Endocrinologia, Diabetes y Nutricion最新文献

{"title":"Estatus nutricional de mujeres con anorexia nerviosa. Valoración morfofuncional","authors":"Abel González-González,&nbsp;Marta Ventosa-Viña,&nbsp;Encarnación Arranz-Sinovas,&nbsp;Isabel Domínguez-Osorio,&nbsp;Cristina Urrios-Gómez,&nbsp;Fernándo García Urruzola,&nbsp;Jose María Palacio-Mures,&nbsp;Luis Cuéllar-Olmedo","doi":"10.1016/j.endinu.2026.501776","DOIUrl":"10.1016/j.endinu.2026.501776","url":null,"abstract":"<div><h3>Objective</h3><div>To provide a descriptive analysis of the nutritional status of a sample of women with anorexia nervosa (AN).</div></div><div><h3>Materials and methods</h3><div>Descriptive observational study of women attending an outpatient clinic for AN.</div></div><div><h3>Results</h3><div>Thirty-five patients were evaluated, with a mean age of 23.6<!--> <!-->±<!--> <!-->10.7 years and a body mass index of 18.3<!--> <!-->±<!--> <!-->3.53<!--> <!-->kg/m². A total of 73.52% were malnourished (40% with severe malnutrition). Muscle strength was 24.3<!--> <!-->±<!--> <!-->3.53<!--> <!-->kg; 16 patients (55.88%) showed strength below the 20th percentile, but only 3 fell below the cutoff defining sarcopenia.</div><div>Muscle mass variables assessed included: appendicular skeletal muscle mass, 14.7<!--> <!-->±<!--> <!-->2.47<!--> <!-->kg/m²; fat-free mass index, 14.8<!--> <!-->±<!--> <!-->1.47<!--> <!-->kg/m²; appendicular skeletal muscle mass index, 5.52<!--> <!-->±<!--> <!-->0.629<!--> <!-->kg/m²; anteroposterior diameter of the rectus femoris muscle (Y-axis), 1.18<!--> <!-->±<!--> <!-->0.32<!--> <!-->cm; and cross-sectional area of the same muscle, 3.54<!--> <!-->±<!--> <!-->1.29<!--> <!-->cm². The ratio of the lateral diameter of the rectus femoris (X-axis) to the Y-axis, used as an index of muscle quality, was 3.09<!--> <!-->±<!--> <!-->1.17.</div><div>Patients with severe malnutrition had lower adipose tissue content and reduced appendicular skeletal muscle mass compared with the rest of the cohort.</div><div>Phase angle was 5.85<!--> <!-->±<!--> <!-->0.77°, and standardized phase angle was<!--> <!-->–<!--> <!-->0.92<!--> <!-->±<!--> <!-->0.89. Both showed a good positive correlation with body cell mass.</div></div><div><h3>Conclusions</h3><div>Malnutrition is extremely prevalent among patients with AN; however, sarcopenia—according to conventional criteria—is not. Morphofunctional differences were observed according to nutritional status.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 8","pages":"Article 501776"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De la tormenta a la calma: el rol de la plasmaféresis en la estabilización de pacientes con tirotoxicosis de alto riesgo","authors":"Agueda María Comisario,&nbsp;Javier Giunta,&nbsp;Teresa Mabel Canteros,&nbsp;Diego Mario Santoro,&nbsp;Sebastian Antelo,&nbsp;María del Pilar Tartaglia,&nbsp;Federico Norberto Cedola,&nbsp;Ivana Leticia Esteban,&nbsp;María Fabiana Russo Picasso","doi":"10.1016/j.endinu.2026.501826","DOIUrl":"10.1016/j.endinu.2026.501826","url":null,"abstract":"<div><h3>Introduction</h3><div>Thyrotoxicosis in high-risk patients is a severe condition requiring prompt management, although conventional therapeutic approaches often present limitations. Therapeutic plasmapheresis has emerged as a potential option to achieve rapid clinical stabilization and facilitate a safe transition to definitive treatment by effectively reducing circulating thyroid hormone levels. The objective of this study was to evaluate the safety and efficacy profile of plasmapheresis in patients with high-risk thyrotoxicosis.</div></div><div><h3>Materials and methods</h3><div>We conducted a retrospective multicenter study with a cohort of 13 patients with high-risk thyrotoxicosis who underwent plasmapheresis due to clinical instability, adverse effects related to antithyroid drugs, or significant cardiovascular comorbidities. Therapeutic success was assessed based on objective clinical improvement and restoration of euthyroidism, determined by hormonal measurements. Adverse events were systematically recorded to evaluate the procedural safety profile.</div></div><div><h3>Results</h3><div>The median age was 50 years, and 84.6% of patients were women. The median number of plasmapheresis sessions was 3. Normalization of T3 and free T4 levels was achieved in 92.3% of patients. Mild adverse events occurred in 30.8% of cases, none of which required treatment discontinuation. Definitive therapy following plasmapheresis was performed in 76.9% of patients, most commonly total thyroidectomy.</div></div><div><h3>Discussion</h3><div>Plasmapheresis appears to be a safe and effective therapeutic option in patients with high-risk thyrotoxicosis, particularly in those with absolute contraindications to conventional treatments or severe cardiovascular comorbidities, facilitating stabilization and transition to definitive therapy.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 8","pages":"Article 501826"},"PeriodicalIF":0.0,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149078519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Carcinoma folicular de tiroides avanzado: Abordaje mutidisciplinar de las metástasis raras","authors":"Lucía Menéndez Muros,&nbsp;Nuria Birruezo Hernández,&nbsp;María Angustias Muros de Fuentes","doi":"10.1016/j.endinu.2026.501823","DOIUrl":"10.1016/j.endinu.2026.501823","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501823"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations for defining incident overweight and obesity in EHR-based cohorts: Response from the authors","authors":"Irene Bretón,&nbsp;Igotz Aranbarri,&nbsp;Anastasia Lampropoulou,&nbsp;Jennifer Redondo-Antón,&nbsp;Javier Ágreda,&nbsp;Atif Adame,&nbsp;Esther Artime","doi":"10.1016/j.endinu.2026.501848","DOIUrl":"10.1016/j.endinu.2026.501848","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501848"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Conocimiento y abordaje de la esteatosis hepática metabólica entre endocrinólogos en España","authors":"María Teresa Julián,&nbsp;Miguel A. Rubio-Herrera,&nbsp;Javier Escalada,&nbsp;Núria Alonso,&nbsp;en representación del Grupo EHMET de la Sociedad Española de Endocrinología y Nutrición","doi":"10.1016/j.endinu.2026.501846","DOIUrl":"10.1016/j.endinu.2026.501846","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most prevalent chronic liver disease and is closely associated with type<!--> <!-->2 diabetes mellitus (T2DM) and obesity. However, it continues to have limited clinical visibility outside the field of Hepatology.</div></div><div><h3>Objective</h3><div>To evaluate knowledge, liver fibrosis screening practices, and perceived barriers related to MASLD among endocrinologists in Spain.</div></div><div><h3>Materials and methods</h3><div>An exploratory cross-sectional observational study was conducted using an online survey promoted by the MASLD Working Group of the Spanish Society of Endocrinology and Nutrition (SEEN) and addressed to all society members. A total of 210 anonymized surveys were analyzed, collecting information on: liver fibrosis screening in patients with T2DM and/or obesity, diagnostic tools used, availability of clinical protocols, access to liver elastography, and the main barriers to MASLD management. A descriptive analysis of the results was performed.</div></div><div><h3>Results</h3><div>Approximately half of the endocrinologists reported performing liver fibrosis screening in patients with T2DM or obesity. FIB-4 was the most frequently used screening tool (78.4%), although automated calculation was available in only 60.8% of centers. Lack of time, insufficient training, and limited protocol availability (31.6%) were identified as the main barriers, and direct access to elastography from Endocrinology departments was limited.</div></div><div><h3>Conclusions</h3><div>This exploratory study shows that MASLD is not yet fully integrated into endocrinology practice in Spain. The lack of systematic screening, together with organizational and educational barriers, limits the early detection of hepatic fibrosis in high-risk populations. Strengthening awareness, training, and protocol development is necessary to integrate liver health into the comprehensive management of patients with metabolic disease.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501846"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary central nervous system lymphoma involving the hypothalamic–pituitary axis presenting with hypopituitarism: A case report with long-term follow-up","authors":"David Sanchis-Pascual,&nbsp;Rosa Cámara Gómez,&nbsp;Pilar Morillas-Amat,&nbsp;Samuel Romero Domínguez,&nbsp;Joan Carreres-Polo,&nbsp;Darío Lara-Gálvez,&nbsp;Lucía Cano-Jiménez,&nbsp;Juan Díaz Nohales,&nbsp;Juan Francisco Merino-Torres","doi":"10.1016/j.endinu.2026.501798","DOIUrl":"10.1016/j.endinu.2026.501798","url":null,"abstract":"<div><div>Primary central nervous system lymphoma (PCNSL) involving the hypothalamic–pituitary axis is a rare condition and may present with nonspecific neurologic and endocrine signs, often mimicking more common sellar lesions. We report the case of a 59-year-old woman admitted with subacute behavioral changes, cognitive decline, and polyuria. Magnetic resonance imaging revealed a pituitary–infundibular mass with suprasellar extension and marked bifrontal edema. Endocrine evaluation demonstrated panhypopituitarism and arginine vasopressin deficiency. The clinical course was complicated by severe dysnatremias requiring intensive care management and hormonal replacement. Histopathologic analysis of a transsphenoidal biopsy confirmed diffuse large B-cell lymphoma, with no systemic disease on PET-CT or bone marrow evaluation. The patient was treated with the MATRix chemotherapy regimen followed by autologous stem cell transplantation, achieving sustained complete remission at 3.5 years. Persistent hypogonadotropic hypogonadism remained as a sequelae. This case underscores the diagnostic challenges of sellar involvement by PCNSL and highlights the importance of including lymphoma in the differential diagnosis of hypothalamic–pituitary masses. Acute pituitary failure with severe electrolyte disturbances may precede oncologic diagnosis, and early multidisciplinary management combined with aggressive therapy can result in long-term remission.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501798"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toxicidad digestiva en el tratamiento de los tumores hematológicos. Influencia en el estado nutricional","authors":"Teresa Alonso Domínguez,&nbsp;Miguel Civera Andrés,&nbsp;Katherine García Malpartida,&nbsp;José González Medina,&nbsp;María José Serna Muñoz,&nbsp;Williana M. Torres Jiménez,&nbsp;Bolívar Luis Díaz Jordán,&nbsp;Francisco Botella Romero","doi":"10.1016/j.endinu.2026.501777","DOIUrl":"10.1016/j.endinu.2026.501777","url":null,"abstract":"<div><h3>Introduction</h3><div>Hematologic neoplasms (lymphomas, leukemias, and myelomas) represent approximately 10% of all tumors. Antineoplastic treatments, including chemotherapy, targeted therapies, and immunotherapy, generate gastrointestinal toxicity that impacts therapeutic efficacy and nutritional status, establishing a vicious cycle of malnutrition and toxicity.</div></div><div><h3>Materials and methods</h3><div>A narrative review was conducted using a literature search of the electronic databases PubMed, Embase, UpToDate, and Medscape for chemotherapy, targeted therapies, and immunotherapy used in lymphomas, leukemias, and multiple myeloma. The frequencies of gastrointestinal adverse effects (diarrhea, nausea/vomiting, mucositis), as well as those of grade ≥3, were analyzed.</div></div><div><h3>Results</h3><div>The results are presented in tables showing the commonly used drugs along with the probability of experiencing gastrointestinal adverse effects. In acute lymphoblastic leukemia, therapies such as Tisa-Cel and Brexu-Cel, with or without cytotoxic agents, cause gastrointestinal toxicity in almost all patients. In acute myeloid leukemia, most drugs produce nausea and vomiting, while diarrhea and mucositis are less frequent (30%). In chronic lymphocytic leukemia, diarrhea is prominent with targeted therapies (ibrutinib [42%], idelalisib [47%]). In chronic myeloid leukemia, bosutinib causes the highest rate of gastrointestinal intolerance (68%). In non-Hodgkin lymphoma, most combinations induce nausea/vomiting (&gt;90%). Regarding multiple myeloma, gastrointestinal effects are generally low, with the exception of some immunotherapies (selinexor, elranatamab, elotuzumab).</div></div><div><h3>Discussion</h3><div>Diarrhea, nausea, vomiting, and mucositis are common complications, with diverse mechanisms depending on the drug. These toxicities directly impact nutritional status and quality of life, potentially requiring modifications to treatments.</div></div><div><h3>Conclusions</h3><div>Understanding the frequency and severity of gastrointestinal side effects of drugs used to treat hematological malignancies can facilitate early diagnosis and medical-nutritional management, which can be key to reducing malnutrition and improving clinical outcomes in hematological tumors.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501777"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hypothalamic–pituitary axis MRI findings in pediatric endocrine disorders: A retrospective study","authors":"Angela Domínguez-García,&nbsp;David Navarro-Domínguez,&nbsp;Sofía Quinteiro-González,&nbsp;Sara López-López,&nbsp;María F. Cabrera-Guedes,&nbsp;Yeray Nóvoa-Medina","doi":"10.1016/j.endinu.2026.501781","DOIUrl":"10.1016/j.endinu.2026.501781","url":null,"abstract":"<div><h3>Background</h3><div>Magnetic resonance imaging (MRI) of the hypothalamic–pituitary axis (HPA) is widely used in pediatric endocrinology, yet the clinical relevance of structural abnormalities remains debated.</div></div><div><h3>Objective</h3><div>To assess the diagnostic yield of HPA MRI in children with endocrine disorders and identify clinical/hormonal predictors of clinically relevant findings.</div></div><div><h3>Methods</h3><div>We retrospectively analysed a total of 202 patients (1 month to 17 years) evaluated from 2018 through 2023 for suspected HPA dysfunction. Diagnostic groups included isolated growth hormone deficiency (IGHD), multiple pituitary hormone deficiency (MPHD), short stature without growth hormone deficiency (SSWGD), central precocious puberty (CPP), central diabetes insipidus (CDI), and pituitary hypersecretion syndrome (PHS). MRI findings were classified as normal, relevant, or incidental. Logistic regression and ROC analysis were used to identify predictive factors.</div></div><div><h3>Results</h3><div>Abnormal MRI findings were identified in 29.2% of patients (59/202); 14.9% (30/202) were clinically relevant and 14.4% (29/202), incidental. Diagnostic yield (any abnormal finding) was highest in MPHD (100%) and CDI (87.5%), followed by PHS (40.0%), SSWGD (30.8%), CPP (26.4%) and IGHD (23.2%). In IGHD, lower GH peaks on the exercise–propranolol test were significantly associated with abnormal MRI findings (OR, 3.98; 95%CI, 1.53–10.30; <em>P</em> <!-->=<!--> <!-->.026). There were no predictors for CPP. Incidental lesions were most common in CPP and IGHD.</div></div><div><h3>Conclusions</h3><div>MRI showed the highest diagnostic yield in MPHD and CDI. In IGHD, lower GH peak values may help guide selective imaging, while in CPP the lack of reliable predictors supports routine MRI. Multidisciplinary interpretation remains essential to contextualise incidental findings.</div></div>","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501781"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological considerations in defining incident overweight and obesity in EHR-based cohorts: A comment on Breton et al.","authors":"Ankur Sharma,&nbsp;Varshini Vadhithala,&nbsp;Arun Kumar,&nbsp;Sushma Verma,&nbsp;Sushma Narsing Katkuri","doi":"10.1016/j.endinu.2026.501782","DOIUrl":"10.1016/j.endinu.2026.501782","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501782"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflexión sobre la necesidad de cribado de la pre-diabetes tipo 1: un año tras la publicación del consenso español","authors":"M. Rigla Cros,&nbsp;M.M. Fernández Balsells,&nbsp;A.M. Wägner","doi":"10.1016/j.endinu.2026.501877","DOIUrl":"10.1016/j.endinu.2026.501877","url":null,"abstract":"","PeriodicalId":37725,"journal":{"name":"Endocrinologia, Diabetes y Nutricion","volume":"73 7","pages":"Article 501877"},"PeriodicalIF":0.0,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148810624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}