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Current Opinion in Systems Biology最新文献

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Sustainable diversity of phage-bacteria systems 噬菌体系统的可持续多样性
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-09-01 Epub Date: 2023-06-01 DOI: 10.1016/j.coisb.2023.100468
Namiko Mitarai, Anastasios Marantos, Kim Sneppen
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引用次数: 0
Corrigendum to: Entropy as a measure of variability and stemness in single-cell transcriptomics 勘误表：熵作为单细胞转录组学变异性和干性的衡量标准
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-09-01 Epub Date: 2023-05-10 DOI: 10.1016/j.coisb.2023.100458
Olivier Gandrillon , Mathilde Gaillard , Thibault Espinasse , Nicolas B. Garnier , Charles Dussiaud , Olivier Kosmider , Pierre Sujobert
{"title":"Corrigendum to: Entropy as a measure of variability and stemness in single-cell transcriptomics","authors":"Olivier Gandrillon ,&nbsp;Mathilde Gaillard ,&nbsp;Thibault Espinasse ,&nbsp;Nicolas B. Garnier ,&nbsp;Charles Dussiaud ,&nbsp;Olivier Kosmider ,&nbsp;Pierre Sujobert","doi":"10.1016/j.coisb.2023.100458","DOIUrl":"10.1016/j.coisb.2023.100458","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"35 ","pages":"Article 100458"},"PeriodicalIF":3.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44077606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Control of tissue dimensions in the developing neural tube and somites 发育中的神经管和小体组织尺寸的控制
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-09-01 Epub Date: 2023-05-17 DOI: 10.1016/j.coisb.2023.100459
Thomas Minchington , Stefanie Lehr , Anna Kicheva
{"title":"Control of tissue dimensions in the developing neural tube and somites","authors":"Thomas Minchington ,&nbsp;Stefanie Lehr ,&nbsp;Anna Kicheva","doi":"10.1016/j.coisb.2023.100459","DOIUrl":"10.1016/j.coisb.2023.100459","url":null,"abstract":"<div><p>Despite its fundamental importance for development, the question of how organs achieve their correct size and shape is poorly understood. This complex process requires coordination between the generation of cell mass and the morphogenetic mechanisms that sculpt tissues. These processes are regulated by morphogen signalling pathways and mechanical forces. Yet, in many systems, it is unclear how biochemical and mechanical signalling are quantitatively interpreted to determine the behaviours of individual cells and how they contribute to growth and morphogenesis at the tissue scale. In this review, we discuss the development of the vertebrate neural tube and somites as an example of the state of knowledge, as well as the challenges in understanding the mechanisms of tissue size control in vertebrate organogenesis. We highlight how the recent advances in stem cell differentiation and organoid approaches can be harnessed to provide new insights into this question.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"35 ","pages":"Article 100459"},"PeriodicalIF":3.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47108392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编委会页面
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-09-01 Epub Date: 2023-09-04 DOI: 10.1016/S2452-3100(23)00031-8
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2452-3100(23)00031-8","DOIUrl":"10.1016/S2452-3100(23)00031-8","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"35 ","pages":"Article 100474"},"PeriodicalIF":3.7,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41253448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
How prebiotic complexity increases through Darwinian evolution 达尔文进化如何增加益生元的复杂性
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-06-01 Epub Date: 2023-04-26 DOI: 10.1016/j.coisb.2023.100456
Kohtoh Yukawa , Ryo Mizuuchi , Norikazu Ichihashi
{"title":"How prebiotic complexity increases through Darwinian evolution","authors":"Kohtoh Yukawa ,&nbsp;Ryo Mizuuchi ,&nbsp;Norikazu Ichihashi","doi":"10.1016/j.coisb.2023.100456","DOIUrl":"10.1016/j.coisb.2023.100456","url":null,"abstract":"<div><p>Present-day life is amazingly diverse and complex owing to Darwinian evolution. Despite the simplicity of the principle of Darwinian evolution, the process and its outcomes are largely unpredictable. Evolutionary simulation and experiments are useful methods for gaining insights into the process and outcomes of Darwinian evolution. In this short review, we discuss recent progress in theoretical and experimental approaches to understanding the possible evolutionary processes of prebiotic self-replicators. We especially focus on research addressing how a prebiotic self-replicator increases complexity through evolution, including our recent experiments, in which a complex replication network consisting of multiple self-replicating molecules spontaneously evolved from a single replicating RNA.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"34 ","pages":"Article 100456"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49417919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Editorial Board Page 编辑委员会页面
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-06-01 Epub Date: 2023-06-02 DOI: 10.1016/S2452-3100(23)00021-5
{"title":"Editorial Board Page","authors":"","doi":"10.1016/S2452-3100(23)00021-5","DOIUrl":"https://doi.org/10.1016/S2452-3100(23)00021-5","url":null,"abstract":"","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"34 ","pages":"Article 100464"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50172800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Regulation of the microtubule network; the shaft matters! 微管网络的调控;轴很重要!
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-06-01 Epub Date: 2023-04-26 DOI: 10.1016/j.coisb.2023.100457
Amine Mehidi , Charlotte Aumeier
{"title":"Regulation of the microtubule network; the shaft matters!","authors":"Amine Mehidi ,&nbsp;Charlotte Aumeier","doi":"10.1016/j.coisb.2023.100457","DOIUrl":"10.1016/j.coisb.2023.100457","url":null,"abstract":"<div><p>In cells, the microtubule network continually assembles and disassembles. The regulation of microtubule growth or shortening has almost exclusively been studied at their dynamic ends. However, microtubules are dynamic all along their entire shaft. A dynamic shaft increases the lifetime and length of a microtubule by reducing the shortening phases and promoting its regrowth. Here, we discuss how shaft dynamics can regulate microtubule network organization, intracellular transport, and polarization of the network.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"34 ","pages":"Article 100457"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44457140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evolutionary implications of host genetic control for engineering beneficial microbiomes 宿主基因控制对工程有益微生物群的进化意义
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-06-01 Epub Date: 2023-04-27 DOI: 10.1016/j.coisb.2023.100455
Lucas P. Henry, Joy Bergelson
{"title":"Evolutionary implications of host genetic control for engineering beneficial microbiomes","authors":"Lucas P. Henry,&nbsp;Joy Bergelson","doi":"10.1016/j.coisb.2023.100455","DOIUrl":"10.1016/j.coisb.2023.100455","url":null,"abstract":"<div><p>Engineering new functions in the microbiome requires understanding how host genetic control and microbe–microbe interactions shape the microbiome. One key genetic mechanism underlying host control is the immune system. The immune system can promote stability in the composition of the microbiome by reshaping the ecological dynamics of its members, but the degree of stability will depend on the interplay between ecological context, immune system development, and higher-order microbe–microbe interactions. The eco-evolutionary interplay affecting composition and stability should inform the strategies used to engineer new functions in the microbiome. We conclude with recent methodological developments that provide an important path forward for both engineering new functionality in the microbiome and broadly understanding how ecological interactions shape evolutionary processes in complex biological systems.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"34 ","pages":"Article 100455"},"PeriodicalIF":3.7,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10242548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9600074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Order from chaos: How mechanics shape epithelia and promote self-organization 混乱中的秩序:力学如何塑造上皮并促进自组织
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-03-01 Epub Date: 2023-02-14 DOI: 10.1016/j.coisb.2023.100446
Filipe Nunes Vicente, Alba Diz-Muñoz
{"title":"Order from chaos: How mechanics shape epithelia and promote self-organization","authors":"Filipe Nunes Vicente,&nbsp;Alba Diz-Muñoz","doi":"10.1016/j.coisb.2023.100446","DOIUrl":"10.1016/j.coisb.2023.100446","url":null,"abstract":"<div><p>Collective cell behaviors are essential for the shape and function of tissues. The last decades have provided unequivocal experimental evidence that tissue mechanics are key drivers of morphogenesis. In particular, the spatiotemporal coordination of cellular contractility, adhesion and volume regulation can drive morphogenetic events in various epithelia. At the same time, the epithelial sheets themselves have remarkable mechanical properties, being able to distribute mechanical stress throughout the whole material to resist the physical deformations necessary for their function. In this review, we address recent findings on epithelia morphogenesis and mechanical resistance and highlight the importance of quantitative new approaches for achieving novel understanding.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"32 ","pages":"Article 100446"},"PeriodicalIF":3.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47110194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Mechanisms of enhancer function in neuronal systems in health and disease 健康和疾病中神经元系统增强子功能的机制
IF 3.7
Current Opinion in Systems Biology Pub Date : 2023-03-01 Epub Date: 2022-12-06 DOI: 10.1016/j.coisb.2022.100443
Luna Zea-Redondo , Ana Pombo
{"title":"Mechanisms of enhancer function in neuronal systems in health and disease","authors":"Luna Zea-Redondo ,&nbsp;Ana Pombo","doi":"10.1016/j.coisb.2022.100443","DOIUrl":"10.1016/j.coisb.2022.100443","url":null,"abstract":"<div><p><span>Enhancers are genomic elements that regulate gene expression through a variety of mechanisms. In neuronal systems, enhancer-promoter interactions regulate cell- and tissue-specific transcriptional programs, during neuronal specification and upon terminal differentiation, and play major roles in the tight regulation of activity-dependent mechanisms, such as in memory formation. Enhancers are also hotspots for non-coding genetic variants associated with neurological disorders, such as schizophrenia and </span>Parkinson's disease (PD). Understanding how enhancer grammar informs gene expression programs in neuronal systems in development and disease remains a major challenge, and is a growing avenue to discover the molecular mechanisms directly altered by non-coding genetic variants. In this review, we discuss the diverse mechanisms by which enhancers integrate internal and external stimuli to regulate the gene expression programs that guide neuronal specification and sustain neuronal-specific and activity-dependent processes.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":"32 ","pages":"Article 100443"},"PeriodicalIF":3.7,"publicationDate":"2023-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48337920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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