Current Opinion in Systems Biology最新文献_第7页

Transcription factor binding and activity on chromatin 转录因子在染色质上的结合和活性

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI: 10.1016/j.coisb.2022.100438

Jorge Trojanowski , Karsten Rippe

引用次数: 4

Editorial overview: The metabolic network 编辑概述:代谢网络

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI: 10.1016/j.coisb.2022.100432

Sarah-Maria Fendt, Markus Ralser

引用次数: 0

Robust cell identity specifications through transitions in the collective state of growing developmental systems 通过生长发育系统的集体状态的转变，健壮的细胞身份规范

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI: 10.1016/j.coisb.2022.100437

Angel Stanoev , Aneta Koseska

引用次数: 1

The energetics of activator–promoter recognition 激活子-启动子识别的能量学

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI: 10.1016/j.coisb.2022.100434

Hinrich Boeger

引用次数: 0

Editorial Board Page 编委会页面

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-09-01 DOI: 10.1016/S2452-3100(22)00025-7

引用次数: 0

Editorial Board Page 编委会页面

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-06-01 DOI: 10.1016/S2452-3100(22)00014-2

引用次数: 0

Enhanced underground metabolism challenges life at high temperature–metabolic thermoadaptation in hyperthermophilic Archaea 增强的地下代谢挑战了超嗜热古菌高温代谢热适应的生命

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-06-01 DOI: 10.1016/j.coisb.2022.100423

Christian Schmerling , Theresa Kouril , Jacky Snoep , Christopher Bräsen , Bettina Siebers

{"title":"Enhanced underground metabolism challenges life at high temperature–metabolic thermoadaptation in hyperthermophilic Archaea","authors":"Christian Schmerling , Theresa Kouril , Jacky Snoep , Christopher Bräsen , Bettina Siebers","doi":"10.1016/j.coisb.2022.100423","DOIUrl":"10.1016/j.coisb.2022.100423","url":null,"abstract":"<div><p><span><span>The text-book picture of a perfect, well organised metabolism with highly specific enzymes<span>, is challenged by non-enzymatic reactions and promiscuous enzymes. This, so-called ‘underground metabolism’, is a special challenge for hyperthermophilic Archaea that thrive at temperatures above 80 °C and possess modified central metabolic pathways often with promiscuous enzymes. Hence, the question arises how extremely </span></span>thermophilic Archaea can operate their unusual metabolism at temperatures where many pathway intermediates are unstable? We herein discuss current insights in the underground metabolism and metabolic </span>thermoadaptation<span><span> of (hyper)thermophilic Archaea. So far, only a few repair enzymes and salvaging pathways have been investigated in Archaea. Studies of the central </span>carbohydrate metabolism indicate that a number of different strategies have evolved: 1) reduction of the concentration of unstable metabolites, 2) different pathway topologies are used with newly induced enzymes, and 3) damaged metabolites are removed via new metabolic pathways.</span></p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46353795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Synthetic metabolism approaches: A valuable resource for systems biology 合成代谢方法:系统生物学的宝贵资源

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-06-01 DOI: 10.1016/j.coisb.2022.100417

Sebastian Wenk , Nico J. Claassens , Steffen N. Lindner

{"title":"Synthetic metabolism approaches: A valuable resource for systems biology","authors":"Sebastian Wenk , Nico J. Claassens , Steffen N. Lindner","doi":"10.1016/j.coisb.2022.100417","DOIUrl":"10.1016/j.coisb.2022.100417","url":null,"abstract":"<div><p>Synthetic biology modifies biological systems with the aim of creating new biological parts, devices, and even organisms. Systems biology deciphers the design principles of biological systems trying to derive the mathematical logic behind biological processes. Although different in their respective research approaches and questions, both disciplines are clearly interconnected. Without sufficient understanding of the biological system, synthetic biology studies cannot be properly designed and conducted. On the other hand, systems biology can profit from new biological systems generated by synthetic biology approaches, which can reveal important insights into cellular processes and allow a better understanding of the principles of life. In this article, we present state-of-the-art synthetic biology approaches that focus on the engineering of synthetic metabolism in microbial hosts and show how their implementation has led to new fundamental discoveries on enzyme reversibility, promiscuity, and “underground metabolism”. We further discuss how the combination of rational engineering and adaptive laboratory evolution has enabled the generation of microbes with a synthetic central metabolism, leading to completely new metabolic phenotypes. These organisms provide a great resource for future studies to deepen our systems-level understanding on the principles that govern metabolic networks and evolution.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310022000038/pdfft?md5=c9f96786811b96040d981e16ebdbfe34&pid=1-s2.0-S2452310022000038-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46772608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Organelle dysfunction and its contribution to metabolic impairments in aging and age-related diseases 细胞器功能障碍及其对衰老和年龄相关疾病代谢损伤的贡献

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-06-01 DOI: 10.1016/j.coisb.2022.100416

Julia C. Heiby, Alessandro Ori

引用次数: 1

Metabolic dynamics during the cell cycle 细胞周期中的代谢动力学

IF 3.7

Current Opinion in Systems Biology Pub Date : 2022-06-01 DOI: 10.1016/j.coisb.2022.100415

Andre Zylstra, Matthias Heinemann

{"title":"Metabolic dynamics during the cell cycle","authors":"Andre Zylstra, Matthias Heinemann","doi":"10.1016/j.coisb.2022.100415","DOIUrl":"10.1016/j.coisb.2022.100415","url":null,"abstract":"<div><p>While we have a solid understanding of the cell biological and biochemical control aspects of the eukaryotic cell growth and division process, much less is known about the metabolic and biosynthetic dynamics during the cell cycle. Here, we review recent discoveries made at the single-cell and population level that show that budding yeast (<em>Saccharomyces cerevisiae</em>) metabolism oscillates in synchrony with the cell cycle in actively dividing cells, as well as independently when the cell cycle is halted. In fact, emerging evidence suggests that the cell cycle-independent metabolic oscillations interact with elements of the cell cycle machinery via several possible mechanisms. Furthermore, recent reports indicate that different biosynthetic processes exhibit temporally changing activity patterns during the cell cycle. Thus, resources are drawn from primary metabolism in a dynamic manner, potentially giving rise to metabolic oscillations. Finally, we highlight work with mammalian cells indicating that similar metabolic dynamics might also exist in higher eukaryotes.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2452310022000014/pdfft?md5=0ceeea28044602a21abcb5841856610a&pid=1-s2.0-S2452310022000014-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41405427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4