Journal of Drug and Alcohol Research最新文献_第2页

CART Peptide Regulates Psychostimulant-Induced Activity and Exhibits a Rate Dependency. CART肽调节精神兴奋剂诱导的活性并表现出速率依赖性。

Journal of Drug and Alcohol Research Pub Date : 2017-01-01 Epub Date: 2017-05-26 DOI: 10.4303/jdar/236032

Michael J Kuhar, Martin O Job

引用次数: 3

Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model. 在实验大鼠模型中，乙醇诱导的白质萎缩与天冬氨酸-天冬酰胺-β-羟化酶(ASPH)和Notch信号表达受损有关。

Journal of Drug and Alcohol Research Pub Date : 2017-01-01 Epub Date: 2017-08-23 DOI: 10.4303/jdar/236033

Ming Tong, Howard Gonzalez-Navarrete, Tyler Kirchberg, Billy Gotama, Emine B Yalcin, Jared Kay, Suzanne M de la Monte

{"title":"Ethanol-Induced White Matter Atrophy Is Associated with Impaired Expression of Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) and Notch Signaling in an Experimental Rat Model.","authors":"Ming Tong, Howard Gonzalez-Navarrete, Tyler Kirchberg, Billy Gotama, Emine B Yalcin, Jared Kay, Suzanne M de la Monte","doi":"10.4303/jdar/236033","DOIUrl":"10.4303/jdar/236033","url":null,"abstract":"Alcohol-induced white matter (WM) degeneration is linked to cognitive-motor deficits and impairs insulin/insulin-like growth factor (IGF) and Notch networks regulating oligodendrocyte function. Ethanol downregulates Aspartyl-Asparaginyl-β-Hydroxylase (ASPH) which drives Notch. These experiments determined if alcohol-related WM degeneration was linked to inhibition of ASPH and Notch. Adult Long Evans rats were fed for 3, 6 or 8 weeks with liquid diets containing 26% ethanol (caloric) and in the last two weeks prior to each endpoint they were binged with 2 g/kg ethanol, 3×/week. Controls were studied in parallel. Histological sections of the frontal lobe and cerebellar vermis were used for image analysis. Frontal WM proteins were used for Western blotting and duplex ELISAs. The ethanol exposures caused progressive reductions in frontal and cerebellar WM. Ethanol-mediated frontal WM atrophy was associated with reduced expression of ASPH, Jagged 1, HES-1, and HIF-1α. These findings link ethanol-induced WM atrophy to inhibition of ASPH expression and signaling through Notch networks, including HIF-1α.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711436/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35219837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats. 大鼠对3,4-亚甲基二氧基丙戊酮(MDPV)运动刺激作用的致敏和对甲基苯丙胺的交叉致敏。

Journal of Drug and Alcohol Research Pub Date : 2016-05-01 DOI: 10.4303/jdar/235967

Lucas R Watterson, Peter R Kufahl, Sara B Taylor, Natali E Nemirovsky, M Foster Olive

{"title":"Sensitization to the motor stimulant effects of 3,4-methylenedioxypyrovalerone (MDPV) and cross-sensitization to methamphetamine in rats.","authors":"Lucas R Watterson, Peter R Kufahl, Sara B Taylor, Natali E Nemirovsky, M Foster Olive","doi":"10.4303/jdar/235967","DOIUrl":"https://doi.org/10.4303/jdar/235967","url":null,"abstract":"Background: In recent years, there has been a dramatic increase in abuse of the synthetic cathinone 3,4-methylenedioxypyrovalerone (MDPV), often in combination with other illicit stimulants.Purpose: We sought to determine if repeated exposure to MDPV would produce sensitization to the motor stimulant effects of the drug, and whether cross-sensitization would develop with the stimulant effects of methamphetamine (METH).Study design: Male Sprague-Dawley rats were administered MDPV (1 or 5 mg/kg) or saline once daily for 5 days at 24 hour intervals, or were administered MDPV (1 mg/kg) or saline once daily for 5 days at 48 hour intervals. For cross-sensitization experiments, rats were administered METH (1 mg/kg) or MDPV (1 or 5 mg/kg) once daily for 5 days at 48 hour intervals, and following a 5 day incubation period, were given an acute challenge injection of either MDPV (0.5 mg/kg) or METH (0.5 mg/kg), respectively.Results: Rats repeatedly administered MDPV (1 mg/kg) every 48 hours, but not every 24 hours, demonstrated increased motor activity when given either a subsequent challenge of MDPV (0.5 mg/kg i.p.) or METH (0.5 mg/kg), indicating the development of behavioral sensitization and cross-sensitization, respectively. Moreover, rats repeatedly administered METH (1 mg/kg) every 48 hours did not exhibit cross-sensitization to the motor stimulating effects of a subsequent challenge with MDPV (0.5 mg/kg).Conclusion: These results suggest that specific patterns of MDPV administration may lead to lasting changes in behavioral responses to subsequent METH exposure.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896315/pdf/nihms-791251.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34629019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 26

Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine. Sigma-1受体在可卡因和甲基苯丙胺作用中的潜在分子机制。

Journal of Drug and Alcohol Research Pub Date : 2016-02-20 DOI: 10.4303/jdar/235970

Yuko Yasui, Tsung-Ping Su

引用次数: 37

Substance Abuse Counselors' Recovery Status and Self-Schemas: Preliminary Implications for Empirically Supported Treatment Implementation. 药物滥用咨询师的康复状态与自我图式:对实证支持治疗实施的初步启示。

Journal of Drug and Alcohol Research Pub Date : 2016-01-01 Epub Date: 2016-08-12 DOI: 10.4303/jdar/235982

Elizabeth M Nielson

{"title":"Substance Abuse Counselors' Recovery Status and Self-Schemas: Preliminary Implications for Empirically Supported Treatment Implementation.","authors":"Elizabeth M Nielson","doi":"10.4303/jdar/235982","DOIUrl":"https://doi.org/10.4303/jdar/235982","url":null,"abstract":"Purpose: The purpose of this paper is to better understand the relationship between substance abuse counselors' personal recovery status, self-schemas, and willingness to use empirically supported treatments for substance use disorders.Methods: A phenomenological qualitative study enrolled 12 practicing substance abuse counselors.Results: Within this sample, recovering counselors tended to see those who suffer from addiction as qualitatively different from those who do not and hence themselves as similar to their patients, while nonrecovering counselors tended to see patients as experiencing a specific variety of the same basic human struggles everyone experiences, and hence also felt able to relate to their patients' struggles.Discussion: Since empirically supported treatments may fit more or less neatly within one or the other of these viewpoints, this finding suggests that counselors' recovery status and corresponding self-schemas may be related to counselor willingness to learn and practice specific treatments.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5473661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35098580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

CART Peptides and Drugs of Abuse: A Review of Recent Progress. CART多肽与药物滥用:最新进展综述。

Journal of Drug and Alcohol Research Pub Date : 2016-01-01 Epub Date: 2016-06-28 DOI: 10.4303/jdar/235984

Michael J Kuhar

引用次数: 19

Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction. 酒精诱发脑动脉收缩的易感性与年龄有关

Journal of Drug and Alcohol Research Pub Date : 2016-01-01 Epub Date: 2016-11-27 DOI: 10.4303/jdar/236002

Anna N Bukiya, Olga Seleverstov, Shivantika Bisen, Alex M Dopico

{"title":"Age-Dependent Susceptibility to Alcohol-Induced Cerebral Artery Constriction.","authors":"Anna N Bukiya, Olga Seleverstov, Shivantika Bisen, Alex M Dopico","doi":"10.4303/jdar/236002","DOIUrl":"10.4303/jdar/236002","url":null,"abstract":"Background: Age has been recognized as an important contributor into susceptibility to alcohol-driven pathology.Purpose: We aimed at determining whether alcohol-induced constriction of cerebral arteries was age-dependent.Study design: We used rat middle cerebral artery (MCA) in vitro diameter monitoring, patch-clamping and fluorescence labeling of myocytes to study an age-dependent increase in the susceptibility to alcohol in 3 (50 g), 8 (250 g), and 15 (440 g) weeks-old rats.Results: An age-dependent increase in alcohol-induced constriction of MCA could be observed in absence of endothelium, which is paralleled by an age-dependent increase in both protein level of the calcium-/voltage-gated potassium channel of large conductance (BK) accessory β1 subunit and basal BK channel activity. Ethanol-induced BK channel inhibition is increased with age.Conclusions: We demonstrate an increased susceptibility of MCA to ethanol-induced constriction in a period equivalent to adolescence and early adulthood when compared to pre-adolescence. Our work suggests that BK β1 constitutes a significant contributor to age-dependent changes in the susceptibility of cerebral arteries to ethanol.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5790172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35785974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice. 甲氧麻黄酮和萘醌对小鼠的可卡因样判别刺激作用。

Journal of Drug and Alcohol Research Pub Date : 2016-01-01 Epub Date: 2016-12-31 DOI: 10.4303/jdar/236009

Brenda M Gannon, William E Fantegrossi

{"title":"Cocaine-Like Discriminative Stimulus Effects of Mephedrone and Naphyrone in Mice.","authors":"Brenda M Gannon, William E Fantegrossi","doi":"10.4303/jdar/236009","DOIUrl":"https://doi.org/10.4303/jdar/236009","url":null,"abstract":"Background In recent years, commercial bath salts products containing synthetic cathinone analogues have emerged as illicit drugs of abuse. These cathinones are structurally similar to the psychostimulants 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), and produce their effects via interactions with monoamine transporters, where smaller compounds (e.g., mephedrone) are amphetamine-like monoamine releasers, while the structurally larger compounds (e.g., naphyrone) are cocaine-like monoamine reuptake inhibitors. Individual cathinones also differ from one another with respect to selectivity among the three monoamine transporters. Statement of purpose of study This study was designed to assess the cocaine-like interoceptive effects of synthetic cathinone analogues functioning as passive monoamine reuptake inhibitors (naphyrone) or as releasers (mephedrone) in mice in order to compare effectiveness (degree of substitution) and potency with positive control psychostimulants cocaine, METH, and MDMA. Procedures In the present study, mice were trained to discriminate 10 mg/kg cocaine from saline, and substitutions with METH, MDMA, mephedrone, naphyrone, and morphine were performed. Main findings Mice reliably discriminated the cocaine training dose from saline, and METH, MDMA, mephedrone, and naphyrone all elicited full cocaine-like responding, while morphine did not. Potency differences were observed such that METH was most potent, while mephedrone, cocaine, MDMA, and naphyrone exhibited roughly equivalent potency. Principal conclusions These data confirm that interaction with DAT is an important component of cocaine-like discriminative stimulus effects, and suggest that synthetic cathinones likely elicit psychostimulant-like abuse-related effects.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393345/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34928182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence. 莫达非尼和r -莫达非尼对脑刺激奖励阈值的影响:它们在精神兴奋剂依赖治疗中的应用意义。

Journal of Drug and Alcohol Research Pub Date : 2015-12-01 Epub Date: 2015-12-29 DOI: 10.4303/jdar/235958

Brian T Burrows, Lucas R Watterson, Meagan A Johnson, M Foster Olive

{"title":"Effects of modafinil and R-modafinil on brain stimulation reward thresholds: implications for their use in the treatment of psychostimulant dependence.","authors":"Brian T Burrows, Lucas R Watterson, Meagan A Johnson, M Foster Olive","doi":"10.4303/jdar/235958","DOIUrl":"https://doi.org/10.4303/jdar/235958","url":null,"abstract":"Background: Modafinil and its enantiomer R-modafinil are approved for the treatment of various sleep disorders, and may also be efficacious in the treatment of psychostimulant abuse. However, the ability of modafinil and R-modafinil to alter brain reward function has not yet been assessed.Purpose: This study assessed the effects of modafinil and R-modafinil on brain reward function using the intracranial self-stimulation (ICSS) paradigm.Study design: Male Sprague-Dawley rats were trained to respond for ICSS using current-intensity threshold determination procedures. Changes in ICSS thresholds were then assessed following administration of modafinil and R-modafinil (50, 100, and 150 mg/kg), or cocaine (2.5 - 20 mg/kg) as a positive control.Results: ICSS thresholds were reduced by modafinil at the 150 mg/kg dose, as well as by cocaine at the 10 and 20 mg/kg doses. R-modafinil only produced non-significant trends towards reducing ICSS thresholds.Conclusion: Modafinil and R-modafinil have limited effects on brain reward function in otherwise drug-naïve subjects. Additional assessments of these effects in the context of psychostimulant dependence are needed.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896318/pdf/nihms791250.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34629018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Alcoholic Steatosis in Different Strains of Rat: A Comparative Study. 不同品系大鼠酒精性脂肪变性的比较研究

Journal of Drug and Alcohol Research Pub Date : 2015-01-01 Epub Date: 2015-05-25 DOI: 10.4303/jdar/235912

Kamlesh K Bhopale, Shakuntala Kondraganti, Harshica Fernando, Paul J Boor, Bhupendra S Kaphalia, G A Shakeel Ansari

{"title":"Alcoholic Steatosis in Different Strains of Rat: A Comparative Study.","authors":"Kamlesh K Bhopale, Shakuntala Kondraganti, Harshica Fernando, Paul J Boor, Bhupendra S Kaphalia, G A Shakeel Ansari","doi":"10.4303/jdar/235912","DOIUrl":"https://doi.org/10.4303/jdar/235912","url":null,"abstract":"Background: Different strains of rats have been used to study alcoholic liver disease (ALD) while the reason for selecting a particular rat strain was not apparent.Purpose: The aim of our study was to compare outbred (Wistar) and inbred (Fischer) strains to evaluate pathological, biochemical changes, and gene expression differences associated with ethanol-induced early hepatic steatosis.Study design: Male Wistar and Fischer-344 rats were pair-fed for 6 weeks with or without 5% ethanol in Lieber-DeCarli liquid diet. Livers were analyzed for histological and lipid-related differences.Results: Hepatic midzonal steatosis was mainly found in Wistar rats while Fischer rats showed mostly pericentral steatosis. Increased hepatic steatosis in ethanol-fed Wistar rats is supported by increases in lipids with related genes and transcription factors involved in fatty acid and triglyceride synthesis.Conclusion: Our data showed that Fischer rats are relatively less prone to ethanol-mediated steatosis with pericentral lipid deposition pattern in the liver which is similar to humans and show no trace level of lipid accumulation in pair-fed controls as observed in Wistar (outbred) strain. Therefore, Fischer rats are better suited for lipid studies in an early development of ALD.","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2015-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4874529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34507873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4