{"title":"Potential Molecular Mechanisms on the Role of the Sigma-1 Receptor in the Action of Cocaine and Methamphetamine.","authors":"Yuko Yasui, Tsung-Ping Su","doi":"10.4303/jdar/235970","DOIUrl":null,"url":null,"abstract":"<p><p>The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum membrane protein that involves a wide range of physiological functions. The Sig-1R has been shown to bind psychostimulants including cocaine and methamphetamine (METH) and thus has been implicated in the actions of those psychostimulants. For example, it has been demonstrated that the Sig-1R antagonists mitigate certain behavioral and cellular effects of psychostimulants including hyperactivity and neurotoxicity. Thus, the Sig-1R has become a potential therapeutic target of medication development against drug abuse that differs from traditional monoamine-related strategies. In this review, we will focus on the molecular mechanisms of the Sig-1R and discuss in such a manner with a hope to further understand or unveil unexplored relations between the Sig-1R and the actions of cocaine and METH, particularly in the context of cellular biological relevance.</p>","PeriodicalId":37818,"journal":{"name":"Journal of Drug and Alcohol Research","volume":"5 ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2016-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4830437/pdf/nihms750939.pdf","citationCount":"37","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Drug and Alcohol Research","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4303/jdar/235970","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 37
Abstract
The sigma-1 receptor (Sig-1R) is an endoplasmic reticulum membrane protein that involves a wide range of physiological functions. The Sig-1R has been shown to bind psychostimulants including cocaine and methamphetamine (METH) and thus has been implicated in the actions of those psychostimulants. For example, it has been demonstrated that the Sig-1R antagonists mitigate certain behavioral and cellular effects of psychostimulants including hyperactivity and neurotoxicity. Thus, the Sig-1R has become a potential therapeutic target of medication development against drug abuse that differs from traditional monoamine-related strategies. In this review, we will focus on the molecular mechanisms of the Sig-1R and discuss in such a manner with a hope to further understand or unveil unexplored relations between the Sig-1R and the actions of cocaine and METH, particularly in the context of cellular biological relevance.
期刊介绍：
The Journal of Drug and Alcohol Research (JDAR) is a scholarly open access, peer-reviewed, and fully refereed journal dedicated to publishing sound papers on advances in the field of drug, opiate, nicotine and alcohol abuse, both basic and clinical. The journal will consider papers from all sub-disciplines and aspects of drug abuse, dependence and addiction research. Manuscripts will be published online as soon as they are accepted, which will reduce the time of publication. Because there are no space limitations or favored topics, all papers, within the scope of the journal, judged to be sound by the reviewers, will be published.
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