Solubilization of hydrophobic bacteriochlorin-based photosensitizers in micelles of surfactants

Q3 Medicine

Biomedical Photonics Pub Date : 2019-03-31 DOI:10.24931/2413-9432-2019-8-1-18-23

E. Plotnikova, V. O. Stramova, N. Morozova, A. Plyutinskaya, P. Ostroverkhov, M. Grin, A. Mironov, R. Yakubovskaya, A. Kaprin

引用次数: 1

Abstract

The aim of the paper was to obtain a stable micellar emulsion of potent photosensitizer (PS) –O-propyloxime-N-propoxybacteriopurpurinimide methyl ester absorbing light in long-wave region of the spectrum (λmax= 800±2 нм). Solubilizates of the dye based on different surfactants (Kolliphor ELP, Poloxamer 407, Emuxol 268) were obtained. Taking into account the physical and chemical parameters, the most potent micellar emulsion for injection was selected and characterized. The emulsion based on Kolliphor ELP remains stable for 4 months, with no changes in the fluorescence spectrum and absorption, as well as the particle diameter.

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疏水细菌氯基光敏剂在表面活性剂胶束中的增溶作用

本文的目的是制备一种稳定的强效光敏剂(PS) - o -丙氧基肟- n -丙氧基细菌嘌呤酰亚胺甲酯胶束乳液，在光谱的长波区(λmax= 800±2 нм)吸收光。得到了不同表面活性剂(Kolliphor ELP, poloxam407, Emuxol 268)对染料的增溶剂。综合考虑理化参数，选择了最有效的注射用胶束乳液，并对其进行了表征。基于Kolliphor ELP的乳液在4个月内保持稳定，荧光光谱和吸收没有变化，颗粒直径也没有变化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Photonics Medicine-Surgery

CiteScore

1.80

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： The main goal of the journal – to promote the development of Russian biomedical photonics and implementation of its advances into medical practice. The primary objectives: - Presentation of up-to-date results of scientific and in research and scientific and practical (clinical and experimental) activity in the field of biomedical photonics. - Development of united Russian media for integration of knowledge and experience of scientists and practitioners in this field. - Distribution of best practices in laser medicine to regions. - Keeping the clinicians informed about new methods and devices for laser medicine - Approval of investigations of Ph.D candidates and applicants.