Journal of Pediatric Pharmacology and Therapeutics最新文献

Do Not Throw Away Your Patient's Shot at Complete Vomiting Control. 不要放弃病人完全控制呕吐的机会。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01210

L Lee Dupuis, Priya Patel

引用次数: 0

Impact of a Procalcitonin Guided Antibiotic Management Strategy in Pediatric Sickle Cell Patients With Fever. 降钙素原引导下的抗生素管理策略对小儿镰状细胞病患者发热的影响。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00085

Hannah Robinson, Andrew B Gainey, Robert Daniels, Shannon DeRienzo, Deborah Hurley, Angie Brown, Carla Roberts, Anna-Kathryn Burch

{"title":"Impact of a Procalcitonin Guided Antibiotic Management Strategy in Pediatric Sickle Cell Patients With Fever.","authors":"Hannah Robinson, Andrew B Gainey, Robert Daniels, Shannon DeRienzo, Deborah Hurley, Angie Brown, Carla Roberts, Anna-Kathryn Burch","doi":"10.5863/JPPT-24-00085","DOIUrl":"10.5863/JPPT-24-00085","url":null,"abstract":"Objective: This study assessed the relationship between antibiotic durations and the use of procalcitonin (PCT) in febrile pediatric patients with sickle cell disease (SCD), including those diagnosed with acute chest syndrome (ACS) and/or vaso-occlusive crisis (VOC).Methods: This multicenter, retrospective cohort study compared antibiotic durations in febrile pediatric SCD patients between 2 cohorts, 1 utilizing PCT (PCT cohort) and 1 not utilizing PCT (no-PCT cohort). Secondary endpoints compared the impact of PCT on antibiotic durations in those also diagnosed with ACS and/or VOC.Results: A total of 258 patient encounters were included. The overall mean antibiotic duration in the PCT cohort was 4.2 days (SD 2.6) vs 4.7 days (SD 3.6) (p = 0.991). For those diagnosed with ACS (n = 17), the mean antibiotic duration was 6 days (SD 2.2) in the PCT cohort vs 9.7 days (SD 3.5) (p = 0.037; n = 7). Those diagnosed with both VOC and ACS (n = 40) averaged 5.6 days (SD 1.9) in the PCT cohort vs 9.3 days (SD 3.2) (p = 0.002; n = 9). Regression analyses revealed an increased odds of longer antibiotic duration in the no-PCT cohort for those with ACS (OR 1.51, 95% CI 1.07-2.13, p = 0.019), and for those with both VOC and ACS (OR 1.72, 95% CI 1.22-2.42, p = 0.002).Conclusions: There was not a significant difference in overall antibiotic durations between cohorts. However, in the PCT cohort there was a significant reduction of antibiotic durations seen in patients diagnosed with ACS or VOC and ACS, averaging 3.7 fewer days of antibiotics.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"464-470"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351458/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of Granulocyte-Colony Stimulating Factor for Beta-Lactam Induced Neutropenia in Children With Bacterial Meningitis. 粒细胞集落刺激因子治疗细菌性脑膜炎患儿β -内酰胺诱导中性粒细胞减少症的应用。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00073

Cheng Yu Yen, Sheldon L Kaplan, Debra L Palazzi, Grant Stimes

引用次数: 0

Do Postnatal Corticosteroids Negatively Impact the Neurodevelopmental Outcomes of Extremely Preterm Infants? 产后皮质类固醇对极早产儿的神经发育结果有负面影响吗？

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-00048

引用次数: 0

The New Wave of Blocking Taste. 阻挡口味的新浪潮。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01212

Hassan Almoazen

引用次数: 0

Intravenous Ceftaroline in Extremely Premature Neonates With Coagulase-Negative Staphylococci Septicemia: A Report of 2 Cases. 静脉注射头孢他林治疗凝血酶阴性葡萄球菌败血症2例

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00087

Suzan S Assfour, Fahad A AlMoghaileth, Adli Abdelrahim, Amal K Hassouneh, Sara O Salem, Raneem S Assfour, Thanaa M Khalil, Mountasser M Al-Mouqdad

{"title":"Intravenous Ceftaroline in Extremely Premature Neonates With Coagulase-Negative Staphylococci Septicemia: A Report of 2 Cases.","authors":"Suzan S Assfour, Fahad A AlMoghaileth, Adli Abdelrahim, Amal K Hassouneh, Sara O Salem, Raneem S Assfour, Thanaa M Khalil, Mountasser M Al-Mouqdad","doi":"10.5863/JPPT-24-00087","DOIUrl":"10.5863/JPPT-24-00087","url":null,"abstract":"Sepsis is one of the primary causes of newborn morbidity and mortality, particularly in preterm infants, and coagulase-negative staphylococci (CoNS) is a major cause of bacterial infections in the neonatal intensive care unit (NICU). The treatment of late-onset neonatal staphylococcal sepsis is challenging owing to increased minimum inhibitory concentrations and the potential side effects of vancomycin. Herein, we describe 2 cases of extremely preterm newborns treated with intravenous (IV) ceftaroline (6 mg/kg/dose every 8 hours) for late-onset neonatal staphylococcal sepsis. Both cases were diagnosed with bacteremia and treated with ceftaroline. However, one of the patients died, most likely from sepsis or other factors, including chronic lung illness and prematurity, despite sterile blood cultures after starting the ceftaroline treatment. Large-scale randomized studies are required to examine the optimal dosing, safety, and effectiveness of IV ceftaroline for sepsis caused by CoNS in neonates.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"508-514"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Myalgia and Rigidity as Adverse Effects of Trametinib Therapy. 曲美替尼治疗的不良反应：肌痛和僵硬。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00002

Charles J Weeks, Victoria Frame, Rohan Vuppala, David Thomas, Abigayle B Simon, Michael Stokes, Colleen McDonough

{"title":"Myalgia and Rigidity as Adverse Effects of Trametinib Therapy.","authors":"Charles J Weeks, Victoria Frame, Rohan Vuppala, David Thomas, Abigayle B Simon, Michael Stokes, Colleen McDonough","doi":"10.5863/JPPT-24-00002","DOIUrl":"10.5863/JPPT-24-00002","url":null,"abstract":"Mitogen-activated extracellular kinase inhibitors, including trametinib and selumetinib, are increasingly used to treat pediatric low-grade gliomas. Trametinib, while administered orally and with minimal myelosuppression, is reported to cause rash, diarrhea, and fatigue. Selumetinib has been associated with skin irritation, diarrhea, and musculoskeletal pain. This case report describes an 8-month-old male with a low-grade glioma (LGG) that progressed 6 months post-chemotherapy and was started on trametinib due to its liquid formulation and minimal side effect profile. However, the patient developed severe diarrhea, abdominal pain, neck pain, rigidity, and decreased stamina. These symptoms necessitated discontinuation of trametinib, after which all symptoms resolved within a week. This case highlights the first reported instance of trametinib-induced myalgia and rigidity in a pediatric patient receiving trametinib therapy for a LGG. Clinicians should consider these rare but significant adverse effects when choosing an antineoplastic therapy for the treatment of progressive LGG.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"515-519"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Under the Influence: Cognitive Effects of Medical Marijuana on Developing Minds. 在影响下：医用大麻对心智发育的认知作用。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-25-01209

Marry Vuong, Kaylee Parkhill

引用次数: 0

A Pilot Assessment of Caregivers' and Patients' Perception of Naloxone Coprescribing in a Pediatric Sickle Cell Population. 儿童镰状细胞人群中护理人员和患者对纳洛酮共同处方认知的初步评估。

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00071

Elizabeth B Ferengul, Lauren M Oliveri, Leslie Briars, Lewis L Hsu, Paige Reilly, Sara W Hovey

{"title":"A Pilot Assessment of Caregivers' and Patients' Perception of Naloxone Coprescribing in a Pediatric Sickle Cell Population.","authors":"Elizabeth B Ferengul, Lauren M Oliveri, Leslie Briars, Lewis L Hsu, Paige Reilly, Sara W Hovey","doi":"10.5863/JPPT-24-00071","DOIUrl":"10.5863/JPPT-24-00071","url":null,"abstract":"Objective: The purpose of this survey was to evaluate knowledge and perception of naloxone among patients with sickle cell disease and their caregivers.Methods: A 13-question survey about naloxone and the subject's perception of naloxone was developed by the research team and reviewed by 5 advocates for pediatric patients with sickle cell disease. The survey was offered to patient-caregivers and patients ≥12 years old with sickle cell disease and a prescription for home opioid medication. The survey was conducted during a clinic visit or inpatient admission with a convenience sampling strategy.Results: A total of 23 surveys were completed (9 patients and 14 caregivers). Nine of 23 subjects (40%) said they had heard of naloxone. Three subjects had naloxone at home. Only 3 caregivers said having naloxone at home would change their opioid use behavior.Conclusion: There is a lack of awareness about naloxone in the pediatric sickle cell disease population. Those who were aware of naloxone did feel it was an important medication and appeared to have a positive view of it.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"498-503"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chemical Stability of Diphenhydramine in "Magic Mouthwash" Stored at Room and Refrigerated Temperatures for 90-Days. 常温冷藏90天“神奇漱口水”中苯海拉明的化学稳定性

Journal of Pediatric Pharmacology and Therapeutics Pub Date : 2025-08-01 Epub Date: 2025-08-11 DOI: 10.5863/JPPT-24-00053

Michelle Tubolino, Kathryn Austin, Daniel DeArazoza, Stacy Brown

{"title":"Chemical Stability of Diphenhydramine in \"Magic Mouthwash\" Stored at Room and Refrigerated Temperatures for 90-Days.","authors":"Michelle Tubolino, Kathryn Austin, Daniel DeArazoza, Stacy Brown","doi":"10.5863/JPPT-24-00053","DOIUrl":"10.5863/JPPT-24-00053","url":null,"abstract":"Objective: This study aimed to investigate the chemical stability of diphenhydramine in a pediatric \"Magic Mouthwash\" preparation, specifically a 1:1 mixture of aluminum hydroxide/magnesium hydroxide/simethicone (Mylanta comparable product) and liquid diphenhydramine over 90 days under different storage conditions.Methods: A high-performance liquid chromatography-ultraviolet method was developed for quantifying diphenhydramine in the mouthwash. A total of 10 bottles of mouthwash were prepared, with half stored in the refrigerator and half kept at room temperature. The method was applied to analyze the stability of diphenhydramine in the mouthwash preparations, with 5-mL aliquots removed from each bottle at 0, 1, 7, 14, 30, 60, and 90 days. Stability was defined as maintaining 90-110% of the initial concentration.Results: Both storage conditions (room temperature: 19.3 ± 0.8°C; refrigeration: 3.01 ± 0.3°C) maintained stable temperatures. The pH remained stable (room temperature: 8.34 ± 0.4; refrigeration: 8.38 ± 0.4). Diphenhydramine concentrations stayed within the 90-110% range for the entire study duration under both conditions. No statistically significant differences in diphenhydramine concentration were observed between storage conditions or over time.Conclusion: The pediatric \"Magic Mouthwash\" demonstrated stable pH and diphenhydramine potency over 90 days, regardless of whether it was stored at room temperature or refrigerated. This supports the feasibility of bulk preparation and extended storage of this formulation, providing a safe and effective alternative to lidocaine-containing mouthwash for pediatric patients.","PeriodicalId":37484,"journal":{"name":"Journal of Pediatric Pharmacology and Therapeutics","volume":"30 4","pages":"494-497"},"PeriodicalIF":0.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12351482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144875665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0