Neurobiology of Sleep and Circadian Rhythms最新文献

Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats 雄性黑线大鼠肌肉时钟的改变需要限时喂食和限时跑步的协同作用

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2024-09-19 DOI: 10.1016/j.nbscr.2024.100106

{"title":"Synergy between time-restricted feeding and time-restricted running is necessary to shift the muscle clock in male wistar rats","authors":"","doi":"10.1016/j.nbscr.2024.100106","DOIUrl":"10.1016/j.nbscr.2024.100106","url":null,"abstract":"<div><div>Circadian disruption is an important factor driving the current-day high prevalence of obesity and type-2 diabetes. While the impact of incorrect timing of caloric intake on circadian disruption is widely acknowlegded, the contribution of incorrect timing of physical activity remains relatively understudied. Here, we modeled the incorrect timing of physical activity in nightshift workers in male Wistar rats, by restricting running wheel access to the innate inactive (light) phase (LR). Controls included no wheel access (NR); access only during the innate active (dark) period (DR); or unrestricted (<em>ad libitum</em>) access (ALR). LR did not shift the phase of the muscle or liver clock, but dampened the muscle clock amplitude. As our previous study demonstrated that light-phase restricted feeding did shift the liver clock, but made the muscle clock arrhythmic, we next combined the time restriction of wheel and food access to either the light phase (LRLF) or dark phase (DRDF). LRLF produced a ∼12 h shift in the majority of clock gene rhythms in both skeletal muscle and liver. On the other hand, DRDF was most effective in reducing body weight and the accumulation of fat mass. Therefore, in order to shift the muscle clock in male Wistar rats, synergy between the timing of feeding and physical activity is necessary. These findings may contribute to further improve the design of lifestyle strategies that try to limit metabolic misalignment caused by circadian disruption.</div></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S245199442400004X/pdfft?md5=55f77d77b927aa3fd8aec6e4581f4bd4&pid=1-s2.0-S245199442400004X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142314481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gender differences in sleep quality among Iranian traditional and industrial drug users 伊朗传统和工业药物使用者睡眠质量的性别差异

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2024-07-02 DOI: 10.1016/j.nbscr.2024.100104

Mohammad Khorrami Ph.D , Fatemeh Khorrami Undergraduate student , Kosar Haghani , Farshid Fathy Karkaragh Ph.D. candidate , Ayda Khodashenas M.A , Sara Souri M.A

引用次数: 0

Development of Sleep and Circadian Rhythms: Function and Dysfunction. 睡眠和昼夜节律的发展：功能与功能障碍

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2024-07-01 DOI: 10.1016/j.nbscr.2024.100105

Miranda M. Lim, Lucia Peixoto, Matthew S. Kayser, C. S. Colwell

引用次数: 0

Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood 年龄和性别对青春期和成年期核团单胺含量和释放的光周期调节作用的影响

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2024-03-26 DOI: 10.1016/j.nbscr.2024.100103

Alexis N. Jameson , Justin K. Siemann , Carrie A. Grueter , BradA. Grueter , Douglas G. McMahon

{"title":"Effects of age and sex on photoperiod modulation of nucleus accumbens monoamine content and release in adolescence and adulthood","authors":"Alexis N. Jameson , Justin K. Siemann , Carrie A. Grueter , BradA. Grueter , Douglas G. McMahon","doi":"10.1016/j.nbscr.2024.100103","DOIUrl":"https://doi.org/10.1016/j.nbscr.2024.100103","url":null,"abstract":"<div><p>Day length, or photoperiod, is a reliable environmental cue encoded by the brain's circadian clock that indicates changing seasons and induces seasonal biological processes. In humans, photoperiod, age, and sex have been linked to seasonality in neuropsychiatric disorders, as seen in Seasonal Affective Disorder, Major Depressive Disorder, and Bipolar Disorder. The nucleus accumbens is a key locus for the regulation of motivated behaviors and neuropsychiatric disorders. Using periadolescent and young adult male and female mice, here we assessed photoperiod's effect on serotonin and dopamine tissue content in the nucleus accumbens core, as well as on accumbal synaptic dopamine release and uptake. We found greater serotonin and dopamine tissue content in the nucleus accumbens from young adult mice raised in a Short winter-like photoperiod. In addition, dopamine release and clearance were greater in the nucleus accumbens from young adult mice raised in a Long summer-like photoperiod. Importantly, we found that photoperiod's effects on accumbal dopamine tissue content and release were sex-specific to young adult females. These findings support that in mice there are interactions across age, sex, and photoperiod that impact critical monoamine neuromodulators in the nucleus accumbens which may provide mechanistic insight into the age and sex dependencies in seasonality of neuropsychiatric disorders in humans.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2451994424000014/pdfft?md5=7e9b52ffbf8421282f84bc3195a513c5&pid=1-s2.0-S2451994424000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140309605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of long haul travel on the sleep of elite athletes 长途旅行对优秀运动员睡眠的影响

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-09-20 DOI: 10.1016/j.nbscr.2023.100102

R. Doherty , S.M. Madigan , A. Nevill , G. Warrington , J.G. Ellis

{"title":"The impact of long haul travel on the sleep of elite athletes","authors":"R. Doherty , S.M. Madigan , A. Nevill , G. Warrington , J.G. Ellis","doi":"10.1016/j.nbscr.2023.100102","DOIUrl":"10.1016/j.nbscr.2023.100102","url":null,"abstract":"<div><p>In order to manage and implement strategies to alleviate the symptoms of jet lag it is essential to assess the impact of jet lag in athletes. The aim of this study was to assess the impact of long haul eastward travel on elite athletes' (n = 7 elite national track cyclists; male n = 3, and female n = 4) sleep. The athletes’ sleep was monitored before, during and after travel using both actigraphy and self-report measures. Participants wore an activity monitor for 5 days prior to travel, during the long haul travel and 5 days upon arrival at their destination and completed a daily online sleep diary Actigraphy highlighted significant reductions in time in bed, total sleep time and sleep efficiency (%) due to long haul eastward travel, particularly in the 48 h after travel. Sleep diary data exhibited significant reductions in time in bed, total sleep time, sleep efficiency, sleep quality and a significant increase in fatigue going to bed as a result of long haul eastward travel. In order to facilitate the development of interventions to reduce the symptoms and severity of jet lag objective and subjective assessments of sleep should be coupled with assessments of chronotype and perceived sleep need.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10520441/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41145816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofibromin 1 regulates early developmental sleep in Drosophila 神经纤维蛋白1调节果蝇早期发育睡眠

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-08-09 DOI: 10.1016/j.nbscr.2023.100101

Jaclyn Durkin , Amy R. Poe , Samuel J. Belfer , Anyara Rodriguez , Si Hao Tang , James A. Walker , Matthew S. Kayser

{"title":"Neurofibromin 1 regulates early developmental sleep in Drosophila","authors":"Jaclyn Durkin , Amy R. Poe , Samuel J. Belfer , Anyara Rodriguez , Si Hao Tang , James A. Walker , Matthew S. Kayser","doi":"10.1016/j.nbscr.2023.100101","DOIUrl":"https://doi.org/10.1016/j.nbscr.2023.100101","url":null,"abstract":"<div><p>Sleep disturbances are common in neurodevelopmental disorders, but knowledge of molecular factors that govern sleep in young animals is lacking. Evidence across species, including <em>Drosophila</em>, suggests that juvenile sleep has distinct functions and regulatory mechanisms in comparison to sleep in maturity. In flies, manipulation of most known adult sleep regulatory genes is not associated with sleep phenotypes during early developmental (larval) stages. Here, we examine the role of the neurodevelopmental disorder-associated gene <em>Neurofibromin 1</em> (<em>Nf1</em>) in sleep during numerous developmental periods. Mutations in <em>Neurofibromin 1</em> (<em>Nf1</em>) are associated with sleep and circadian disorders in humans and adult flies. We find in flies that <em>Nf1</em> acts to regulate sleep across the lifespan, beginning during larval stages. <em>Nf1</em> is required in neurons for this function, as is signaling via the Alk pathway. These findings identify <em>Nf1</em> as one of a small number of genes positioned to regulate sleep across developmental periods.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50171060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The unified theory of sleep: Eukaryotes endosymbiotic relationship with mitochondria and REM the push-back response for awakening 统一的睡眠理论：真核生物与线粒体和快速眼动的内共生关系——觉醒的推回反应

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-07-06 DOI: 10.1016/j.nbscr.2023.100100

Graham Joseph Adams , Philip A. O'Brien

{"title":"The unified theory of sleep: Eukaryotes endosymbiotic relationship with mitochondria and REM the push-back response for awakening","authors":"Graham Joseph Adams , Philip A. O'Brien","doi":"10.1016/j.nbscr.2023.100100","DOIUrl":"10.1016/j.nbscr.2023.100100","url":null,"abstract":"<div><p>The Unified Theory suggests that sleep is a process that developed in eukaryotic animals from a relationship with an endosymbiotic bacterium. Over evolutionary time the bacterium evolved into the modern mitochondrion that continues to exert an effect on sleep patterns, e.g. the bacterium <em>Wolbachia</em> establishes an endosymbiotic relationship with Drosophila and many other species of insects and is able to change the host's behaviour by making it sleep. The hypothesis is supported by other host-parasite relationships, e.g., <em>Trypanosoma brucei</em> which causes day-time sleepiness and night-time insomnia in humans and cattle. For eukaryotes such as Monocercomonoids that don't contain mitochondria we find no evidence of them sleeping.</p><p>Mitochondria produce the neurotransmitter gamma aminobutyric acid (GABA), and ornithine a precursor of the neurotransmitter GABA, together with substances such as 3,4dihydroxy phenylalanine (DOPA) a precursor for the neurotransmitter dopamine: These substances have been shown to affect the sleep/wake cycles in animals such as <em>Drosophilia</em> and <em>Hydra.</em></p><p>Eukaryote animals have traded the very positive side of having mitochondria providing aerobic respiration for them with the negative side of having to sleep. NREM (Quiet sleep) is the process endosymbionts have imposed upon their host eukaryotes and REM (Active sleep) is the push-back adaptation of eukaryotes with brains, returning to wakefulness.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/38/db/main.PMC10362302.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9867118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy 婴儿期行为发展和睡眠脑电图简化地形标志物之间缺乏相关性

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-06-19 DOI: 10.1016/j.nbscr.2023.100098

Matthieu Beaugrand , Valeria Jaramillo , Andjela Markovic , Reto Huber , Malcolm Kohler , Sarah F. Schoch , Salome Kurth

{"title":"Lack of association between behavioral development and simplified topographical markers of the sleep EEG in infancy","authors":"Matthieu Beaugrand , Valeria Jaramillo , Andjela Markovic , Reto Huber , Malcolm Kohler , Sarah F. Schoch , Salome Kurth","doi":"10.1016/j.nbscr.2023.100098","DOIUrl":"10.1016/j.nbscr.2023.100098","url":null,"abstract":"<div><p>The sleep EEG mirrors neuronal connectivity, especially during development when the brain undergoes substantial rewiring. As children grow, the slow-wave activity (SWA; 0.75–4.25 Hz) spatial distribution in their sleep EEG changes along a posterior-to-anterior gradient. Topographical SWA markers have been linked to critical neurobehavioral functions, such as motor skills, in school-aged children. However, the relationship between topographical markers in infancy and later behavioral outcomes is still unclear. This study aims to explore reliable indicators of neurodevelopment in infants by analyzing their sleep EEG patterns. Thirty-one 6-month-old infants (15 female) underwent high-density EEG recordings during nighttime sleep. We defined markers based on the topographical distribution of SWA and theta activity, including central/occipital and frontal/occipital ratios and an index derived from local EEG power variability. Linear models were applied to test whether markers relate to concurrent, later, or retrospective behavioral scores, assessed by the parent-reported Ages & Stages Questionnaire at ages 3, 6, 12, and 24 months. Results indicate that the topographical markers of the sleep EEG power in infants were not significantly linked to behavioral development at any age. Further research, such as longitudinal sleep EEG in newborns, is needed to better understand the relationship between these markers and behavioral development and assess their predictive value for individual differences.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/06/eb/main.PMC10329166.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9799557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cardiorespiratory changes associated with micro-arousals during naps 小睡时与微觉醒相关的心肺变化

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-05-01 DOI: 10.1016/j.nbscr.2023.100093

Elpidio Attoh-Mensah, Ivan Igor-Gaez, Lydie Vincent, Nicolas Bessot, Clément Nathou, Olivier Etard

{"title":"Cardiorespiratory changes associated with micro-arousals during naps","authors":"Elpidio Attoh-Mensah, Ivan Igor-Gaez, Lydie Vincent, Nicolas Bessot, Clément Nathou, Olivier Etard","doi":"10.1016/j.nbscr.2023.100093","DOIUrl":"10.1016/j.nbscr.2023.100093","url":null,"abstract":"<div><p>The autonomic nervous system (ANS) and the central nervous system (CNS) interplay during sleep, particularly during phasic events such as micro-arousals, has been the subject of several studies. The underlying mechanisms of such relationship which remain unclear, specifically during daytime sleep, were partly investigated in this study. Napping polysomnography was performed on two occasions at least one week apart in 15 healthy subjects. The following cardiorespiratory variables were extracted from the recordings: tachogram, pulse transit time (PTT), pulse wave amplitude, respiratory cycle amplitude, and frequency. Two experts first detected micro-arousal events, then, cardiorespiratory variables were averaged by 30-s epochs over 2 min centered on the onset of the micro-arousals. We found that in the 30 s preceding the arousal events as detected on the electroencephalogram (EEG) recordings, there was a decrease in tachogram, pulse wave amplitude, and PTT values while the respiratory amplitude increased. These changes were more prominent in stage N2 and N3 sleep than in stage N1. The present findings provide new insights into the autonomic changes during the pre-arousal period in daytime naps, as all the variables investigated suggest a sympathetic physiological origin for the changes.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/fc/af/main.PMC10038786.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9198262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Activation of mGluR1 negatively modulates glutamate-induced phase shifts of the circadian pacemaker in the mouse suprachiasmatic nucleus mGluR1的激活负调控谷氨酸诱导的小鼠视交叉上核昼夜节律起搏器的相移

Neurobiology of Sleep and Circadian Rhythms Pub Date : 2023-05-01 DOI: 10.1016/j.nbscr.2023.100089

Yoon Sik Kim , C Justin Lee , Ji-Hyeon Kim , Young-Beom Kim , Christopher S. Colwell , Yang In Kim

{"title":"Activation of mGluR1 negatively modulates glutamate-induced phase shifts of the circadian pacemaker in the mouse suprachiasmatic nucleus","authors":"Yoon Sik Kim , C Justin Lee , Ji-Hyeon Kim , Young-Beom Kim , Christopher S. Colwell , Yang In Kim","doi":"10.1016/j.nbscr.2023.100089","DOIUrl":"10.1016/j.nbscr.2023.100089","url":null,"abstract":"<div><p>In mammals, photic information delivered to the suprachiasmatic nucleus (SCN) via the retinohypothalamic tract (RHT) plays a crucial role in synchronizing the master circadian clock located in the SCN to the solar cycle. It is well known that glutamate released from the RHT terminals initiates the synchronizing process by activating ionotropic glutamate receptors (iGluRs) on retinorecipient SCN neurons. The potential role of metabotropic glutamate receptors (mGluRs) in modulating this signaling pathway has received less attention. In this study, using extracellular single-unit recordings in mouse SCN slices, we investigated the possible roles of the G<sub>q/11</sub> protein-coupled mGluRs, mGluR1 and mGluR5, in photic resetting. We found that mGluR1 activation in the early night produced phase advances in neural activity rhythms in the SCN, while activation in the late night produced phase delays. In contrast, mGluR5 activation had no significant effect on the phase of these rhythms. Interestingly, mGluR1 activation antagonized phase shifts induced by glutamate through a mechanism that was dependent upon Ca<sub>V</sub>1.3 L-type voltage-gated Ca<sup>2+</sup> channels (VGCCs). While both mGluR1-evoked phase delays and advances were inhibited by knockout (KO) of Ca<sub>V</sub>1.3 L-type VGCCs, different signaling pathways appeared to be involved in mediating these effects, with mGluR1 working via protein kinase G in the early night and via protein kinase A signaling in the late night. We conclude that, in the mouse SCN, mGluR1s function to negatively modulate glutamate-evoked phase shifts.</p></div>","PeriodicalId":37827,"journal":{"name":"Neurobiology of Sleep and Circadian Rhythms","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/81/4a/main.PMC9982032.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10845568","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0