1型糖尿病和2型糖尿病患者与健康对照者的神经素U和BMI相关性的比较研究

4区医学 Q3 Nursing

Endocrinologia, Diabetes y Nutricion Pub Date : 2025-06-18 DOI:10.1016/j.endinu.2025.501631

Yasemin Çalışkan , Emre Sarandöl , Nizameddin Koca

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引用次数: 0

摘要

目的比较1型糖尿病（T1DM）和2型糖尿病（T2DM）患者与健康对照者血清神经medin U （NmU）水平，并评价NmU与体重指数（BMI）的相关性。研究设计和方法我们对134名参与者进行了横断面研究：45名1型糖尿病患者，49名2型糖尿病患者，40名健康对照。采用酶联免疫吸附试验（ELISA）测定血清NmU水平，并评估与BMI的相关性。结果糖尿病患者血清snmu水平与健康对照组无显著差异。T1DM组和T2DM组NmU与BMI无显著相关性。而健康对照组NmU与BMI呈显著负相关（rho = - 0.373, p < 0.05）。结论snmu可能不是糖尿病的直接生物标志物，但其与健康个体BMI的显著相关性提示其在代谢调节中可能发挥作用。这是有史以来第一个比较糖尿病亚型中NmU水平的研究，为其在代谢稳态中的作用提供了新的见解。

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Neuromedin U and BMI correlation in T1DM and T2DM vs healthy controls: A comparative study

Objective

This study aimed to assess serum Neuromedin U (NmU) levels in patients with Type 1 (T1DM) and Type 2 diabetes mellitus (T2DM) vs healthy controls and evaluate the correlation between NmU and body mass index (BMI).

Research design and methods

We conducted a cross-sectional study with 134 participants: 45 with T1DM, 49 with T2DM, and 40 healthy controls. Serum NmU levels were measured using enzyme-linked immunosorbent assay (ELISA), and the correlation with BMI was assessed.

Results

NmU levels were not significantly different between diabetic patients and healthy controls. No significant correlation was observed between NmU and BMI in T1DM or T2DM groups. However, the healthy control group found a significant inverse correlation between NmU and BMI (rho = −0.373, p < 0.05).

Conclusions

NmU may not be a direct biomarker for diabetes, but its significant correlation with BMI in healthy individuals suggests a potential role in metabolic regulation. This is the first study ever conducted to compare NmU levels across diabetic subtypes, offering novel insights into the role of in metabolic homeostasis.

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来源期刊

Endocrinologia, Diabetes y Nutricion Nursing-Nutrition and Dietetics

CiteScore

2.10

自引率

0.00%

发文量

169

审稿时长

35 days

期刊介绍： Endocrinología, Diabetes y Nutrición is the official journal of the Spanish Society of Endocrinology and Nutrition (Sociedad Española de Endocrinología y Nutrición, SEEN) and the Spanish Society of Diabetes (Sociedad Española de Diabetes, SED), and was founded in 1954. The aim of the journal is to improve knowledge and be a useful tool in practice for clinical and laboratory specialists, trainee physicians, researchers, and nurses interested in endocrinology, diabetes, nutrition and related disciplines. It is an international journal published in Spanish (print and online) and English (online), covering different fields of endocrinology and metabolism, including diabetes, obesity, and nutrition disorders, as well as the most relevant research produced mainly in Spanish language territories. The quality of the contents is ensured by a prestigious national and international board, and by a selected panel of specialists involved in a rigorous peer review. The result is that only manuscripts containing high quality research and with utmost interest for clinicians and professionals related in the field are published. The Journal publishes Original clinical and research articles, Reviews, Special articles, Clinical Guidelines, Position Statements from both societies and Letters to the editor. Endocrinología, Diabetes y Nutrición can be found at Science Citation Index Expanded, Medline/PubMed and SCOPUS.