Respiratory Science最新文献

{"title":"Mycobacterium tuberculosis Involvement in Tetralogy of Fallot: A Case Report of Tetralogy of Fallot Patient with Pulmonary Tuberculosis in A Tertiary Health Care in Indonesia","authors":"Harik Firman Thahadian, S. Sumardi, Eko Budiono","doi":"10.36497/respirsci.v3i3.87","DOIUrl":"https://doi.org/10.36497/respirsci.v3i3.87","url":null,"abstract":"ckground: Pulmonary tuberculosis in patients with congenital heart disease is a rare case and remains challenging to diagnose and treat. This study aimed to emphasize the association between pulmonary tuberculosis infection and management in patients with congenital heart disease.\u0000Case: This case study presents 18-year-old male with Tetralogy of Fallot (ToF) who had pulmonary tuberculosis. The tuberculosis diagnosis was confirmed clinically, followed by positive IGRA. The patient underwent standard care within the hospital and upon discharge, he was prescribed with standard anti-tuberculosis regimen consisting of rifampicin, isoniazid, pyrazinamide, and ethambutol (RHZE) for a week then discontinued it. After 3 months the patient initiated intensive phase (RHZE) for 2 months and followed by 4-month maintenance phase of Isoniazid and Rifampicin. Immediate evaluation showed improved patient’s chest radiography and symptoms’ remission. This study presented provisioning therapy regimen and nutritional care delivery for pulmonary tuberculosis patient with ToF. Further patient’s clinical evaluation suggested a substantial recovery process. The patient prescribed with infection control and dietary management upon hospital discharge. Counseling to improve patient’s knowledge was performed to prevent recurrent TB. Collaborative care established between internal medicine specialists, cardiologist, pulmonologist, and clinical nutritionist appeared to be effective to promote patient’s recovery and quality of life (QoL).\u0000Conclusion: Appropriate management of cases improves patient outcomes and QoL. Early screening, diagnosis and treatment should be introduced regardless of the patient’s clinical status. Adequate support from the patient’s family and relatives are required to eliminate TB infection.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134309165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocard Injury in COVID-19 Patients After Application Of Umbilical Cord Mesenchymal Stem Cell (UC-MSC) as Adjuvant Therapy in Persahabatan Hospital","authors":"M. Juliana, Triya Damayanti, Yasmina Hanifah, E. Burhan","doi":"10.36497/respirsci.v3i3.89","DOIUrl":"https://doi.org/10.36497/respirsci.v3i3.89","url":null,"abstract":"Background: Myocardial injury was a frequent cardiovascular manifestation of COVID-19 and associated with high mortality.  Cell-based approaches, primarily using mesenchymal stem cell (MSC) has demonstrated safety and possible efficacy as adjuvant therapy in COVID-19 patients. This study aims to evaluate myocardial injury in patients with moderate-severe and critically ill COVID-19 after the application of umbilical cord mesenchymal stem cell (UC-MSC) as adjuvant therapy in Persahabatan hospital.\u0000Method: This is a retrospective and prospective cohort study. A total of 28 subjects were allocated to 13 subjects in the control and 15 subjects in the experimental group. Subjects were given the standard treatment and UC-MSC or placebo. Myocardial injury is defined by an increase of troponin I >26 pg/ml. The biomarkers of troponin I, NT-proBNP and CRP was examined periodically. Cardiac pump evaluated by EF and TAPSE from echocardiography examination before and after UC-MSC application. The evaluation of myocardial injury, biomarkers, cardiac pump and 15-day mortality were observed between the two groups.\u0000Results: The incidence of myocardial injury was 28,6% of total subjects. Subjects with worsening myocardial injury were higher in the control group (6 subjects) than the experimental group (4 subjects) although not statistically significant. The difference in biomarkers (troponin I, NT- pro-BNP and CRP), cardiac pump function (EF and TAPSE) and 15-day mortality between two groups were not statistically significant. There was a trend of decreasing troponin I, NT-proBNP and CRP in the experimental group.\u0000Conclusion: UC-MSC application can be an option as adjuvant therapy in improving myocardial injury of moderate-severe and critically ill COVID-19 patients.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"291 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116867809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of C-Reactive Protein, Neutrophil-to-Lymphocyte Ratio, PaO2/FiO2 Ratio on the Success of High Flow Nasal Cannula Usage in Hospitalized COVID-19 Patients","authors":"Arina Aftritia Izzati, U. Setyawan, Rezki Tantular","doi":"10.36497/respirsci.v3i3.85","DOIUrl":"https://doi.org/10.36497/respirsci.v3i3.85","url":null,"abstract":"Background: Several studies had shown High Flow Nasal Cannula (HFNC) is effective in treating hypoxemic COVID-19 patients. The C-Reactive Protein and Neutrophil-to-Lymphocyte Ratio is an inflammatory marker that could predict the severity of COVID-19, where the P/F ratio infers oxygenation status. Since COVID-19-related ARDS is closely related to a hyper-inflammatory state and HFNC becomes widely utilized for hypoxemic patients, it has become important to discover reliable inflammatory biomarkers related to therapeutic HFNC success. This study aims to assess the factors that influence the success of HNFC therapy, in terms of demographic and laboratory profiles of CRP, NLR, and P/F ratio.\u0000Method: A retrospective, single-center cohort study was conducted in a tertiary care hospital in Malang, East Java from January to March 2022. Subjects of 31 PCR-confirmed, hospitalized COVID-19 patients who were treated with HFNC were included.\u0000Results: This study involved 2 groups comprised of 19 subjects with successful HFNC and 12 patients who failed. Significant demographic factors affecting successful HFNC were female gender (OR=1.46 95% CI=1.08-1.99; P=0.037) and occupation type (P=0.023). Whereas, biomarkers of CRP (8.90±6.8 mg/L vs 12.39±11.7 mg/L; P=0.656), NLR (7.24±4.66 vs 12.85±12.9; P=0.243) and P/F ratio (171.40±54 vs 148.00±40; P=0.219) were found to be non-significant between successful and failed HFNC cohorts, respectively.\u0000Conclusion: HFNC could provide a specific positive end-expiratory pressure in COVID-19 patients with contributing factors of successful HFNC being female and occupational type. However, CRP, NLR, and P/F did not contribute significantly to HFNC's success.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130759621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory Markers of ARDS Events among Patients with Severe and Critical COVID-19 Infection at Adam Malik General Hospital, Medan, North Sumatera","authors":"Eva Susanti Debora Hutabarat, Fajrinur Syarani, S. Bihar, P. Eyanoer","doi":"10.36497/respirsci.v3i3.78","DOIUrl":"https://doi.org/10.36497/respirsci.v3i3.78","url":null,"abstract":"Background: COVID-19 can cause fatal outcomes, especially acute respiratory distress syndrome (ARDS). It manifests as organ dysfunction during COVID-19's hyperinflammatory phase, which is associated with a high mortality rate. Data on the clinical characteristics and inflammation markers of patients with severe and critical degrees of COVID-19 with ARDS events are limited.\u0000Method: This study is carried out at the Haji Adam Malik General Hospital in Medan. We grouped 204 medical records from February to July 2022 of hospitalized patients with severe and critical COVID-19 cases into two groups, ARDS and non-ARDS. Characteristics of demographic and laboratory inflammatory markers upon admission between each group were collected. After collecting data and serving as categorical data in the frequency distribution table by SPSS ver 25.0.\u0000Results: We identified 116 patients (56.9%) who had ARDS event upon hospital admission. ARDS event are most commonly found in the elderly group and the median age of ARDS group patients was 59.5 years higher than the non-ARDS group. Male patients were more likely to have ARDS than female patients. Compared with the non-ARDS group, ARDS group patients had lymphocytopenia, neutrophilia, increased neutrophil-to-lymphocyte ratio (NLR), Procalcitonin and C-Reactive Protein levels.\u0000Conclusion: Lymphocytopenia, neutrophilia, increased NLR, procalcitonin and CRP levels upon admission revealed that they were higher in ARDS patients compared to non-ARDS patients. It is critical to identify high-risk groups, such as male sex, the elderly, those with comorbidities, and patients with impaired inflammatory markers to prevent severe complications from COVID-19.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123243612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gut-Lung Axis","authors":"Anggie Indari, M. Rasmin, Ari Fahrial Syam","doi":"10.36497/respirsci.v3i2.68","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.68","url":null,"abstract":"Microbiota and the body's immune system have a two-way interaction that is interconnected. The microbiota plays a role in the formation and maturation of the immune system, on the other hand, the immune system shapes the composition and function of the microbiota. This interaction is important in maintaining the body’s immune system’s homeostasis. The human intestine contains various types of microbes that form the gut microbiota. Various studies have found that changes in the gut microbiota are associated with immunity in distal tissues such as the lung. This gives rise to the concept of a feedback relationship between the gut and lung organs called the gut-lung axis. Through this axis, changes in the composition of the gut microbiota not only cause abnormalities in the gut but also affect microbiota in the lungs and can cause disease. One of the important routes in the transmission of substances from the intestine is through the mesenteric lymphatics. Probiotics can help improve the gut’s defense mechanism. A high-fiber diet can also reduce pathogenic bacteria by increasing levels of short-chain fatty acids. Therefore, a healthy lifestyle is needed to maintain the balance of the microbiota.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114640784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal Intensity of Aerobic Exercise Training for Patient With Chronic Obstructive Pulmonary Disease (COPD): Systematic Review and Meta-Analysis","authors":"Christian James Ibrahim, A. Probandari, Yusup Subagio Susanto, J. Aphridasari","doi":"10.36497/respirsci.v3i2.74","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.74","url":null,"abstract":"Background: Intensity for aerobic exercise is unclear in patient with COPD. Previous systematic review comparing effects of different levels of training intensity was done in 2011 and did not reach any conclusion. We conducted this systematic review to see the differences in aerobic training intensity on various aspects of health in COPD patients with updated information.\u0000Method: We included RCTs, comparing the differences in intensity of aerobic training between groups. The primary search was done through Pubmed, Scopus, Science Direct, Proquest, and PEdro. The PEdro scale and Risk of Bias 2 tool was used to rate the studies. Lastly, we also rate the certainty of evidence using GRADE approach. The assessment was carried out by two reviewers independently. Data were extracted by one reviewer then evaluated by second reviewer.\u0000Results: We found and analysed data from four studies with total of 472 patients. The primary outcomes extracted were Disease-specific Health-Related Quality of Life (HRQoL), Activities of Daily Living (ADL), Functional exercise capacity, Dyspnea symptoms. There was a significant difference only in St George’s Respiratory Questionnaire (SGRQ) symptoms domain for HRQoL outcome (MD=5.53; 95% CI=1.08-9.97), favoured lower intensity group. No other significant results were found for any other outcomes/ outcome measures. According to GRADE, quality of the studies was very low to moderate.\u0000Conclusion: The evidence we collected is very limited and difficult to evaluate. Further research comparing higher intensity with lower intensity of aerobic training is needed.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129286470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MANAGEMENT OF FEBRILE NEUTROPENIA IN LUNG CANCER","authors":"H. Haryati, Nida Amalia","doi":"10.36497/respirsci.v3i2.72","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.72","url":null,"abstract":"Febrile neutropenia (FN) is defined as an oral temperature of >38.3° C or two consecutive measures > 38° C within 2 hours accompanied by an absolute neutrophil count (ANC) of 500/L or a predicted decrease below 500/L in individuals undergoing systemic chemotherapy for cancer. FN is one of the oncological emergencies that can influence cancer patients' outcomes since it can increase morbidity, treatment delays, decreased survival, and expanded costs. The incidence of FN is 3.7-28% in lung cancer patients. Mortality associated with FN episodes is 15%. FN risk factors include chemotherapy regimen, age, comorbidities, mucositis, performance status, and previous FN history. Validated predicted instruments such as The Multinational Association for Supportive Care in Cancer (MASCC) or The Clinical Index of Stable Febrile Neutropenia (CISNE) score could assist in risk assessment of FN and determine advanced management. Effective therapy of FN requires investigation of diagnosis as soon as possible and acknowledging the potential source of infection. The prophylactic granulocyte colony-stimulating factors (G-CSF) and anti-microbials successfully reduced mortality due to FN.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130458318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Smoking Habit and Level of Nicotine Dependence in University Students","authors":"Dio Alief Supriyanto, T. Damayanti","doi":"10.36497/respirsci.v3i2.54","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.54","url":null,"abstract":"Background: Smoking habits are still a global problem. One of the harmful compounds in cigarettes is nicotine which gives a dependence effect on its users because long-term exposure can cause desensitisation of nicotinic acetyhlcoline receptor. This study aimed to determine the correlation between degree of smoking habit and level of nicotine dependence in actively smoking university students.\u0000Method: A cross-sectional study was conducted using questionnaires, consisted of relating factors questionnaire (age, BMI, academic major, allowance, family smoking habits, and social environment), degree of smoking behavior questionnaire (Brinkman Index/IB), and Fagerstorm Test for Nicotine Dependence/FTND questionnaire.\u0000Results: There were 124 active smoker university students included in this study. This study found that the higher the BI score, the higher the FTND score (P<0.001; r=0.420). In addition, this study also found that there were positive correlations between age (P=0.009; r=0.223), personal income (P=0.003; r=0.261), and academic major (P=0.042) with the levels of smoking habit. There was also correlation between allowance (P=0.005; r=0.249) with level of nicotine dependence.\u0000Conclusion: These results indicate a significant moderate correlation between smoking habit with nicotine dependence among university students.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123690115","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper Airway Resistance Syndrome : An Underdiagnosed Sleep-related Breathing Disorder","authors":"Dennis Rafi, Larasati Budiyarto","doi":"10.36497/respirsci.v3i2.79","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.79","url":null,"abstract":"Upper Airway Resistance Syndrome (UARS) is an example of sleep-related breathing disorders. UARS was first reported by Guilleminault in 1992 and it is known as excessive daytime sleepiness without obvious apnea or hypopnea that is characterized by more than 50% of respiratory effort related arousals (RERAs) during sleep. The prevalence of UARS was 15% in population in São Paulo. Although clinical manifestations, electroencephalogram (EEG) findings, and pathogenesis differ between UARS and OSA (Obstructive Sleep Apnea), it still sparked a debate among researchers as to whether UARS should be categorized as a distinct disorder. The International Classification of Sleep Disorders - Third Edition (ICSD3) integrated UARS into OSA diagnosis, resulting in underdiagnosed and undertreated patients with sleep-related breathing disorders who did not necessarily meet OSA criteria. Untreated UARS, on the other hand, has a variety of clinical consequences, including poor weight and height growth, daytime irritability, worsening of quality of life, and cardiovascular complications. Continuous positive airway pressure therapy, oral appliances, surgical management, weight reduction, and positional therapy are all considered as options in management of UARS. \u0000 ","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"81 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127625885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Nutritional Status, Physical Activity, Type of Work and Smoking Activity with Fitness Level Measured by 6-Minute Walking Test on Non-staff Employees of Universitas Indonesia, Depok","authors":"M. Rasmin, Hilma Nur Faiza, Kemal Akbar Suryoadji, Neny Husnaini Zain, Sakinasha Siva Utami, F. F. Taufik, Dewi Friska, N. C. Sudarsono, Elisna Syahrudin","doi":"10.36497/respirsci.v3i2.70","DOIUrl":"https://doi.org/10.36497/respirsci.v3i2.70","url":null,"abstract":"Background: Fitness is inextricable to health and has a significant correlation with the habits and behaviour of individuals such as dietary practice, sedentary behaviour, physical activities, and smoking habits. Many ways can be used to assess an individual fitness level, one of them is using the 6-minute walking test. This study aims to find the correlation between smoking intensity, nutritional status, occupation, and physical activity with the fitness level of outdoor janitors in Universitas Indonesia, Depok.\u0000Method: The research method was the cross-sectional design. The determination of the subjects was carried out by a consecutive sampling method. The data obtained results from the assessment of nutritional status, occupation, physical activity, and smoking intensity, as well as result from the 6-minute walking test. Univariate data analysis was used to assess the distribution of subjects based on sociodemographics, nutritional status, physical activity, occupation, and smoking activity. Furthermore, categorical correlative tests used were Man-Whitney, Kruskal-Wallis, and Fisher's Exact test.\u0000Results: The subjects obtained are 109 outdoor janitors from UI, Depok in which 59.6% age 18-44 years old, and 56% are male. Based on the correlative test between the fitness level and the nutritional status, value of P=0.086, as value of P between the physical activity and the fitness level is 0.0523. No significant correlation between fitness level and occupation based on location of the job, duration of work and based on the work time (P=1.00; P=1.00; P=0.108) The correlation between smoking intensity with the fitness level has value of P=0.681.\u0000Conclusion: There is no significant correlation between nutritional status, physical activity, type of work, and smoking intensity with the fitness level as measured by the 6-minute walking test method for outdoor janitors of UI, Depok.","PeriodicalId":377868,"journal":{"name":"Respiratory Science","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127480065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}