Diagnóstico y tratamiento de tumores fibrosos solitarios en la glándula tiroides. Importancia de una prueba diagnóstica adecuada

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion Pub Date : 2026-05-01 Epub Date: 2025-12-30 DOI:10.1016/j.endinu.2025.501744

Maria Teresa Soriano Palao , Miriam Abellán Lucas , Juan José Ruiz Manzanera , Álvaro Cerezuela Fernández de Palencia , Beatriz Febrero Sánchez , José Manuel Rodríguez González

引用次数: 0

Abstract

Solitary fibrous tumor (SFT) is a type of fibroblastic neoplasm with characteristic histological features, typically showing cytoplasmic expression of CD34 and nuclear expression of STAT6, associated with NAB2-STAT6 gene fusion. Thyroid localization is exceptionally rare, with only 51 cases reported worldwide to date. Its behavior in the thyroid is generally benign, although it may exhibit rapid growth, and its treatment is primarily surgical. The NAB2-STAT6 gene fusion, detected by immunohistochemistry, is pathognomonic for SFT. As exemplified in the present case, core needle biopsy (CNB) is more likely to provide sufficient material for microscopic, immunohistochemical, and other diagnostic techniques.

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甲状腺孤立性纤维肿瘤的诊断和治疗。适当诊断测试的重要性

孤立性纤维性肿瘤（SFT）是一种具有特征性组织学特征的纤维母细胞肿瘤，典型表现为细胞质表达CD34和细胞核表达STAT6，与NAB2-STAT6基因融合有关。甲状腺定位异常罕见，迄今为止全球仅报道了51例。它在甲状腺中的表现通常是良性的，尽管它可能表现出快速的生长，它的治疗主要是手术。免疫组织化学检测NAB2-STAT6基因融合是SFT的病理特征。如本病例所示，穿刺活检（CNB）更有可能为显微镜、免疫组织化学和其他诊断技术提供足够的材料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrinologia, Diabetes y Nutricion Nursing-Nutrition and Dietetics

CiteScore

2.10

自引率

0.00%

发文量

169

审稿时长

35 days

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.