Endocrinologia, Diabetes y Nutricion最新文献

{"title":"Panhypopituitarism and hypothalamic obesity in pediatric patients due to Langerhans cell histiocytosis: An aggressive and rare condition","authors":"Ignacio Jiménez Hernando, Marta Pérez Noguero, Mónica Gómez-Gordo Hernanz, Rogelio García Centeno","doi":"10.1016/j.endinu.2025.501725","DOIUrl":"10.1016/j.endinu.2025.501725","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501725"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El eco de una pregunta, 10 años después: carta para Amanda y Jesús","authors":"Camila Milad , Alex Mesa","doi":"10.1016/j.endinu.2026.501772","DOIUrl":"10.1016/j.endinu.2026.501772","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501772"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entendiendo la experiencia de las mujeres que viven con obesidad y patología reproductiva","authors":"Alba Andreu ,&nbsp;Jessica Farré ,&nbsp;Eva Palou ,&nbsp;Gemma Casals ,&nbsp;Olga Rubio ,&nbsp;Violeta Moizé ,&nbsp;Dolors Manau ,&nbsp;Lilliam Flores ,&nbsp;Eva Antúnez ,&nbsp;Miriam Redondo ,&nbsp;Josep Vidal ,&nbsp;Joan Escarrabill","doi":"10.1016/j.endinu.2025.501746","DOIUrl":"10.1016/j.endinu.2025.501746","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity in women of reproductive age is a significant risk factor for infertility. Current treatment strategies primarily focus on weight reduction through lifestyle modifications, pharmacological interventions, or surgical procedures. However, there is still a lack of consensus on the most effective approach. Moreover, such interventions have limited effectiveness in maintaining weight loss and optimizing assisted reproduction results following assisted reproductive techniques, which may lead to stigmatization and negative experiences for patients.</div><div>Although qualitative evidence regarding preconception and gestational stages has increased, literature specifically addressing women who simultaneously present obesity and infertility, as well as the impact of these conditions on their physical and emotional well-being, remains limited.</div></div><div><h3>Aim</h3><div>To explore the care trajectory of women with obesity and infertility.</div></div><div><h3>Methods</h3><div>We designed a mixed-methods study involving 10 healthcare professionals, a focus group and a co-creation workshop with 6 and 8 patients respectively, and an online survey was administered and completed by 33 out of a total of 150 women with obesity and reproductive pathology who were invited to participate (response rate 22%).</div></div><div><h3>Results</h3><div>While some aspects of preconception care were positively evaluated, the overall patient journey is complex. We identified four areas for improvement: providing personalized information, offering stigma-free emotional support, ensuring efficient time management, and promoting shared decision-making.</div></div><div><h3>Conclusions</h3><div>A comprehensive, multidisciplinary approach emerges as a key element to optimize care and enhance the experience of these women.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501746"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum miR-21 and miR-192 levels in type 2 diabetes: Association with albuminuria and renal function","authors":"Nosaiba M. Abd Alrahim ,&nbsp;Alshaymaa A. Abd Elalim ,&nbsp;Enas A. Farrag ,&nbsp;Shimaa M. Abdel-Kareem ,&nbsp;Sahar SaadEldeen Shaban ,&nbsp;Aya A. Eldamanhory ,&nbsp;Sammar Ahmed Kasim ,&nbsp;Radwa M. Fath Allah ,&nbsp;Fatma I. Mayah ,&nbsp;Aya A. Ghamry ,&nbsp;Sabah M. Alkhawagah ,&nbsp;Emad Gamil Khidr","doi":"10.1016/j.endinu.2025.501721","DOIUrl":"10.1016/j.endinu.2025.501721","url":null,"abstract":"<div><h3>Background and aims</h3><div>Albuminuria is a widely used clinical marker for diabetic nephropathy (DN); however, its limited sensitivity and specificity in detecting early renal alterations highlight the need for additional indicators. MicroRNAs (miRNAs) are emerging as molecular regulators involved in the pathogenesis of DN and may provide insight into early renal involvement in type 2 diabetes mellitus (T2DM). This study aimed to evaluate the serum expression levels of miR-21 and miR-192 in normo- and microalbuminuric patients with T2DM, and explore their associations with metabolic and renal parameters.</div></div><div><h3>Methods</h3><div>This case–control study included 104 individuals, including 60 patients with T2DM and 44 age- and sex-matched healthy controls. Individuals with diabetes were further classified into 30 normoalbuminuric and 30 microalbuminuric individuals based on the urinary albumin-to-creatinine ratio. Serum levels of miR-21 and miR-192 were quantified using real-time quantitative reverse transcription PCR.</div></div><div><h3>Results</h3><div>Both miR-21 and miR-192 were significantly upregulated in Patients with T2DM vs healthy controls. Notably, miR-21 expression exhibited a stepwise increase from normo- to microalbuminuria and showed strong correlations with metabolic and renal parameters, including HbA1c, ACR, and lipid profile. In ROC analysis, miR-21 demonstrated better discriminative ability between study groups vs miR-192.</div></div><div><h3>Conclusion</h3><div>Serum miR-21 may reflect early renal involvement in patients with T2DM. Its progressive increase with albuminuria and strong associations with clinical parameters suggest potential value as a supportive molecular indicator in the early evaluation of diabetic nephropathy. Further prospective studies are needed to validate its clinical applicability.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501721"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipodystrophies: A diagnostic and therapeutic challenge","authors":"David Araújo-Vilar,&nbsp;Antía Fernández-Pombo","doi":"10.1016/j.endinu.2026.501825","DOIUrl":"10.1016/j.endinu.2026.501825","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501825"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of carbohydrate assessment metrics for predicting fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus","authors":"Qianqian Tian ,&nbsp;Qing Jiang ,&nbsp;Shanshan Ma ,&nbsp;Fangyi Yu ,&nbsp;Xiaohan Tan ,&nbsp;Bin Liu ,&nbsp;Jifang Zhu ,&nbsp;Xiaohua Wang","doi":"10.1016/j.endinu.2025.501742","DOIUrl":"10.1016/j.endinu.2025.501742","url":null,"abstract":"<div><h3>Background</h3><div>Fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) are critical short-term indicators of glycemic control in type 2 diabetes mellitus (T2DM). Although carbohydrate assessment metrics – carbohydrate (g/d), carbohydrate portion, carbohydrate (%), low carbohydrate diet (LCD) score, carbohydrate to fiber ratio (CFR), and dietary fiber (DF) – may differ in predicting FPG and PPG, their comparative efficacy is unclear. This study aims to identify the most predictive carbohydrate assessment metrics for FPG and PPG, facilitating timely dietary interventions to optimize glycemic management in patients with T2DM.</div></div><div><h3>Methods</h3><div>This cross-sectional study assessed six carbohydrate metrics in 238 patients with T2DM. FPG and PPG were measured (uncontrolled: FPG ≥7.0<!--> <!-->mmol/L, PPG ≥10.0<!--> <!-->mmol/L). Multiple logistic regression and the receiver operating characteristic curve (ROC) analyses evaluated predictive performance.</div></div><div><h3>Results</h3><div>Carbohydrate (%) and LCD score were the strongest predictors of FPG and PPG. Higher carbohydrate (%) was significantly associated with poorer FPG (OR, 0.942, 95%CI, 0.907–0.979, <em>P</em> <!-->&lt;<!--> <!-->0.01) and PPG control (OR, 0.920, 95%CI, 0.875–0.968, <em>P</em> <!-->&lt;<!--> <!-->0.01), while higher LCD score improved odds of control (FPG: OR, 1.073; PPG: OR, 1.128, both <em>P</em> <!-->&lt;<!--> <!-->0.01). ROC analysis identified carbohydrate (%) as the optimal predictor for PPG (AUC, 0.7201, cutoff &gt;51.50%; sensitivity, 80.77%) and FPG (AUC, 0.6751, cutoff &gt;55.50%; sensitivity, 66.47%), followed by LCD score (PPG AUC, 0.7153; FPG AUC, 0.6689).</div></div><div><h3>Conclusion</h3><div>Carbohydrate (%) and LCD score most effectively predict short-term glycemic control in T2DM. Limiting carbohydrate intake to ≤51.5% (PPG) or ≤55.5% (FPG) of energy and achieving LCD scores &gt;23.5 (PPG) or &gt;16.5 may optimize outcomes, guiding personalized dietary interventions.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501742"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoglobin Yanase can lead to inaccurate diabetes diagnoses when using HbA1c measurement by HPLC","authors":"Pedro Moral Parras ,&nbsp;Alba Martínez Chamorro ,&nbsp;Luis Romero Reyes ,&nbsp;Paloma Ropero Gradilla ,&nbsp;Antonio Fernández Suárez","doi":"10.1016/j.endinu.2025.501716","DOIUrl":"10.1016/j.endinu.2025.501716","url":null,"abstract":"<div><div>Glycated hemoglobin (HbA1c) is essential for diagnosing and monitoring diabetes mellitus (DM). However, hemoglobin (Hb) variants can alter its measurement using high-performance liquid chromatography (HPLC), compromising the patients’ diagnosis and follow-up. The limited information in databases such as HbVar and IthaNet makes it difficult to interpret and classify these variants.</div><div>HbA1c levels in the patient group were uninterpretable when measured using ion-exchange HPLC (Tosoh G8), suggesting possible assay interference. By using alternative methods of immunoassay and capillary electrophoresis, normal HbA1c concentrations were obtained. Genetic testing in all patients confirmed the presence of a variant in the Hb α2 gene, Hb-Yanase.</div><div>Hb-Yanase is a poorly documented variant globally, which could be underestimated in Spain. Its phenotype and degree of pathogenicity are uncertain due to the small number reported and the existence of outdated databases. In the described group, no patient showed variant-related pathophysiological alterations.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501716"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypoglycemia in older adults with type 2 diabetes mellitus: Prevalence and associated risk factor: A systematic review and meta-analysis","authors":"Yuelin Wang ,&nbsp;Yunlan Jiang ,&nbsp;Le Li ,&nbsp;Hong Chen ,&nbsp;Jing Wang ,&nbsp;Mengjie Zhang ,&nbsp;Xiaoyu Bai ,&nbsp;Senlin Wu","doi":"10.1016/j.endinu.2025.501759","DOIUrl":"10.1016/j.endinu.2025.501759","url":null,"abstract":"<div><h3>Background</h3><div>Currently, hypoglycemia poses a critical challenge in managing older patients with type 2 diabetes mellitus (T2DM), threatening their long-term health and overall well-being. This meta-analysis is the first to comprehensively quantify the pooled prevalence of hypoglycemia and identify its key influencing factors specifically in the elderly population.</div></div><div><h3>Methods</h3><div>We conducted a systematic study across 11 databases to identify relevant observational studies reporting the prevalence of hypoglycemia or its influencing factors. The search was limited from database inception all the way until July 9th, 2025, and updated November 13th, 2025. In addition, we conducted a meta-analysis of the overall prevalence of hypoglycemia and its influencing factors using Stata 17.0 and RevMan 5.4, respectively.</div></div><div><h3>Results</h3><div>Among the 37 studies included, the overall prevalence of hypoglycemia in elderly patients with T2DM was 21% (95%CI, 20–23%). The results of this meta-analysis showed that age, diabetes duration, insulin treatment, hypertension, malignant tumors, renal impairment, cognitive dysfunction, and glycosylated hemoglobin were the key determinants influencing the risk of hypoglycemia in the elderly T2DM population.</div></div><div><h3>Conclusion</h3><div>Early clinical risk assessment is essential for older adults with type 2 diabetes mellitus at high risk of hypoglycemic complications, along with the implementation of evidence-based diagnostic and therapeutic protocols for hypoglycemia management.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501759"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entre el beneficio y el riesgo: el papel de los suplementos alimenticios en endocrinología","authors":"Cristina Tejera-Pérez","doi":"10.1016/j.endinu.2025.501711","DOIUrl":"10.1016/j.endinu.2025.501711","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 4","pages":"Article 501711"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myostatin in the pituitary–muscle axis: Roles in health and disease","authors":"Pedro Iglesias","doi":"10.1016/j.endinu.2025.501757","DOIUrl":"10.1016/j.endinu.2025.501757","url":null,"abstract":"<div><div>Myostatin (GDF-8), a TGF-β family myokine, regulates skeletal muscle growth and systemic metabolism and influences pituitary development and hormone secretion. This review summarizes experimental, translational, and clinical data linking myostatin to pituitary biology, including recent mouse evidence identifying muscle-derived myostatin as an endocrine driver of FSH synthesis via activin-type II/TGFBR1 signaling, with human confirmation pending. We analyze how pituitary disorders – growth hormone deficiency, acromegaly, hypercortisolism, central thyroid disease, central hypogonadism, and hypopituitarism – modify myostatin signaling, contributing to sarcopenia, anabolic resistance, and metabolic dysfunction. Across these conditions, human evidence remains limited and confounded by assay heterogeneity and comorbidities, as circulating myostatin often fails to mirror intramuscular changes. We propose an evidence framework emphasizing standardized assays (mature vs latent forms), longitudinal clinical cohorts, and integration of hormonal and functional endpoints. Myostatin remains a promising yet unvalidated biomarker and therapeutic target in endocrine-related muscle disease.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 4","pages":"Article 501757"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147631549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}