Revista Colombiana de Reumatologia最新文献

{"title":"Guía de Práctica Clínica multidisciplinaria para la osteoporosis en Colombia: recomendaciones basadas en la evidencia y adaptadas al contexto nacional","authors":"Geraldine Altamar-Canales ,&nbsp;Daniel G. Fernández-Ávila ,&nbsp;Miguel Ángel González-Reyes ,&nbsp;Francisco Bernardo Linares-Restrepo ,&nbsp;Adriana Medina-Orjuela ,&nbsp;Francisco Oscar Fernando Rosero-Olarte ,&nbsp;Javier Armando Velásquez-Mendoza ,&nbsp;Ximena Castro-Flórez ,&nbsp;Edgar Eduardo Castro-Osorio ,&nbsp;Monique Chalem ,&nbsp;Carlos Augusto Pérez-Niño ,&nbsp;Ariana Margarita Sierra-Osorio ,&nbsp;Regulo Andrés Vidal-Barragán ,&nbsp;Susan Martínez ,&nbsp;Linda Ibatá","doi":"10.1016/j.rcreu.2025.504840","DOIUrl":"10.1016/j.rcreu.2025.504840","url":null,"abstract":"<div><h3>Introduction</h3><div>Osteoporosis is a skeletal disease characterized by low bone mineral density and deterioration of bone microarchitecture, which increases the risk of fractures. Between 2012 and 2018, 249,803 cases of osteoporosis were reported in individuals over 50 years of age in Colombia, with the incidence of fragility fractures doubling between 2015 and 2019. Despite its clinical and economic impact, over 80% of patients do not receive adequate treatment.</div></div><div><h3>Objective</h3><div>To develop an evidence-based clinical practice guideline (CPG) to improve the diagnosis, treatment, and follow-up of osteoporosis in Colombia, in order to patient care and the use of healthcare resources.</div></div><div><h3>Methods</h3><div>A multidisciplinary panel was assembled, including clinical specialists, guideline development experts, and patient representatives. Systematic reviews were conducted using electronic databases to build the evidence base, with methodological quality and certainty of evidence assessed using the GRADE approach. The evidence-to-decision framework was used to formulate 32 recommendations and 14 good practice points.</div></div><div><h3>Results</h3><div>The recommendations include diagnosis by bone densitometry and FRAX®, non-pharmacological treatment involving adequate nutrition, vitamin D, dietary and supplemental calcium as required, exercise, and fall prevention. These interventions are integrated with pharmacological treatment, which is selected based on fracture risk and the need for sequential therapy with bisphosphonates, denosumab, or osteoanabolic agents. The importance of a multidisciplinary approach, therapeutic adherence, and implementing fracture liaison services is emphasized.</div></div><div><h3>Conclusions</h3><div>Osteoporosis is an underdiagnosed and undertreated public health issue in Colombia. Implementing this CPG will help improve detection, optimize treatment, and reduce the associated disease burden.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 2","pages":"Article 504840"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Percepciones de mujeres con fibromialgia en España sobre el impacto de la pandemia de COVID-19 en su salud","authors":"Daniel Sanjuán-Sánchez ,&nbsp;Cristina Bravo ,&nbsp;Carolina Climent-Sanz ,&nbsp;Francesc Rubí-Carnacea ,&nbsp;Erica Briones-Vozmediano","doi":"10.1016/j.rcreu.2025.03.005","DOIUrl":"10.1016/j.rcreu.2025.03.005","url":null,"abstract":"<div><h3>Introduction</h3><div>The COVID-19 pandemic significantly affected individuals with chronic pain, leading to increased pain severity, reduced functionality, compromised mental health, and a decline in overall quality of life.</div></div><div><h3>Objective</h3><div>To explore the perceived impact of the pandemic on women with fibromyalgia, including their physical and mental health, physical activity and exercise, employment status, and access to and quality of healthcare services.</div></div><div><h3>Methodology</h3><div>Eleven women with fibromyalgia were recruited using snowball sampling. Semi-structured, in-depth interviews were conducted, and an inductive thematic analysis was implemented following Braun and Clarke.</div></div><div><h3>Results</h3><div>Five main themes emerged: 1)<!--> <!-->impact of the pandemic and lockdown on physical symptoms; 2)<!--> <!-->impact of lockdown on mental health; 3)<!--> <!-->physical activity and exercise during lockdown; 4)<!--> <!-->influence of work-related changes, and 5)<!--> <!-->experiences with healthcare services. Participants reported increased pain and stiffness due to immobility. Negative emotions, exacerbated by social isolation and uncertainty, were predominant. Telephone contact with loved ones was identified as a protective factor. Participants expressed a sense of abandonment, highlighting difficulties in accessing healthcare services, while the empathy of healthcare professionals was crucial in alleviating this feeling.</div></div><div><h3>Conclusion</h3><div>The findings underscore the importance of addressing mental health in this population during periods of social isolation, promoting physical activity and exercise, maintaining active employment, and ensuring healthcare services are tailored to their needs.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 2","pages":"Article 102181"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754198","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integración de las enfermedades huérfanas/raras (EHR) en los planes locales/territoriales de salud de Colombia: revisión sistemática exploratoria","authors":"Diego Andrés Vásquez Lesmes ,&nbsp;Lina María Acero Ruge ,&nbsp;Erwin Hernando Hernández Rincón ,&nbsp;Lina Paola Avella Pérez","doi":"10.1016/j.rcreu.2026.504862","DOIUrl":"10.1016/j.rcreu.2026.504862","url":null,"abstract":"<div><h3>Introduction</h3><div>Orphans/Rare diseases (ORD) in Colombia have a prevalence of 1 per 5000 persons. Globally, public policies have shown inefficacy. International efforts to raise awareness for these patients have progressed, but challenges persist in integrating them into local and territorial health plans in Colombia. Overcoming barriers in healthcare delivery and assessing the need for structural reforms are crucial.</div></div><div><h3>Objective</h3><div>To synthesize available evidence on the integration of ORD into local/territorial health plans in Colombia, providing a comprehensive view of the Colombian healthcare system in the global context.</div></div><div><h3>Methods</h3><div>An exploratory systematic review, known as a “Scoping Review,” was conducted in PubMed, Embase, Scopus, and grey literature from 2009 to 2024; 49 documents were selected for analysis.</div></div><div><h3>Results</h3><div>Of the evidence found, 20.5% (n<!--> <!-->=<!--> <!-->10) were primary studies, highlighting global public policies, and 79.5% (n<!--> <!-->=<!--> <!-->39) comprised grey literature; (n<!--> <!-->=<!--> <!-->8) discussed access barriers, health models, (n<!--> <!-->=<!--> <!-->31) addressed public policies with Colombian intervention pillars, and only (n<!--> <!-->=<!--> <!-->6) included local and territorial health plans in Colombia.</div></div><div><h3>Conclusions</h3><div>The information gathered shows that ORD pose significant challenges to healthcare systems due to their low prevalence and the lack of specific research and treatment. Despite regulatory efforts in Colombia, a comprehensive and coordinated approach is needed to effectively address these conditions.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 2","pages":"Article 504862"},"PeriodicalIF":0.0,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enfermedad relacionada con los implantes mamarios de silicona o síndrome de ASIA relacionado con los implantes mamarios: consenso de expertos","authors":"Andrés A. Hormaza-Jaramillo ,&nbsp;Damaris Romero Chamorro ,&nbsp;Yeison Santamaría Alza ,&nbsp;Alejandro Duque Restrepo ,&nbsp;David Enrique Guarín Sastre ,&nbsp;Jaime Eduardo Pachón Suárez ,&nbsp;María Isabel Cadena Ríos ,&nbsp;Diana Rocío Gil Calderón ,&nbsp;Daniel G. Fernández-Ávila ,&nbsp;Felipe Mesa Betancur ,&nbsp;Gloria María Vásquez D. ,&nbsp;Héctor Ernesto Barbosa Landínez ,&nbsp;Adriana Rojas-Villarraga","doi":"10.1016/j.rcreu.2025.04.004","DOIUrl":"10.1016/j.rcreu.2025.04.004","url":null,"abstract":"<div><h3>Introduction</h3><div>Breast augmentation surgeries are very common, but in recent years there has been a growing interest in their possible relationship with the appearance of nonspecific symptoms and signs, as well as the development of autoimmune disorders. The lack of a consensus about the syndrome is a controversial issue for the scientific community and generates uncertainty among women with breast implants in Colombia.</div></div><div><h3>Objective</h3><div>To provide guidelines for the evaluation, approach, and follow-up of silicone breast implant-related disease, or ASIA syndrome, based on evidence and clinical expert opinion.</div></div><div><h3>Methods</h3><div>Experts from the Colombian Society of Rheumatology and the Colombian Society of Plastic Surgery and an independent methodological team developed a systematic literature review and consensus using a modified Delphi method.</div></div><div><h3>Results</h3><div>The evidence for an association between silicone breast implants and the development of symptoms, autoimmune or rheumatic diseases is limited, and a definitive causal relationship has not been demonstrated. The low certainty of the evidence is due to bias, study heterogeneity, and non-specific, self-reported symptoms. On this basis, 22 consensus statements were formulated, highlighting the importance of an individualized medical approach, comprehensive evaluation, and effective communication with patients about risks and expectations before implantation and explantation procedures.</div></div><div><h3>Conclusions</h3><div>Evaluation and therapeutic decisions in women with suspected silicone implant-associated disease should be based on available scientific evidence. Future research should explore the causality of the syndrome and improve disease characterization.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102186"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfil de uso y costo de la atención en osteoartrosis de rodilla","authors":"Erick Baltazar Pano Nogueda ,&nbsp;Enrique Villarreal Ríos ,&nbsp;Liliana Galicia Rodríguez ,&nbsp;Mireya Franco Saldaña ,&nbsp;Mariana Del Rayo Guerrero Mancera ,&nbsp;Laura Alicia Cu Flores","doi":"10.1016/j.rcreu.2024.09.004","DOIUrl":"10.1016/j.rcreu.2024.09.004","url":null,"abstract":"<div><h3>Introduction</h3><div>The profile of health service use in the care of knee osteoarthritis determines the cost of care.</div></div><div><h3>Objective</h3><div>To determine the profile of use and cost of care in knee osteoarthritis.</div></div><div><h3>Materials and methods</h3><div>Study of health service profile of use and cost, 258 clinical records were studied. The profile of use identified the type and number of services used in 1 year. The average annual cost was determined by identifying the fixed unit cost, estimated using the time and motion technique, and the variable unit cost, identified using the micro-costing technique, the sum of both resulted in the average unit cost and was multiplied by the profile of use to identify the average annual cost. With this result, projections were made adopting assumptions for specific populations.</div></div><div><h3>Results</h3><div>The average annual cost of knee osteoarthrosis care was USD $ 205.82; the highest cost corresponds to the fixed cost of consultation and hospitalization services. The total projected cost for 6,408 patients with osteoarthritis is USD $ 1,318,917 and for 4,644 patients with osteoarthrosis is USD $ 955,844,529.</div></div><div><h3>Conclusion</h3><div>The cost of care for knee osteoarthritis is high, the projections for the average cost of care for knee osteoarthritis are worrying, this scenario will be true as long as the adopted assumptions are met.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102158"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147410790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnóstico de osteoporosis en pacientes con espondilitis anquilosante, revisión sistemática y metaanálisis","authors":"Pedro Arbey Quevedo Mayorga ,&nbsp;Andrés Alfonso González Romero ,&nbsp;Javier Mauricio Mora Méndez ,&nbsp;Juan Carlos Vela Quevedo ,&nbsp;Lilian Marcela Estupiñán Moya ,&nbsp;Angelica María Quintero ,&nbsp;Carlos Eduardo García Morón ,&nbsp;César Augusto Cantillo Moreno","doi":"10.1016/j.rcreu.2025.01.004","DOIUrl":"10.1016/j.rcreu.2025.01.004","url":null,"abstract":"<div><h3>Introduction</h3><div>The variability in the identification of osteopenia and osteoporosis in ankylosing spondylitis is related to the possible overestimation of bone mineral density, identified by dual x-ray absorptiometry in the lumbar spine and femoral neck due to changes in bone neoformation in the anterior vertebral ligament and enthesis, which leads to the under-identification of alterations in the bone mineral density of this group of patients. This justifies evaluating different bone mineral density estimation techniques, such as quantitative dual-energy tomography, to optimize the identification of this complication. Our objective was to evaluate the available evidence regarding the identification of osteoporosis and osteopenia through dual x-ray absorptiometry versus quantitative dual-energy tomography techniques in patients with ankylosing spondylitis.</div></div><div><h3>Methodology</h3><div>A systematic review and meta-analysis were carried out following the PRISMA-P 2015 Checklist methodology. The databases consulted were Medline Central (Cochrane Central Register of Controlled Trials), Embase, Lilacs, Google Scholar, SciELO from 2010 to December 2021; we included randomized clinical trials, cohort studies, cases and controls, as well as cross-sectional studies. It was registered in PROSPERO (CRD42023472431). The Mantel-Haenszel method was used to evaluate weighted effects for the identification of osteoporosis and osteopenia using both methods. The effect was estimated based on fixed- or random-effects models, depending on the heterogeneity assessment using the I² statistic.</div></div><div><h3>Results</h3><div>The search yielded 287 studies, of which only 3 were included. There were 109 patients in total, the mean age was 49.5<!--> <!-->±<!--> <!-->4.8 years, a greater probability of osteoporosis was evident (RR<!--> <!-->=<!--> <!-->1.91; 95% CI<!--> <!-->=<!--> <!-->0.65-5.62; p<!--> <!-->=<!--> <!-->0.23) and osteopenia (RR<!--> <!-->=<!--> <!-->1.44; 95% CI<!--> <!-->=<!--> <!-->0.86-2.42; p<!--> <!-->=<!--> <!-->0.16) with quantitative dual-energy tomography vs. dual x-ray absorptiometry, without statistical significance. The difference in means in the bone density was significant between the 2 techniques, being lower in quantitative dual-energy tomography (MD<!--> <!-->=<!--> <!-->−833; Z<!--> <!-->=<!--> <!-->−8.38; p<!--> <!-->=<!--> <!-->0.001). Although the results did not show significant differences between the two techniques, it is important to highlight the high heterogeneity among the different studies for the respective outcomes.</div></div><div><h3>Conclusions</h3><div>Quantitative dual-energy tomography is a useful technique in determining bone mineral density in these patients, but the available evidence is still insufficient to conclude which is the least effective technique for diagnosing osteoporosis in ankylosing spondylitis.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102175"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hallazgos capilaroscópicos en individuos con síndrome de Sjögren, esclerosis sistémica y fenómeno de Raynaud primario en un centro de referencia de capilaroscopia en Medellín, Colombia","authors":"Simón Hoyos-Patiño ,&nbsp;Alejandro Arango-Martínez ,&nbsp;Libia María Rodriguez-Padilla ,&nbsp;Andrés Chavarriaga-Restrepo ,&nbsp;Carlos Jaime Velasquez-Franco","doi":"10.1016/j.rcreu.2024.11.006","DOIUrl":"10.1016/j.rcreu.2024.11.006","url":null,"abstract":"<div><h3>Introduction</h3><div>Nailfold capillaroscopy is a fundamental technique for studying systemic autoimmune diseases such as Sjögren's syndrome, particularly in patients with Raynaud's phenomenon and sclerodermiform features. However, in this condition, studies are scarce and often use less precise instruments than digital videocapillaroscopy, limiting the available evidence.</div></div><div><h3>Objective</h3><div>To compare capillaroscopic findings among individuals with Sjögren's syndrome, primary Raynaud's phenomenon, and systemic sclerosis at a national referral centre for nailfold videocapillaroscopy in Medellin, Colombia, between 2016 and 2022.</div></div><div><h3>Materials and methods</h3><div>An analytical cross-sectional observational study that included individuals over 18 years old with Sjögren's syndrome, systemic sclerosis, and primary Raynaud's phenomenon. Clinical and capillaroscopic characteristics information was obtained from capillaroscopy reports at an expert centre. Pearson's χ² test was used to compare qualitative variables, and the Kruskal-Wallis test for quantitative variables. A <em>P</em> value &lt;<!--> <!-->.05 was considered statistically significant.</div></div><div><h3>Results</h3><div>A total of 195 patients were included. Subjects with Sjögren's syndrome had a lower prevalence of abnormal capillaroscopic variables than patients with systemic sclerosis (<em>P</em> <!-->&lt;<!--> <!-->.001). All abnormal capillaroscopic variables were more frequent in the Sjögren's syndrome group compared to primary Raynaud's phenomenon. There were statistically significant differences among the 3<!--> <!-->patient groups in the capillaroscopic pattern (<em>P</em> <!-->&lt;<!--> <!-->.001). The main capillaroscopic finding in Sjögren's syndrome was the presence of dilated capillaries (55.4%; 36/65). In the Sjögren's syndrome group, an early scleroderma pattern was present in 4.6%, and an active scleroderma pattern in 13.8%, both findings less frequent than in systemic sclerosis but more common than in primary Raynaud's phenomenon group.</div></div><div><h3>Conclusions</h3><div>In a population of Sjögren's syndrome patients with a high prevalence of secondary Raynaud's phenomenon and anticentromere antibodies, a high prevalence of capillaroscopic abnormalities was found. Although less frequent compared to the systemic sclerosis group, these abnormalities were more common than in the primary Raynaud's phenomenon group.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102165"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A case of rhupus treated with filgotinib: A promising therapeutic perspective","authors":"Raffaele Barile ,&nbsp;Cinzia Rotondo ,&nbsp;Valeria Rella ,&nbsp;Francesco Paolo Cantatore ,&nbsp;Addolorata Corrado","doi":"10.1016/j.rcreu.2025.04.001","DOIUrl":"10.1016/j.rcreu.2025.04.001","url":null,"abstract":"<div><h3>Rhupus syndrome</h3><div>Rhupus syndrome, characterized by overlapping clinical features of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), presents significant therapeutic challenges due to its complex pathogenesis and limited treatment options. This case report evaluates the efficacy of filgotinib, a selective JAK1 inhibitor, in a patient with refractory rhupus syndrome.</div></div><div><h3>Case presentation</h3><div>A 42-year-old male, initially diagnosed with SLE in 2013, presented with persistent polyarthritis, cutaneous manifestations, and constitutional symptoms. Conventional treatments including hydroxychloroquine, methotrexate, and belimumab failed to achieve adequate disease control.</div></div><div><h3>Diagnosis and treatment</h3><div>In October 2022, the diagnosis was revised to rhupus based on the evolution of clinical manifestations and laboratory findings, leading to the initiation of filgotinib, a JAK1 inhibitor. Disease activity was monitored over 24 months using standardized assessment tools.</div></div><div><h3>Results</h3><div>Significant clinical improvement was observed within weeks of filgotinib initiation, enabling prednisone dose reduction and maintaining low disease activity throughout the 24-month follow-up period.</div></div><div><h3>Conclusion</h3><div>This case highlights the therapeutic potential of filgotinib in managing rhupus syndrome but further research and larger clinical trials are necessary to establish filgotinib's therapeutic potential and safety profile in the management of SLE.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102180"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond expectations: Concurrent presence of beta thalassemia and Sjögren's syndrome","authors":"Mateo Aguirre Flórez ,&nbsp;Daniel Toro Restrepo ,&nbsp;Lina María Saldarriaga Rivera ,&nbsp;Henry Idrobo Quintero ,&nbsp;Laura Alejandra Jiménez Osorio ,&nbsp;Valeria López Pulgarín ,&nbsp;Daniel Millán Morales","doi":"10.1016/j.rcreu.2024.12.002","DOIUrl":"10.1016/j.rcreu.2024.12.002","url":null,"abstract":"<div><h3>Background</h3><div>Beta thalassaemia and Sjögren's syndrome are rare diseases with distinct aetiologies. Beta thalassaemia is an inherited haemoglobinopathy that causes chronic anemia, while Sjögren's syndrome is an autoimmune disease that affects exocrine glands.</div></div><div><h3>Case report</h3><div>We present a 45-year-old female with beta-thalassaemia diagnosed by genetic testing who developed Sjögren's syndrome symptoms. The diagnosis was confirmed by clinical, serological, and histopathological criteria. This is the first documented case in a Colombian tertiary institution.</div></div><div><h3>Conclusions</h3><div>Beta-thalassaemia and Sjögren's syndrome coexistence is extremely rare, highlighting the need for a multidisciplinary diagnostic approach. Further investigation into possible molecular and genetic links is needed.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 102168"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisión narrativa: células madre mesenquimales de cordón umbilical y osteoartritis","authors":"Sofía Arias-Correal ,&nbsp;Ana María Santos ,&nbsp;María Helena Pedraza ,&nbsp;John Londoño ,&nbsp;Igor Rueda-Cárdenas ,&nbsp;Keisy Orduz-Uribe ,&nbsp;Laura Manuela Olarte-Bermúdez ,&nbsp;Luz Mabel Ávila-Portillo","doi":"10.1016/j.rcreu.2025.504859","DOIUrl":"10.1016/j.rcreu.2025.504859","url":null,"abstract":"<div><div>Osteoarthritis (OA) is the leading cause of articular pain in adult patients, with a high worldwide prevalence and a trend towards increasing. By 2050, 642 million people are expected to suffer from knee OA. Current treatment focuses on measures to prevent progressive joint wear and control symptoms such as pain. Research in regenerative medicine, including the infiltration of platelet-rich plasma, has not yet provided solid evidence for its efficacy. With the advent of cellular therapy, the isolation and expansion of mesenchymal stem cells (MSCs) from various origins have shown promise in reducing inflammation and creating a suitable environment for the regeneration of articular cartilage. This narrative review focuses on umbilical cord-derived mesenchymal stem cells (UC-MSCs), which have certain advantages over other types of MSCs. It summarizes the various clinical trials conducted in recent years, based on a search of multiple databases.</div></div>","PeriodicalId":37643,"journal":{"name":"Revista Colombiana de Reumatologia","volume":"33 1","pages":"Article 504859"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147409805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}