{"title":"Mujeres trans y cis en el deporte: citius, altius, fortius, sed aequitas","authors":"Óscar Moreno-Perez , Inés Modrego-Pardo","doi":"10.1016/j.endinu.2025.501547","DOIUrl":"10.1016/j.endinu.2025.501547","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 4","pages":"Article 501547"},"PeriodicalIF":0.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Antonio Bustos-Merlo, Carlos Javier García Calvente, Antonio Rosales-Castillo
{"title":"Addendum a «La importancia de la técnica MLPA en el diagnóstico de la neoplasia endocrina múltiple tipo 1», Endocrinología, Diabetes y Nutrición 71 (2024) 221-225","authors":"Antonio Bustos-Merlo, Carlos Javier García Calvente, Antonio Rosales-Castillo","doi":"10.1016/j.endinu.2025.01.001","DOIUrl":"10.1016/j.endinu.2025.01.001","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101540"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Atypical development of hypopituitarism due to septic embolism: A case report","authors":"Jordi Tortosa-Carreres , Lorena Hernández-Rienda , Susana Tenés-Rodrigo , Amparo Alba-Redondo , María Luisa Martínez-Triguero","doi":"10.1016/j.endinu.2024.09.005","DOIUrl":"10.1016/j.endinu.2024.09.005","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101529"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Luis Francisco de Miguel Rodríguez , Julieta Romina Arbat , Katherine García Malpartida , Pablo Fernández Collazo , Carlos Morillas Ariño
{"title":"Tumor fibroso solitario en la glándula tiroides como hallazgo incidental","authors":"Luis Francisco de Miguel Rodríguez , Julieta Romina Arbat , Katherine García Malpartida , Pablo Fernández Collazo , Carlos Morillas Ariño","doi":"10.1016/j.endinu.2024.09.002","DOIUrl":"10.1016/j.endinu.2024.09.002","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101524"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143520409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ricard Onieva Carbajo , Joan Carles Ferreres Piñas , Flavia Alberto , Ismael Capel Flores , Martina Pérez , María Rosa Bella Cueto
{"title":"Estudio de la altura de las células en el subtipo de célula alta del carcinoma papilar de tiroides. ¿Es un factor clave en el pronóstico?","authors":"Ricard Onieva Carbajo , Joan Carles Ferreres Piñas , Flavia Alberto , Ismael Capel Flores , Martina Pérez , María Rosa Bella Cueto","doi":"10.1016/j.endinu.2024.09.006","DOIUrl":"10.1016/j.endinu.2024.09.006","url":null,"abstract":"<div><h3>Introduction</h3><div>The tall cell subtype of papillary thyroid carcinoma (PTC) is considered to have poor prognosis, but its diagnostic criteria have been modified on several occasions. The aim of our study was to find the best diagnostic criteria to relate the tall cell subtype with aggressiveness and poor prognosis.</div></div><div><h3>Material and methods</h3><div>In 171 cases of classic subtype and tall cell subtype of PTC, the percentage of cells between two and three times taller than wide (C2-3) and cells more than three times taller than wide (Cx3) was determined by two observers, after obtaining reference images. Groups were made based on the percentage of cells of each component (<2%, between 2 and 10%, between 11 and 30%, between 31 and 50% and ><!--> <!-->50%) and were correlated with clinical and histopathological data. Interobserver agreement was also assessed.</div></div><div><h3>Results</h3><div>According to the current WHO classification criteria, only 8 cases (5%) of tall cell subtype were identified. The comparison of the risk of recurrence at 5 years based on the percentage and type of cells showed that it increased significantly from ><!--> <!-->10% of the Cx3 cell component, while there were no significant differences in recurrence rate with any C2-3 cell percentages. Very good interobserver agreement was obtained (Kappa index: 0.83).</div></div><div><h3>Conclusions</h3><div>We consider relevant reporting the presence of Cx3 cells from 10% in PTC as it is associated with a significant increase in the recurrence rate at 5 years. Interobserver agreement is very good if reference images are available.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101530"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519772","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Esther Delgado-García , Juan José López-Gómez , Rebeca Jiménez-Sahagún , Emilia Gómez-Hoyos , Ana Ortolá-Buigues , Paloma Pérez-López , Beatriz Torres-Torres , Daniel A. De Luis-Román
{"title":"Hyperglycemia-related risk factors in enteral nutrition in non-critically ill patients","authors":"Esther Delgado-García , Juan José López-Gómez , Rebeca Jiménez-Sahagún , Emilia Gómez-Hoyos , Ana Ortolá-Buigues , Paloma Pérez-López , Beatriz Torres-Torres , Daniel A. De Luis-Román","doi":"10.1016/j.endinu.2024.09.008","DOIUrl":"10.1016/j.endinu.2024.09.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Carbohydrate metabolism can change in hospitalized patients due to stress, or the use of enteral nutrition (EN). The aim of this study was to determine the risk factors triggering these changes.</div></div><div><h3>Material and Methods</h3><div>We conducted a retrospective observational study in non-diabetic patients with low levels of stress on EN. Five groups were categorized based on changes to the metabolism of hydrocarbons produced before or after EN: plasma glycemia prior to EN >126<!--> <!-->mg/dL (stress hyperglycemia – SH) (35.1%); plasma glycaemia prior to EN <126<!--> <!-->mg/dL (non-HE) (64.89%). Hyperglycemia with EN (HyperEN): at least, two capillary blood glucose readings >140<!--> <!-->mg/dL or 1 >180<!--> <!-->mg/dL during EN (71%); non-HyperEN: capillary blood glucose readings with EN <140<!--> <!-->mg/dL (29%).</div></div><div><h3>Results</h3><div>A total of 131 patients were included (45.8% men) with a median age of 81 (71–87) years. A total of 52 patients exceeded 180<!--> <!-->mg/dL at one measurement, and 24 patients required insulin detemir with a median of 16 (12–27) IU per day. Risk factors for HyperEN were identified as patient age (OR, 1.186; 95% CI, 1.051–1.341; <em>p</em> <!--><<!--> <!-->0.01) and duration of nutritional treatment (OR, 1.320; 95% CI, 1.086–1.605; <em>p</em> <!--><<!--> <!-->0.01).</div></div><div><h3>Conclusions</h3><div>Our study shows a high prevalence of carbohydrate metabolism disorders in hospitalized patients on total EN, with age and duration of nutritional treatment being the main risk factors.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101534"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Carrillo-López, Maria Sara Tapia-Sanchiz, Sara Jiménez-Blanco, Begoña Molina-Baena
{"title":"Short bowel syndrome and d-lactic acidosis: A case report with supplemental home parenteral nutrition and teduglutide","authors":"Elena Carrillo-López, Maria Sara Tapia-Sanchiz, Sara Jiménez-Blanco, Begoña Molina-Baena","doi":"10.1016/j.endinu.2024.09.009","DOIUrl":"10.1016/j.endinu.2024.09.009","url":null,"abstract":"<div><div><span>d</span>-Lactic acidosis is an uncommon cause of acidosis that occurs in patients with short bowel syndrome (SBS). Reduced intestinal absorption surface leads to carbohydrate malabsorption, fermented by abnormal colonic bacterial flora, resulting in elevated <span>d</span>-lactate levels. It should be suspected in SBS patients who exhibit typical neurological symptoms without other apparent causes, along with metabolic acidosis with normal <span>l</span>-lactate levels. Treatment involves correcting acidosis and managing bacterial overgrowth with non-absorbable antibiotics.</div><div>This report presents a case of a patient on teduglutide for SBS who experienced an episode of <span>d</span>-lactic acidosis. To date, there are no documented cases in the literature of similar episodes in adult patients undergoing therapy with GLP2 analogs.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101535"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Juan José Díez , Emma Anda , Irene Bretón , Cintia González-Blanco , María Miguélez , Ana Zugasti , Alberto Fernández , en representación de la Sociedad Española de Endocrinología y Nutrición
{"title":"Recomendaciones de la Sociedad Española de Endocrinología y Nutrición (SEEN) sobre «qué no hacer» en la práctica clínica","authors":"Juan José Díez , Emma Anda , Irene Bretón , Cintia González-Blanco , María Miguélez , Ana Zugasti , Alberto Fernández , en representación de la Sociedad Española de Endocrinología y Nutrición","doi":"10.1016/j.endinu.2024.11.001","DOIUrl":"10.1016/j.endinu.2024.11.001","url":null,"abstract":"<div><div>Quality healthcare should be grounded on clinical practice with the highest benefit-risk ratio and cost-effectiveness according to the available scientific evidence. The overuse of unproven diagnostic or therapeutic procedures is common in our setting and leads to increased healthcare spending and even iatrogenic harm. Previous cost-effectiveness initiatives have proposed identifying diagnostic and therapeutic measures that are better ‘not done’ in certain clinical contexts under the lens of the available scientific evidence. In this regard, the Spanish Society of Endocrinology and Nutrition (SEEN) has compiled a series of ‘not-to-do’ recommendations from its various working groups. These recommendations cover common clinical situations classified into the following thematic areas: diabetes, nutrition, pituitary gland, neuroendocrine tumors, thyroid, and hormone replacement therapy in postmenopausal women.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 3","pages":"Article 101531"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143519774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meriem El Fessikh , Hanaa Skhoun , Zohra Ouzzif , Jamila El Baghdadi
{"title":"Deciphering deleterious missense variants in the MC4R gene in the pathogenesis of obesity","authors":"Meriem El Fessikh , Hanaa Skhoun , Zohra Ouzzif , Jamila El Baghdadi","doi":"10.1016/j.endinu.2025.501559","DOIUrl":"10.1016/j.endinu.2025.501559","url":null,"abstract":"<div><div>The <em>MC4R</em> gene plays a critical role in regulating food intake, making it an important model for studying genetic mutations that impact the protein function. This study aimed to identify the most deleterious functional and structural variants in individuals with obesity by analyzing SNPs from the NCBI dbSNP database and selecting pathogenic variants from ClinVar. Bioinformatics tools were employed to predict deleterious SNPs, and conservation analysis was performed using ConSurf. Stability predictions were made with MUpro, I-Mutant2.0, and iStable. The 3D structure of the MC4R protein was examined using YASARA view. A total of 20 out of 348 missense mutations were associated with obesity. Fifteen of these variants were predicted to be the most deleterious. Eight variants located in conserved regions were found to significantly reduce protein stability and cause structural changes (S58C, E61K, N62S, I69R, D90N, R165Q, P299H, and I316S), indicating their potential as obesity biomarkers and therapeutic targets.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"72 4","pages":"Article 501559"},"PeriodicalIF":0.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143698101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}