Endocrinologia, Diabetes y Nutricion最新文献

{"title":"Association between ambient air pollution exposure and pubertal development: An ecological study","authors":"Diego Rivas-Otero ,&nbsp;Tomás González-Vidal ,&nbsp;Cristina Rodríguez-Dehli ,&nbsp;Alicia Pérez-Pérez ,&nbsp;Pablo Agüeria-Cabal ,&nbsp;Aroa Alonso-Alonso ,&nbsp;Miguel García-Villarino ,&nbsp;Elías Delgado-Álvarez ,&nbsp;Edelmiro Menéndez-Torre ,&nbsp;Isolina Riaño-Galán","doi":"10.1016/j.endinu.2025.501740","DOIUrl":"10.1016/j.endinu.2025.501740","url":null,"abstract":"<div><h3>Background</h3><div>The incidence rate of precocious puberty (PP) is rising, and ambient air pollutants may influence pubertal timing. This study explores the association between air pollution and PP and normal variants of puberty (NVP) in a Spanish pediatric population.</div></div><div><h3>Methods</h3><div>We conducted a retrospective ecological study in Asturias, Spain. Children ≤9 years diagnosed with PP or NVP between 2021 and 2024 were included. Data on pollutants (PM₁₀, PM_2.5, SO₂, NO₂, CO, O₃, NO, NO_<em>x</em>) from the 2 years prior to diagnosis were obtained from the nearest monitoring stations. The region was divided into 12 zones, yielding 48 zone-years across the 4-year study period. Incidence rates and mean pollutant levels were calculated for each zone. Each zone-year was classified as having high or low exposure according to the median pollutant concentration.</div></div><div><h3>Results</h3><div>A total of 96 children were diagnosed with central PP (<em>n</em> <!-->=<!--> <!-->53), peripheral PP (<em>n</em> <!-->=<!--> <!-->3) or NVP (<em>n</em> <!-->=<!--> <!-->40). Overall PP incidence (either central or peripheral PP) was positively correlated with CO (rho<!--> <!-->=<!--> <!-->0.479, <em>p</em> <!-->=<!--> <!-->0.024) and NO_<em>x</em> (rho<!--> <!-->=<!--> <!-->0.391, <em>p</em> <!-->=<!--> <!-->0.033) concentrations. We found no statistically significant associations between the incidence of central PP and any air pollutant. However, there was a trend toward a positive correlation between central PP incidence and CO exposure (rho<!--> <!-->=<!--> <!-->0.389; <em>p</em> <!-->=<!--> <!-->0.074). In addition, central PP incidence was higher in high-exposure areas for all pollutants, although these differences were not statistically significant (<em>p</em> <!-->&gt;<!--> <!-->0.05).</div></div><div><h3>Conclusions</h3><div>The findings of our study suggest a possible environmental influence on PP that needs to be explored in larger, longitudinal studies.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501740"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional dentition and chronic noncommunicable diseases among adults in Brazil","authors":"Galileu Bottermund Galli ,&nbsp;Milene Rossi ,&nbsp;Pedro Bohlke Barcellos ,&nbsp;Luísa Casarin Rickes ,&nbsp;Jivago da Fonseca Lopes ,&nbsp;Eduardo Ribes Kohn ,&nbsp;Maristela Bohlke","doi":"10.1016/j.endinu.2026.501770","DOIUrl":"10.1016/j.endinu.2026.501770","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the association between functional dentition and a prior diagnosis of diabetes mellitus (DM) and/or chronic kidney disease (CKD) in a nationally representative sample of the Brazilian population.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional analysis using data from the 2019 Brazilian National Health Survey (PNS). The PNS is representative of the Brazilian population. The associations between self-reported diagnoses of DM and/or CKD and the absence of functional dentition were assessed using multilevel logistic regression models, adjusted for sociodemographic and behavioral variables, such as age, sex, skin color, income, education, and smoking status.</div></div><div><h3>Results</h3><div>Functional dentition was absent in 9.3% of the sample (95%CI, 8.9–9.7). Additionally, 8.8% (95%CI, 8.5–9.0) reported a previous diagnosis of DM, and 1.4% (95%CI, 1.3–1.5) a prior diagnosis of CKD. The proportion of individuals with both CKD and DM was 0.29% (95%CI, 0.27–0.32). In adjusted models, DM was significantly associated with the absence of functional dentition (OR, 1.16; 95%CI, 1.07; 1.23, <em>p</em> <!-->&lt;<!--> <!-->0.001). No significant association was observed for CKD (OR, 1.06; 95%CI, 0.89; 1.26, <em>p</em> <!-->=<!--> <!-->0.48) or for individuals with both DM and CKD (OR, 1.08; 95%CI, 0.74; 1.57, <em>p</em> <!-->=<!--> <!-->0.66).</div></div><div><h3>Conclusion</h3><div>Diabetes is associated with a higher risk of functional dentition loss in the Brazilian population. Promoting collaboration between dental and medical professionals is essential to improve the prevention and management of tooth loss, particularly among individuals with diabetes, ultimately contributing to better overall health outcomes.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501770"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico y tratamiento de tumores fibrosos solitarios en la glándula tiroides. Importancia de una prueba diagnóstica adecuada","authors":"Maria Teresa Soriano Palao ,&nbsp;Miriam Abellán Lucas ,&nbsp;Juan José Ruiz Manzanera ,&nbsp;Álvaro Cerezuela Fernández de Palencia ,&nbsp;Beatriz Febrero Sánchez ,&nbsp;José Manuel Rodríguez González","doi":"10.1016/j.endinu.2025.501744","DOIUrl":"10.1016/j.endinu.2025.501744","url":null,"abstract":"<div><div>Solitary fibrous tumor (SFT) is a type of fibroblastic neoplasm with characteristic histological features, typically showing cytoplasmic expression of CD34 and nuclear expression of STAT6, associated with NAB2-STAT6 gene fusion. Thyroid localization is exceptionally rare, with only 51 cases reported worldwide to date. Its behavior in the thyroid is generally benign, although it may exhibit rapid growth, and its treatment is primarily surgical. The NAB2-STAT6 gene fusion, detected by immunohistochemistry, is pathognomonic for SFT. As exemplified in the present case, core needle biopsy (CNB) is more likely to provide sufficient material for microscopic, immunohistochemical, and other diagnostic techniques.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501744"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Panhypopituitarism and hypothalamic obesity in pediatric patients due to Langerhans cell histiocytosis: An aggressive and rare condition","authors":"Ignacio Jiménez Hernando,&nbsp;Marta Pérez Noguero,&nbsp;Mónica Gómez-Gordo Hernanz,&nbsp;Rogelio García Centeno","doi":"10.1016/j.endinu.2025.501725","DOIUrl":"10.1016/j.endinu.2025.501725","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501725"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"El eco de una pregunta, 10 años después: carta para Amanda y Jesús","authors":"Camila Milad ,&nbsp;Alex Mesa","doi":"10.1016/j.endinu.2026.501772","DOIUrl":"10.1016/j.endinu.2026.501772","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501772"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Entendiendo la experiencia de las mujeres que viven con obesidad y patología reproductiva","authors":"Alba Andreu ,&nbsp;Jessica Farré ,&nbsp;Eva Palou ,&nbsp;Gemma Casals ,&nbsp;Olga Rubio ,&nbsp;Violeta Moizé ,&nbsp;Dolors Manau ,&nbsp;Lilliam Flores ,&nbsp;Eva Antúnez ,&nbsp;Miriam Redondo ,&nbsp;Josep Vidal ,&nbsp;Joan Escarrabill","doi":"10.1016/j.endinu.2025.501746","DOIUrl":"10.1016/j.endinu.2025.501746","url":null,"abstract":"<div><h3>Introduction</h3><div>Obesity in women of reproductive age is a significant risk factor for infertility. Current treatment strategies primarily focus on weight reduction through lifestyle modifications, pharmacological interventions, or surgical procedures. However, there is still a lack of consensus on the most effective approach. Moreover, such interventions have limited effectiveness in maintaining weight loss and optimizing assisted reproduction results following assisted reproductive techniques, which may lead to stigmatization and negative experiences for patients.</div><div>Although qualitative evidence regarding preconception and gestational stages has increased, literature specifically addressing women who simultaneously present obesity and infertility, as well as the impact of these conditions on their physical and emotional well-being, remains limited.</div></div><div><h3>Aim</h3><div>To explore the care trajectory of women with obesity and infertility.</div></div><div><h3>Methods</h3><div>We designed a mixed-methods study involving 10 healthcare professionals, a focus group and a co-creation workshop with 6 and 8 patients respectively, and an online survey was administered and completed by 33 out of a total of 150 women with obesity and reproductive pathology who were invited to participate (response rate 22%).</div></div><div><h3>Results</h3><div>While some aspects of preconception care were positively evaluated, the overall patient journey is complex. We identified four areas for improvement: providing personalized information, offering stigma-free emotional support, ensuring efficient time management, and promoting shared decision-making.</div></div><div><h3>Conclusions</h3><div>A comprehensive, multidisciplinary approach emerges as a key element to optimize care and enhance the experience of these women.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501746"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Serum miR-21 and miR-192 levels in type 2 diabetes: Association with albuminuria and renal function","authors":"Nosaiba M. Abd Alrahim ,&nbsp;Alshaymaa A. Abd Elalim ,&nbsp;Enas A. Farrag ,&nbsp;Shimaa M. Abdel-Kareem ,&nbsp;Sahar SaadEldeen Shaban ,&nbsp;Aya A. Eldamanhory ,&nbsp;Sammar Ahmed Kasim ,&nbsp;Radwa M. Fath Allah ,&nbsp;Fatma I. Mayah ,&nbsp;Aya A. Ghamry ,&nbsp;Sabah M. Alkhawagah ,&nbsp;Emad Gamil Khidr","doi":"10.1016/j.endinu.2025.501721","DOIUrl":"10.1016/j.endinu.2025.501721","url":null,"abstract":"<div><h3>Background and aims</h3><div>Albuminuria is a widely used clinical marker for diabetic nephropathy (DN); however, its limited sensitivity and specificity in detecting early renal alterations highlight the need for additional indicators. MicroRNAs (miRNAs) are emerging as molecular regulators involved in the pathogenesis of DN and may provide insight into early renal involvement in type 2 diabetes mellitus (T2DM). This study aimed to evaluate the serum expression levels of miR-21 and miR-192 in normo- and microalbuminuric patients with T2DM, and explore their associations with metabolic and renal parameters.</div></div><div><h3>Methods</h3><div>This case–control study included 104 individuals, including 60 patients with T2DM and 44 age- and sex-matched healthy controls. Individuals with diabetes were further classified into 30 normoalbuminuric and 30 microalbuminuric individuals based on the urinary albumin-to-creatinine ratio. Serum levels of miR-21 and miR-192 were quantified using real-time quantitative reverse transcription PCR.</div></div><div><h3>Results</h3><div>Both miR-21 and miR-192 were significantly upregulated in Patients with T2DM vs healthy controls. Notably, miR-21 expression exhibited a stepwise increase from normo- to microalbuminuria and showed strong correlations with metabolic and renal parameters, including HbA1c, ACR, and lipid profile. In ROC analysis, miR-21 demonstrated better discriminative ability between study groups vs miR-192.</div></div><div><h3>Conclusion</h3><div>Serum miR-21 may reflect early renal involvement in patients with T2DM. Its progressive increase with albuminuria and strong associations with clinical parameters suggest potential value as a supportive molecular indicator in the early evaluation of diabetic nephropathy. Further prospective studies are needed to validate its clinical applicability.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501721"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lipodystrophies: A diagnostic and therapeutic challenge","authors":"David Araújo-Vilar,&nbsp;Antía Fernández-Pombo","doi":"10.1016/j.endinu.2026.501825","DOIUrl":"10.1016/j.endinu.2026.501825","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501825"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of carbohydrate assessment metrics for predicting fasting and postprandial plasma glucose in patients with type 2 diabetes mellitus","authors":"Qianqian Tian ,&nbsp;Qing Jiang ,&nbsp;Shanshan Ma ,&nbsp;Fangyi Yu ,&nbsp;Xiaohan Tan ,&nbsp;Bin Liu ,&nbsp;Jifang Zhu ,&nbsp;Xiaohua Wang","doi":"10.1016/j.endinu.2025.501742","DOIUrl":"10.1016/j.endinu.2025.501742","url":null,"abstract":"<div><h3>Background</h3><div>Fasting plasma glucose (FPG) and postprandial plasma glucose (PPG) are critical short-term indicators of glycemic control in type 2 diabetes mellitus (T2DM). Although carbohydrate assessment metrics – carbohydrate (g/d), carbohydrate portion, carbohydrate (%), low carbohydrate diet (LCD) score, carbohydrate to fiber ratio (CFR), and dietary fiber (DF) – may differ in predicting FPG and PPG, their comparative efficacy is unclear. This study aims to identify the most predictive carbohydrate assessment metrics for FPG and PPG, facilitating timely dietary interventions to optimize glycemic management in patients with T2DM.</div></div><div><h3>Methods</h3><div>This cross-sectional study assessed six carbohydrate metrics in 238 patients with T2DM. FPG and PPG were measured (uncontrolled: FPG ≥7.0<!--> <!-->mmol/L, PPG ≥10.0<!--> <!-->mmol/L). Multiple logistic regression and the receiver operating characteristic curve (ROC) analyses evaluated predictive performance.</div></div><div><h3>Results</h3><div>Carbohydrate (%) and LCD score were the strongest predictors of FPG and PPG. Higher carbohydrate (%) was significantly associated with poorer FPG (OR, 0.942, 95%CI, 0.907–0.979, <em>P</em> <!-->&lt;<!--> <!-->0.01) and PPG control (OR, 0.920, 95%CI, 0.875–0.968, <em>P</em> <!-->&lt;<!--> <!-->0.01), while higher LCD score improved odds of control (FPG: OR, 1.073; PPG: OR, 1.128, both <em>P</em> <!-->&lt;<!--> <!-->0.01). ROC analysis identified carbohydrate (%) as the optimal predictor for PPG (AUC, 0.7201, cutoff &gt;51.50%; sensitivity, 80.77%) and FPG (AUC, 0.6751, cutoff &gt;55.50%; sensitivity, 66.47%), followed by LCD score (PPG AUC, 0.7153; FPG AUC, 0.6689).</div></div><div><h3>Conclusion</h3><div>Carbohydrate (%) and LCD score most effectively predict short-term glycemic control in T2DM. Limiting carbohydrate intake to ≤51.5% (PPG) or ≤55.5% (FPG) of energy and achieving LCD scores &gt;23.5 (PPG) or &gt;16.5 may optimize outcomes, guiding personalized dietary interventions.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501742"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemoglobin Yanase can lead to inaccurate diabetes diagnoses when using HbA1c measurement by HPLC","authors":"Pedro Moral Parras ,&nbsp;Alba Martínez Chamorro ,&nbsp;Luis Romero Reyes ,&nbsp;Paloma Ropero Gradilla ,&nbsp;Antonio Fernández Suárez","doi":"10.1016/j.endinu.2025.501716","DOIUrl":"10.1016/j.endinu.2025.501716","url":null,"abstract":"<div><div>Glycated hemoglobin (HbA1c) is essential for diagnosing and monitoring diabetes mellitus (DM). However, hemoglobin (Hb) variants can alter its measurement using high-performance liquid chromatography (HPLC), compromising the patients’ diagnosis and follow-up. The limited information in databases such as HbVar and IthaNet makes it difficult to interpret and classify these variants.</div><div>HbA1c levels in the patient group were uninterpretable when measured using ion-exchange HPLC (Tosoh G8), suggesting possible assay interference. By using alternative methods of immunoassay and capillary electrophoresis, normal HbA1c concentrations were obtained. Genetic testing in all patients confirmed the presence of a variant in the Hb α2 gene, Hb-Yanase.</div><div>Hb-Yanase is a poorly documented variant globally, which could be underestimated in Spain. Its phenotype and degree of pathogenicity are uncertain due to the small number reported and the existence of outdated databases. In the described group, no patient showed variant-related pathophysiological alterations.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 5","pages":"Article 501716"},"PeriodicalIF":0.0,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147756450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}