Pedro Iglesias , Javier Arias , Guillermo López , Iago Romero , Juan J. Díez
{"title":"Integration of big data analytics in the investigation of the relationship between acromegaly and cancer","authors":"Pedro Iglesias , Javier Arias , Guillermo López , Iago Romero , Juan J. Díez","doi":"10.1016/j.endinu.2024.05.005","DOIUrl":"10.1016/j.endinu.2024.05.005","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the association between acromegaly and cancer and different types of cancer by using natural language processing systems and big data analytics.</div></div><div><h3>Material and methods</h3><div>We conducted an observational, retrospective study utilizing data from the electronic health records (EHRs) of Hospital Universitario Puerta de Hierro Majadahonda, Madrid, Spain. Information from the EHRs was extracted using artificial intelligence techniques and analyzed using Savana Manager 4.0 software.</div></div><div><h3>Results</h3><div>Out of a total of 708,047 registered patients (54.7% females), 544 patients (0.08%; 330 women, 60.7%; mean age at diagnosis 53.0<!--> <!-->±<!--> <!-->15.8 yr) were diagnosed with acromegaly. The incidence of cancer was higher in patients with acromegaly vs those without this condition (7.7% vs 3.9%, <em>p</em> <!--><<!--> <!-->0.001; OR, 2.047, 95%CI, 1.493–2.804). Male acromegalic patients had a higher prevalence of cancer vs females (57.1% vs 42.9%, <em>p</em> <!-->=<!--> <!-->0.012). A significantly higher prevalence of colorectal cancer (2.9% vs 1.4%, <em>p</em> <!-->=<!--> <!-->0.006), bladder cancer (1.1% vs 0.3%, <em>p</em> <!-->=<!--> <!-->0.005), and lymphoma (1.1% vs 0.3%, <em>p</em> <!-->=<!--> <!-->0.009) was observed in patients with acromegaly vs those without the condition. Acromegalic men had significantly higher prevalence rates of colorectal cancer (4.7% vs 1.3%, <em>p</em> <!-->=<!--> <!-->0.001), bladder cancer (2.8% vs 0.4%, <em>p</em> <!--><<!--> <!-->0.001), breast cancer (0.9% vs 0.2%, <em>p</em> <!-->=<!--> <!-->0.042), gastric cancer (0.9% vs 0.1%, <em>p</em> <!-->=<!--> <!-->0.011), lymphoma (1.4% vs 0.3%, <em>p</em> <!-->=<!--> <!-->0.037), and liver cancer (0.9% vs 0.1%, <em>p</em> <!-->=<!--> <!-->0.012) vs non-acromegalic men. On the other hand, acromegalic women showed a higher prevalence of thyroid cancer (1.2% vs 0.4%, <em>p</em> <!-->=<!--> <!-->0.043) vs non-acromegalic women.</div></div><div><h3>Conclusion</h3><div>Our study, based on artificial intelligence techniques and analysis of real-world data and information, revealed a significant association between acromegaly and cancer in our hospital population, mainly acromegalic men, with a higher frequency of colorectal cancer, bladder cancer and lymphoma in particular.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"71 8","pages":"Pages 324-331"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Francis Rojas-Torres , Héctor Infanzón-Talango , Ana Cristina García-Ulloa , Sergio Hernández-Jiménez , Gerardo Rodríguez-Reyes
{"title":"Exploring plantar pressure distribution in patients with newly diagnosed diabetes: Implications for foot ulcer prevention in an overweight Mexican population","authors":"Francis Rojas-Torres , Héctor Infanzón-Talango , Ana Cristina García-Ulloa , Sergio Hernández-Jiménez , Gerardo Rodríguez-Reyes","doi":"10.1016/j.endinu.2024.05.008","DOIUrl":"10.1016/j.endinu.2024.05.008","url":null,"abstract":"<div><h3>Introduction</h3><div>Elevated plantar pressure (PP) constitutes a risk factor for developing foot ulcers. Once present, elevated PP increases morbidity and mortality in patients with diabetes. Given the high prevalence of overweight and obesity in the Mexican population, this study aimed to describe the magnitudes and the distribution of the PP observed in a sample of newly diagnosed patients with diabetes, adjusting for body mass index (BMI) groups (normal weight, overweight, grade I obesity, and grade II and III obesity).</div></div><div><h3>Materials and methods</h3><div>A total of 250 volunteers attending a comprehensive care program for the management of type 2 diabetes received foot assessments that included vascular and neurological evaluation, the identification of musculoskeletal changes, and measurements of PP.</div></div><div><h3>Results</h3><div>Diabetic neuropathy and peripheral arterial disease were present in 21.6% and 11.2% of all participants. Musculoskeletal alterations were present in 70.8% of participants. A positive and significant correlation (<em>p</em> <!--><<!--> <!-->0.001) was observed between BMI and the peak PP of all anatomical regions assessed. After adjusting for BMI, significant differences (<em>p</em> <!--><<!--> <!-->0.001) were seen between groups. The metatarsal region, particularly under the third metatarsal head, denoted the highest magnitudes across all BMI.</div></div><div><h3>Conclusions</h3><div>Periodic PP assessment is recommended to identify the distribution of high-pressure points along the plantar surface. However, as a preventive measure, it is suggested to encourage patients with diabetes and overweight or obesity to wear appropriate footwear and pressure-relief insoles to relieve high-pressure areas – often seen in these populations – to help prevent foot complications.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"71 8","pages":"Pages 340-347"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142424929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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