{"title":"How prebiotic complexity increases through Darwinian evolution","authors":"Kohtoh Yukawa , Ryo Mizuuchi , Norikazu Ichihashi","doi":"10.1016/j.coisb.2023.100456","DOIUrl":null,"url":null,"abstract":"<div><p>Present-day life is amazingly diverse and complex owing to Darwinian evolution. Despite the simplicity of the principle of Darwinian evolution, the process and its outcomes are largely unpredictable. Evolutionary simulation and experiments are useful methods for gaining insights into the process and outcomes of Darwinian evolution. In this short review, we discuss recent progress in theoretical and experimental approaches to understanding the possible evolutionary processes of prebiotic self-replicators. We especially focus on research addressing how a prebiotic self-replicator increases complexity through evolution, including our recent experiments, in which a complex replication network consisting of multiple self-replicating molecules spontaneously evolved from a single replicating RNA.</p></div>","PeriodicalId":37400,"journal":{"name":"Current Opinion in Systems Biology","volume":null,"pages":null},"PeriodicalIF":3.4000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Opinion in Systems Biology","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S2452310023000136","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Present-day life is amazingly diverse and complex owing to Darwinian evolution. Despite the simplicity of the principle of Darwinian evolution, the process and its outcomes are largely unpredictable. Evolutionary simulation and experiments are useful methods for gaining insights into the process and outcomes of Darwinian evolution. In this short review, we discuss recent progress in theoretical and experimental approaches to understanding the possible evolutionary processes of prebiotic self-replicators. We especially focus on research addressing how a prebiotic self-replicator increases complexity through evolution, including our recent experiments, in which a complex replication network consisting of multiple self-replicating molecules spontaneously evolved from a single replicating RNA.
期刊介绍：
Current Opinion in Systems Biology is a new systematic review journal that aims to provide specialists with a unique and educational platform to keep up-to-date with the expanding volume of information published in the field of Systems Biology. It publishes polished, concise and timely systematic reviews and opinion articles. In addition to describing recent trends, the authors are encouraged to give their subjective opinion on the topics discussed. As this is such a broad discipline, we have determined themed sections each of which is reviewed once a year. The following areas will be covered by Current Opinion in Systems Biology: -Genomics and Epigenomics -Gene Regulation -Metabolic Networks -Cancer and Systemic Diseases -Mathematical Modelling -Big Data Acquisition and Analysis -Systems Pharmacology and Physiology -Synthetic Biology -Stem Cells, Development, and Differentiation -Systems Biology of Mold Organisms -Systems Immunology and Host-Pathogen Interaction -Systems Ecology and Evolution
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