Respiratory Science最新文献_第4页

Role of miRNA in Non-Small Cell Lung Carcinoma miRNA在非小细胞肺癌中的作用

Respiratory Science Pub Date : 2022-06-02 DOI: 10.36497/respirsci.v2i3.39

A. Arfan, S. Andarini

引用次数: 1

Associations Between Severity Of Symptoms, D-Dimer and Incidence of ARDS In COVID-19 COVID-19患者症状严重程度、d -二聚体与ARDS发病率的关系

Respiratory Science Pub Date : 2022-06-02 DOI: 10.36497/respirsci.v2i3.40

Herani Mutia Riandini, Fajrinur Syaran, S. Bihar, P. Eyanoer

{"title":"Associations Between Severity Of Symptoms, D-Dimer and Incidence of ARDS In COVID-19","authors":"Herani Mutia Riandini, Fajrinur Syaran, S. Bihar, P. Eyanoer","doi":"10.36497/respirsci.v2i3.40","DOIUrl":"https://doi.org/10.36497/respirsci.v2i3.40","url":null,"abstract":"Background: Severe acute respiratory injury caused by COVID-19 (ARDS) is a serious emerging complication. ARDS results from a cytokine storm that occurs in the second week of the disease course and acute-onset hypoxemia can be seen with bilateral infiltrates on chest radiograph. This study aimed to relate the severity of symptoms and D-dimer level to the incidence of ARDS in COVID-19 at H. Adam Malik Hospital as the referral center for COVID-19 in North Sumatra.\u0000Method: This was a descriptive study with a retrospective cohort design. The sample of this study was secondary data from medical records of positive RT-PCR COVID-19 patients from November 2020 to April 2021. The inclusion criteria were patients with moderate to critical COVID-19 cases with D-dimer examination taken from the first day of admission. Subjects were then followed up until discharge from the hospital to assess for ARDS episodes which were confirmed by the results of PaO2/FiO2 in arterial blood gases and bilateral infiltrations in chest X-Ray. The exclusion criteria were incomplete medical records.\u0000Results: The association between the severity of symptoms and the incidence of ARDS, 1 of which was found to be moderate, 19 cases were severe and 20 were critical. However, there was a statistically significant correlation between the severity of symptoms and the incidence of ARDS (P=0.0001).\u0000Conclusion: There was a significant correlation between the severity of symptoms and the D-dimer value on the incidence of ARDS.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124016811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Calculation of Pleural Fluid Estimation Using Ultrasonography 超声胸膜液估算的计算

Respiratory Science Pub Date : 2022-06-02 DOI: 10.36497/respirsci.v2i3.51

Adityo Wibowo, M. Elhidsi, A. Susanto

引用次数: 0

Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera 北苏门答腊省棉兰市哈吉·亚当·马利克综合医院新冠肺炎患者特征分析

Respiratory Science Pub Date : 2022-06-02 DOI: 10.36497/respirsci.v2i3.53

Dyana Destylya, B. Y. Sinaga, P. Siagian, P. Eyanoer

{"title":"Characteristics of COVID-19 Patients in Haji Adam Malik General Hospital, Medan, North Sumatera","authors":"Dyana Destylya, B. Y. Sinaga, P. Siagian, P. Eyanoer","doi":"10.36497/respirsci.v2i3.53","DOIUrl":"https://doi.org/10.36497/respirsci.v2i3.53","url":null,"abstract":"Background: Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The increase in the number of COVID-19 cases was happening quite quickly and has spread between countries so that COVID-19 has become a pandemic in the world. This study aimed to determine the characteristics of COVID-19 patients at Haji Adam Malik General Hospital Medan.\u0000Method: This was a descriptive study. Data were taken from the medical records of 110 hospitalized patients with positive RT-PCR results for COVID-19 from December 2020 to April 2021. The inclusion criteria for the case samples were patients diagnosed with COVID-19 based on RT-PCR and the exclusion criteria were incomplete medical records. Characteristic analysis was carried out using the Kruskal Wallis test.\u0000Results: The most common comorbidities found in patients with severe COVID-19 were diabetes mellitus and HIV. The most common comorbidity found in moderate-level COVID-19 patients was pregnant women. The most common chest X-rays finding in severe and critical levels was bilateral infiltrates. Recovered patients were mostly obtained at moderate level, while deceased patients were mostly observed at critical levels.\u0000Conclusion: Characteristics of COVID-19 patients at Haji Adam Malik General Hospital were classified based on the degree of disease by age, lymphocyte value, N/L ratio, levels of CRP, D-dimer, procalcitonin, fibrinogen, ferritin, and comorbidities as well as the appearance of infiltrates in both lung fields.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116611943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients' Sputum Conversion During Intensive Phase Category I Treatment in Medan 补充维生素C可改善棉兰I类强化治疗期间肺结核患者的痰转化

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.30

Elok Ariyani Safitri, P. Siagian, B. Sinaga, P. Eyanoer

{"title":"Vitamin C Supplementation Improves Pulmonary Tuberculosis Patients' Sputum Conversion During Intensive Phase Category I Treatment in Medan","authors":"Elok Ariyani Safitri, P. Siagian, B. Sinaga, P. Eyanoer","doi":"10.36497/respirsci.v2i2.30","DOIUrl":"https://doi.org/10.36497/respirsci.v2i2.30","url":null,"abstract":"Background: Many factors influence the success of the acceleration of Acid-Fast Bacilli (AFB) sputum conversion in the treatment of the intensive phase of pulmonary tuberculosis (TB). One of these factors is the nutritional status or nutrition of pulmonary TB patients. Through a fenton reaction, Vitamin C is known to be able to sterilize Mycobacterium tuberculosis. This study aims to determine the effect of giving vitamin C on the conversion of AFB sputum in the intensive phase of pulmonary TB treatment.\u0000Method: This study was an inferential, quasi-experimental evaluation of the acceleration of AFB sputum conversion following vitamin C supplementation in patients with category I pulmonary TB. The study group was separated into two groups: 40 TB patients getting Anti Tuberculosis Treatment (ATT) with vitamin C, and 40 TB patients receiving ATT with placebo. Every two weeks, AFB sputum was examined, and vitamin C levels were measured before and after two months of therapy.\u0000Results: Conversion of AFB occurred sooner in the vitamin C group of pulmonary TB patients, with as many as 29 patients (72.5%) experiencing conversion of AFB sputum at the end of the second week of therapy, whereas there was no conversion in the placebo group. At the end of the fourth week, all patients (100%) given vitamin C showed AFB sputum conversion, whereas only eight patients (20%) in the placebo group had conversion at the end of the fourth week of treatment. Vitamin C levels increased significantly in the group of pulmonary tuberculosis patients who received vitamin C supplementation.\u0000Conclusion: Vitamin C supplementation in the treatment of pulmonary TB can accelerate the conversion of AFB sputum, which is statistically significant.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130573768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Chemotherapy in Lung Cancer With Hepatic and Renal Impairment 肺癌伴肝肾损害的化疗

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.42

Aida Hastuti, Erna Kusumawardhani, H. Haryati

引用次数: 0

Association of Acquired Resistance EGFR Exon 20 T790M Mutation and Treatment Response in Lung Adenocarcinoma Patients Receiving EGFR-TKI 接受EGFR- tki治疗的肺腺癌患者获得性耐药EGFR外显子20t790m突变与治疗反应的关系

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.32

Muhammad Harbi Praditya, N. Soeroso, S. Tarigan, T. Ashar

{"title":"Association of Acquired Resistance EGFR Exon 20 T790M Mutation and Treatment Response in Lung Adenocarcinoma Patients Receiving EGFR-TKI","authors":"Muhammad Harbi Praditya, N. Soeroso, S. Tarigan, T. Ashar","doi":"10.36497/respirsci.v2i2.32","DOIUrl":"https://doi.org/10.36497/respirsci.v2i2.32","url":null,"abstract":"Background: Lung adenocarcinoma patients receiving EGFR-TKI may develop acquired resistance within 7-16 months of treatment initiation, which is characterized by the presence of exon 20 T790M mutations in treatment response patients and can be assessed objectively by CECT and then evaluated by RECIST 1.1. The purpose of this study is to look into the association between acquired resistance EGFR Exon 20 T790M mutation and treatment response in lung adenocarcinoma patients receiving EGFR-TKI.\u0000Method: This research is an analytic study with a retrospective cohort design carried out at the Oncology Polyclinic at Haji Adam Malik Hospital from October 2020 to January 2021 in all patients with adenocarcinoma lung cancer who were treated with EGFR-TKI for more than 6 months. After that, an evaluation was carried out based on RECIST 1.1 and then examined for EGFR mutations from liquid biopsy specimens in the form of circulating tumor plasma DNA (ct-DNA) with the droplet digital Polymerase Chain Reaction (ddPCR) method to detect EGFR exon 20 T790M mutations as a marker of acquired resistance.\u0000Results: It was found that the majority of subjects were female (64.5%), aged 20-69 years (58%), and non-smokers (67.7%). The most common EGFR mutation was exon 19 deletion (58.1%). The incidence of acquired resistance was found in 10 subjects (32.3%). The distribution of RECIST 1.1 results on positive acquired resistance includes progressive diseases of 35.2%; stable disease of 11.1%; partial response of 33.4%; and 100% complete response. Negative acquired resistance includes 64.8% progressive disease, 88.9% stable disease, 66.6% partial response, and 0% complete response (P=0.93).\u0000Conclusion: There is no significant association between the incidence of acquired resistance mutations EGFR exon 20 T790M and treatment response in patients with lung adenocarcinoma who received EGFR-TKI therapy.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123077343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Multiple Possible Causes Of Dyspnea In An Unusual Pickwickian Syndrome On Covid-19 Pandemic: A Case Study Covid-19大流行异常匹克威克综合征中呼吸困难的多种可能原因:案例研究

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.44

S. Jonathan, M. Rasmin

{"title":"Multiple Possible Causes Of Dyspnea In An Unusual Pickwickian Syndrome On Covid-19 Pandemic: A Case Study","authors":"S. Jonathan, M. Rasmin","doi":"10.36497/respirsci.v2i2.44","DOIUrl":"https://doi.org/10.36497/respirsci.v2i2.44","url":null,"abstract":"Introduction: Pickwickian Syndrome (PS) or obesity hypoventilation syndrome (OHS) is a diagnosis of exclusion with features of obesity, sleep disordered breathing, and chronic daytime hypercapnia. Patients with PS could present into general OSA or respiratory failure. We are presenting an unusual case of PS with acute respiratory failure resulting in organ failure and mortality. \u0000Case report: A 41-year-old male was admitted to hospital due to shortness of breath. He had a trouble sleeping; frequently awoke as the breathing briefly stopped and gasping. There were history of diabetes melitus (DM) and hypertension for >10 years, smoking with moderate Brinkman Index. Patient appeared to have somnolence, tachypnea, hypoxemia, morbid obesity. We assessed him as PS, bronchopneumonia, respiratory failure, pulmonary edema, hypertensive heart disease (HHD), DM, acute on CKD. We managed him with pharmacotherapy, oxygen (BiPAP), and hemodialysis. After transferred from ICU to regular ward, patient was suddenly apneic and CPR was performed; ended in mortality. \u0000Discussion: This unusual case (malignant OHS) was a subgroup among OHS with greater morbidity and multiorgan system dysfunction. There were multiple causes of dyspnea on our patient which concluded to a death case. There are three modalities of management in stable PS: positive airway pressure (PAP), weight reduction, and pharmacotherapy. The management of respiratory failure in PS mainly involved oxygen therapy in positive pressure. \u0000Conclusion: There were multiple causes of dyspnea in this patient. Optimal management of patient ought to treat not only the PS but also all the comorbidities.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114736462","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Air Pollution and Respiratory Diseases During The Hajj Season in The Holy City of Makkah 麦加圣城朝觐期间的空气污染和呼吸道疾病

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.37

Mukhtar Ikhsan

引用次数: 0

Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta 中性粒细胞-淋巴细胞比率(NLR)和c反应蛋白(CRP)水平在雅加达Persahabatan医院稳定和加重慢性阻塞性肺疾病(COPD)患者

Respiratory Science Pub Date : 2022-02-28 DOI: 10.36497/respirsci.v2i2.38

Astari Pranindya Sari, R. Ratnawati, W. Aniwidyaningsih, S. Andarini, F. Yunus

{"title":"Neutrophyl – Lymphocyte Ratio (NLR) and C-Reactive Protein (CRP) Levels in Stable and Exacerbated Chronic Obstructive Pulmonary Disease (COPD) Patients in Persahabatan Hospital Jakarta","authors":"Astari Pranindya Sari, R. Ratnawati, W. Aniwidyaningsih, S. Andarini, F. Yunus","doi":"10.36497/respirsci.v2i2.38","DOIUrl":"https://doi.org/10.36497/respirsci.v2i2.38","url":null,"abstract":"Background: Although COPD has been believed to be characterized by respiratory disease, there are currently limited study conducted to evaluate inflammation markers and exacerbation rate in COPD by noninvasive methods. We did a prospective cohort study to observe the alteration of Neutrophyl-Lymphocyte Ratio (NLR) and C-reactive protein (CRP) in COPD patients to find any possible correlation with COPD exacerbation status.\u0000Method: From July to December 2018, a prospective cohort study was performed with blood and spirometry test on 31 COPD patients during exacerbation (AE-COPD) and stable. The mean of NLR and CRP were compared and analyzed.\u0000Results: Both NLR and CRP decreased during stable condition (from 7.95±6.8 to 4.6±5.5 and 43.4±71 to 12.2±18.5) with P<0.01 respectively. We also found a significant inverse correlation between NLR and FEV1/FVC in AE-COPD and CRP showed an inverse correlation only with FEV1 in AE-COPD. Another interesting finding was a subject with very high CRP whose value remained above the nomal limit during stable, and died within 2 months after exacerbation.\u0000Conclusion: NLR and CRP levels in COPD patients increased during exacerbation, which may reflect lung function and exacerbation status.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122534765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0