Biomedical Photonics最新文献_第6页

Specialized medical care for patients with malignant neoplasms of the maxillofacial area in the Penza region of Russia 对俄罗斯奔萨地区颌面恶性肿瘤患者的专门医疗护理

Biomedical Photonics Pub Date : 2021-10-28 DOI: 10.24931/2413-9432-2021-10-3-23-31

M. V. Lebedev, Yu. A. Abdullina, I. Zakharova

{"title":"Specialized medical care for patients with malignant neoplasms of the maxillofacial area in the Penza region of Russia","authors":"M. V. Lebedev, Yu. A. Abdullina, I. Zakharova","doi":"10.24931/2413-9432-2021-10-3-23-31","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-3-23-31","url":null,"abstract":"This article analyzes domestic and foreign sources, regulatory documents of the Russian Federation, in order to determine the etiological factors of oral cancer, assess the statistical data on morbidity and mortality from malignant neoplasms of the maxillofacial region in the Penza region. The results of changing the routing, an interdisciplinary approach to treating patients with malignant neoplasms of the maxillofacial region in the Penza region are presented. The epidemiology, clinical manifestations, main diagnostic methods, routing, treatment and rehabilitation of patients with head and neck oncology are considered. The results of treatment of patients with oral cavity and lower lip cancer using photodynamic therapy (PDT), both alone and in combination with radiation and chemotherapy, are analyzed. The study showed that PDT of tumors of the lower lip and buccal mucosa in mono-mode made allowed achieving 100% efficiency. After the completed treatment, all participants in the experiment were provided with a complex of rehabilitation, including nutritional support, psychological assistance, exercise therapy, training in correct swallowing tactics, percutaneous endoscopic gastrostomy, and a course of oral cavity massage. An interdisciplinary approach to treating malignant neoplasms of the maxillofacial region is the most correct in modern practice.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42299743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Photodynamic therapy of the experimental tumors of different morphological types with liposomal boronated chlorin е6 硼氯化氢脂质体对不同形态肿瘤的光动力治疗

Biomedical Photonics Pub Date : 2021-10-28 DOI: 10.24931/2413-9432-2021-10-3-12-22

O. Abramova, V. V. Drozhzhina, T. P. Churikova, E. A. Kozlovtceva, L. Arkhipova, M. A. Kaplan, S. A. Ivanov, A. Kaprin

{"title":"Photodynamic therapy of the experimental tumors of different morphological types with liposomal boronated chlorin е6","authors":"O. Abramova, V. V. Drozhzhina, T. P. Churikova, E. A. Kozlovtceva, L. Arkhipova, M. A. Kaplan, S. A. Ivanov, A. Kaprin","doi":"10.24931/2413-9432-2021-10-3-12-22","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-3-12-22","url":null,"abstract":"The article summarizes the results of studies of the effectiveness of photodynamic therapy using a new domestic photosensitizer liposomal borated chlorin e6 (LBC) after its parenteral administration (intraperitoneal and intravenous). Antitumor efficacy was evaluated in rats with M-1 sarcoma and PC-1 alveolar liver cancer and mice with B16 melanoma and Ehrlich’s carcinoma, which were transplanted subcutaneously into the thigh area of the animals. The aim of the study was to determine the optimal regimes of photodynamic therapy that would allow achieving the maximum antitumor effect up to 21 days after the photodynamic therapy. The therapy was carried out under the control of the accumulation of the photosensitizer in the tumor and surrounding tissues of the thigh by selecting the doses of the drug and the parameters of laser radiation (energy density and power density). The effectiveness of therapy was assessed by the inhibition of tumor growth, by the percentage of animals with complete tumor regression, by the absolute growth rate in animals with continued tumor growth compared to controls. The results of our studies have shown that the domestic photosensitizer liposomal borated chlorin e6 has high antitumor activity in vivo. In an experimental study of the photosensitizer under certain PDT modes, the maximum antitumor effect (complete tumor regression in 100% of animals) was obtained up to 21 days after PDT in all tumor models used.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45140911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Photodynamic reparative skin regeneration using application of photosensitizer gel based on chlorin e6 氯e6光敏剂凝胶的光动力修复性皮肤再生

Biomedical Photonics Pub Date : 2021-10-28 DOI: 10.24931/2413-9432-2021-10-3-4-11

O. S. Panova, V. V. Dubensky, V. Petunina, M. A. Beimanova, E. A. Sanches, M. Gelfond, B. Shilov, R. Belkharoeva

{"title":"Photodynamic reparative skin regeneration using application of photosensitizer gel based on chlorin e6","authors":"O. S. Panova, V. V. Dubensky, V. Petunina, M. A. Beimanova, E. A. Sanches, M. Gelfond, B. Shilov, R. Belkharoeva","doi":"10.24931/2413-9432-2021-10-3-4-11","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-3-4-11","url":null,"abstract":"The results of a study of the clinical effectiveness of the correction of involutional changes in the skin by the method of photodynamic therapy (PDT) with the use of a photosensitizer gel (PS), the active substance of which is the trismeglumine salt of chlorin e6, are presented. The data of fluorescence spectroscopy for monitoring the level of PS fluorescence in order to determine the optimal time of its exposure are demonstrated. The study of the optimal exposure time involved 80 patients with different skin phototypes. The study of the effectiveness of PDT involved 42 patients aged 44–68 years with signs of chrono- and photoaging. The PDT procedure was performed by irradiating the entire surface treated with the PS with a power density of 100 mW/cm2, a light dose of 120–140 J/cm2, a laser radiation wavelength of 660 nm, and a light beam area of 400–800 cm2. It was found that exposure to PS for 10–20 min gives the highest fluorescence and does not depend on the skin phototype. The clinical effect of PDT was achieved in 85.7% of patients; there were no negative subjective sensations. Moisture metrics increased on the skin of the face by 53%, reaching the control values in young healthy volunteers, on the skin of the hands - by 64%. Elastometry indicators on the skin of the face and hands increased by 19% and 16%, respectively. Thus, the PDT procedure with PS based on chlorin e6 is an effective method for correcting involutional changes in the skin, leads to a pronounced clinical effect, improves the parameters of skin moisture measurement and elastometry, and passes without undesirable local reactions. Optical coherence tomography showed an increase in collagen ordering.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47382821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Photobiomodulation of acute pain syndrome after septoplasty 中隔成形术后急性疼痛综合征的光生物调节

Biomedical Photonics Pub Date : 2021-08-03 DOI: 10.24931/2413-9432-2021-10-2-34-41

I. Kastyro, Y. Romanko, G. Muradov, V. I. Popadyuk, I. K. Kalmykov, M. Kostyaeva, Y. Gushchina, S. Dragunova

{"title":"Photobiomodulation of acute pain syndrome after septoplasty","authors":"I. Kastyro, Y. Romanko, G. Muradov, V. I. Popadyuk, I. K. Kalmykov, M. Kostyaeva, Y. Gushchina, S. Dragunova","doi":"10.24931/2413-9432-2021-10-2-34-41","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-2-34-41","url":null,"abstract":"The paper evaluates the effectiveness of the use of therapeutic laser exposure (photobiomodulation therapy – PBMT) to minimize acute pain in the early postoperative period in patients after septoplasty. The study included two groups of patients. Patients of the first group (31 patients) underwent septoplasty with standard management in the postoperative period. Patients of the second group (31 patients) also underwent septoplasty, and then added PBMT to the standard measures of the postoperative period at 3, 6 and 24 h after septoplasty (λ = 0.890 μm, P = 10 W, 2 min) and then intranasally 48 h after septoplasty (λ = 0.630 μm, P = 8 W, 2 min). In patients of both groups, heart rate variability and pain were assessed using a visual analog scale within 48 hours after septoplasty. In patients of the second group, after the use of PBMT, the indicators of heart rate variability had a significantly lower total power, compared with patients of the first group. So, after PBMT, the ultra-low-frequency component of the spectral analysis of heart rate variability in the first group was 18580 ± 2067 ms2, which is significantly higher than in the second group (8086 ± 3003 ms2) (p <0.001). The low-frequency component of heart rate variability was also significantly higher in the first group (1871 ± 405 ms2) compared to the second (1095 ± 190 ms2) (p <0.005), which indicates an increase in the tension of the sympathetic part of the autonomic nervous system in the group without the use of PBMT. In the first 3 hours after surgery, the severity of pain between the groups did not differ significantly (p = 0.07). In the period from 6 to 24 hours after surgery, patients who did not undergo PBMT experienced significantly higher pain than patients with PBMT (p <0.001). Thus, in our study, the group of patients with PBMT showed better results in pain and heart rate variability compared to the classical rehabilitation of patients after septoplasty.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"68974738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Optimization of antibacterial therapy in patients with endo-periodontal lesions 牙周内病变患者抗菌治疗的优化

Biomedical Photonics Pub Date : 2021-04-18 DOI: 10.24931/2413-9432-2021-10-1-17-24

R. Saleev, S. L. Blashkova, E. Krikun, G. T. Saleeva, J. V. Blashkova, E. Valeeva

{"title":"Optimization of antibacterial therapy in patients with endo-periodontal lesions","authors":"R. Saleev, S. L. Blashkova, E. Krikun, G. T. Saleeva, J. V. Blashkova, E. Valeeva","doi":"10.24931/2413-9432-2021-10-1-17-24","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-1-17-24","url":null,"abstract":"To improve the quality and effectiveness of medical care for patients with inflammatory periodontal diseases, it is necessary to search for new approaches in both diagnosis and treatment. The aim of our study is to determine the effect of the diode laser on the pathogenic microflora of periodontal pockets and root canals in patients with endo-periodontal lesions (EPL). We carried out a comparative assessment of the bacterial contents of the root canals and periodontal pockets by polymerase chain reaction (PCR) before and after treatment with a diode laser (Doctor Smile Simpler, wavelength 980 nm) for 54 patients with EPL. The control group consisted of 56 patients who were treated according to the generally accepted method, including professional oral hygiene, endodontic treatment, and curettage of periodontal pockets. Evaluation criteria were a qualitative assessment of the content of periodontopathogens in the root canal and periodontal pocket before and after and treatment. As a result of our study, we found a statistically significant (p<0.01) reduction in the colonization of periodontal pockets and root canals in patients with EPL after laser decontamination. The high technological effectiveness of the methods used in combination with the low risk of complications at the stages of endodontic and periodontological treatment provides an antibacterial effect and reduces the duration of inflammation. The results of treatment of patients using a diode laser give reason to recommend their use in the dental practice.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43126675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimization of provision of specialized medical care for patients with maxillofacial neoplasms in the Penza region of Russia 俄罗斯奔萨地区颌面肿瘤患者专科医疗护理的优化

Biomedical Photonics Pub Date : 2021-04-18 DOI: 10.24931/2413-9432-2021-10-1-32-38

M. V. Lebedev, K. I. Kerimova

引用次数: 2

Antimicrobial and antimycotic photodynamic therapy (review of literature) 抗菌和抗真菌光动力疗法(文献综述)

Biomedical Photonics Pub Date : 2021-04-18 DOI: 10.24931/2413-9432-2021-10-1-25-31

D. Y. Semyonov, Y. Vasil'ev, S. Dydykin, E. F. Stranadko, V. Shubin, Y. Bogomazov, V. Morokhotov, A. N. Shcherbyuk, S. Morozov, Y. I. Zakharov

引用次数: 13

Preliminary investigation on performance of photodiode sensor as a dosimeter 光电二极管传感器用作剂量计性能的初步研究

Biomedical Photonics Pub Date : 2021-04-18 DOI: 10.24931/2413-9432-2021-10-1-4-10

Y. Radzi, N. Zulkafli, A. Omar

{"title":"Preliminary investigation on performance of photodiode sensor as a dosimeter","authors":"Y. Radzi, N. Zulkafli, A. Omar","doi":"10.24931/2413-9432-2021-10-1-4-10","DOIUrl":"https://doi.org/10.24931/2413-9432-2021-10-1-4-10","url":null,"abstract":"Radiation dosimetry in the health and medicine field is crucial to ensure there is no unnecessary ionizing radiation exposure to patients and personnel. While various types of semiconductor dosimeters are available, photodiode sensors are seen as a reliable and cost-effective immediate dosimeter. This study investigates the capabilities of a monolithic photodiode with an on-chip trans-impedance amplifier as a dosimeter in diagnostic radiology. A photodiode sensor covered with black insulation tape is irradiated with the diagnostic x-ray of potential in range between 40 to 90 kV with constant tube current-time product of 50 mAs at 60 cm source-to-detector distance (SDD). Exposures of different tube current at the range of 10 to 250 mA with a constant tube voltage of 70 kVp at the same setup are made. The photodiode sensor connected to the electrometer gives out readings in the millivolt (mV), and the output of the photodiode and semiconductor detector is recorded. The photodiode’s energy dependency, reproducibility, dose response, and distance dependency were evaluated as the capabilities of the photodiode to be used as a dosimeter. For energy dependency, it shows a linearity of 0.9458, while the response to increasing tube current with a constant tube voltage shows the R2 of 0.912. The photodiode shows good dependency on the tube voltage and tube current. Other than that, it also showed a linear coefficient of 0.5138 for distance dependence which is considered as a good linearity fit value for a photodiode as initial performance. However, its reproducibility is poor due to its large capacitance. This monolithic photodiode with an on-chip trans-impedance amplifier has demonstrated good results for energy dependency but poor results for reproducibility. However, the photodiode can be improvised in the future to ensure it is suitable as a dosimeter.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44634928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Antimicrobial photodynamic therapy in voice rehabilitation of patients after laryngectomy 抗菌光动力疗法在喉切除术后语音康复中的应用

Biomedical Photonics Pub Date : 2021-04-18 DOI: 10.24931/2413-9432-2021-10-1-11-16

S. Shinkarev, S. V. Boldyrev, A. P. Zagadaev, V. Podolsky, V. Borisov, Y. I. Kostyushina

引用次数: 3

Photodynamic therapy in the treatment of intraepithelial neoplasia of the cervix, vulva and vagina 光动力疗法治疗宫颈、外阴及阴道上皮内瘤变

Biomedical Photonics Pub Date : 2021-02-04 DOI: 10.24931/2413-9432-2020-9-4-31-39

E. Filonenko, O. Trushina, E. Novikova, N. V. Zarochentseva, O. Rovinskaya, V. Ivanova-Radkevich, A. Kaprin

引用次数: 4