Neurobiology of Sleep and Circadian Rhythms最新文献_第7页

Juvenile hormone affects the development and strength of circadian rhythms in young bumble bee (Bombus terrestris) workers 幼崽激素影响小黄蜂(Bombus terrestris)工蜂昼夜节律的发育和强度

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-05-25 DOI: 10.1101/2020.05.24.101915

A. Pandey, U. Motro, G. Bloch

{"title":"Juvenile hormone affects the development and strength of circadian rhythms in young bumble bee (Bombus terrestris) workers","authors":"A. Pandey, U. Motro, G. Bloch","doi":"10.1101/2020.05.24.101915","DOIUrl":"https://doi.org/10.1101/2020.05.24.101915","url":null,"abstract":"The circadian and endocrine systems influence many physiological processes in animals, but little is known on the ways they interact in insects. We tested the hypothesis that juvenile hormone (JH) influences circadian rhythms in the social bumble bee Bombus terrestris. JH is the major gonadotropin in this species coordinating processes such as vitellogenesis, oogenesis, wax production, and behaviors associated with reproduction. It is unknown however, whether it also influences circadian processes. We topically treated newly-emerged bees with the allatoxin Precocene-I (P-I) to reduce circulating JH titers and applied the natural JH (JH-III) for replacement therapy. We repeated this experiment in three trials, each with bees from different source colonies. Measurements of ovarian activity confirmed that our JH manipulations were effective; bees treated with P-I had inactive ovaries, and this effect was fully reverted by subsequent JH treatment. We found that JH augments the strength of circadian rhythms and the pace of rhythm development in individually isolated newly emerged worker bees. JH manipulation did not affect the free-running circadian period, overall level of locomotor activity, or the amount of sleep. Given that acute manipulation at an early age produced relatively long-lasting effects, we propose that JH effect on circadian rhythms is mostly organizational, accelerating the development or integration of the circadian system.","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47889545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Suprachiasmatic lesions restore object recognition in down syndrome model mice 视交叉上损伤恢复唐氏综合症模型小鼠的物体识别能力

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-05-01 DOI: 10.1016/j.nbscr.2020.100049

Bayarsaikhan Chuluun , Elsa Pittaras , Hyunseung Hong, Nathan Fisher, Damien Colas, Norman F. Ruby, H. Craig Heller

{"title":"Suprachiasmatic lesions restore object recognition in down syndrome model mice","authors":"Bayarsaikhan Chuluun , Elsa Pittaras , Hyunseung Hong, Nathan Fisher, Damien Colas, Norman F. Ruby, H. Craig Heller","doi":"10.1016/j.nbscr.2020.100049","DOIUrl":"10.1016/j.nbscr.2020.100049","url":null,"abstract":"<div><p>The Ts65Dn mouse is a well-studied model of trisomy 21, Down syndrome. This mouse strain has severe learning disability as measured by several rodent learning tests that depend on hippocampal spatial memory function. Hippocampal long-term potentiation (LTP) is deficient in these mice. Short-term daily treatment with low-dose GABA receptor antagonists rescue spatial learning and LTP in Ts65Dn mice leading to the hypothesis that the learning disability is due to GABAergic over-inhibition of hippocampal circuits. The fact that the GABA receptor antagonists were only effective if delivered during the daily light phase suggested that the source of the excess GABA was controlled directly or indirectly by the circadian system. The central circadian pacemaker of mammals is the suprachiasmatic nucleus (SCN), which is largely a GABAergic nucleus. In this study we investigated whether elimination of the SCN in Ts65Dn mice would restore their ability to form recognition memories as tested by the novel object recognition (NOR) task. Full, but not partial lesions of the SCN of Ts65Dn mice normalized their ability to perform on the NOR test. These results suggest that the circadian system modulates neuroplasticity over the time frame involved in the process of consolidation of recognition memories.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"8 ","pages":"Article 100049"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2020.100049","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37757344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017 2017年，在伊朗克尔曼沙阿的一个多发性硬化症中心调查了多发性硬化症患者的睡眠质量和疲劳

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-05-01 DOI: 10.1016/j.nbscr.2020.100050

Saba Karimi , Milad Jalilian , Alireza Abdi , Habibolah Khazaie , Pegah Ahmadi Sarbarzeh

{"title":"Surveying sleep quality and fatigue in multiple sclerosis patients at a multiple sclerosis center in Kermanshah, Iran, in 2017","authors":"Saba Karimi , Milad Jalilian , Alireza Abdi , Habibolah Khazaie , Pegah Ahmadi Sarbarzeh","doi":"10.1016/j.nbscr.2020.100050","DOIUrl":"10.1016/j.nbscr.2020.100050","url":null,"abstract":"<div><h3>Background</h3><p>Multiple sclerosis (MS) is an autoimmune disease of the nervous system which appears with de-myelination of the central nervous system. Sleep disorder and fatigue are very common in MS patients and are part of the main debilitating factors in patients. The present study was conducted to survey sleep quality and fatigue in MS patients.</p></div><div><h3>Methods</h3><p>A descriptive-analytical study was conducted on 87 MS patients, who were referred to the Kermanshah MS Center in 2017. Data collection tools include a demographics form, fatigue severity scale, and Pittsburg sleep quality inventory. The questionnaires were self-reporting. The collected data was analyzed in SPSS23.</p></div><div><h3>Results</h3><p>The mean age of the participants was 35.50±9.25 years and the majority of the participants were married (54; 62.1%). Quality of sleep was related to family history of MS and history of using medications (antidepressants like tricyclics, MAOIs, SSRIs, and SNRIs and anxiety drugs such as diazepam, oxazepam, and alprazolam (p < 0.05). Moreover, there was a significant relationship between length of sleep and history of using medicines (p < 0.05). Finally, the results showed that there was a strong statistical relationship between performance during the day and fatigue (p < 0.05).</p></div><div><h3>Conclusions</h3><p>The results recommend holding relaxation and exercise courses by nurses to ease fatigue in MS patients. Clinics can also play a more effective role by being more supportive and holding more efficient training programs. The program is taught by the researchers.</p></div><div><h3>Trial registration</h3><p>This study was carried out following the permission from Ethics Committee, Department of Research and Technology, Kermanshah University of Medical Sciences (approval number: KUMS.REC.1395.680).</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"8 ","pages":"Article 100050"},"PeriodicalIF":0.0,"publicationDate":"2020-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2020.100050","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37974918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Delayed Sleep-Wake Phase Disorder 延迟睡眠-觉醒阶段障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_6

Gregory S. Carter, R. Robert Auger

引用次数: 1

Shift Work Sleep Disorder 轮班工作睡眠障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_11

Alok Sachdeva, Cathy A Goldstein

引用次数: 1

Irregular Sleep-Wake Rhythm Disorder 不规则睡眠-觉醒节律障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_10

Danielle Goldfarb, K. Sharkey

引用次数: 1

Non-physiologic Methods of Assessment Relevant to Circadian Rhythm Sleep-Wake Disorders 与昼夜节律睡眠-觉醒障碍相关的非生理性评估方法

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2020-01-01 DOI: 10.1007/978-3-030-43803-6_5

Vincent A. LaBarbera, K. Sharkey

引用次数: 1

Circadian melatonin profile in opium and amphetamine dependent patients: A preliminary study 鸦片和安非他明依赖患者的昼夜褪黑激素特征:初步研究

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-11-01 DOI: 10.1016/j.nbscr.2019.100046

Habibolah Khazaie MD , Hamid Reza Ahmadi MD , Amir Kiani PhD , Mohammad Rasoul Ghadami MD

{"title":"Circadian melatonin profile in opium and amphetamine dependent patients: A preliminary study","authors":"Habibolah Khazaie MD , Hamid Reza Ahmadi MD , Amir Kiani PhD , Mohammad Rasoul Ghadami MD","doi":"10.1016/j.nbscr.2019.100046","DOIUrl":"10.1016/j.nbscr.2019.100046","url":null,"abstract":"<div><h3>Aim</h3><p>The aim of this study was to investigate the relationship between opium and amphetamine dependency with the serum melatonin levels in the presence of circadian rhythm sleep disorders (CRSD).</p></div><div><h3>Participants</h3><p>Forty four male amphetamine-dependent and opium-dependent patients with CRSD and with more than one year substance dependency were enrolled in this study. Control group consisted of twelve healthy male subjects.</p></div><div><h3>Design</h3><p>The diagnoses of sleep disorders were established by a psychiatrist and were made on the basis of the criteria of ICSD-II using the patients’ sleep logs. Blood samples were drawn every 4 h through an intravenous catheter. Serum melatonin levels were assayed using an enzyme-linked immunosorbent assay (ELISA) kit. Repeated Measures Analysis of variance (ANOVA) was used to assess differences between the melatonin levels at six separate times.</p></div><div><h3>Finding</h3><p>The serum melatonin levels of the control subjects were significantly higher than both opium-dependent and amphetamine-dependent patients at 24:00, 4:00 and 8:00. The serum melatonin level of the opium-dependent patients were significantly lower than the amphetamine-dependent patients at 24:00 (26.9 ± 11.4 vs. 41 ± 19.4, respectively; p = 0.006) and were significantly higher than the amphetamine-dependent patients at 16:00 (12.7 ± 5.1 vs. 8.9 ± 4.1, respectively; p = 0.011).</p></div><div><h3>Conclusion</h3><p>This is an evidence of negative effects of substance dependence on circadian cycle of melatonin secretion among opium and amphetamine dependent patients.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"7 ","pages":"Article 100046"},"PeriodicalIF":0.0,"publicationDate":"2019-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.100046","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43443040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series 在妊娠晚期褪黑素谱和后代的健康状况在白班和夜班工人:一个案例系列

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2019.04.001

P.A. Nehme , F.G. Amaral , B. Middleton , A. Lowden , E. Marqueze , I. França-Junior , J.L.F. Antunes , J. Cipolla-Neto , D.J. Skene , C.R.C. Moreno

{"title":"Melatonin profiles during the third trimester of pregnancy and health status in the offspring among day and night workers: A case series","authors":"P.A. Nehme , F.G. Amaral , B. Middleton , A. Lowden , E. Marqueze , I. França-Junior , J.L.F. Antunes , J. Cipolla-Neto , D.J. Skene , C.R.C. Moreno","doi":"10.1016/j.nbscr.2019.04.001","DOIUrl":"10.1016/j.nbscr.2019.04.001","url":null,"abstract":"<div><p>Successful pregnancy requires adaptation in maternal physiology. During intrauterine life the mother's circadian timing system supports successful birth and postnatal development. Maternal melatonin is important to transmit circadian timing and day length to the fetus. This study aims to describe the third trimester of pregnancy among day (n = 5) and night (n = 3) workers by assessing their melatonin levels in a natural environment. Additionally, we describe the worker's metabolic profiles and compare the health status of the newborns between groups of day and night working mothers. Our results indicate an occurrence of assisted delivery (cesarean and forceps) among night workers. Moreover, the newborns of night workers showed lower Apgar index and breastfeeding difficulty indicating a worse condition to deal with the immediate outside the womb environment. Additionally, there was lower night-time melatonin production among pregnant night workers compared to day workers. These findings may be related to light-induced suppression of melatonin that occurs during night work. We conclude that night work and consequent exposure to light at unconventional times might compromise the success of pregnancy and the health of the newborn. Further studies need to be carried out to monitor pregnancy and newborn health in pregnant night workers.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 70-76"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.04.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37362396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 20

Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases 临床一例睡眠嗜睡症患者睡眠宏观与微观结构的比较

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2019-01-01 DOI: 10.1016/j.nbscr.2019.02.001

Alyssa Cairns , Richard Bogan

{"title":"Comparison of the macro and microstructure of sleep in a sample of sleep clinic hypersomnia cases","authors":"Alyssa Cairns , Richard Bogan","doi":"10.1016/j.nbscr.2019.02.001","DOIUrl":"10.1016/j.nbscr.2019.02.001","url":null,"abstract":"<div><p>The purpose of this study was to elucidate the differentiating or grouping EEG characteristics in various hypersomnias (type 1 and type 2 narcolepsy (N-1 and N-2) and idiopathic hypersomnia (IH) compared to an age-matched snoring reference group (SR). Polysomnogram sleep EEG was decomposed into a 4-frequency state model. The IH group had higher sleep efficiency (SE; 92.3% vs. 85.8%; sp < 0.05), lower WASO (IH = 35.4 vs. N-1 = 65.5 min; p < 0.01), but similar (i.e. high) arousal indices as N-1 (~33/h). N-1 and N-2 had earlier REM latency than IH and SR (N-1 = 64.8, N-2 = 76.3 vs. IH/SR = 118 min, p < 0.05). N-1 and N-2 showed an increase in MF1 segments (characteristic of stage 1 and REM) across the night as well as distinct oscillations every 2 h, but MF1 segment timing was advanced by 30 min compared to the SR group (p < 0.05). This suggests the presence of circadian organization to sleep that is timed earlier or of increased pressure and/or lability. MF1 demonstrated a mixed phenotype in IH, with an early 1<sup>st</sup> oscillation (like N-1 and N-2), 2<sup>nd</sup> oscillation that overlapped with the SR group, and a surge prior to wake (higher than all groups). This phenotype may reflect a heterogeneous group of individuals, with some having more narcolepsy-like characteristics (i.e. REM) than others. LF domain (delta surrogate) was enhanced in IH and N-1 and more rapidly dissipated compared to N-2 and SR (p < 0.05). This suggests an intact homeostatic sleep pattern that is of higher need/reduced efficiency whereas rapid dissipation may be an underlying mechanism for sleep disruption.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":"6 ","pages":"Pages 62-69"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/j.nbscr.2019.02.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37359314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13