Journal of Organometallic Chemistry最新文献

{"title":"Cardioprotective effect of Ag nanoparticles green-formulated by Nigella Sativa on isoproterenol-induced cardiotoxicity following the PI3K/Akt/mTOR and Keap1/Nrf2/HO-1 pathways and its catalytic application for A3 coupling reaction","authors":"Yuan Yuan ,&nbsp;Junwen Zhang ,&nbsp;Narinderjit Singh Sawaran Singh ,&nbsp;Dilbar Urazbaeva ,&nbsp;Yodgor Kenjayev ,&nbsp;Mashkhura Sultonova","doi":"10.1016/j.jorganchem.2025.123979","DOIUrl":"10.1016/j.jorganchem.2025.123979","url":null,"abstract":"<div><div>Herein, we report the synthesis and assessment of a new biogenic nanocomposite with silver nanoparticles based on a core-shell structure created by functionalising phytochemicals found in Nigella Sativa flower extract. UV-Vis spectroscopy, XRD, TEM, EDX, ICP-OES, and FE-SEM methods were used to evaluate the resultant nanocatalyst (Ag NPs/<em>N. Sativa</em>). Based on TEM images, the Ag NPs were spherical, monodispersed, and about 25–30 nm in size. Following a C-H activation method, the material's catalytic performance was evaluated in the high-yield synthesis of many propargylamine derivatives employing A³ coupling processes. The performance of the catalyst did not significantly decline even after seven consecutive uses. There were forty-five Wister rats used in the medical segment. These groups included two that received pretreatment with Ag NPs at varying dosages for 14 days, a normal group, and a group that received just isoproterenol treatment to induce myocardial infarction. Isoproterenol was subsequently administered to these pretreated groups. In addition to other downstream apoptotic and inflammatory mediators, the PI3K/Akt/mTOR expression was monitored. ECG, cardiac indicators, Nrf2, Keap1 expression, and other downstream antioxidant enzymes were also evaluated. Ag NPs treatment improved myocardial autophagy, inflammation, and apoptosis. It also controlled the PI3K/Akt/mTOR pathway, activated the Keap1/Nrf2/HO-1 pathway, and enhanced the effectiveness of antioxidant enzymes. By inhibiting the Keap1/Nrf2 pathway, SOD, GSH, GPx, GST, TNF-α, IL-6, IL-1β, NF-κB, Bcl2, Bax, caspase-3, caspase-9, and PI3K/Akt/mTOR pathway, the findings imply that Ag NPs may have a cardioprotective efficacy on myocardial infarction. Additionally, the therapy reduced the cardiac markers levels, lowered the infarct zone size, and lessened immune cell infiltration and myocardial necrosis.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123979"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advancing Suzuki couplings: The role of metal-organic frameworks in efficient biaryl compound synthesis","authors":"Khadijeh Rabiei","doi":"10.1016/j.jorganchem.2025.123961","DOIUrl":"10.1016/j.jorganchem.2025.123961","url":null,"abstract":"<div><div>The reactions that create carbon-carbon bonds have consistently fascinated chemists due to their vast spectrum of applications in organic chemistry. In particular, the Suzuki reaction is renowned for forming C–C bonds, which are utilized to prepare a broad spectrum of biological and pharmaceutical compounds. Furthermore, investigators are endeavoring to develop easy, inexpensive, rapid, and more effective procedures in various coupling reactions, with the Suzuki coupling being a widely employed cross-coupling reaction in current organic synthesis. Metal-organic frameworks (MOFs) have emerged as materials that can serve as solid supports with a large surface area, positioning themselves at the forefront of research in catalysis. Over the past years, MOFs have attracted special attention as a type of organic-inorganic-based material, primarily due to their tunable structures and high porosity, which allow for the incorporation of various metal centers. Notably, they have been utilized for numerous organic transformations as eco-friendly replacements for traditional heterogeneous catalysts, achieving satisfactory catalytic performance while enhancing the efficiency of organic conversion processes. The significance of MOFs is expected to be further underscored in the upcoming 2025 Nobel Prize in Chemistry, as their innovative applications in catalysis could revolutionize the field and offer sustainable solutions to traditional chemical processes. Consequently, MOFs could be an excellent support choice for creating ideal metal-based catalysts, which exhibit greater availability of active sites and remarkable catalytic performance. Ultimately, the primary objective of this review is to highlight the utility of MOF-based catalyst systems in the Suzuki reaction for the construction of valuable biaryl compounds, encompassing developments leading up to 2025.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123961"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Towards understanding the molecular mechanism of Cadiot-Chodkiewicz cross-coupling reaction","authors":"C Rajalakshmi ,&nbsp;Lakshmi Anil ,&nbsp;Harry Wilson ,&nbsp;Leemol Roy ,&nbsp;Gopinathan Anilkumar ,&nbsp;Vibin Ipe Thomas","doi":"10.1016/j.jorganchem.2025.123969","DOIUrl":"10.1016/j.jorganchem.2025.123969","url":null,"abstract":"<div><div>The Cadiot-Chodkiewicz cross-coupling reaction is an important synthetic method in which terminal alkynes couple with alkynyl halides in the presence of transition metal catalysts to produce unsymmetrical 1,3-diynes. Among the different transition metal catalysts, zinc has recently garnered significant attention due to its affordability and environmentally benign characteristics. Computational studies on the catalytic mechanisms of Cadiot-Chodkiewicz cross-coupling reactions remain scarce, despite significant progress in their experimental methodologies. In this study, we present a detailed mechanistic investigation of the Zn-catalyzed Cadiot Chodkiewicz cross-coupling reaction between <em>p</em>-tolyl acetylene and 1-bromo phenyl acetylene using the Density Functional Theory (DFT) method. The catalytic pathway commences with base-assisted transmetalation, subsequently proceeding through a concerted nucleophilic substitution-reductive elimination sequence. The mechanism adheres to a redox-neutral pathway, wherein the catalytic zinc center remains in the +2 oxidation state throughout the catalytic cycle. This in-depth analysis of the reaction pathway provides crucial insights for designing more sustainable protocols for the synthesis of unsymmetrical 1,3-diynes.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123969"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145748576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SAR study on the cytotoxic triosmium carbonyl clusters Os3(μ-H)(μ-EC6H4X)(CO)10: The effects of E and X","authors":"Xin Liang ,&nbsp;Kumaran Elumalai ,&nbsp;Lihui Zhang ,&nbsp;Dang Lan Tran ,&nbsp;Weng Kee Leong","doi":"10.1016/j.jorganchem.2025.123983","DOIUrl":"10.1016/j.jorganchem.2025.123983","url":null,"abstract":"<div><div>A structure–activity relationship (SAR) study on triosmium carbonyl clusters of the general formulae Os₃(μ-H)(μ-EC₆H₄X)(CO)₁₀ with differing bridging moieties (E = S, O, OOC) and positional substituents (<em>o</em>-, <em>m</em>-, <em>p</em>-X) was carried out. Correlation of their anti-proliferative effects on MDA-MB-231 cells against reactivity computed as the free energy change associated with nucleophilic addition via μ-E to κE bonding mode change shows that a more electron-withdrawing X exhibited higher reactivity and hence higher cytotoxicity but this holds only among clusters with the same bridging moiety E. The <em>o</em>-X clusters were also found to exhibit reduced cytotoxicity. The thiolato-bridged clusters displayed the highest cytotoxicity overall, with <strong>3-<em>m</em>-OH</strong> the most promising.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123983"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cyclometalated iridium complexes: Synthesis, photoluminescence, and catalysis","authors":"Pacifique Muhoza ,&nbsp;Yu Sun ,&nbsp;Harald Kelm ,&nbsp;Subham Burai ,&nbsp;Maximilian Luczak ,&nbsp;Katharina Rediger ,&nbsp;Philipp Weber ,&nbsp;Mahir Sönmez ,&nbsp;Ann-Katrin Britzius ,&nbsp;Maria Wächtler ,&nbsp;Gereon Niedner-Schatteburg ,&nbsp;Marc H. Prosenc ,&nbsp;Werner R. Thiel","doi":"10.1016/j.jorganchem.2025.123976","DOIUrl":"10.1016/j.jorganchem.2025.123976","url":null,"abstract":"<div><div>In this study we describe the synthesis and characterization of iridium(III) complexes coordinated with bidentate 2-(amino)-4-(2-pyridinyl)pyrimidine ligands. Starting from [Ir(ppy)₂(μ-Cl)]₂ (ppy = 2-phenylpyridine), these ligands coordinate to the metal center via their <em>N,N</em>'-binding pocket leading to cationic iridium(III) complexes. In contrast, starting with [Ir(ppy)₂(μ-OH)]₂, provides threefold cyclometalated complexes. The photophysical properties of both types of iridium(III) complexes have been studied in detail. Furthermore, [Ir(ppy)₂(μ-OH)]₂ is a highly active catalyst for the transfer hydrogenation of ketones with 2-propanol as hydrogen source, operating without the addition of a base. To achieve comparable catalytic activity with [Ir(ppy)₂(μ-Cl)]₂, a 20-fold excess of KOH (relative to the amount of catalyst) must be used.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1045 ","pages":"Article 123976"},"PeriodicalIF":2.1,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145797749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Syntheses, structures, and catalytic investigation of dicationic ruthenium(II)-CNC pincer complexes with multiple NHCs donor ligands","authors":"Rahul Kumar Singh ,&nbsp;Dibya Yadav ,&nbsp;Ashu Singh ,&nbsp;Shilpi Misra ,&nbsp;Amrendra K. Singh","doi":"10.1016/j.jorganchem.2025.123939","DOIUrl":"10.1016/j.jorganchem.2025.123939","url":null,"abstract":"<div><div>We report the reactivity of cationic Ru(II) pincer complexes [Ru(CNC^Me)(CN^Me)I]PF₆ (<strong>1a</strong>), [Ru(CNC<em>^i-</em>^Pr)(CN^Me)I]PF₆ (<strong>1b</strong>) and [Ru(CNC^Cy)(CN^Me)I]PF₆ (<strong>1c</strong>) with CH₃CN and PPh₃ ligands and afforded dicationic Ru(II)-CNC pincer complexes namely, [Ru(CNC^Me)(CN^Me)CH₃CN]2PF₆ (<strong>2a</strong>), [Ru(CNC<em>^i-</em>^Pr)(CN^Me)CH₃CN]2PF₆ (<strong>2b</strong>), [Ru(CNC^Cy)(CN^Me)CH₃CN]2PF₆ (<strong>2c</strong>), [Ru(CNC^Me)(CN^Me)PPh₃]2PF₆ (<strong>3a</strong>), [Ru(CNC<em>^i-</em>^Pr)(CN^Me)PPh₃]2PF₆ (<strong>3b</strong>) and [Ru(CNC^Cy)(CN^Me)PPh₃]2PF₆ (<strong>3c</strong>). All the new complexes were characterized spectroscopically by multinuclear NMR and HRMS, and molecular structures of complexes <strong>2a</strong> and <strong>3a</strong> have been determined by the single-crystal X-ray diffraction technique. The structures and electronic properties of all complexes are probed through UV–vis and electrochemical investigations for a comparison of ancillary ligand effects. Investigation of the catalytic activity of new complexes towards nitrile hydration reveals that the reaction proceeds through a common Ru-OH intermediate generated by removal of the I⁻, CH₃CN, or PPh₃ ligands, and I⁻ based catalysts (<strong>1a</strong>-<strong>c</strong>) are more active than those with CH₃CN (<strong>2a</strong>-<strong>c</strong>) and PPh₃ (<strong>3a</strong>-<strong>c</strong>) ligands.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123939"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of Fe3O4–GO@Mn magnetic nanocatalyst for green synthesis of 1,2,3-triazole derivatives","authors":"Mohammad Abushuhel ,&nbsp;Hayjaa Mohaisen Mousa ,&nbsp;G. PadmaPriya ,&nbsp;Ahmad-Al Shaker ,&nbsp;Subhashree Ray ,&nbsp;Amrita Pal ,&nbsp;Renu Sharma ,&nbsp;Ashish Singh Chauhan ,&nbsp;Kamran Hedayat","doi":"10.1016/j.jorganchem.2025.123945","DOIUrl":"10.1016/j.jorganchem.2025.123945","url":null,"abstract":"<div><div>In the present research study, the Fe₃O₄–GO@Mn magnetic nanocatalyst was synthesized and successfully characterized by a range of techniques (XRD, FTIR, TEM, SEM, EDS, VSM, BET, and XPS) for a comprehensive characterization. This nanocomposite has good catalytic and magnetic characteristics because it has a Fe₃O₄ magnetic core, Mn layers, and is supported by graphene oxide; it is magnetic and allows for simple separation and multiple recycling. The reaction should be successful using this nanocatalyst for the synthesis of a variety of 1,2,3-triazole compounds with high efficiency and shorter reaction time, which was recommended under optimal conditions (temperature 80 °C, ethanol/water solvent, and time 40 min). Moreover, using a variety of substrates also showed the potential of the nanocatalyst to react with a diverse set of substrates, indicating good performance and versatility. The structural and functional stability of this nanocatalyst was confirmed, considering multiple recycling cycles, making it a choice for the industries and green chemistry.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123945"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and characterization of R2Sn(IV)L complexes with O,N,S-tridentate Schiff base ligands: Electrochemistry, photophysical properties and antioxidant activity","authors":"Daria A. Burmistrova ,&nbsp;Nadezhda P. Pomortseva ,&nbsp;Yulia K. Voronina ,&nbsp;Andrey I. Poddel'sky ,&nbsp;Nadezhda T. Berberova ,&nbsp;Igor L. Eremenko ,&nbsp;Arthur S. Vashurin ,&nbsp;Ivan V. Smolyaninov","doi":"10.1016/j.jorganchem.2025.123936","DOIUrl":"10.1016/j.jorganchem.2025.123936","url":null,"abstract":"<div><div>New diorganotin(IV) complexes R₂Sn(Lⁿ) <strong>1</strong>–<strong>5</strong> (where <em>R</em> = Et, t-Bu, Ph) with O,N,S-donor tridentate Schiff bases containing chlorine or trifluoromethyl groups were synthesized in 49–67% yields. Compounds <strong>1–5</strong> were characterized by ¹H, ¹³C NMR, IR spectroscopy, and elemental analysis. The molecular structures of <strong>2, 3</strong>, and <strong>5</strong> in the crystalline state were determined by single-crystal X-ray diffraction. The organotin complexes are mononuclear and five-coordinate, with ligands adopting a dianionic form. Electrochemical studies revealed that the electrooxidation process is irreversible while the electrochemical reduction generates relatively stable monoanionic complexes. Complex <strong>3</strong>, along with previously reported related phenyl- or ethyl-substituted tin compounds, exhibits luminescence in chloroform. The radical scavenging activity of the complexes was evaluated in reactions with ABTS radical cation or superoxide radical anion in NBT assay. The highest neutralizing properties were observed for complexes with ethyl substituents at tin atom; their IC₅₀ values ranged from 6 to 35 µM. In the oxidative DNA damage assays, most compounds exhibited a promoting effect suggesting their potential role in DNA cleavage under oxidative stress. However, in the lipid peroxidation model reaction in vitro, an antioxidant effect was observed for most compounds, particularly for hydrophobic <em>tert</em>‑butyl‑containing complexes <strong>2</strong> and <strong>4</strong>.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123936"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green formulation and chemical characterization of copper nanoparticles by Dendrobium officinalis extract: Evaluation of its catalytic activity for Ullmann coupling reaction and determination of the antibacterial activity against oral pathogens","authors":"Jing Chen ,&nbsp;Yuting Li ,&nbsp;Xinyue Wang ,&nbsp;Qin Feng ,&nbsp;Shenhong Zhang ,&nbsp;Ping Yang","doi":"10.1016/j.jorganchem.2025.123930","DOIUrl":"10.1016/j.jorganchem.2025.123930","url":null,"abstract":"<div><div>One of the most common oral infections that afflict people of all ages globally is dental caries. In order to prevent and treat oral infections as well as other bacterial infections, many medicinal plants and herbal nanoparticles have been used in various medical systems to combat dental caries and other oral infections. These are currently in demand for the development of innovative therapeutic drugs with few side effects. In terms of easy, green, and applicable chemical research, a bio-inspired method for producing copper nanoparticles employing <em>Dendrobium officinalis</em> as a natural reducing and stabilizing agent without the need for hazardous or toxic chemicals is being presented. Cu₂O NPs/<em>D. officinalis</em>' capacity to suppress dental bacterial growth and anti-adherence in vitro was investigated in this work. Detailed analysis using methods like TEM, FE-SEM, EDX, ICP-OES, and XRD verified the creation of the Cu₂O NPs/<em>D. officinalis</em> nanocomposite. TEM pictures showed spherical nanoparticles with a narrow size distribution, nearing 15–25 nm in dimension. The fabricated Cu₂O NPs/<em>D. officinalis</em> showed good activity for <em>N</em>-arylation of imidazole through Ullmann-type C-N coupling. Different aryl halides were transformed into <em>N</em>-arylated imidazoles with good outcomes. Moreover, the Cu₂O NPs/<em>D. officinalis</em> could be reused for 7 times with keeping their efficiency. Following that, an investigation was conducted into the biomolecules biological performance that were functionalized Cu₂O NPs/<em>D. officinalis</em>. The Cu₂O NPs/<em>D. officinalis</em> addition greatly decreased the in vitro adherence of <em>Porphyromonas gingivalis</em> and <em>Streptococcus mutans</em> (MIC = 8 µg/mL). Additionally, <em>P. gingivalis</em> and <em>S. mutans</em> were eliminated by the Cu₂O NPs/<em>D. officinalis</em> with an MBC of 8–16 µg/mL. According to the study's findings, Cu₂O NPs/<em>D. officinalis</em> could provide an excellent oral hygiene product to prevent dental cavities and periodontal diseases.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123930"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145570474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemistry and bioactivity of ferrocenyl quinone methides","authors":"Michael J. McGlinchey","doi":"10.1016/j.jorganchem.2025.123958","DOIUrl":"10.1016/j.jorganchem.2025.123958","url":null,"abstract":"<div><div>The antiproliferative behaviour of the ferrocifens, derived by replacing a phenyl substituent in tamoxifen by ferrocenyl, and also in their diphenol counterparts, against both ER+ and ER- breast cancers may be attributed to two key factors: the redox-mediated formation of reactive oxygen species (ROS), and the formation of ferrocenyl quinone methides (Fc-QMs) that react with nucleophilic thiols, and also inhibit the ability of thioredoxin reductase to function, thereby weakening the cell’s defence towards ROS. Metabolites arising from the reactions of these Fc-QMs are generated from a variety of novel reactions and molecular rearrangements. These include the formation of dihydrofurans and pyrans, spirobonded tetrahydrofurans, and ferrocenyl migrations, all arising in a stepwise manner via the intermediacy of ferrocenyl-stabilized quinone methide cations. X-ray crystal structures of Fc-QMs bearing alkyl-imido substituents reveal the existence of novel lone pair-π* interactions that enhance their stabilities and lifetimes and allow a rationalisation of their effectiveness against a wide range of tumours.</div></div>","PeriodicalId":374,"journal":{"name":"Journal of Organometallic Chemistry","volume":"1044 ","pages":"Article 123958"},"PeriodicalIF":2.1,"publicationDate":"2026-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145615606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}