Biomedical Photonics最新文献_第9页

Профессору Евгению Филипповичу Странадко – 75 лет 叶夫根尼·菲利波维奇·斯特拉纳科教授，75岁

Biomedical Photonics Pub Date : 2019-07-11 DOI: 10.24931/2413-9432-2012-1-1-17

Статья Редакционная

引用次数: 0

Роль и место фотодинамической терапии в мультимодальных программах лечения злокачественных опухолей 光动力疗法在恶性肿瘤多模式治疗方案中的作用和地位

Biomedical Photonics Pub Date : 2019-07-11 DOI: 10.24931/2413-9432-2012-1-1-3-5

В. А. Титова

引用次数: 0

Сравнение эффективности фотодинамической терапии при использовании источников излучения с различными длинами волн в лечении синуситов 不同波长辐射源光动力疗法治疗窦炎的疗效比较

Biomedical Photonics Pub Date : 2019-07-10 DOI: 10.24931/2413-9432-2019-8-2-14-18

Г. П. Попова, Я. А. Накатис, М. А. Рымша

{"title":"Сравнение эффективности фотодинамической терапии при использовании источников излучения с различными длинами волн в лечении синуситов","authors":"Г. П. Попова, Я. А. Накатис, М. А. Рымша","doi":"10.24931/2413-9432-2019-8-2-14-18","DOIUrl":"https://doi.org/10.24931/2413-9432-2019-8-2-14-18","url":null,"abstract":"Inflammatory diseases of the sinuses – one of the most common nosologies in the practice of otorhinolaryngologist; its pathogenesis is well studied, and treatment recommendations are detailed. Following them, however, cannot completely prevent chronic disease or recurrence. Antimicrobial photodynamic therapy is a promising method of treating sinusitis, which has proved its effectiveness, but has not yet been widely used. This work describes our experience in photodynamic therapy with chlorin e6 of chronic sinusitis using a new laser diode-based irradiation source. For patients who had previous sinus surgery an adapter for penetration into the sinus through anastomosis was developed and tested. First group of the patients underwent photodynamic therapy (PDT) according to the conventional scheme, using a laser with a wavelength of 662 nm; while the second one underwent PDT using a 405 nm laser. With daily washing of the nasal sinus, the period of inflammation relief (evaluated by the absence of pathological discharge during washing) amounted to 3.8 full days on average in the first group of patients, compared to 5.4 days on average for the second group. We carried out the comparative analysis of the treatment results based on clinical assessment and radiological evaluation (CT) at the time of discharge from the hospital and 1 month later.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":"8 1","pages":"14-18"},"PeriodicalIF":0.0,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48004494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Experience of using photodynamic therapy in the treatment of esophageal cancer 光动力疗法治疗食管癌的体会

Biomedical Photonics Pub Date : 2019-07-10 DOI: 10.24931/2413-9432-2019-8-2-19-24

A. N. Tumanina, A. Polezhaev, V. Apanasevich, L. Gurina, M. Volkov, A. Y. Tarasenko, E. Filonenko

{"title":"Experience of using photodynamic therapy in the treatment of esophageal cancer","authors":"A. N. Tumanina, A. Polezhaev, V. Apanasevich, L. Gurina, M. Volkov, A. Y. Tarasenko, E. Filonenko","doi":"10.24931/2413-9432-2019-8-2-19-24","DOIUrl":"https://doi.org/10.24931/2413-9432-2019-8-2-19-24","url":null,"abstract":"Photodynamic therapy (PDT) is a worthy alternative to surgical esophageal resection or endoscopic mucosal resection and dissection (EMR, ESD) in patients with superficial esophageal cancer with severe concomitant diseases as well as in patients with a common form of esophageal cancer with severe malignant dysphagia. Patients with superficial (7) and advanced (15) esophageal cancer received PDT as an independent method and as a supplement to complex treatment. Radachlorin was used as a photosensitizer at a dose of 0.6–0.8 mg/kg, administered intravenously 3 hours before irradiation. A PDT session was carried out using a laser with a wavelength of 662 nm. The light dose used was 150–300 J/cm2 . The use of PDT made it possible to achieve the full effect in 7 (100%) patients in the group of superficial (T1a-T1b) esophageal cancer where PDT was either the only method of treatment or in combination with radiation therapy. In the group of patients with stenotic cancer the use of PDT made it possible to achieve full recovery of food intake after recanalization for 20% of patients, and partial – for 66.7%. Thus, complete natural food intake was restored for 86.7% of patients which improved their quality of life. PDT is also a method of choice for cancer of the upper esophagus as esophageal stenting in this situation can cause unwanted subjective sensations. ","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68973897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Improving the efficiency of bladder cancer diagnostic cystoscopy with 5-ALA hexyl ester 提高5-ALA己基酯膀胱镜诊断膀胱癌的效率

Biomedical Photonics Pub Date : 2019-03-31 DOI: 10.24931/2413-9432-2019-8-1-29-37

A. Kaprin, A. Trushin, M. P. Golovachenko, V. Ivanova-Radkevich, V. Chissov, E. Filonenko

{"title":"Improving the efficiency of bladder cancer diagnostic cystoscopy with 5-ALA hexyl ester","authors":"A. Kaprin, A. Trushin, M. P. Golovachenko, V. Ivanova-Radkevich, V. Chissov, E. Filonenko","doi":"10.24931/2413-9432-2019-8-1-29-37","DOIUrl":"https://doi.org/10.24931/2413-9432-2019-8-1-29-37","url":null,"abstract":"This article presents the results of a clinical study that examined the diagnostic efficacy of fluorescent diagnostics (FD) of non-muscularinvasive bladder cancer using a photosensitizer of FD of malignant neoplasms – 5-aminolevulinic acid hexyl ester (5-ALA HE) compared with standard cystoscopy. The study involved 110 patients. The study began with intravesical administration of 50 ml of 0.2% solution of 5-ALA HE, the exposure time was 1 hour, after which the drug was removed from the organ. During the next hour, the mucous membranes were examined in two cystoscopy modes, followed by a standard transurethral resection of all urothelium sites with suspicion for tumor lesion based on white light and visible red fluorescence, and a control blind biopsy from the visually unchanged and non-fluorescent mucous tissue in each patient. The results of the study indicate the high effectiveness of the developed FD methodology with 5-ALA HE in detecting non-muscularinvasive bladder cancer during intravesical administration of the drug, due to selective accumulation of hexasens-induced PPIX in the tumor tissue compared with healthy mucosa. Compared with the results of standard cystoscopy, fluorescence diagnostics significantly increased diagnostic sensitivity by 24.4% (from 75.1% to 99.5%), diagnostic accuracy – by 15.8% (from 82.4% to 98.2%) and a negative predictive value – by 33.2% (from 65.8% to 99%) (p≤0.05). Additionally, a total of 37 (33.6%) patients was found to have 63 foci of fluorescence with a diameter of 2.5 to 3.0 mm. 59 of these were morphologically confirmed to contain cancer cells.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68973829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants 疏水细菌氯基光敏剂在表面活性剂胶束中的增溶作用

Biomedical Photonics Pub Date : 2019-03-31 DOI: 10.24931/2413-9432-2019-8-1-18-23

E. Plotnikova, V. O. Stramova, N. Morozova, A. Plyutinskaya, P. Ostroverkhov, M. Grin, A. Mironov, R. Yakubovskaya, A. Kaprin

引用次数: 1

Комбинированное эндоскопическое лечение больного раком гортаноглотки с распространением на верхнюю треть пищевода 喉咽癌的内镜联合治疗，扩散到食管上三分之一

Biomedical Photonics Pub Date : 2019-01-14 DOI: 10.24931/2413-9432-2018-7-4-35-40

В. М. Легостаев, О. Ю. Бабенков, Г. В. Балицкий

引用次数: 1

Cluster analysis of the results of intraoperative optical spectroscopic diagnostics In brain glioma neurosurgery 脑胶质瘤神经外科术中光谱诊断结果的聚类分析

Biomedical Photonics Pub Date : 2019-01-14 DOI: 10.24931/2413-9432-2018-7-4-23-34

I. Osmakov, T. Savelieva, V. Loschenov, S. Goryajnov, A. Potapov

{"title":"Cluster analysis of the results of intraoperative optical spectroscopic diagnostics In brain glioma neurosurgery","authors":"I. Osmakov, T. Savelieva, V. Loschenov, S. Goryajnov, A. Potapov","doi":"10.24931/2413-9432-2018-7-4-23-34","DOIUrl":"https://doi.org/10.24931/2413-9432-2018-7-4-23-34","url":null,"abstract":"The paper presents the results of a comparative study of methods of cluster analysis of optical intraoperative spectroscopy data during surgery of glial tumors with varying degree of malignancy. The analysis was carried out both for individual patients and for the entire dataset. The data were obtained using combined optical spectroscopy technique, which allowed simultaneous registration of diﬀuse reﬂectance spectra of broadband radiation in the 500–600 nm spectral range (for the analysis of tissue blood supply and the degree of hemoglobin oxygenation), ﬂuorescence spectra of 5‑ALA induced protoporphyrin IX (Pp IX) (for analysis of the malignancy degree) and signal of diffusely reﬂected laser light used to excite Pp IX ﬂuorescence (to take into account the scattering properties of tissues). To determine the threshold values of these parameters for the tumor, the infltration zone and the normal white matter, we searched for the natural clusters in the available intraoperative optical spectroscopy data and compared them with the results of the pathomorphology. It was shown that, among the considered clustering methods, EM‑algorithm and k‑means methods are optimal for the considered data set and can be used to build a decision support system (DSS) for spectroscopic intraoperative navigation in neurosurgery. Results of clustering relevant to thepathological studies were also obtained using the methods of spectral and agglomerative clustering. These methods can be used to postprocess combined spectroscopy data.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48430580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Study of pharmacokinetics of liposomal photosensitiser based on hydroxyaluminium tetra-3-phenylthiophthalocyanine on mice 羟基铝四-3-苯硫酞脂质体光敏剂在小鼠体内的药动学研究

Biomedical Photonics Pub Date : 2019-01-14 DOI: 10.24931/2413-9432-2018-7-4-16-22

A. Budko, Z. G. Deichman, G. Meerovich, L. Borisova, I. G. Мeerovich, A. Lantsova, Kulbachevskaya N.Yu. Kulbachevskaya N.Yu. Kulbachevskaya N.Yu.

{"title":"Study of pharmacokinetics of liposomal photosensitiser based on hydroxyaluminium tetra-3-phenylthiophthalocyanine on mice","authors":"A. Budko, Z. G. Deichman, G. Meerovich, L. Borisova, I. G. Мeerovich, A. Lantsova, Kulbachevskaya N.Yu. Kulbachevskaya N.Yu. Kulbachevskaya N.Yu.","doi":"10.24931/2413-9432-2018-7-4-16-22","DOIUrl":"https://doi.org/10.24931/2413-9432-2018-7-4-16-22","url":null,"abstract":"The present work is devoted to the study of pharmacokinetics of infrared photosensitizer (PS) based on hydroxyaluminium tetra‑3‑phenylthiophthalocyanine in a sterically stabilized liposomal form. The study was carried out on adult female mice. The PS was administered once intravenously at a dose of 6 mg / kg. Evaluation of the PS accumulation dynamics in the mice tissues and organs was performed at time intervals from 5 minutes to 7 days using spectral‑ﬂuorescent method. The maximum accumulation of the PS photoactive form was recorded in lungs (32 µg / g in the interval of 5–30 minutes after introduction), liver (20.8 µg / g in the interval of 4–24 hours after introduction) and spleen (28 µg / g 4 hours after introduction). At the same time, by the end of the observation period (7 days after administration), trace amounts of the PS photoactive form were still detected in the liver and the spleen at a calculated concentration of 0.5‑1 µg / g. The PS accumulated the least in muscles and skin. The ﬂuorescent signal from the PS accumulated in skin was detectable almost immediately, and its concentration remained at the same level (1.2‑1.5 µg / g) for up to 3 days of observation. In the muscles, the concentration of the PS reached 1.5 µg / g 15 minutes after administration, and then gradually decreased until 0.25 µg / g at 24 hours. Data on the pharmacokinetics of PS in blood, basic organs and tissues of animals were obtained, pharmacokinetic parameters were calculated. 7 days after the administration, the PS concentration in the skin and muscles was below the detection limit. The studies confrmed that PEGylation of the PS liposomal form slows down the process of its capture by reticulo‑endothelial system. It was shown that the PS circulates in blood and organs of mice for a long time and it completely distributes only when 4 hours pass after administration.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68974106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Cytological effects in lymph nodes of abdominal lymphodissection zone after intraoperative photodynamic therapy of gastrointestinal cancers 胃肠癌术中光动力治疗后腹腔淋巴夹层淋巴结的细胞学影响

Biomedical Photonics Pub Date : 2019-01-14 DOI: 10.24931/2413-9432-2018-7-4-11-15

V. Kravtsov, E. S. Pirozhenko, K. V. Pavelec, M. A. Protchenkov, U. A. Drozd

引用次数: 0