Biomedical Photonics最新文献_第4页

Photodynamic therapy in the treatment of extramammary paget’s disease 光动力疗法治疗乳腺外佩吉特病

Biomedical Photonics Pub Date : 2022-11-15 DOI: 10.24931/2413-9432-2022-11-3-24-34

E. Filonenko, V. Ivanova-Radkevich

引用次数: 5

Correlation of spectroscopic and structural properties of indocyanine green j-aggregates 吲哚菁绿j聚集体的光谱与结构特性的相关性

Biomedical Photonics Pub Date : 2022-11-15 DOI: 10.24931/2413-9432-2022-11-3-4-16

D. Farrakhova, I. Romanishkin, D. Yakovlev, Yuliya Maklygina, V. Oleinikov, P. Fedotov, M. V. Kravchik, L. Bezdetnaya, V. Loschenov

{"title":"Correlation of spectroscopic and structural properties of indocyanine green j-aggregates","authors":"D. Farrakhova, I. Romanishkin, D. Yakovlev, Yuliya Maklygina, V. Oleinikov, P. Fedotov, M. V. Kravchik, L. Bezdetnaya, V. Loschenov","doi":"10.24931/2413-9432-2022-11-3-4-16","DOIUrl":"https://doi.org/10.24931/2413-9432-2022-11-3-4-16","url":null,"abstract":"Indocyanine green (ICG), when in free form in a liquid, can form stable nanoparticle structures or colloidal solution, while changing its spectroscopic properties. In the work, the aggregation degree and the average size of nanoparticles depending on the concentration of a colloidal solution of indocyanine green (ICG NPs) in the form of J-aggregates were investigated by various methods based on light scattering. The size of nanoparticles is an important parameter from the point of view of clinical application, because the technique of intravenous administration of drugs, in order to avoid microvascular thrombosis and embolism, provides dosage forms with inclusions of individual molecules or their clusters, not exceeding 500 nm diameter. In turn, small nanoparticles less than 30 nm lead to prolonged circulation of the drug in the body with an increased possibility of permeation into cells of healthy tissue. In the course of studies, it was found that an increase in the concentration of ICG NPs in the solution leads to an increase in the average size of spontaneously formed J-aggregates, which, in turn, leads to a decrease in the absorption coefficient in the aggregates. Presumably, this phenomenon, i.e. the established nonlinear dependence of the J-aggregate absorption on its size, can be explained by the formation of absorption centers on the J-aggregate surface in the form of mobile surface molecules. The threshold range of ICG molecule concentration was determined, at which there is a transition from aggregation with an increase in size with a slow addition of ICG J-aggregate molecules in height to a rapid addition in width.","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43535180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photodynamic therapy in a patient with hpv-associated lsil of the cervice (clinical case) 光动力疗法治疗一例hpv相关宫颈lsil患者（临床病例）

Biomedical Photonics Pub Date : 2022-11-15 DOI: 10.24931/2413-9432-2022-11-3-40-44

E. Filonenko, N. I. Grigoryevykh, A. Kaprin

引用次数: 0

Photodynamic therapy of primary and recurrent forms of weakly pigment choroidal melanoma 光动力疗法治疗原发性和复发性弱色素性脉络膜黑色素瘤

Biomedical Photonics Pub Date : 2022-11-15 DOI: 10.24931/2413-9432-2022-11-3-17-23

K. Zhyliayeva, P. Demeshko, L. V. Navumenka, S. Krasny, D. Tzerkovsky, I. Zherko

{"title":"Photodynamic therapy of primary and recurrent forms of weakly pigment choroidal melanoma","authors":"K. Zhyliayeva, P. Demeshko, L. V. Navumenka, S. Krasny, D. Tzerkovsky, I. Zherko","doi":"10.24931/2413-9432-2022-11-3-17-23","DOIUrl":"https://doi.org/10.24931/2413-9432-2022-11-3-17-23","url":null,"abstract":"Treatment of poorly-pigmented tumors of small sizes can be carried out using photodynamic therapy (PDT). The material for the analysis was data on 112 patients. We used data from the Belarusian Cancer Registry, medical records of patients with clinically diagnosed choroid melanoma (C69.3 according to ICD-10) for the period 2013–2021. The size and level of blood flow in the tumors were assessed using an ultrasound machine with a doppler attachment. PDT was carried out using a «UPL PDT» semiconductor laser (Lemt, Republic of Belarus, λ=661 nm) with a light spot diameter of 1 to 3 mm for 60 s per field with a light dose of 50 J/cm2. The entire surface of the tumor was exposed to the action, with the fields “tiled”, from the periphery to the top of the tumor, with overlapping fields. Tumor pigmentation was assessed visually. To evaluate the treatment outcome, the general group of patients was divided into three subgroups according to thickness and basal diameter. Group I – 40 (35.7%) patients, with an average tumor thickness of 1.4±0.2 mm, basal diameter – 5.8±1.5 mm. II – 51 (45.5%) patients, with an average tumor thickness of 2.3 ± 0.3 mm, basal diameter – 7.9 ± 1.5 mm. III – 21 (18.8%) patients. The mean value of the tumor thickness was 3.8±0.4 mm, the basal diameter was 9.8±1.4 mm. After PDT in the general group (n=112), 29 (25.9%) patients had complete tumor resorption, and 83 (74.1%) patients had stabilization. The eyeball was saved in 107 (95.5%) patients. Continued growth and relapse were recorded in 34 patients: 25 (22.3%) and 9 (8.0%), respectively. In 29 (85.3%) patients, the eyeball was preserved after treatment of relapse and continued growth. 5 (4.5%) enucleations were performed. Adjusted one-year cumulative survival was 100%, 3-year and 5-year 95.8±2.4%, 93.7±3.1%, respectively","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43686812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Study of acute toxicity of monocationic chlorin e6 derivative, a perspective photosensitizer for antimicrobial and antitumor photodynamic therapy 一种有前景的抗菌和抗肿瘤光动力光敏剂——单氯e6衍生物的急性毒性研究

Biomedical Photonics Pub Date : 2022-07-27 DOI: 10.24931/2413-9432-2022-11-2-23-32

N. Y. Zhidomorov, O. A. Nazarenko, V. Demidov, A. Kustov, N. V. Kukushkina, O. Koifman, A. K. Gagua, I. Tomilova, D. B. Berezin

引用次数: 3

Opportunities of using oral intraluminal laser lithotripsy for a large calculus of the common bile duct (clinical report) 口腔腔内激光碎石术治疗胆总管大结石的机会（临床报告）

Biomedical Photonics Pub Date : 2022-07-27 DOI: 10.24931/2413-9432-2022-11-2-33-38

Y. Ivanov, D. Sazonov, A. Smirnov, A. Mamoshin, A. Baranov, D. N. Panchenkov

引用次数: 0

Cancer cell survival model after photodynamic therapy 光动力治疗后癌细胞存活模型

Biomedical Photonics Pub Date : 2022-07-26 DOI: 10.24931/2413-9432-2022-11-2-4-11

L. Karami-Gadallo, M. Pouladian

引用次数: 1

Application of biophantomes to evaluate the thermal effects of laser radiation with wavelengths of 970 nm and 1560 nm under different exposure modes 生物膜在评估不同曝光模式下波长970nm和1560nm激光辐射热效应中的应用

Biomedical Photonics Pub Date : 2022-07-26 DOI: 10.24931/2413-9432-2022-11-2-12-22

O. V. Ostreiko, M. Galkin, G. Papayan, T. Grishacheva, N. Petrishchev

引用次数: 0

Photodynamic therapy in the treatment of patients with mycosis fungoides 光动力疗法治疗蕈样肉芽肿

Biomedical Photonics Pub Date : 2022-05-25 DOI: 10.24931/2413-9432-2022-11-1-27-37

E. Filonenko, V. Ivanova-Radkevich

引用次数: 5

Actinic keratosis (review of literature) 光化性角化病(文献回顾)

Biomedical Photonics Pub Date : 2022-05-25 DOI: 10.24931/2413-9432-2022-11-1-37-48

E. Filonenko, S. S. Okushko

{"title":"Actinic keratosis (review of literature)","authors":"E. Filonenko, S. S. Okushko","doi":"10.24931/2413-9432-2022-11-1-37-48","DOIUrl":"https://doi.org/10.24931/2413-9432-2022-11-1-37-48","url":null,"abstract":"Actinic keratosis is an important medical and social problem, the correct diagnosis and treatment of which will help to avoid the development of invasive forms of cutaneous squamous cell carcinoma. With the further development of the early diagnosis of cancer, including skin cancer, the increase in human life expectancy, and the popularization of travel to exotic countries, the number of cases of actinic keratosis among the population will continue to grow. In this regard, it is important to discuss the causes and pathogenesis of the disease, the varied clinical picture of the disease, methods of non-invasive diagnostics, as well as methods of treatment, of which there are a great many in the treatment of actinic keratosis today. However, each of the methods has both advantages and disadvantages, and in the global trend towards a personalized approach to treatment, it is important to choose from the standpoint of evidence-based medicine the most suitable for each individual patient. Moreover, after treatment of actinic keratosis, relapses often occur, which are the result of insufficient diagnosis and the development of incorrect treatment tactics. The review article provides the clinical picture of actinic keratosis, diagnostic and therapeutic methods, and their comparison with each other in terms of efficacy and safety","PeriodicalId":37713,"journal":{"name":"Biomedical Photonics","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43480991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1