20.10, 5.94]. The subgroup meta-analysis did not show any significant differences between groups. The long versus short sleep duration meta-analysis showed a significant association between sleep duration and NAFLD (OR: 0.8 [95 % CI, 0.74–0.91]). The results of the dose-response meta-analysis do not suggest a linear or nonlinear relationship between sleep duration and NAFLD (<em>p</em>-value = 0.9).</div></div><div><h3>Conclusion</h3><div>The highest category of sleep duration was associated with a lower risk of NAFLD. However, no dose-response association was observed.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102968"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11783128/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143081487","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiovascular diseases health literacy among Italian navy personnel: A cross-sectional survey","authors":"L. Rondinini ,&nbsp;V. Di Fiore ,&nbsp;M. Pasquale ,&nbsp;G. Cruschelli ,&nbsp;D. Rocchi ,&nbsp;F. Baglivo ,&nbsp;A. Baggiani ,&nbsp;A.D. Porretta","doi":"10.1016/j.pmedr.2025.102978","DOIUrl":"10.1016/j.pmedr.2025.102978","url":null,"abstract":"<div><h3>Objectives</h3><div>This study assesses cardiovascular disease (CVD) awareness among Italian Navy personnel, emphasizing the understanding of risk factors. It aims to provide insights that could enhance health education initiatives tailored to military settings.</div></div><div><h3>Study Design</h3><div>Cross-sectional survey.</div></div><div><h3>Methods</h3><div>From February 2021 to March 2022, participants were enrolled through opportunistic sampling among Italian Navy personnel. They were surveyed using a structured questionnaire divided into two parts. It was designed to elicit open-ended and closed-ended responses on their knowledge of CVD, its risk factors, and associated diagnostic thresholds. Statistical analyses included logistic regression conducted with R software.</div></div><div><h3>Results</h3><div>A total of 785 participants were enrolled. The findings indicate a higher recognition of acute myocardial infarction and hypertension compared to other diseases like atherosclerosis and cardiomyopathy. For risk factors, smoking was recognized by 57 % of respondents, while only 60 % correctly identified the diagnostic threshold for total cholesterol. Logistic regression analysis showed significant differences in awareness levels based on sex and rank (<em>p</em> &lt; 000000.1); officers had higher awareness than enlisted personnel (p &lt; 000000.1).</div></div><div><h3>Conclusions</h3><div>The results demonstrate significant disparities in CVD risk awareness among different ranks and sexes within the Italian Navy, highlighting the need for tailored educational programs. Through specific interventions, Addressing these knowledge gaps could enhance the health outcomes of military personnel and the overall efficacy of Navy health strategies. Furthermore, the work and life environment of the Navy could allow for more in-depth health education initiatives, leading to the adoption of healthier lifestyles by the personnel.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102978"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143090601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Independent and joint associations of neighbourhood greenness and walkability with transportational and recreational physical activity among youth and adults in Canada","authors":"Natalie Doan ,&nbsp;Sebastian A. Srugo ,&nbsp;Stephanie A. Prince ,&nbsp;Rachel C. Colley ,&nbsp;Daniel G. Rainham ,&nbsp;Taru Manyanga ,&nbsp;Gregory P. Butler ,&nbsp;Richard Larouche ,&nbsp;Sarah E. Turner ,&nbsp;Justin J. Lang","doi":"10.1016/j.pmedr.2025.102974","DOIUrl":"10.1016/j.pmedr.2025.102974","url":null,"abstract":"<div><h3>Objectives</h3><div>Greener neighbourhoods may support physical activity; however, it is also important to consider whether greener neighbourhoods are walkable. We assessed whether neighbourhood greenness and walkability were independently and jointly associated with transportational (PA_TRA) and recreational (PA_REC) physical activity among a nationally representative sample of urban-dwelling youth and adults in Canada.</div></div><div><h3>Methods</h3><div>We analyzed repeated cross-sectional data from 132,927 urban-dwelling youth (12–17 years) and adults (≥18 years) who participated in the Canadian Community Health Survey (2015–2018). To derive an indicator of neighbourhood greenness, for each survey year, we aggregated mean Normalized Difference Vegetation Index (NDVI) values within 2016 dissemination areas. As a proxy for neighbourhood walkability, we used 2016 Canadian Active Living Environments (Can-ALE) metrics. We used weighted linear regressions to examine whether, and the extent to which, neighbourhood NDVI and the Can-ALE index were independently and jointly associated with self-reported and log-transformed PA_TRA and PA_REC, while adjusting for individual and neighbourhood characteristics.</div></div><div><h3>Results</h3><div>Among adults, but not youth, higher NDVI was independently associated with higher PA_TRA (β = 0.2, 95 % CI 0.02, 0.36) and PA_REC (β = 0.3, 95 % CI 0.14, 0.47). Among both youth (β = 0.4, 95 % CI 0.21, 0.66) and adults (β = 0.3, 95 % CI 0.22, 0.35), NDVI and Can-ALE were jointly associated with PA_TRA.</div></div><div><h3>Conclusion</h3><div>Living in a neighbourhood that is both greener and more walkable was more strongly associated with higher transportational, but not recreational, physical activity, than either feature alone. These novel findings highlight the importance of designing cities that are both greener and more walkable to promote active living.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102974"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of cannabidiol use among marijuana users in the United States","authors":"Ji-Yeun Park","doi":"10.1016/j.pmedr.2025.102985","DOIUrl":"10.1016/j.pmedr.2025.102985","url":null,"abstract":"<div><h3>Background</h3><div>As more and more states are legalizing marijuana use for medical purposes, cannabidiol (CBD) products have gained significant popularity as self-medications for treating conditions. Despite the increasing use, there is insufficient data about how CBD use varies across different populations, particularly in relation to marijuana use status. Understanding these patterns is crucial to inform public health recommendations that address appropriate CBD use.</div></div><div><h3>Methods</h3><div>Data came from the 2022 National Survey on Drug Use and Health (NSDUH). NSDUH is a cross-sectional national survey that provides in-depth data about drug use and mental health in the representative sample of the United States. Descriptive analyses were used to assess the prevalence of CBD use overall and by marijuana use status. Additionally, adjusted logistic regression analyses were performed to examine demographic characteristics associated with CBD use.</div></div><div><h3>Results</h3><div>Overall, 10.5 % of the United States population reported using CBD in the past 30 days (current use). Prevalence of current CBD use was significantly higher among marijuana users (current users: 40.7 %, past-year users: 32.2 %, ever users: 19.1 %) than among non-marijuana users (non-current users: 5.09 %, non-past year users: 4.38 %, never users: 5.09 %). Females, adults, Whites, and individuals with fair/poor health status were more likely to use CBD than their respective counterparts.</div></div><div><h3>Conclusion</h3><div>CBD use was commonly reported among people who use marijuana. Public health initiatives targeting individuals who use marijuana are crucial for educating them about the potential benefits and risks of CBD use, as well as the safety of using CBD in conjunction with marijuana.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102985"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143092333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Socioeconomic position and breast cancer screening use in Chile: A population-based study","authors":"Camilo Guerrero-Nancuante ,&nbsp;Pamela Eguiguren ,&nbsp;Isabel Abarca-Baeza ,&nbsp;Isabel Guzmán ,&nbsp;María Luisa Garmendia","doi":"10.1016/j.pmedr.2025.102973","DOIUrl":"10.1016/j.pmedr.2025.102973","url":null,"abstract":"<div><h3>Background</h3><div>Breast cancer screening is crucial for the early detection of the disease. Although several studies have examined the relationship between socioeconomic factors and mammography use, the impact of socioeconomic position (SEP) in countries undergoing demographic and epidemiological transitions—marked by a rising cancer incidence—and passive breast cancer screening programs in the search of the target population remains understudied.</div></div><div><h3>Objective</h3><div>To analyze the relationship between SEP in the use of breast cancer screening in Chile during 2022.</div></div><div><h3>Methods</h3><div>Data from the 2022 National Socioeconomic Characterization Survey was utilized for this study. The sample consisted of women aged 50–69 who were asked about their mammography screening history within the past three years. The relationship between SEP and breast cancer screening was analyzed using multilevel logit-binomial regression models.</div></div><div><h3>Results</h3><div>The study included 26,337 women, of whom 66.9 % reported having undergone mammography in the past three years. Three SEP indicators were associated with non-use of mammography. These factors were primary education level or lower (Prevalence ratio = 1.20; 95 % CI 1.08–1.33. Ref: tertiary level), belonging to the low-income quintiles (eg: Quintile I (Prevalence ratio = 1.49; 95 % CI 1.30–1.69) and II (Prevalence ratio = 1.41; 95 % CI 1.24–1.60). Ref: quintile V) and being unemployed (Prevalence ratio = 1.34; 95 % CI 1.18–1.51) or working in service and commerce (Prevalence ratio = 1.21; 95 % CI 1.06–1.39) (Ref: Managers and professionals).</div></div><div><h3>Conclusions</h3><div>Low SEP was significantly associated with the non-use of mammography. To improve mammography screening rates, it is essential to adopt strategies that incorporate both equity and territorial considerations.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102973"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143084213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A descriptive study of blood pressure in people with self-reported substance use seeking health care in region F, Johannesburg, South Africa","authors":"K.E. Oladimeji,&nbsp;S. Gumede,&nbsp;A. Nyatela,&nbsp;S. Nonyukela,&nbsp;R. Mohale,&nbsp;S.T. Lalla-Edward,&nbsp;D. Dwarka","doi":"10.1016/j.pmedr.2025.102977","DOIUrl":"10.1016/j.pmedr.2025.102977","url":null,"abstract":"<div><h3>Background</h3><div>Elevated blood pressure is a major risk factor for cardiovascular diseases like hypertension and leading cause of death in sub-Saharan Africa. Substance use such as alcohol, tobacco and drugs, is one of various factors attributable to elevated blood pressure This study describes the prevalence of elevated blood pressure and associated factors among individuals who self-reported to substance use.</div></div><div><h3>Methods</h3><div>This descriptive cross-sectional study involved use of secondary data from the Integrating HIV and Heart Health in South Africa study collected between August 2022 to May 2024. Primary outcome, elevated blood pressure was classified as systolic blood pressure ≥ 140 mmHg, and diastolic blood pressure ≥ 90 mmHg. Data was analysed using STATA version 17. Logistic regression analysis was performed to identify factors associated with elevated blood pressure.</div></div><div><h3>Results</h3><div>Of the 2148 participants included, 57.3 % (1230/2148) were males. The participants' median age was 41 years, and 35.9 % (772/2148) had elevated blood pressure, however only 16,9 % of the participants were receiving anti-hypertensive treatment. Independent factors associated with elevated blood pressure were increasing age - 30-39 years old (adjusted odds ratio (aOR) 2.78 [95 %CI 1.42–5.41], 40–49 years old (aOR 3.81 [95 %CI 1.95–7.46]), 50+ years (aOR 5.00 [95 %CI 2.45–10.20] and having comorbidities (aOR 2.35 [95 %CI 1.31–4.22]).</div></div><div><h3>Conclusions</h3><div>Prevalence of elevated blood pressure was high and only a few of these were on anti-hypertensive treatment. Most participants reported using alcohol, including both alcohol and tobacco concurrently. Findings highlight the need for substance use interventions as part of cardiovascular disease management strategies.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102977"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143084204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-marketing safety surveillance for the recombinant zoster vaccine (Shingrix), vaccine adverse event reporting system, United States, October 2017–April 2024","authors":"Yamin Shu ,&nbsp;Wenxin Cheng ,&nbsp;Xucheng He ,&nbsp;Liu Huang ,&nbsp;Wei Chen ,&nbsp;Qilin Zhang","doi":"10.1016/j.pmedr.2025.102981","DOIUrl":"10.1016/j.pmedr.2025.102981","url":null,"abstract":"<div><h3>Background</h3><div>Recombinant zoster vaccine (RZV), received its first marketing authorization in October 2017 to prevent herpes zoster and its complications in older adults. The purpose of this study was to provide comprehensively worldwide post-marketing safety information about RZV using data from the Vaccine Adverse Event Reporting System (VAERS).</div></div><div><h3>Methods</h3><div>We searched for and analyzed adverse event (AE) reports of RZV submitted to U.S. VAERS between October 20, 2017 and April 26, 2024. Descriptive analyses included sex, age, time-to-onset, seriousness, most commonly reported AEs, AE of special interest, and cause of death. The empirical Bayesian data mining was employed to identify potential disproportionalities in reporting.</div></div><div><h3>Results</h3><div>During the study period, 1,279,596 AE reports for vaccines were received by VAERS after excluding any duplicates, including 66,849 reports specifically related to RZV. Most reports were classified as non-serious (97.3 %). Among reports with age or sex reported, individuals were mainly 50–79 years (71.2 %) and females (63.1 %). The most commonly reported AEs included injection site reactions, pyrexia, chills, headache and fatigue. A total of 86 reports documenting deaths were identified following RZV vaccination. In addition to cardiovascular events and falls, Guillain-Barre syndrome was the most common cause of death. The median TTO for RZV-related AEs was 1 day in all cohort groups over 50 years old.</div></div><div><h3>Conclusion</h3><div>The safety profile of RZV, based on the large sample post-marketing use, was reassuring and consistent with that observed in clinical trials. Further studies are needed to continue generating real-world safety data and further characterize RZV-AE pairs systematically.</div></div>","PeriodicalId":38066,"journal":{"name":"Preventive Medicine Reports","volume":"50 ","pages":"Article 102981"},"PeriodicalIF":2.4,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143084207","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}