Journal Of The Indonesian Medical Association最新文献_第9页

In Vitro Synergism of Sulbactam- Cefoperazone and Fosfomycin Against Escherichia Coli and Klebsiella Aeromobilis from Indonesia 舒巴坦-头孢哌酮和磷霉素对印尼产大肠杆菌和航空克雷伯菌的体外增效作用

Journal Of The Indonesian Medical Association Pub Date : 2021-11-27 DOI: 10.47830/jinma-vol.71.5-2021-546

Agus Syahrurachman, Atna Permana

{"title":"In Vitro Synergism of Sulbactam- Cefoperazone and Fosfomycin Against Escherichia Coli and Klebsiella Aeromobilis from Indonesia","authors":"Agus Syahrurachman, Atna Permana","doi":"10.47830/jinma-vol.71.5-2021-546","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.5-2021-546","url":null,"abstract":"Introduction: There is no susceptibility data of E. coli and K. aeromobilis in Indonesia, even data regarding minimal inhibitory concentration (MIC)-based susceptibility of E. coli and K. aeromobilis towards single antibiotic or combination of fosfomycin (FOS) and sulbactam-cepoferazone (SUL-CPZ) is very scarce, even though the data is required by clinicians. Methods: A descriptive observational study was carried out at the Microbiology Clinical Laboratory of the Faculty of Medicine, Universitas Indonesia. Thirty strains each of clinical isolates of E. coli and K. aeromobilis were subjected to MIC determination against FOS and SUL-CPZ. For susceptibility criteria, we adopted the Eucast guideline. The synergism of the combined antibiotics was determined by checkerboard titration. One strain of E. coli and K. aeromobilis showing a synergistic and independent effect against the combined antibiotics was subjected to a time-kill assay. The post-antibiotic effect (PAE) was determined on a strain of E. coli showing synergism against the combined antibiotics. Results: The MIC level of all strains decreased when the bacteria were exposed to the combined antibiotics. Synergism was observed in 53.3% of E. coli and 56.8% of K. aeromobilis. No antagonism was observed. Higher bacterial death during the first four hours occurred with the isolate, showing synergism compared to the isolate showing an independent effect. The PAE of E. coli was longer when exposed to combined antibiotics. Conclusion: In vitro synergism of FOS and SUL-CPZ was observed in the majority of isolates and could be used as the basis for further research on empirical treatment","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134588494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tatalaksana Kejang Demam pada Anak Terkini

Journal Of The Indonesian Medical Association Pub Date : 2021-11-27 DOI: 10.47830/jinma-vol.71.5-2021-558

Setyo Handryastuti

{"title":"Tatalaksana Kejang Demam pada Anak Terkini","authors":"Setyo Handryastuti","doi":"10.47830/jinma-vol.71.5-2021-558","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.5-2021-558","url":null,"abstract":"Kejang demam (KD) adalah kejang yang berkaitan dengan kenaikan suhu tubuh di atas 38°C, bukan disebabkan oleh infeksi susunan saraf pusat (SSP), kelainan elektrolit maupun metabolik, dapat terjadi pada usia 6 bulan sampai 6 tahun. Kejang demam merupakan penyebab tersering kejang pada anak, dengan perjalanan penyakit yang benign, mempunyai prognosis yang baik dan menghilang pada usia 6 tahun. Diagnosis KD adalah diagnosis klinis, yang perlu diperhatikan adalah menyingkirkan infeksi SSP, terutama pada KD kompleks. Dari telaah literatur, indikasi pemeriksaan penunjang serta tata laksana mengalami banyak perubahan. Pemeriksaan penunjang laboratorium, elektroensefalografi, maupun pencitraan hanya atas indikasi sesuai rekomendasi. Tatalaksana meliputi terapi simtomatik dan profilaksis. Rekomendasi tata laksana meliputi tatalaksana pada saat kejang dan terapi profilaksis intermiten maupun rumatan jangka panjang. Rekomendasi terapi profilaksis telah disusun dan disesuaikan dengan kondisi di Indonesia. Kejang demam kerap menyebabkan kecemasan yang berlebihan pada orang tua sehingga diperlukan edukasi yang baik tentang prognosis, perjalanan penyakit, risiko dan manfaat pemberian terapi profilaksis. Dokter umum, dokter anak, maupun dokter neurologi anak diharapkan menerapkan rekomendasi yang telah disusun agar pemeriksaan penunjang dan tatalaksana yang berlebihan dapat dihindari.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128420205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Experience in Diagnosing Neuronal Ceroid Lipofuscinosis Type-2 2型神经性脑蜡样脂褐质病的诊断体会

Journal Of The Indonesian Medical Association Pub Date : 2021-11-27 DOI: 10.47830/jinma-vol.71.5-2021-452

Lanny C. Gultom, Valensia Vivian The

{"title":"Experience in Diagnosing Neuronal Ceroid Lipofuscinosis Type-2","authors":"Lanny C. Gultom, Valensia Vivian The","doi":"10.47830/jinma-vol.71.5-2021-452","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.5-2021-452","url":null,"abstract":"Introduction: Developmental regression is always an alarming symptom in children as it is an early sign of some genetic disorders, one of which is neuronal ceroid lipofuscinosis (NCL). NCL is a group of rare neurodegenerative disorder caused by accumulation of intracellular ceroid lipofuscin. Since 2017 an enzyme replacement therapy (ERT) has been approved by Food and Drug Administration (FDA) for this disease. The symptoms of NCL could be managed by ERT if detected early, and the child could live normally.Case: We present a case of a 6-year-and-5-month-old boy with developmental regression, speech delay, recurrent seizure, and visual impairment, who was diagnosed with NCL type 2 after genetic testing. Compound heterozygous mutations in tripeptidyl-peptidase 1 (TPP1) gene was revealed, consistent with very low level of TPP1 enzyme in this patient.Discussion: NCL is a fatal disease which is often misdiagnosed in early stage. Diagnostic delay of NCL often occurs due to lack of awareness which often leads to premature death.Conclusion: Knowledge regarding the disease is important for early detection and to slow down the disease progression. \u0000 ","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"97 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117210146","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Karakteristik Pasien Trombosis Vena Dalam: Tinjauan Sistematik 静脉血栓形成患者特征:系统回顾

Journal Of The Indonesian Medical Association Pub Date : 2021-09-21 DOI: 10.47830/jinma-vol.71.4-2021-479

Ebenezer Verian Hutagalung, Teddy Arnold Sihite, Dimmy Prasetya

{"title":"Karakteristik Pasien Trombosis Vena Dalam: Tinjauan Sistematik","authors":"Ebenezer Verian Hutagalung, Teddy Arnold Sihite, Dimmy Prasetya","doi":"10.47830/jinma-vol.71.4-2021-479","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.4-2021-479","url":null,"abstract":"Introduction: Deep vein thrombosis (DVT) is one of the biggest causes of death in the world. DVT has various risk factors so that DVT patient presentation can be different in each age, sex, and race group. This review aimed to obtain information regarding characteristics of deep vein thrombosis patients.Method: This study used qualitative approach that is library research using books and other literatures as the main object. This study was conducted using search engine, such as Pubmed, Google Scholar, and Clinical Key to obtain journals related with characteristics of deep vein thrombosis patients. Result: From 17 literatures, we found that characteristics of deep thrombosis patients are different in each age, sex, and race group. The severity of DVT increased with increasing age because of other conditions usually found in older age. Men are more susceptible to have DVT than women without reproductive risk factors such as pregnancy and menopause. African has more severe DVT presentation than other races. Lowest risk is found in Asian, although there is no significant difference in mortality between races.Conclusions: Characteristics of DVT patients (incidence rate, risk factors, location, and severity) vary in each age, sex, and race group.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127990297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Konstipasi Fungsional pada Anak 男孩的功能便秘

Journal Of The Indonesian Medical Association Pub Date : 2021-09-21 DOI: 10.47830/jinma-vol.71.4-2021-371

Muzal Kadim

引用次数: 0

Uji Diagnostik Rasio Neutrofil-Limfosit Pada Apendisitis Akut Di Rumah Sakit Umum Zainoel Abidin Banda Aceh

Journal Of The Indonesian Medical Association Pub Date : 2021-09-21 DOI: 10.47830/jinma-vol.71.4-2021-426

Idham Adyasa Manggala Putra, D. Syahputra, Muhammad Yusuf, M. M. Isa, Safrizal Rahman, Jufriady Ismy

{"title":"Uji Diagnostik Rasio Neutrofil-Limfosit Pada Apendisitis Akut Di Rumah Sakit Umum Zainoel Abidin Banda Aceh","authors":"Idham Adyasa Manggala Putra, D. Syahputra, Muhammad Yusuf, M. M. Isa, Safrizal Rahman, Jufriady Ismy","doi":"10.47830/jinma-vol.71.4-2021-426","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.4-2021-426","url":null,"abstract":"Pendahuluan: Apendisitis akut adalah inflamasi yang terjadi pada apendiks vermiformis. Respon inflamasi pada apendisitis akut ditandai dengan aktivasi efektor seluler dan molekuler, termasuk rekrutmen dan aktivasi neutrofil. Rasio Neutrofil-Limfosit (RNL) adalah perbandingan jumlah neutrofil dengan limfosit digunakan sebagai tolak ukur sederhana. Metode: Penelitian uji diagnostik observasional analitik, desain studi cross sectional retrospektif. Subjek penelitian adalah pasien apendisitis akut di RSU Zainal Abidin tahun 2018-2019. Subjek saat kedatangan dilakukan pemeriksaan darah, kemudian dihitung RNL, hasil hitung RNL dibandingkan dengan pemeriksaan patologi anatomi posapendektomi. Data dianalisis dengan analisis statistik deskriptif, kurva ROC dan uji diagnostik. Hasil: Sebanyak 176 pasien yang datang ke IGD dengan diagnosis apendisitis akut, didapatkan usia terbanyak 17-25 tahun (31,2%), 81 orang penderita laki-laki (46%), 95 orang penderita perempuan (54%). Dari hasil patologi anatomi (PA) terdapat 129 apendisitis akut dan 47 apendisitis kronik. Dari AUC ROC 0,96 didapatkan cut off point RNL > 3,209. Uji diagnostic didapatkan nilai sensitivitas 83,72% spesifisitas 82,98%, nilai duga positif 97,71% dan nilai duga negatif 65,00% dengan akurasi 83,52%. Kesimpulan: NLR dapat mendiagnosis apendisitis akut dengan NLR > 3,209, sensitivitas 93,72%, spesifisitas 82,98%.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"98 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126617539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Close Reduction Percutaneous Pinning (CRPP) versus Open Reduction Internal Fixation (ORIF) for Pediatric Supracondylar Humerus Fractures Gartland Type II and III: A Systematic Review and Meta-analysis 闭合复位经皮钉钉(CRPP)与开放复位内固定(ORIF)治疗儿童肱骨髁上骨折Gartland II型和III型:系统回顾和荟萃分析

Journal Of The Indonesian Medical Association Pub Date : 2021-09-21 DOI: 10.47830/jinma-vol.71.4-2021-389

P. Astawa, M. Maharjana, Surya Adisthanaya, Made Winatra Satya Putra, A. S. Putra, S. Savio

{"title":"Close Reduction Percutaneous Pinning (CRPP) versus Open Reduction Internal Fixation (ORIF) for Pediatric Supracondylar Humerus Fractures Gartland Type II and III: A Systematic Review and Meta-analysis","authors":"P. Astawa, M. Maharjana, Surya Adisthanaya, Made Winatra Satya Putra, A. S. Putra, S. Savio","doi":"10.47830/jinma-vol.71.4-2021-389","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.4-2021-389","url":null,"abstract":"Introduction: Displaced supracondylar fracture in children is a challenging injury that may result in impaired functional and cosmetic outcome if not well-treated. Utilization of Closed Reduction and Percutaneus Pinning (CRPP) increased for this pathology, some authors believe ORIF results better anatomical reduction and lower rate of loss of reduction. Study aims to compare CRPP and ORIF for pediatric supracondylar humerus fracture. Method: Systematic review was conducted based on PRISMA guideline. Inclusion criteria were age <18 years old, comparing CRPP and ORIF for Supracondylar Humerus Fractures Gartland Type II, II.Studies of one surgical technique, Gartland type I, case reports were excluded. For meta-analysis, 6 studies were included and fixed effect model used to pool the result. In each study, mean difference (MD) with 95% confidence interval (CI) was calculated for dichotomous outcomes using Review Manager. Result: Total of 252 patients aged 0-15 years old were included. CRPP more often performed than ORIF. Satisfactory outcomes measured by Flynn’s criteria were achieved in 87.74% in CRPP and 86.73% in ORIF patient group, indicating significant difference (Heterogeneity, I2 = 23%; WMD, 1.26; 0.58 to 2.73; P =0.56). Conclusion: Current systematic review and meta-analysis suggest that for displaced supracondylar humerus fractures, ORIF offers a comparable functional and cosmetic outcome compared to CRPP.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133780942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Cerebral Oxygen Saturation Measured by Near-Infrared Spectroscopy (NIRS) in Evaluating Pediatric Shock Resuscitation Outcome 近红外光谱(NIRS)测量脑氧饱和度在评估儿童休克复苏结果中的作用

Journal Of The Indonesian Medical Association Pub Date : 2021-09-21 DOI: 10.47830/jinma-vol.71.4-2021-367

Arifah Nur Shadrina, I. Yuniar

引用次数: 0

Sindroma Sheehan dengan Hiponatremia Berulang, Miositis dan Amenorrhea Sekunder 希恩氏综合征与再生血吸虫病复发、心肌炎和次要血小板

Journal Of The Indonesian Medical Association Pub Date : 2021-09-20 DOI: 10.47830/jinma-vol.71.4-2021-561

Luse Loe, Nanny N. M. Soetedjo, Hikmat Permana

{"title":"Sindroma Sheehan dengan Hiponatremia Berulang, Miositis dan Amenorrhea Sekunder","authors":"Luse Loe, Nanny N. M. Soetedjo, Hikmat Permana","doi":"10.47830/jinma-vol.71.4-2021-561","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.4-2021-561","url":null,"abstract":"Pendahuluan. Sindroma sheehan dapat timbul paska melahirkan disebabkan oleh gangguan perfusi kelenjar hipofisis akibat tekanan darah rendah selama atau setelah melahirkan. Gejala sindroma sheehan bervariasi dan tidak spesifik. Diagnosis dan terapi segera sangat penting untuk mencegah mortalitas. Laporan Kasus: Berikut ini adalah laporan kasus mengenai seorang wanita 39 tahun dengan kondisi hiponatremia berulang, disertai dengan myositis dan amenorrhea sekunder, yang konsisten dengan temuan pada sindroma sheehan. Diskusi: Pasien memiliki riwayat perdarahan berat paska melahirkan. Pada pasien ini didapatkan hiponatremia, hipokalemia, dan hipokalsemia. Gangguan elektrolit pada pasien ini dapat disebabkan oleh adanya defisit hormon hipofisis anterior, kemungkinan adanya defisit hormon hipofisis posterior, gangguan hormon adrenokortikal dan estrogen. Peningkatan kreatinin kinase pada pasien menandakan adanya miositis, yang dapat disebabkan oleh penggunaan obat herbal atau kondisi lain. Kesimpulan: Pada kasus ini, pasien mengalami perbaikan setelah mendapat terapi elektrolit dan substitusi hormon, tanpa penggunaan steroid.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127251514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analisis Sosiodemografis Pada Kesehatan Mental Ibu Dari Anak yang Belajar di Rumah Selama Pandemi COVID-19 社会人口分析，一个在科维-19大流行期间在家学习的孩子的母亲心理健康的母亲

Journal Of The Indonesian Medical Association Pub Date : 2021-09-20 DOI: 10.47830/jinma-vol.71.4-2021-540

Miranda Rachellina, Asri C. Adisasmita

{"title":"Analisis Sosiodemografis Pada Kesehatan Mental Ibu Dari Anak yang Belajar di Rumah Selama Pandemi COVID-19","authors":"Miranda Rachellina, Asri C. Adisasmita","doi":"10.47830/jinma-vol.71.4-2021-540","DOIUrl":"https://doi.org/10.47830/jinma-vol.71.4-2021-540","url":null,"abstract":"Pendahuluan: Pemberlakuan Pembelajaran Jarak Jauh (PJJ) karena pandemi COVID-19 tidak hanya memengaruhi anak didik, tapi juga orangtua terutama ibu. Penelitian ini bertujuan untuk mengetahui gambaran kesehatan mental (stres dan ansietas) ibu dengan anak SD-SMA yang menjalani PJJ di Jabodetabek dan kaitannya dengan tingkat pendidikan dan status pekerjaan ibu, jumlah anak, serta jumlah anak yang menjalani PJJ selama pandemi COVID-19.Metode: Penelitian ini adalah penelitian potong lintang dengan menyebarkan kuesioner daring yang ditujukan pada wanita menikah yang memiliki >1 anak di SD-SMA yang menjalani PJJ di Jabodetabek. Data dikumpulkan pada periode 2-20 Desember 2020. Instrumen yang digunakan untuk mengukur tingkat stres dan ansietas adalah PSS-10 dan GAD-7. Hasil: Terdapat 311 ibu berusia 27-61 tahun yang mengikuti survey ini. Rata-rata responden mengalami stres derajat sedang dan ansietas derajat ringan. Terdapat peningkatan risiko stres berat secara signifikan pada ibu berlatar belakang pendidikan dasar-menengah (crude RR 2,1; 95%CI 1,04-4,4), dan peningkatan risiko ansietas sedang-berat pada ibu dengan > 3 anak (crude RR 1,9; 95%CI 1,1-3,1).Kesimpulan: Lebih dari 50% ibu dengan anak yang duduk di SD-SMA di Jabodetabek mengalami stres derajat sedang, dan 31% menunjukkan gejala ansietas ringan. Faktor sosiodemografis ibu yang berhubungan dengan risiko stres berat adalah tingkat pendidikan, sedangkan yang berasosiasi dengan risiko ansietas sedang-berat adalah jumlah anak yang tinggal serumah.","PeriodicalId":378619,"journal":{"name":"Journal Of The Indonesian Medical Association","volume":"58 2","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120839355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0