Acupuncture in medicine : journal of the British Medical Acupuncture Society最新文献

{"title":"Laser acupuncture versus oral glucose administration for pain prevention in term neonates: an observer-blinded non-inferiority randomized controlled clinical trial.","authors":"Jasmin Stadler,&nbsp;Alexander Avian,&nbsp;Gerhard Pichler,&nbsp;Katrin Posch,&nbsp;Berndt Urlesberger,&nbsp;Wolfgang Raith","doi":"10.1177/09645284211009544","DOIUrl":"https://doi.org/10.1177/09645284211009544","url":null,"abstract":"<p><strong>Background: </strong>Neonates undergoing intensive care are routinely submitted to minor painful procedures such as heel lances. Pharmacological treatment is limited in neonatal care and not recommended for minor painful interventions. Hence, non-pharmacological acute pain management is an important subject. Acupuncture could be a new strategy for neonatal pain prevention. Accordingly, the aim of the present study was to investigate whether laser acupuncture is non-inferior to oral sweet solutions in pain prevention.</p><p><strong>Methods: </strong>In total, 96 healthy term neonates were randomly assigned to receive either laser acupuncture with 10 mW at LI4 bilaterally (AG, acupuncture group) or 30% oral glucose solution (GG, glucose group) before heel lance for metabolic screening. The primary outcome was the difference in premature infant pain profile (PIPP) score between groups in a non-inferiority concept. Secondary outcomes were changes in heart rate and crying time.</p><p><strong>Results: </strong>Median (interquartile range) PIPP scores were comparable in the AG and GG (12 (10-14) vs 12 (9-14), p = 0.981). Nevertheless, the 95% confidence interval (CI) of location shift exceeded the predefined margin for non-inferiority of 1 (95% CI: -1.000006 to 1.000059). Heart rate was found to be significantly lower after intervention (p = 0.048) and after heel lance (p = 0.015) in the AG versus GG. There was no difference in crying time between groups (p = 0.890).</p><p><strong>Conclusion: </strong>Laser acupuncture was not shown to be non-inferior to an oral glucose solution, possibly due to the higher than expected variability in PIPP scores within the studied groups. Future neonatal laser acupuncture studies for pain prevention with higher sample sizes are therefore warranted.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"589-595"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/09645284211009544","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39062141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture stimulation at BL20, BL23 and SP6 prevents hind limb unloading-induced osteoporosis in rats.","authors":"Honghui Wang,&nbsp;Desheng Wang,&nbsp;Zhili Li,&nbsp;Shujuan Liu,&nbsp;Jingjing Dong,&nbsp;Jianfeng Zhang,&nbsp;Huijuan Wang,&nbsp;Minjie Wang,&nbsp;Bo Ji,&nbsp;Yinghui Li","doi":"10.1177/0964528421995494","DOIUrl":"https://doi.org/10.1177/0964528421995494","url":null,"abstract":"<p><strong>Background: </strong>Bone loss induced by microgravity is a serious problem in space flight. However, the effects of acupuncture stimulation on osteoporosis induced by microgravity have not been studied. With the goal of developing an effective countermeasure, our aim was to evaluate the effects of electroacupuncture (EA) stimulation at BL20, BL23, and SP6 on osteoporosis induced by simulated microgravity in rats.</p><p><strong>Methods: </strong>Thirty male Wistar rats (aged 10 weeks) were randomly divided into three groups: healthy control group (CON, <i>n</i> = 10), hind limb unloading by tail-suspension group (T-S, <i>n</i> = 10), and EA treatment group (TRE, <i>n</i> = 10). Rats in the T-S and TRE groups were subjected to tail-suspension at -30° for 30 days, while the CON group experienced freedom of activity. In this period, the TRE group received EA treatment at BL20, BL23, and SP6 for 30 min every other day, which continued for 30 days. The microarchitecture of the proximal tibia and the biomechanical features of the femur in the rats were analyzed. In addition, the levels of serum biomarkers bone alkaline phosphatase (BALP) and osteocalcin (BGP) were measured.</p><p><strong>Results: </strong>Compared with the CON group, the value of bone volume/total volume (BV/TV) and trabecular number (Tb.N) of the tibias in the TRE group remarkably decreased (<i>p</i> <i><</i> 0.01). However, these changes were markedly less than those of the T-S group after 4 weeks of EA treatment (<i>p</i> <i><</i> 0.05). Moreover, the serum concentration of BGP in the TRE group was also significantly higher than that of the T-S group (<i>p</i> <i><</i> 0.05).</p><p><strong>Conclusions: </strong>These findings indicate that EA stimulation at BL20, BL23, and SP6 retards osteoporosis induced by hind limb unloading in rats.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"656-662"},"PeriodicalIF":2.5,"publicationDate":"2021-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1177/0964528421995494","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"25476474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture treatment of insulin resistance in diabetes mellitus.","authors":"Philip V Peplow","doi":"10.1136/acupmed-2015-010942","DOIUrl":"https://doi.org/10.1136/acupmed-2015-010942","url":null,"abstract":"Insulin resistance is closely associated with obesity, type 2 diabetes mellitus (DM), hypertension and the metabolic syndrome, and is also a risk factor for cardiovascular disease. There is increasing clinical evidence for the effectiveness of acupuncture as a treatment for insulin resistance.1\u0000\u0000From a mechanistic point of view, the post-receptor responses and signal transduction pathways that are initiated when insulin binds to its receptor in the cell plasma membrane are well described (http://themedicalbiochemistrypage.org/insulin.php). These include the association of insulin receptor substrates (IRSs) with the insulin receptor (IR), which results in the activation of phosphatidylinositol-3-kinase (PI3K) and growth factor receptor binding protein 2 (GRB2). Activated PI3K phosphorylates membrane phospholipids and the main product is phosphatidylinositol-3,4,5-triphosphate (PIP3), which in turn activates PIP3-dependent kinase 1 (PDK1). PDK1 activates another kinase called protein kinase B (PKB, also known as Akt). Insulin-mediated activation of Akt causes inhibition of lipolysis and gluconeogenesis and activation of protein and glycogen synthesis. Insulin signalling also activates the mitogen activated protein kinase (MAPK) pathway either by IR phosphorylation of Src homology 2 domain-containing protein (SHC), which then interacts with GRB2, or via IRS1 activation. Insulin decreases hepatic glucose production (HGP) and increases the rate of glucose uptake, primarily in striated muscle and adipose tissue. In muscle and fat cells, the clearance of circulating glucose depends on the insulin-stimulated translocation of the glucose transporter 4 (GLUT4) isoform to the …","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"347-9"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2015-010942","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34070603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1136/acupmed-2014-010573corr1","DOIUrl":"https://doi.org/10.1136/acupmed-2014-010573corr1","url":null,"abstract":"","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"424"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2014-010573corr1","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34070604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of transcutaneous electrical nerve stimulation on rats with the third lumbar vertebrae transverse process syndrome.","authors":"Huan Li,&nbsp;Xiao-Jun Shang,&nbsp;Qi-Rong Dong","doi":"10.1136/acupmed-2014-010752","DOIUrl":"https://doi.org/10.1136/acupmed-2014-010752","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the analgesic and anti-inflammatory effects of transcutaneous electrical nerve stimulation (TENS) at local or distant acupuncture points in a rat model of the third lumbar vertebrae transverse process syndrome.</p><p><strong>Methods: </strong>Forty Sprague-Dawley rats were randomly divided into control, model, model plus local acupuncture point stimulation at BL23 (model+LAS) and model plus distant acupuncture point stimulation at ST36 (model+DAS) groups. All rats except controls underwent surgical third lumbar vertebrae transverse process syndrome modelling on day 2. Thereafter, rats in the model+LAS and model+DAS groups were treated daily with TENS for a total of six treatments (2/100 Hz, 30 min/day) from day 16 to day 29. Thermal pain thresholds were measured once a week during treatment and were continued until day 57, when local muscle tissue was sampled for RT-PCR and histopathological examination after haematoxylin and eosin staining. mRNA expression of interleukin-1 β (IL-1β), tumour necrosis factor-α (TNF-α) and inducible nitric oxide synthase (iNOS) was determined.</p><p><strong>Results: </strong>Thermal pain thresholds of all model rats decreased relative to the control group. Both LAS and DAS significantly increased the thermal pain threshold at all but one point during the treatment period. Histopathological assessment revealed that the local muscle tissues around the third lumbar vertebrae transverse process recovered to some degree in both the model+LAS and model+DAS groups; however, LAS appeared to have a greater effect. mRNA expression of IL-1β, TNF-α and iNOS in the local muscle tissues was increased after modelling and attenuated in both model+LAS and model+DAS groups. The beneficial effect was greater after LAS than after DAS.</p><p><strong>Conclusions: </strong>TENS at both local (BL23) and distant (ST36) acupuncture points had a pain-relieving effect in rats with the third lumbar vertebrae transverse process syndrome, and LAS appeared to have greater anti-inflammatory and analgesic effects than DAS.</p><p><strong>Trial registration number: </strong>09073.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"400-5"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2014-010752","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33414393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain responses to acupuncture stimulation in the prosthetic hand of an amputee patient.","authors":"In-Seon Lee,&nbsp;Won-Mo Jung,&nbsp;Ye-Seul Lee,&nbsp;Christian Wallraven,&nbsp;Younbyoung Chae","doi":"10.1136/acupmed-2015-010785","DOIUrl":"https://doi.org/10.1136/acupmed-2015-010785","url":null,"abstract":"<p><p>This report describes the brain responses to acupuncture in an upper limb amputee patient. A 62-year-old male had previously undergone a lower left arm amputation following an electrical accident. Using functional MRI, we investigated brain responses to acupuncture stimulation in the aforementioned amputee under three conditions: (a) intact hand, (b) prosthetic hand (used by the patient), and (c) fake fabric hand. The patient described greater de qi sensation when he received acupuncture stimulation in his prosthetic hand compared to a fake hand, with both stimulations performed in a similar manner. We found enhanced brain activation in the insula and sensorimotor cortex in response to acupuncture stimulation in the amputee's prosthetic hand, while there was only minimal activation in the visual cortex in response to acupuncture stimulation in a fake hand. The enhanced brain responses to acupuncture stimulation of the patient's prosthetic hand might be derived from cortical reorganisation, as he has been using his prosthetic hand for over 40 years. Our findings suggest the possible use of acupuncture stimulation in a prosthetic hand as an enhanced sensory feedback mechanism, which may represent a new treatment approach for phantom limb pain.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"420-4"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2015-010785","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33354586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture plus metformin lowers glucose levels and facilitates insulin sensitivity by activating MAPK in steroid-induced insulin-resistant rats.","authors":"Hsien-Yin Liao,&nbsp;Mao-Feng Sun,&nbsp;Jaung-Geng Lin,&nbsp;Shih-Liang Chang,&nbsp;Yu-Chen Lee","doi":"10.1136/acupmed-2014-010724","DOIUrl":"https://doi.org/10.1136/acupmed-2014-010724","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus is the predominant form of diabetes. Although metformin is the preferred first-line drug for treatment of the disease, it is associated with a risk of secondary failure. Electroacupuncture (EA) can enhance insulin sensitivity and reduce blood glucose levels.</p><p><strong>Objectives: </strong>To examine, in an animal study, whether EA combined with metformin (EA-metformin) results in a better glucose-lowering effect and greater insulin sensitivity than metformin alone in steroid-induced insulin-resistant rats.</p><p><strong>Methods: </strong>Adult Wistar rats were injected with dexamethasone to induce diabetes and subsequently treated with EA plus metformin or metformin alone. Variations in plasma glucose, plasma insulin, and plasma free fatty acid levels were studied at the midpoint and end of the experimental course. Insulin receptor substrate 1 (IRS-1) and peroxisome proliferator-activated receptor γ (PPAR-γ), which are associated with glucose transporter type 4 (GLUT4) translocation, and mitogen-activated protein kinase (MAPK), which is related to GLUT4 activation, were measured after EA treatment.</p><p><strong>Results: </strong>We found that EA-metformin resulted in a better glucose-lowering effect, greater insulin sensitivity, lower plasma free fatty acid levels and higher levels of MAPK than metformin alone (p<0.05). There were no significant differences between treatment groups in expression of IRS-1 or PPAR-γ.</p><p><strong>Conclusions: </strong>The glucose-lowering effect and increased insulin sensitivity associated with EA-metformin administration is governed, at least in part, by its ability to stimulate the activation of GLUT4 via upregulation of MAPK expression.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"388-94"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2014-010724","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33347362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of electroacupuncture on overactive bladder refractory to anticholinergics: a single-blind randomised controlled trial.","authors":"Jie Zhang,&nbsp;Wei Cheng,&nbsp;Mingming Cai","doi":"10.1136/acupmed-2015-010770","DOIUrl":"https://doi.org/10.1136/acupmed-2015-010770","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the clinical effects and safety of electroacupuncture (EA) in the treatment of overactive bladder (OAB) refractory to first-line anticholinergic treatment.</p><p><strong>Methods: </strong>Women diagnosed with OAB who were refractory to first-line anticholinergic treatment were referred for EA therapy. 50 women enrolled in this single-blind randomised controlled trial and were randomised 1:1 to EA or sham EA (SEA). The EA and SEA groups were treated with 30 sessions (5 sessions a week for 6 weeks), and each session lasted 30 min. OAB symptom scores (OABSS), King's Health Questionnaire scores (KHQ) and urodynamic parameters were used to assess treatment effects. Safety was also evaluated.</p><p><strong>Results: </strong>45 women completed all aspects of the study (23 in the EA group and 22 in the SEA group). The OABSS and KHQ showed statistically significant improvements in the EA group compared with the SEA group after 6 weeks of treatment (p<0.05). There were no statistical differences in the maximum flow rate and postvoid residual (p>0.05), but there were statistical improvements in the first sensation of bladder filling, first urge to void and maximum cystometric capacity (p<0.05) in the EA group compared with the SEA group. No serious adverse events occurred in either group.</p><p><strong>Conclusions: </strong>EA appears to be an effective, safe and minimally invasive treatment for women with OAB. Further studies with longer follow-up are needed to evaluate whether it could be a therapeutic option for OAB refractory to treatment with anticholinergics.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"368-74"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2015-010770","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33359872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effects of pretreatment with repeated electroacupuncture at GV20 and ST36 on fatigue in rats.","authors":"Kai Guo,&nbsp;Jinyu Zhu,&nbsp;Xin Quan,&nbsp;Dawei Zhang,&nbsp;Xiaoyong Chen,&nbsp;Chongfei Yang,&nbsp;Xiaojie Li,&nbsp;Jun Shi,&nbsp;Wendong Hu,&nbsp;Qingsheng Zhu","doi":"10.1136/acupmed-2014-010686","DOIUrl":"https://doi.org/10.1136/acupmed-2014-010686","url":null,"abstract":"<p><strong>Objective: </strong>To investigate and compare the effects of electroacupuncture (EA) pretreatment at GV20 and ST36 on fatigue in rats.</p><p><strong>Methods: </strong>Rats were randomly allocated into 4 groups: control, fatigue, fatigue+GV20 and fatigue+ST36. The last two groups received EA pretreatment at GV20 or ST36 for 5 days before being maintained in cages filled with water to a height of 1.5 cm to establish an animal model of fatigue. We used the weight-loaded forced swimming test and open-field test and measured 5-hydroxyindoleacetic acid (5-HIAA)/5-hydroxytryptamine (5-HT) ratios and serum levels of blood urea nitrogen (BUN), lactic dehydrogenase (LDH) and testosterone as behavioural and biochemical markers of fatigue in the rats.</p><p><strong>Results: </strong>Compared with controls, rats in the (untreated) fatigue group exhibited reduced weight-loaded swimming times and total movement/distance in the open-field test, plus higher BUN/LDH and lower testosterone levels. Both EA pretreatment at GV20 and ST36 increased swimming times, and reduced serum BUN/LDH. EA pretreatment at GV20 (but not ST36) increased serum testosterone. The 5-HIAA/5-HT ratios in four brain regions were decreased in the fatigue+GV20 group compared with the fatigue group (p<0.05). By contrast, 5-HIAA/5-HT ratios in striatum and hypothalamus (but not hippocampus or midbrain) were decreased in the fatigue+ST36 group compared with the fatigue group (p<0.05). Furthermore, only pretreatment at GV20 affected the results of the open-field test.</p><p><strong>Conclusions: </strong>These results suggest that EA pretreatment had a positive effect on the prevention of fatigue. Pretreatment at GV20 had a greater anti-fatigue effect than pretreatment at ST36.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"406-12"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2014-010686","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33431745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intracellular signalling pathways associated with the glucose-lowering effect of ST36 electroacupuncture in streptozotocin-induced diabetic rats.","authors":"Chung-Yuh Tzeng,&nbsp;Yu-Chen Lee,&nbsp;Tin-Yun Ho,&nbsp;Ying-I Chen,&nbsp;Tai-Hao Hsu,&nbsp;Jaung-Geng Lin,&nbsp;Kuan-Rong Lee,&nbsp;Shih-Liang Chang","doi":"10.1136/acupmed-2014-010718","DOIUrl":"https://doi.org/10.1136/acupmed-2014-010718","url":null,"abstract":"<p><strong>Background and aim: </strong>Previous animal studies have reported a glucose-lowering effect of electroacupuncture (EA) and suggested that the mechanisms are closely related to intracellular signalling pathways. The aim of this study was to screen for potential intracellular signalling pathways that are upregulated by EA at ST36 bilaterally in rats with diabetes mellitus (DM) using microarray analysis.</p><p><strong>Methods: </strong>Streptozotocin (STZ)-induced diabetic rats were randomly assigned to experimental (EA, n=8) or control (non-EA, n=8) groups. Plasma glucose levels were measured at baseline and after 30 and 60 min, and microarray analysis was performed on samples of gastrocnemius muscle.</p><p><strong>Results: </strong>Relative to baseline values, EA significantly reduced plasma levels of glucose at 30 and 60 min. The microarray pathway analysis showed that cell adhesion molecules and type 1 DM gene sets were both upregulated in EA versus non-EA groups (p<0.05).</p><p><strong>Conclusions: </strong>Cell adhesion molecules might be related to the glucose-lowering effect induced by EA in rats with STZ-induced type 1 diabetes. Further research will be required to examine the involvement of related intracellular signalling pathways.</p>","PeriodicalId":378725,"journal":{"name":"Acupuncture in medicine : journal of the British Medical Acupuncture Society","volume":" ","pages":"395-9"},"PeriodicalIF":2.5,"publicationDate":"2015-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1136/acupmed-2014-010718","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33347360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}