Revista Colombiana de Reumatologia最新文献

{"title":"Efecto protector de propóleo frente al daño oxidativo inducido con peróxido de hidrógeno en células mononucleares de sangre periférica cultivadas in vitro mediante conteo celular","authors":"Luz Elena Triana Vidal,&nbsp;Armando Lucumi Moreno,&nbsp;Ivonne Valeria Ortiz","doi":"10.1016/j.rcreu.2024.05.003","DOIUrl":"10.1016/j.rcreu.2024.05.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Oxidative stress occurs when there is an imbalance between the production of reactive oxygen species (ROS) and cellular antioxidant activity. Overproduction of ROS causes oxidative damage to major macromolecules, alters homeostasis and leads to the generation of different pathologies. At present, there is no totally effective treatment to counteract these diseases involved with oxidative stress, so it is necessary to investigate new treatment alternatives that suppress the ROS generated. One promising alternative is the use of plant extracts, which have demonstrated a potent antioxidant effect. Efficient cells for the study of pathological diseases related to reactive oxygen species are T<!--> <!-->lymphocytes, which share systems with neurons such as: the dopaminergic system, death signaling and survival. In vitro lymphocytes are an optimal model for the evaluation of oxidative mechanisms.</div></div><div><h3>Objective</h3><div>To determine the protective effect of ethanolic extract of propolis against oxidative damage induced by hydrogen peroxide (H₂O₂) in human lymphocytes in vitro, by means of the cell viability test with trypan blue.</div></div><div><h3>Results</h3><div>Anova test shows that the concentrations of 0.0225 and 0.045<!--> <!-->mg/mL of ethanolic extract of propolis, present protective activity against cell damage caused by H₂O₂.</div></div><div><h3>Conclusion</h3><div>This study proposes the ethanolic extract of propolis as a potential pharmacological, useful for treatments against autoimmune disorders.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 315-320"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimación de la calidad de vida en pacientes hospitalizados con lupus eritematoso sistémico en una institución de tercer nivel en Colombia","authors":"Ana Ospina-Caicedo ,&nbsp;Beatriz Eugenia Bastidas Sánchez ,&nbsp;Daniel Camilo Bastidas Burbano ,&nbsp;Andrea Milena Villota Enríquez ,&nbsp;María Fernanda Muñoz Rivera ,&nbsp;Cristian Alfonso Campo Guzmán","doi":"10.1016/j.rcreu.2024.06.001","DOIUrl":"10.1016/j.rcreu.2024.06.001","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) is a chronic and systemic autoimmune disease, to which high morbidity and mortality are attributed that affect quality of life.</div></div><div><h3>Objective</h3><div>To estimate the quality of life of patients hospitalized with SLE in a tertiary institution in Colombia.</div></div><div><h3>Materials and methods</h3><div>Descriptive, observational cross-sectional design of patients with SLE, hospitalized between July 2022 and January 2023, to whom an instrument that included the SF-36 quality of life scale was applied.</div></div><div><h3>Results</h3><div>Forty-four patients were included, with an average age of 37 years, 88.6% women. The main cause of hospitalization was disease activity at 61.3%. The physical role was the most affected with an average of 23.5 points and 78.9% of the participants had deterioration in physical functioning, especially among women, mixed race, with more than one year from diagnosis and independently of the manifestations of the disease. The dimension of health change and social role were especially affected in patients with moderate to high activity, and the use of glucocorticoids was related to this negative impact on health change.</div></div><div><h3>Conclusion</h3><div>It is necessary to study the quality of life in hospitalized patients with SLE for a comprehensive approach to treatment, taking into account that physical role and functioning are the dimensions most affected globally, and that the health change and social role dimensions are the most affected in those with moderate to high disease activity.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 335-343"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Costo de atención hospitalaria en pacientes con lupus eritematoso sistémico en un hospital de alta complejidad en Colombia","authors":"Juan Camilo Pérez-Correa ,&nbsp;Darwin Jhoan Ariza-Rodríguez ,&nbsp;María Claudia Díaz-Jiménez ,&nbsp;Daniel G. Fernández-Ávila ,&nbsp;Juan Martín Gutiérrez ,&nbsp;Diego Rosselli","doi":"10.1016/j.rcreu.2024.06.002","DOIUrl":"10.1016/j.rcreu.2024.06.002","url":null,"abstract":"<div><h3>Introduction</h3><div>Systemic lupus erythematosus (SLE) entails high direct medical costs, derived from the complexity of diagnosis, treatment, and management of associated complications. In Colombia, there are studies on direct outpatient medical costs, and hospital studies are scarce.</div></div><div><h3>Objective</h3><div>The present study describes the direct medical costs derived from hospital care in a high complexity hospital in Bogotá.</div></div><div><h3>Materials and methods</h3><div>Observational, retrospective, partial economic study. A descriptive analysis of the direct medical costs of caring for hospitalized patients with SLE was performed. The data was obtained by reviewing medical records between January and December 2019; Cost data were taken from the amounts billed by the hospital. Costs in Colombian pesos were expressed in dollars.</div></div><div><h3>Results</h3><div>Costs of 68 patients and 100 hospitalizations were analysed. The mean age was 39 years<!--> <!-->±<!--> <!-->12.4. The mean hospital stay was 6.8 days<!--> <!-->±<!--> <!-->6.1. Total direct medical costs were 267,980 USD with a median per hospitalization of 1,622 USD. Non-surgical procedures represented 64% of the costs (170,708 USD), drugs 25% (67,494 USD), medical supplies and procedures 9% (24,936 USD), and 2% (4,842 USD) respectively.</div></div><div><h3>Conclusion</h3><div>Hospitalizations of patients with SLE entail high direct medical costs, which do not differ significantly from hospital costs in other countries. Non-surgical procedures and drugs accounted for the largest share of these costs, followed by supplies and surgical procedures.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 344-350"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Uso de cucharas con mango engrosado en la mejora del desempeño para la alimentación en pacientes con artritis reumatoide","authors":"Kaori Mitchell Gil-Rivasplata,&nbsp;Valeria Katiuska Rojas-Del Aguila,&nbsp;Carlos Manuel Escobar-Galindo,&nbsp;Jesús Martin Trinidad-López","doi":"10.1016/j.rcreu.2024.07.004","DOIUrl":"10.1016/j.rcreu.2024.07.004","url":null,"abstract":"<div><h3>Introduction/objective</h3><div>Rheumatoid arthritis (RA) primarily affects the hand joints, limiting independence for feeding and requiring the use of assistive technology. The thickening of the handles on the spoon is used as a treatment strategy. However, few studies address how much it helps in RA. Therefore, the study aimed to determine the effect of the use of thickened handle spoons on time, performance quality, and perceived hand effort in the improvement of feeding in users simulating RA with restricted han</div><div>d movements.</div></div><div><h3>Materials and methods</h3><div>A quasi-experimental design was used in which RA was simulated with a simulator glove, comparing feeding experiences with regular spoons.</div></div><div><h3>Results</h3><div>Using spoons with thickened handles had statistically significant effects on the reduction of perceived effort when eating different foods (p<!--> <!-->=<!--> <!-->.005); however, there was no significant difference between the number of times food was dropped and the time to complete the activity (p<!--> <!-->=<!--> <!-->.78).</div></div><div><h3>Conclusions</h3><div>Spoons with thickened handles reduce the level of perceived effort, which allows for better joint protection and pain management. It also equals the time and efficiency of eating with a conventional spoon.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 351-358"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Análisis de las desigualdades y modelo de corrección del método de Goh usado en la cuantificación de la enfermedad pulmonar intersticial","authors":"Luis Javier Cajas Santana ,&nbsp;Daniela Rojas Carvajal ,&nbsp;Wendy Torres Chazatar ,&nbsp;Laura Mendoza Galindo ,&nbsp;Yensi Romero Díaz ,&nbsp;Daniel Ramírez Muñoz ,&nbsp;Gisella Fernández Salamanca","doi":"10.1016/j.rcreu.2024.05.006","DOIUrl":"10.1016/j.rcreu.2024.05.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Interstitial lung disease is a significant complication in autoimmune diseases. The extent of involvement is crucial in determining both onset and treatment response. While there are computational methods for this calculation, manual methods, such as the Goh method, remain the most commonly used. However, it has some disadvantages, such as presuming that areas across the lung are equivalent and thus influence the calculation equally. The aim of this study is to analyse these difficulties and find a mathematical correction method.</div></div><div><h3>Materials and Methods</h3><div>High-resolution chest tomography images were obtained from patients with and without ILD. Pulmonary areas were analysed and compared in the slices referenced in the Goh method. Through geometric analysis of lung structure, the slice closest to the average of its areas was identified for comparison with other measurements. Based on this, a correction equation was formulated, and through simulation of various interstitial involvement patterns, the degree of variation was determined.</div></div><div><h3>Results</h3><div>Images from 80 patients were analysed, mostly women diagnosed with systemic sclerosis. It was found that apical areas (slices 1 and 2) and the sum of left-sided pulmonary areas were 20% smaller compared to basal and right-sided areas, respectively. Simulation with different involvement components found that apical or left-sided disease overestimates extension by 5% to 10%, especially when it exceeds 15%. The third slice was determined to be closest to the average of the areas, and a correction formula was devised based on this.</div></div><div><h3>Conclusions</h3><div>The Goh method incorrectly assumes the equivalence of pulmonary areas, which can impact calculations. We propose a mathematical correction for this purpose.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 328-334"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145289600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristic and outcomes of psoriasis patients in a multicentre outpatient healthcare institution in Colombia","authors":"Julio Roberto Amador ,&nbsp;Carolina Becerra-Arias ,&nbsp;Wilmer Gerardo Rojas-Zuleta ,&nbsp;Juan Raul Castro-Ayarza ,&nbsp;Manuel Franco ,&nbsp;Mario Barbosa-Rengifo ,&nbsp;Jorge Donado-Gómez ,&nbsp;Natalia Duque-Zapata","doi":"10.1016/j.rcreu.2024.04.008","DOIUrl":"10.1016/j.rcreu.2024.04.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Psoriasis is a chronic inflammatory disease characterized by scaly erythematous plaques, systemic inflammation, and an elevated cardiovascular risk. Due to its complexity in treatment and the frequent occurrence of comorbidities, characterizing patients diagnosed with psoriasis enrolled in care programmes becomes paramount for enhancing health outcomes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To provide a comprehensive description of the sociodemographic, clinical features, and outcomes of a cohort of patients diagnosed with psoriasis in a multicentre outpatient healthcare institution in Colombia.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Materials and methods&lt;/h3&gt;&lt;div&gt;A cohort study was conducted involving patients diagnosed with psoriasis. Inclusion criteria required a minimum follow-up duration of three months. Quantitative variables were summarized using the median and interquartile range, while qualitative variables were presented with measures of frequency and 95% confidence interval. Changes in the final values of PASI&lt;span&gt;, DLQI&lt;span&gt;, NAPSI&lt;span&gt;, and BSA from baselines were assessed through percentage comparisons, analysed using chi-square test.&lt;/span&gt;&lt;/span&gt;&lt;/span&gt;&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 1155 patients were included, with a median age of 53 years and the majority were men (58%). Plaque psoriasis was the predominant type, observed in 78.7%. Psoriatic arthritis was diagnosed in 18.9%. The most prevalent comorbidity was hypertension, identified in 23.0% (95% CI 20.6 to 25.6%), followed by diabetes at 12.5% (95% CI 10.6 to 14.5%) and cardiovascular disease at 10.6%. A significant proportion of patients were classified as overweight and obese, 43.9% (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;479) and 20.9% (n&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;228), respectively. Regarding treatment modalities, the majority received biological therapies (39%), followed by systemic therapy (22.2%), and topical therapy (17.5%).&lt;/div&gt;&lt;div&gt;During the follow-up period, a considerable percentage of patients experienced some decrease in disease activity. A PASI75 response was achieved by 28.5% (95% CI 25.4% to 31.8%), and PASI90% was achieved by 18% (95% CI 15.4% to 20.9%). A bivariate analysis based on Body Mass Index showed a lower response in patients with overweight or obesity, thought these differences were not statistically significant (p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.937). Notably, a higher percentage of patients with no response were observed among those with hypertension (62.9% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.123), diabetes mellitus (64.7% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.393), cardiovascular disease (51.5% p&lt;&lt;!--&gt; &lt;!--&gt;.001), and chronic kidney disease (55.6% p&lt;!--&gt; &lt;!--&gt;=&lt;!--&gt; &lt;!--&gt;.014) when compared with patients who achieved therapeutic goals.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusions&lt;/h3&gt;&lt;div&gt;We present the largest psoriasis cohort in Colombia. A majority of our patients showed improvement in disease activity based on clinimetric measures. Nevertheless, the presence of comorb","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 301-308"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hacia una cuantificación más precisa de la fibrosis pulmonar en esclerodermia: reflexiones sobre el método de Goh y su corrección geométrica","authors":"Bibiana Andrea Pinzón Valderrama","doi":"10.1016/j.rcreu.2025.08.001","DOIUrl":"10.1016/j.rcreu.2025.08.001","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages 299-300"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comite Editorial online","authors":"","doi":"10.1016/S0121-8123(25)00047-7","DOIUrl":"10.1016/S0121-8123(25)00047-7","url":null,"abstract":"","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 4","pages":"Pages E1-E3"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145290107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"History of 50 years of the Rheumatology Service of Universidad Nacional de Colombia: The first in Colombia and a pioneer in Latin America","authors":"Yimy F. Medina,&nbsp;Antonio Iglesias Gamarra","doi":"10.1016/j.rcreu.2024.09.003","DOIUrl":"10.1016/j.rcreu.2024.09.003","url":null,"abstract":"<div><h3>Introduction</h3><div>The Rheumatology Unit of the National University of Colombia (UNAL) has a history spanning over half a century, producing many prominent rheumatologists. This article provides a description of its history to understand its trajectory, historical context, challenges, achievements, and contributions.</div></div><div><h3>Reflections</h3><div>In 1960, the Rheumatology Section at UNAL was officially approved, founded by professors Mario Peña, Humberto Lizarazo, and Fernando Chalem. In 1962, Drs. Peña, Chalem, and Lizarazo established the Rheumatology Service at San Juan de Dios Hospital. In 1963, the outpatient clinic for rheumatic patients began operating at the same hospital. Dr. Enrique Clavijo Acero became the first rheumatologist qualified through a Colombian university in 1971. By 1973, various specialty programmes at UNAL, including rheumatology, were officially approved, and the Rheumatology Unit was elevated to the status of a section.</div></div><div><h3>Discussion</h3><div>For more than 50 years, the Rheumatology Unit has trained medical students and specialists, who have played a critical role in the field. It remains a vital part of rheumatology both in Colombia and the region.</div></div><div><h3>Conclusion</h3><div>The Rheumatology Unit at the National University of Colombia, as the first academic institution in this field within the country, celebrates over 60 years of activity and 50 years of official recognition. It has achieved numerous milestones and has been a pioneering force in rheumatology.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 3","pages":"Pages 276-285"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"De la inmunosupresión a la autoinmunidad: vasculitis ANCA-PR3+ en una paciente inmunosuprimida por trasplante hepático. Reporte de un caso","authors":"Oscar Vicente Vergara Serpa ,&nbsp;Carlos Jaime Velásquez-Franco ,&nbsp;Luis Fernando Pinto ,&nbsp;Neil Smith Pertuz Charris ,&nbsp;Andrés Felipe Echeverri García ,&nbsp;Alejandro Cardona Palacio ,&nbsp;Javier Darío Márquez Hernández","doi":"10.1016/j.rcreu.2024.05.005","DOIUrl":"10.1016/j.rcreu.2024.05.005","url":null,"abstract":"<div><h3>Objective</h3><div>To present the case of an immunosuppressed patient who developed an autoimmune disease.</div></div><div><h3>Patients and methods</h3><div>30-year-old woman, immunosuppressed due to a history of orthotopic liver transplant, who developed intestinal infection by cytomegalovirus and alveolar haemorrhage.</div></div><div><h3>Results</h3><div>Patient presented a positive serological finding for PR3 ANCA, classified as granulomatosis with polyangiitis. Due to her history, induction, and maintenance with an anti-CD20 were considered, with no further relapse over 6-month follow-up.</div></div><div><h3>Conclusion</h3><div>Immunosuppressed patients have risk factors for developing autoimmune diseases.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"32 3","pages":"Pages 286-293"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144623429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}