Dhouha Sahnoun, Myriam Agrebi, Bahaeddine Dridi, Hanen Zayani, Lamia Boughamoura, Chaker Ben Salem
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Carbamazepine-Induced DRESS Syndrome During Epstein-Barr Virus Reactivation in an Adolescent.
Drug reaction with eosinophilia and systemic symptoms (DRESS) is a rare and potentially life-threatening syndrome. Herein, we present the case of a 14-year-old female who developed a diffuse erythematous rash with fever and facial edema 6 weeks after initiating treatment with carbamazepine and sertraline. Laboratory tests showed an inflammatory reaction, elevated liver enzymes, and mild eosinophilia. Serology tests were negative for viral hepatitis, cytomegalovirus, herpes simplex virus, and parvovirus B19, but positive anti-VCA IgM and anti-EBNA IgG confirmed the presence of Epstein-Barr virus reactivation. Drugs were withdrawn, and the patient was treated with corticosteroid. Carbamazepine was identified as the culprit drug after performing patch tests. Even though DRESS is rare in childhood, we present another case of carbamazepine-induced DRESS in an adolescent associated with EBV activation.
期刊介绍：
The Journal of Pediatric Pharmacology and Therapeutics is the official journal of the Pediatric Pharmacy Advocacy Group. JPPT is a peer-reviewed multi disciplinary journal that is devoted to promoting the safe and effective use of medications in infants and children. To this end, the journal publishes practical information for all practitioners who provide care to pediatric patients. Each issue includes review articles, original clinical investigations, case reports, editorials, and other information relevant to pediatric medication therapy. The Journal focuses all work on issues related to the practice of pediatric pharmacology and therapeutics. The scope of content includes pharmacotherapy, extemporaneous compounding, dosing, methods of medication administration, medication error prevention, and legislative issues. The Journal will contain original research, review articles, short subjects, case reports, clinical investigations, editorials, and news from such organizations as the Pediatric Pharmacy Advocacy Group, the FDA, the American Academy of Pediatrics, the American Society of Health-System Pharmacists, and so on.
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