人类昼夜节律反应的空间敏感性:轴上和离轴光照射对褪黑激素的抑制

Q2 Medicine
Rohan Nagare, Mark S. Rea, Mariana G. Figueiro
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引用次数: 5

摘要

更好地了解人类昼夜节律系统对光刺激的空间敏感性可以为优化昼夜节律光暴露提供实用的解决方案。2项心理物理实验,实验1涉及25名成人受试者,平均年龄= 34.0岁[SD 15.5];实验2中13名女性参与者和15名成人参与者(平均年龄= 43.0岁[SD 12.6];12名女性),旨在研究仅改变环境中发光刺激的空间分布,同时保持眼睛恒定的光谱加权辐照度是否会影响夜间褪黑激素的抑制。采用两种空间分布,一种是光刺激在轴上呈现(沿着视线),另一种是两个光刺激都在轴外呈现(在中心横向位移14°)。实验采用两种窄带LED光源,第一种为蓝色光源(λmax = 451 nm),第二种为绿色光源(λmax = 522 nm),分别用于顺轴和离轴空间分布。针对中央窝和副中央窝(轴上)的蓝色发光刺激在抑制褪黑激素方面的效果是针对更外围视网膜(轴外)的光度和光谱匹配刺激的三倍。针对中央凹和副中央凹(轴上)的绿色发光刺激抑制褪黑激素的效果是针对更外围视网膜(轴外)的光度和光谱匹配刺激的两倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures

Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures

Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures

Spatial sensitivity of human circadian response: Melatonin suppression from on-axis and off-axis light exposures

A better understanding of the spatial sensitivity of the human circadian system to photic stimulation can provide practical solutions for optimized circadian light exposures. Two psychophysical experiments, involving 25 adult participants in Experiment 1 (mean age = 34.0 years [SD 15.5]; 13 females) and 15 adult participants in Experiment 2 (mean age = 43.0 years [SD 12.6]; 12 females), were designed to investigate whether varying only the spatial distribution of luminous stimuli in the environment while maintaining a constant spectrally weighted irradiance at the eye could influence nocturnal melatonin suppression. Two spatial distributions were employed, one where the luminous stimulus was presented On-axis (along the line of sight) and one where two luminous stimuli were both presented Off-axis (laterally displaced at center by 14°). Two narrowband LED light sources, blue (λmax = 451 nm) for first experiment and green (λmax = 522 nm) for second experiment, were used in both the On-axis and the Off-axis spatial distributions. The blue luminous stimulus targeting the fovea and parafovea (On-axis) was about three times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis). The green luminous stimulus targeting the fovea and parafovea (On-axis) was about two times more effective for suppressing melatonin than the photometrically and spectrally matched stimulus targeting the more peripheral retina (Off-axis).

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来源期刊
Neurobiology of Sleep and Circadian Rhythms
Neurobiology of Sleep and Circadian Rhythms Neuroscience-Behavioral Neuroscience
CiteScore
4.50
自引率
0.00%
发文量
9
审稿时长
69 days
期刊介绍: Neurobiology of Sleep and Circadian Rhythms is a multidisciplinary journal for the publication of original research and review articles on basic and translational research into sleep and circadian rhythms. The journal focuses on topics covering the mechanisms of sleep/wake and circadian regulation from molecular to systems level, and on the functional consequences of sleep and circadian disruption. A key aim of the journal is the translation of basic research findings to understand and treat sleep and circadian disorders. Topics include, but are not limited to: Basic and translational research, Molecular mechanisms, Genetics and epigenetics, Inflammation and immunology, Memory and learning, Neurological and neurodegenerative diseases, Neuropsychopharmacology and neuroendocrinology, Behavioral sleep and circadian disorders, Shiftwork, Social jetlag.
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