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Applied In Vitro Toxicology最新文献

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Assessment of Endocrine Disruption Potential of Chemicals Using Combined Quantitative Structure-Activity Relationship Modeling of In Vitro and In Vivo Assays 使用体外和体内分析的定量构效关系模型评估化学品的内分泌破坏潜力
Applied In Vitro Toxicology Pub Date : 2022-12-01 DOI: 10.1089/aivt.2022.0015
M. Girireddy, R. Saiakhov, S. Chakravarti
{"title":"Assessment of Endocrine Disruption Potential of Chemicals Using Combined Quantitative Structure-Activity Relationship Modeling of In Vitro and In Vivo Assays","authors":"M. Girireddy, R. Saiakhov, S. Chakravarti","doi":"10.1089/aivt.2022.0015","DOIUrl":"https://doi.org/10.1089/aivt.2022.0015","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47043250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds. 应用确定的方法评估异噻唑啉酮类化合物的皮肤致敏效力。
Applied In Vitro Toxicology Pub Date : 2022-12-01 DOI: 10.1089/aivt.2022.0014
Judy Strickland, David G Allen, Dori Germolec, Nicole Kleinstreuer, Victor J Johnson, Travis Gulledge, Jim Truax, Anna Lowit, Timothy Dole, Timothy McMahon, Melissa Panger, Judy Facey, Stephen Savage
{"title":"Application of Defined Approaches to Assess Skin Sensitization Potency of Isothiazolinone Compounds.","authors":"Judy Strickland,&nbsp;David G Allen,&nbsp;Dori Germolec,&nbsp;Nicole Kleinstreuer,&nbsp;Victor J Johnson,&nbsp;Travis Gulledge,&nbsp;Jim Truax,&nbsp;Anna Lowit,&nbsp;Timothy Dole,&nbsp;Timothy McMahon,&nbsp;Melissa Panger,&nbsp;Judy Facey,&nbsp;Stephen Savage","doi":"10.1089/aivt.2022.0014","DOIUrl":"https://doi.org/10.1089/aivt.2022.0014","url":null,"abstract":"<p><strong>Introduction: </strong>Isothiazolinones (ITs) are widely used as antimicrobial preservatives in cosmetics and as additives for preservation of consumer and industrial products to control bacteria, fungi, and algae. Although they are effective biocides, they have the potential to produce skin irritation and sensitization, which poses a human health hazard. In this project, we evaluated nonanimal defined approaches (DAs) for skin sensitization that can provide point-of-departure estimates for use in quantitative risk assessment for ITs.</p><p><strong>Materials and methods: </strong>The skin sensitization potential of six ITs was evaluated using three internationally harmonized nonanimal test methods: the direct peptide reactivity assay, KeratinoSens™, and the human cell line activation test. Results from these test methods were then applied to two versions of the Shiseido Artificial Neural Network DA.</p><p><strong>Results: </strong>Sensitization hazard or potency predictions were compared with those of the in vivo murine local lymph node assay (LLNA). The nonanimal methods produced skin sensitization hazard and potency classifications concordant with those of the LLNA. EC3 values (the estimated concentration needed to produce a stimulation index of three, the threshold positive response) generated by the DAs had less variability than LLNA EC3 values, and confidence limits from the DAs overlapped those of the LLNA EC3 for most substances.</p><p><strong>Conclusion: </strong>The application of <i>in silico</i> models to <i>in chemico</i> and in vitro skin sensitization data is a promising data integration procedure for DAs to support hazard and potency classification and quantitative risk assessment.</p>","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":"8 4","pages":"117-128"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9814110/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9134764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Machine Learning and In Vitro Toxicology 机器学习与体外毒理学
Applied In Vitro Toxicology Pub Date : 2022-12-01 DOI: 10.1089/aivt.2022.29031.editorial
B. Lidbury
{"title":"Machine Learning and In Vitro Toxicology","authors":"B. Lidbury","doi":"10.1089/aivt.2022.29031.editorial","DOIUrl":"https://doi.org/10.1089/aivt.2022.29031.editorial","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47858404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Synergistic Effect of Selenium/Zinc with Sulfasalazine on the Human Colorectal Cancer Cell Line (HT-29) 硒/锌与柳氮磺胺吡啶对人结直肠癌细胞株HT-29的协同作用
Applied In Vitro Toxicology Pub Date : 2022-11-22 DOI: 10.1089/aivt.2022.0007
F. Motafeghi, B. Khayambashi, P. Mortazavi, M. Eghbali, Amirhossein Salmanmahiny, Romina Shahsavari, M. Shokrzadeh
{"title":"Synergistic Effect of Selenium/Zinc with Sulfasalazine on the Human Colorectal Cancer Cell Line (HT-29)","authors":"F. Motafeghi, B. Khayambashi, P. Mortazavi, M. Eghbali, Amirhossein Salmanmahiny, Romina Shahsavari, M. Shokrzadeh","doi":"10.1089/aivt.2022.0007","DOIUrl":"https://doi.org/10.1089/aivt.2022.0007","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47501993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Machine-Learning Model Predicts Interaction with γ-Amino Butyric Acid (GABA)ergic Neurotransmission 机器学习模型预测与γ-氨基丁酸（GABA）能神经传递的相互作用
Applied In Vitro Toxicology Pub Date : 2022-11-10 DOI: 10.1089/aivt.2021.0028
Sanjeeva J. Wijeyesakere, Daniel M. Wilson, T. Auernhammer, Amanda K. Parks, S. Marty
{"title":"Machine-Learning Model Predicts Interaction with γ-Amino Butyric Acid (GABA)ergic Neurotransmission","authors":"Sanjeeva J. Wijeyesakere, Daniel M. Wilson, T. Auernhammer, Amanda K. Parks, S. Marty","doi":"10.1089/aivt.2021.0028","DOIUrl":"https://doi.org/10.1089/aivt.2021.0028","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48964158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes 研究甲状腺激素破坏的一种新方法：评估人肝微粒体中DIO1酶抑制作用的方法的优化和标准化
Applied In Vitro Toxicology Pub Date : 2022-09-01 DOI: 10.1089/aivt.2022.0010
A. Weber, B. Birk, Chantal Herrmann, H. Huener, K. Renko, S. Coecke, S. Schneider, D. Funk-Weyer, R. Landsiedel
{"title":"A New Approach Method to Study Thyroid Hormone Disruption: Optimization and Standardization of an Assay to Assess the Inhibition of DIO1 Enzyme in Human Liver Microsomes","authors":"A. Weber, B. Birk, Chantal Herrmann, H. Huener, K. Renko, S. Coecke, S. Schneider, D. Funk-Weyer, R. Landsiedel","doi":"10.1089/aivt.2022.0010","DOIUrl":"https://doi.org/10.1089/aivt.2022.0010","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44479659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Characterizing Local Acute Irritation Properties of Captan and Folpet with New Approach Methods 用新方法表征Captan和Folpet的局部急性刺激特性
Applied In Vitro Toxicology Pub Date : 2022-09-01 DOI: 10.1089/aivt.2022.0004
F. Kluxen, C. Roper, Signe M. Jensen, C. Koenig
{"title":"Characterizing Local Acute Irritation Properties of Captan and Folpet with New Approach Methods","authors":"F. Kluxen, C. Roper, Signe M. Jensen, C. Koenig","doi":"10.1089/aivt.2022.0004","DOIUrl":"https://doi.org/10.1089/aivt.2022.0004","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44251101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
An Integrated In Vitro Approach for Human Health and Environmental Risk Assessment of Mediterranean Ostreopsis cf. ovata, Prorocentrum lima, and Coolia monotis Strains 地中海卵形Ostreopsis cff . ovata, proocentrum lima和Coolia monotis菌株的人体健康和环境风险综合体外评估方法
Applied In Vitro Toxicology Pub Date : 2022-09-01 DOI: 10.1089/aivt.2022.0008
Francesco Misurale, Cristina Scarone, L. Pezzolesi, R. Pistocchi, A. Bassi, A. Novellino, Matilde Calderoni, A. Pagano, Valentina Giussani, S. Alloisio
{"title":"An Integrated In Vitro Approach for Human Health and Environmental Risk Assessment of Mediterranean Ostreopsis cf. ovata, Prorocentrum lima, and Coolia monotis Strains","authors":"Francesco Misurale, Cristina Scarone, L. Pezzolesi, R. Pistocchi, A. Bassi, A. Novellino, Matilde Calderoni, A. Pagano, Valentina Giussani, S. Alloisio","doi":"10.1089/aivt.2022.0008","DOIUrl":"https://doi.org/10.1089/aivt.2022.0008","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45436707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Scientific Usefulness of New Approach Methodologies 新方法论的科学实用性
Applied In Vitro Toxicology Pub Date : 2022-09-01 DOI: 10.1089/aivt.2022.29030.editorial
Andrew Gow
{"title":"Scientific Usefulness of New Approach Methodologies","authors":"Andrew Gow","doi":"10.1089/aivt.2022.29030.editorial","DOIUrl":"https://doi.org/10.1089/aivt.2022.29030.editorial","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45592635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48 使用Vitrocell Ames 48表征可燃香烟、加热烟草制品和电子尼古丁输送系统的气溶胶输送
Applied In Vitro Toxicology Pub Date : 2022-06-01 DOI: 10.1089/aivt.2022.0001
B. Keyser, R. Leverette, M. Hollings, Adam Seymour, Randy J. Weidman, Carlton J. Bequette, Kristen G. Jordan
{"title":"Characterization of Aerosol Deliveries from Combustible Cigarettes, Heated Tobacco Products, and Electronic Nicotine Delivery Systems Using the Vitrocell Ames 48","authors":"B. Keyser, R. Leverette, M. Hollings, Adam Seymour, Randy J. Weidman, Carlton J. Bequette, Kristen G. Jordan","doi":"10.1089/aivt.2022.0001","DOIUrl":"https://doi.org/10.1089/aivt.2022.0001","url":null,"abstract":"","PeriodicalId":37448,"journal":{"name":"Applied In Vitro Toxicology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41815192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
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