Endocrinologia, Diabetes y Nutricion最新文献

{"title":"Primary hepatic gastrinoma as a clinical mimic: Favorable clinical outcomes","authors":"David Sanchis-Pascual ,&nbsp;Luis de Miguel-Rodríguez ,&nbsp;Pilar Morillas-Amat ,&nbsp;Jorge Hernando ,&nbsp;Alejandro García-Álvarez ,&nbsp;Stefania Landolfi ,&nbsp;Fernando Guerrero-Pérez ,&nbsp;María Isabel Del Olmo-García ,&nbsp;Jaume Capdevila","doi":"10.1016/j.endinu.2026.501769","DOIUrl":"10.1016/j.endinu.2026.501769","url":null,"abstract":"<div><div>Gastrinomas are functional neuroendocrine tumors characterized by autonomous gastrin secretion, which leads to acid hypersecretion and chronic diarrhea. They are most widely located in the duodenum or pancreas, while primary hepatic gastrinomas are exceptionally rare. At diagnosis, most cases already present with liver metastases.</div><div>We present the case of a 19-year-old man with a 2-year history of chronic diarrhea and epigastric discomfort. Imaging revealed the presence of a 12<!--> <!-->cm hepatic mass without extrahepatic involvement. Functional PET/CT with ⁶⁸Ga-DOTATOC showed intense uptake confined to the liver. Lab test results included markedly elevated gastrin and chromogranin A levels. Core needle biopsy confirmed a well-differentiated NET G2 positive for gastrin. Treatment with long-acting somatostatin analogs led to rapid symptom improvement, and the patient was ultimately cured following surgical resection of the hepatic tumor. Although rare, primary hepatic gastrinomas should be considered in the differential diagnosis of functional NETs with isolated liver lesions.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501769"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148235917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"La endocrinología en el epicentro de la esteatosis hepática metabólica","authors":"Miguel Ángel Rubio-Herrera ,&nbsp;Javier Escalada San Martín","doi":"10.1016/j.endinu.2026.501847","DOIUrl":"10.1016/j.endinu.2026.501847","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501847"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148235912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of diabetes and its complications on nutritional assessment in disease-related malnutrition: A cross-sectional study","authors":"Jaime González-Gutiérrez ,&nbsp;Juan José López-Gómez ,&nbsp;Paloma Pérez-López ,&nbsp;Ángela Cebriá ,&nbsp;Olatz Izaola-Jáuregui ,&nbsp;Lucía Estévez-Asensio ,&nbsp;David Primo-Martín ,&nbsp;Eduardo Jorge Godoy ,&nbsp;Daniel A. De Luis-Román","doi":"10.1016/j.endinu.2025.501720","DOIUrl":"10.1016/j.endinu.2025.501720","url":null,"abstract":"<div><h3>Background/Objectives</h3><div>This study seeks to assess the influence of type 2 diabetes mellitus (T2DM) and its complications on the deterioration of muscle mass and function in patients with disease-related malnutrition (DRM).</div></div><div><h3>Methods</h3><div>We conducted a descriptive cross-sectional study in a sample of 206 patients (57.6% women) with DRM. Patients were compared based on the presence or absence of diabetes mellitus (DM). Differences were also observed based on the duration of DM and the presence of complications. Age, gender, body mass index (BMI), bioimpedanciometry (BIA) parameters, ultrasonography parameters and the diagnosis of dynapenia or sarcopenia were recorded.</div></div><div><h3>Results</h3><div>A total of 46 (22.33%) patients had DM, which was associated with higher values of skeletal muscle index (SMI) (DM, 7.73 (1.98)<!--> <!-->kg/m² vs NoDM, 6.75 (1.34)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01) in BIA analysis. Furthermore, it was associated with lower values of rectus femoris muscle thickness (RFMT) (DM, 0.85 (0.25) vs NoDM, 0.94 (0.29), <em>p</em> <!-->&lt;<!--> <!-->0.05). Long-standing DM was associated with lower values of SMI (DM<!--> <!-->&gt;10 years: 7.25 (1.46)<!--> <!-->kg/m² vs DM<!--> <!-->&lt;<!--> <!-->10 years: 8.18 (2.30)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01) and with complicated DM (complicated DM, 7.57 (2.40)<!--> <!-->kg/m² vs non-complicated DM, 7.90 (1.48)<!--> <!-->kg/m², <em>p</em> <!-->&lt;<!--> <!-->0.01). Moreover, these conditions were associated with lower values of RFMT (DM<!--> <!-->&gt;<!--> <!-->10 years: 0.76 (0.18)<!--> <!-->cm vs DM<!--> <!-->&lt;<!--> <!-->10 years: 0.93 (0.29) cm, <em>p</em> <!-->&lt;<!--> <!-->0.05; Complicated DM, 0.77 (0.17) cm vs Non-complicated DM, 0.94 (0.29)<!--> <!-->cm, <em>p</em> <!-->&lt;<!--> <!-->0.05). DM was a risk factor for the development for dynapenia (OR, 3.56, 95%CI, 1.52–8.29, <em>p</em> <!-->&lt;<!--> <!-->0.01) and sarcopenia (OR, 3.08, 95%CI, 1.35–7.02, <em>p</em> <!-->&lt;<!--> <!-->0.05) adjusted for age, gender, BMI and inflammatory status (determined by CRP). The presence of diabetic complications was a risk factor for dynapenia (OR, 2.08, 95%CI, 1.18–3.66; <em>p</em> <!-->=<!--> <!-->0.01) and sarcopenia (OR, 1.92, 95%CI, 1.12–3.28; <em>p</em> <!-->=<!--> <!-->0.02), after adjusting for gender, age, oncologic condition, BMI and CRP levels.</div></div><div><h3>Conclusions</h3><div>In patients with DRM, poorly controlled T2DM was associated with worse muscle quantity and quality in muscle ultrasound. Long-standing DM and complicated DM were risk factors of dynapenia and sarcopenia. For clinical practice, multidisciplinary management to prevent these events is essential.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501720"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148235918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time in range and its association with sudomotor dysfunction in individuals with type 1 diabetes mellitus","authors":"Ismael A. Quintal-Medina ,&nbsp;Rossy S. López-Prieto ,&nbsp;Karen A. Romero-Torres ,&nbsp;Ana Cristina Garcia Ulloa ,&nbsp;Francisco J. Gómez-Pérez ,&nbsp;Paloma Almeda-Valdes","doi":"10.1016/j.endinu.2025.501758","DOIUrl":"10.1016/j.endinu.2025.501758","url":null,"abstract":"<div><h3>Introduction</h3><div>Time in range (TIR), a novel metric to evaluate glycemic control, is relevant to predict microvascular complications of diabetes. Sudomotor dysfunction is among the earliest findings detectable in diabetic peripheral neuropathy (DPN). This study aimed to evaluate the relationship between TIR obtained from continuous glucose monitoring (CGM) and sudomotor function evaluated by SUDOSCAN in subjects with type 1 diabetes mellitus (T1DM).</div></div><div><h3>Materials and methods</h3><div>We enrolled 90 individuals with T1DM. All of them underwent SUDOSCAN and 14-day CGM. SUDOSCAN measured feet electrochemical skin conductance (FESC), and sudomotor dysfunction was defined as average FESC<!--> <!-->&lt;<!--> <!-->70<!--> <!-->μS. Logistic regressions were applied to examine the independent association between TIR and glycated hemoglobin (HbA1c) and sudomotor function.</div></div><div><h3>Results</h3><div>The overall prevalence of sudomotor dysfunction was 65.6%. Patients with sudomotor dysfunction showed a decreased level of TIR (53.3<!--> <!-->±<!--> <!-->17.4% vs 64.4<!--> <!-->±<!--> <!-->12.7%, <em>P</em> <!-->&lt;<!--> <!-->.05). No significant differences in HbA1c were observed between the groups with and without sudomotor dysfunction (median 8.1% [65<!--> <!-->mmol/mol] vs 7.6% [60<!--> <!-->mmol/mol]; <em>P</em> <!-->=<!--> <!-->.094). Correlation analysis showed that the relationship between TIR and FESC was stronger than between HbA1c and FESC. Finally, logistic regression revealed that TIR was inversely associated with the risk of sudomotor dysfunction detected by SUDOSCAN (<em>P</em> <!-->&lt;<!--> <!-->.05).</div></div><div><h3>Conclusions</h3><div>TIR is a glycemic control target inversely associated with sudomotor dysfunction assessed by SUDOSCAN in T1DM regardless of HbA1c.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501758"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148235790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Debut de diabetes tipo 1 en niños y adolescentes: análisis clínico y temporal en un hospital terciario","authors":"Alicia Pérez Pérez,&nbsp;Rebeca García García,&nbsp;Oihane Salcedo Fresneda,&nbsp;Aroa Alonso Alonso,&nbsp;Ana Cristina Rodríguez Dehli,&nbsp;Isolina Riaño Galán","doi":"10.1016/j.endinu.2026.501771","DOIUrl":"10.1016/j.endinu.2026.501771","url":null,"abstract":"<div><h3>Background</h3><div>Diabetic ketoacidosis (DKA) is the leading cause of morbidity and mortality in pediatric patients with type 1 diabetes mellitus (T1DM). The objectives of this study were to analyze the incidence of DKA at the time of T1DM diagnosis and to evaluate changes in its presentation over recent years. We also assessed whether a family history of T1DM or specific HLA haplotypes influenced the incidence of DKA at diagnosis.</div></div><div><h3>Materials and methods</h3><div>We conducted a descriptive, observational, and retrospective study of all patients younger than 14 years diagnosed with T1DM at a tertiary referral center from from 2017 through 2024. Data collected included age at onset, sex, date of diagnosis, and initial laboratory values. Data were, then, grouped into 2 periods of time (2017-2020; 2020-2024) for comparison purposes.</div></div><div><h3>Results</h3><div>A total of 85 patients were included (41 women), with a mean age at diagnosis of 7.9 years. DKA at disease onset was observed in 29 patients (34.1%), including 15 cases (17.6%) classified as severe. Mean C-peptide level was 0.8 ng/mL, mean plasma glucose level was 423<!--> <!-->mg/dL, and mean hemoglobin A1c level was 11.1%.</div><div>Between 2017 and 2020, 37 new diagnoses were established, 37.8% with DKA (13.5% severe) and from 2021 to 2024, 48, 31.2% with DKA (20.8% severe).</div><div>A total of 12 patients had first-degree relatives with T1DM, and 0 exhibited DKA (p &lt; 0.05). No significant associations were found between HLA haplotypes and the incidence rate of DKA.</div></div><div><h3>Conclusions</h3><div>The prevalence of DKA at diagnosis was similar to that reported in other Spanish studies. Having a family history of T1DM seems to be a protective factor against the development of DKA. No significant association was found between HLA haplotypes and DKA prevalence.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501771"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148236079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ectopic ACTH-producing pheochromocytoma in a patient with an APC gene mutation: A case report","authors":"Sara Gil dos Santos ,&nbsp;Raquel Calheiros ,&nbsp;Daniela Salazar ,&nbsp;Joana Oliveira ,&nbsp;Manuel Fernandes ,&nbsp;Ana Luísa Cunha ,&nbsp;Catarina Santos ,&nbsp;Sofia Conde ,&nbsp;António Verdelho ,&nbsp;Ana Paula Santos","doi":"10.1016/j.endinu.2025.501741","DOIUrl":"10.1016/j.endinu.2025.501741","url":null,"abstract":"<div><div>ACTH-producing pheochromocytomas are rare. Familial adenomatous polyposis (FAP), caused by mutations in the <em>Adenomatous Polyposis Coli</em> (<em>APC</em>) gene, increases the risk of colorectal neoplasia, as well as adrenal lesions. This is the case of a 21-year-old male presenting with a 10<!--> <!-->cm right adrenal mass and rapidly progressive Cushing's syndrome (CS). Biochemical workup confirmed ACTH-dependent CS and catecholamine excess and a ⁶⁸Ga-DOTA-NOC PET/CT showed SSR expression limited to the adrenal mass. Methyrapone and alpha/beta blockade were initiated, followed by right adrenalectomy. Histopathology confirmed an ACTH-secreting pheochromocytoma (pheochromocytoma of the adrenal gland scaled score – PASS: 16; grading system for adrenal pheochromocytoma and paraganglioma – GAPP: 8). A truncating germline mutation in the APC gene (c.6189_6190del) was detected, associated with attenuated FAP. This is, to our knowledge, the first case ever reported of an ACTH-producing pheochromocytoma in a patient with an APC gene mutation. This case raises the possibility of a broader phenotypic spectrum in FAP and highlights the importance of vigilance for unusual tumor presentations in hereditary cancer syndromes.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501741"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148236054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between low free T4 values and prevalence of tinnitus in US adults: 2009–2012","authors":"Weiyu Zhang,&nbsp;Yongtao Xiao","doi":"10.1016/j.endinu.2025.501726","DOIUrl":"10.1016/j.endinu.2025.501726","url":null,"abstract":"<div><h3>Purpose</h3><div>Tinnitus is a prevalent subjective auditory sensation affecting over 740 million people worldwide and often co-occurs with various systemic diseases. To date, the relationship between tinnitus and thyroid hormones has not been thoroughly studied. This study aimed to investigate the association between tinnitus and thyroid hormone levels in US adults.</div></div><div><h3>Methods</h3><div>We used data from the 2009–2012 National Health and Nutrition Examination Survey (NHANES). A total of 1527 participants were included and stratified by the presence or absence of tinnitus. Logistic regression analysis was performed to assess the association between thyroid hormone levels and tinnitus. Furthermore, subgroup analyses were performed to explore the relationship between FT4 levels and tinnitus in different subgroups.</div></div><div><h3>Results</h3><div>Each 1<!--> <!-->ng/dL increase in FT4 was associated with approximately 67% lower odds of tinnitus (adjusted OR, 0.33; 95%CI, 0.11–0.94, <em>p</em> <!-->=<!--> <!-->0.0387). FT3 and TSH showed no significant association with tinnitus after adjustment.</div></div><div><h3>Conclusion</h3><div>Lower FT4 levels were independently associated with higher tinnitus prevalence.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 6","pages":"Article 501726"},"PeriodicalIF":0.0,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148236078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between ambient air pollution exposure and pubertal development: An ecological study","authors":"Diego Rivas-Otero ,&nbsp;Tomás González-Vidal ,&nbsp;Cristina Rodríguez-Dehli ,&nbsp;Alicia Pérez-Pérez ,&nbsp;Pablo Agüeria-Cabal ,&nbsp;Aroa Alonso-Alonso ,&nbsp;Miguel García-Villarino ,&nbsp;Elías Delgado-Álvarez ,&nbsp;Edelmiro Menéndez-Torre ,&nbsp;Isolina Riaño-Galán","doi":"10.1016/j.endinu.2025.501740","DOIUrl":"10.1016/j.endinu.2025.501740","url":null,"abstract":"<div><h3>Background</h3><div>The incidence rate of precocious puberty (PP) is rising, and ambient air pollutants may influence pubertal timing. This study explores the association between air pollution and PP and normal variants of puberty (NVP) in a Spanish pediatric population.</div></div><div><h3>Methods</h3><div>We conducted a retrospective ecological study in Asturias, Spain. Children ≤9 years diagnosed with PP or NVP between 2021 and 2024 were included. Data on pollutants (PM₁₀, PM_2.5, SO₂, NO₂, CO, O₃, NO, NO_<em>x</em>) from the 2 years prior to diagnosis were obtained from the nearest monitoring stations. The region was divided into 12 zones, yielding 48 zone-years across the 4-year study period. Incidence rates and mean pollutant levels were calculated for each zone. Each zone-year was classified as having high or low exposure according to the median pollutant concentration.</div></div><div><h3>Results</h3><div>A total of 96 children were diagnosed with central PP (<em>n</em> <!-->=<!--> <!-->53), peripheral PP (<em>n</em> <!-->=<!--> <!-->3) or NVP (<em>n</em> <!-->=<!--> <!-->40). Overall PP incidence (either central or peripheral PP) was positively correlated with CO (rho<!--> <!-->=<!--> <!-->0.479, <em>p</em> <!-->=<!--> <!-->0.024) and NO_<em>x</em> (rho<!--> <!-->=<!--> <!-->0.391, <em>p</em> <!-->=<!--> <!-->0.033) concentrations. We found no statistically significant associations between the incidence of central PP and any air pollutant. However, there was a trend toward a positive correlation between central PP incidence and CO exposure (rho<!--> <!-->=<!--> <!-->0.389; <em>p</em> <!-->=<!--> <!-->0.074). In addition, central PP incidence was higher in high-exposure areas for all pollutants, although these differences were not statistically significant (<em>p</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>The findings of our study suggest a possible environmental influence on PP that needs to be explored in larger, longitudinal studies.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501740"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dentition and chronic noncommunicable diseases among adults in Brazil","authors":"Galileu Bottermund Galli ,&nbsp;Milene Rossi ,&nbsp;Pedro Bohlke Barcellos ,&nbsp;Luísa Casarin Rickes ,&nbsp;Jivago da Fonseca Lopes ,&nbsp;Eduardo Ribes Kohn ,&nbsp;Maristela Bohlke","doi":"10.1016/j.endinu.2026.501770","DOIUrl":"10.1016/j.endinu.2026.501770","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the association between functional dentition and a prior diagnosis of diabetes mellitus (DM) and/or chronic kidney disease (CKD) in a nationally representative sample of the Brazilian population.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis using data from the 2019 Brazilian National Health Survey (PNS). The PNS is representative of the Brazilian population. The associations between self-reported diagnoses of DM and/or CKD and the absence of functional dentition were assessed using multilevel logistic regression models, adjusted for sociodemographic and behavioral variables, such as age, sex, skin color, income, education, and smoking status.</div></div><div><h3>Results</h3><div>Functional dentition was absent in 9.3% of the sample (95%CI, 8.9–9.7). Additionally, 8.8% (95%CI, 8.5–9.0) reported a previous diagnosis of DM, and 1.4% (95%CI, 1.3–1.5) a prior diagnosis of CKD. The proportion of individuals with both CKD and DM was 0.29% (95%CI, 0.27–0.32). In adjusted models, DM was significantly associated with the absence of functional dentition (OR, 1.16; 95%CI, 1.07; 1.23, <em>p</em> <!-->&lt;<!--> <!-->0.001). No significant association was observed for CKD (OR, 1.06; 95%CI, 0.89; 1.26, <em>p</em> <!-->=<!--> <!-->0.48) or for individuals with both DM and CKD (OR, 1.08; 95%CI, 0.74; 1.57, <em>p</em> <!-->=<!--> <!-->0.66).</div></div><div><h3>Conclusion</h3><div>Diabetes is associated with a higher risk of functional dentition loss in the Brazilian population. Promoting collaboration between dental and medical professionals is essential to improve the prevention and management of tooth loss, particularly among individuals with diabetes, ultimately contributing to better overall health outcomes.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501770"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico y tratamiento de tumores fibrosos solitarios en la glándula tiroides. Importancia de una prueba diagnóstica adecuada","authors":"Maria Teresa Soriano Palao ,&nbsp;Miriam Abellán Lucas ,&nbsp;Juan José Ruiz Manzanera ,&nbsp;Álvaro Cerezuela Fernández de Palencia ,&nbsp;Beatriz Febrero Sánchez ,&nbsp;José Manuel Rodríguez González","doi":"10.1016/j.endinu.2025.501744","DOIUrl":"10.1016/j.endinu.2025.501744","url":null,"abstract":"<div><div>Solitary fibrous tumor (SFT) is a type of fibroblastic neoplasm with characteristic histological features, typically showing cytoplasmic expression of CD34 and nuclear expression of STAT6, associated with NAB2-STAT6 gene fusion. Thyroid localization is exceptionally rare, with only 51 cases reported worldwide to date. Its behavior in the thyroid is generally benign, although it may exhibit rapid growth, and its treatment is primarily surgical. The NAB2-STAT6 gene fusion, detected by immunohistochemistry, is pathognomonic for SFT. As exemplified in the present case, core needle biopsy (CNB) is more likely to provide sufficient material for microscopic, immunohistochemical, and other diagnostic techniques.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501744"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}