Biomedical Glasses最新文献_第7页

Mesoporous bioactive glasses: Relevance of their porous structure compared to that of classical bioglasses 介孔生物活性玻璃:它们的多孔结构与经典生物玻璃的相关性

Biomedical Glasses Pub Date : 2015-11-03 DOI: 10.1515/bglass-2015-0014

I. Izquierdo-Barba, M. Vallet‐Regí

引用次数: 78

Novel antibacterial bioactive glass nanocomposite functionalized with tetracycline hydrochloride 新型四环素功能化抗菌生物活性玻璃纳米复合材料

Biomedical Glasses Pub Date : 2015-10-21 DOI: 10.1515/bglass-2015-0012

J. Rivadeneira, Gisela M. Luz, M. Audisio, João F. Mano, Alejandro A. Gorustovich

{"title":"Novel antibacterial bioactive glass nanocomposite functionalized with tetracycline hydrochloride","authors":"J. Rivadeneira, Gisela M. Luz, M. Audisio, João F. Mano, Alejandro A. Gorustovich","doi":"10.1515/bglass-2015-0012","DOIUrl":"https://doi.org/10.1515/bglass-2015-0012","url":null,"abstract":"Abstract To prevent the high frequency of wound infections, anti-bacterial agents can be loaded onto composites. In the present study, the antibiotic tetracycline hydrochloride (TC)was incorporated, for the first time, in collagen type I membranes coated with nano-sized SiO2-CaOP2O5 bioactive glass (n-BG) obtained by a sol-gel chemical route. Collagen membranes coated with n-BG were immersed in simulated body fluid (SBF) containing 0.25, 0.75 or 1.25 mg mL−1 of TC for 48 h at 37∘C following a coprecipitation method. The antibiotic was released in distilledwater at 37∘C for up to 72 h. The antibacterial activity of the composites was evaluated in vitro by the inhibition zone test and plate count method. Two different Staphylococcus aureus strains, S. aureus ATCC29213 and S. aureus ATCC25923, were exposed to the biomaterials. The results showed that the incorporation but not the release of TC was dependent on the initial concentration of TC in SBF. The biomaterials inhibited S. aureus growth, although the efficacy was similar for all the concentrations. The results allow us to conclude that the new composite could have potential in the prevention of wound infections.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0012","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Enhanced apatite precipitation on a biopolymer-coated bioactive glass 生物聚合物涂层生物活性玻璃上磷灰石的增强沉淀

Biomedical Glasses Pub Date : 2015-10-20 DOI: 10.1515/bglass-2015-0011

M. Araújo, M. Miola, A. Venturello, G. Baldi, J. Pérez, E. Verné

引用次数: 3

Novel Highly Degradable Chloride Containing Bioactive Glasses 新型高降解含氯生物活性玻璃

Biomedical Glasses Pub Date : 2015-09-15 DOI: 10.1515/bglass-2015-0010

Xiaojing Chen, N. Karpukhina, D. Brauer, R. Hill

{"title":"Novel Highly Degradable Chloride Containing Bioactive Glasses","authors":"Xiaojing Chen, N. Karpukhina, D. Brauer, R. Hill","doi":"10.1515/bglass-2015-0010","DOIUrl":"https://doi.org/10.1515/bglass-2015-0010","url":null,"abstract":"Abstract Addition of CaF2 to a silicate bioactive glass favours formation of fluorapatite, which is less soluble in acidic environment than hydroxyapatite. However, excess CaF2 in the glass is problematic, owing to the formation of crystalline calcium fluoride rather than fluorapatite on immersion. In this paper we investigate chloride as an alternative to fluoride in bioactive silicate glasses and in particular their bioactivity for the first time. Meltderived bioactive glasses based on SiO2-P2O5-CaO-CaCl2 with varying CaCl2 contents were synthesised and characterised by DSC. Chemical analysis of the chloride content was performed by using an ion selective electrode. Glass density was determined using Helium Pycnometry. The glass bioactivity was investigated in Tris buffer. Ion release measurements were carried out by using ICP-OES. The chemical analysis results indicated that the majority of the chloride is retained in the Q2 type silicate glasses during synthesis. Tg and glass density reduced with increasing CaCl2 content. Apatite-like phase formation was confirmed by FITR, XRD and 31P MAS-NMR. The results of the in vitro studies demonstrated that the chloride containing bioactive glasses are highly degradable and form apatite-like phase within three hours in Tris buffer and, therefore, are certainly suitable for use in remineralising toothpastes. The dissolution rate of the glass was found to increase with CaCl2 content. Faster dissolving bioactive glasses may be attractive for more resorbable bone grafts and scaffolds.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0010","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Influence of zinc and magnesium substitution on ion release from Bioglass 45S5 at physiological and acidic pH 生理和酸性pH下锌和镁取代对45S5生物玻璃离子释放的影响

Biomedical Glasses Pub Date : 2015-09-14 DOI: 10.1515/bglass-2015-0009

M. Blochberger, L. Hupa, D. Brauer

{"title":"Influence of zinc and magnesium substitution on ion release from Bioglass 45S5 at physiological and acidic pH","authors":"M. Blochberger, L. Hupa, D. Brauer","doi":"10.1515/bglass-2015-0009","DOIUrl":"https://doi.org/10.1515/bglass-2015-0009","url":null,"abstract":"Abstract Ion release of Mg- and Zn-substituted Bioglass 45S5 (46.1 SiO2-2.6 P2O5-26.9 CaO-24.3Na2O; mol%; with 0, 25, 50, 75 or 100% of calcium replaced bymagnesium/zinc) was investigated at pH 7.4 (Tris buffer) and pH 4 (acetic acid/sodium acetate buffer) in static and dynamic dissolution experiments. Despite Mg2+ and Zn2+ having the same charge and comparable ionic radii, they influenced the dissolution behaviour in very different ways. In Tris, Mgsubstituted glasses showed similar ion release as 45S5, while Zn-substituted glasses showed negligible ion release. At low pH, however, release behaviour was similar, with all glasses releasing large percentages of ions within a few minutes. Precipitation of crystalline phases also varied, as Mg- and Zn-substitution inhibited apatite formation, and Zn-substitution resulted in formation of zinc phosphate phases at low pH. These results are relevant for glasses used in aluminium-free glass ionomer bone cements, as they show that Zn/Mg-substituted glasses release ions similarly fast as glasses containing no Zn/Mg, suggesting that these ions are no prerequisite for ionomer glasses. Zn-substituted glasses may potentially be used as controlled-release materials, which release antibacterial zinc ions when needed only, i.e. at low pH conditions (e.g. bacterial infection), but not at normal physiological pH conditions.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Preparation and Characterization of Low Temperature Heat-Treated 45S5 Bioactive Glass-Ceramic Analogues 低温热处理45S5生物活性玻璃陶瓷类似物的制备与表征

Biomedical Glasses Pub Date : 2015-09-07 DOI: 10.1515/bglass-2015-0008

K. Xie, Lei Zhang, Xianyan Yang, Xiao-qiang Wang, Guojing Yang, Licheng Zhang, H. Shao, Yong He, Jianzhong Fu, Z. Gou

{"title":"Preparation and Characterization of Low Temperature Heat-Treated 45S5 Bioactive Glass-Ceramic Analogues","authors":"K. Xie, Lei Zhang, Xianyan Yang, Xiao-qiang Wang, Guojing Yang, Licheng Zhang, H. Shao, Yong He, Jianzhong Fu, Z. Gou","doi":"10.1515/bglass-2015-0008","DOIUrl":"https://doi.org/10.1515/bglass-2015-0008","url":null,"abstract":"Abstract The 45S5 Bioglassr and its sintered bioactive glass-ceramic (BGC) have been widely investigated as bone implants, mainly for its ability to bond to hard tissues. However, high temperature treatment is not enough to improve its poor mechanical properties, but compromise its biologically relevant performances. The innovative BGC compositions based on the thermally treated 45S5 Bioglassr were developed by decreasing the P2O5 quantity and adding B2O3 (0-6%) into the Na2O–2CaO–3SiO2- based bioactive glasses (BG). The thermally treated BGCs were fully characterized from the microstructural and mechanical points of view and compared to each other. Their bioactivity and bio-dissolutionwere established by means of in vitro soaking tests. The new B2O3-added 45S5 BG analogues, named NCS-xB, can be transformed to crystalline phase (Na2Ca2Si3O9)-based BGCs of high compactness and bioactivity at a relatively low temperature heat treatment (≤ 900ºC), since their bioactivity is preserved. Our experimental results suggest that the new 45S5 BGC analogues with optimized composition exhibit improved micro- structural and mechanical properties, and are beneficial for making specific products such as porous scaffolds or composites for bone defect repair.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0008","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

"Imageable" Zinc-Silicate Glass Microspheres For Transarterial Embolization: A Renal Artery Embolization Study. “可成像”的锌硅酸盐玻璃微球经动脉栓塞:肾动脉栓塞研究。

Biomedical Glasses Pub Date : 2015-08-26 DOI: 10.1515/bglass-2015-0007

S. Kehoe, Salma Amensag, M. Looney, R. Abraham, D. Boyd

{"title":"\"Imageable\" Zinc-Silicate Glass Microspheres For Transarterial Embolization: A Renal Artery Embolization Study.","authors":"S. Kehoe, Salma Amensag, M. Looney, R. Abraham, D. Boyd","doi":"10.1515/bglass-2015-0007","DOIUrl":"https://doi.org/10.1515/bglass-2015-0007","url":null,"abstract":"Abstract Intrinsically radiopaque (imageable) microspheres for transarterial embolization (TAE) are required to enable real-time intraprocedural feedback and definition of spatial distribution patterns of embolic materials in target tissues. This pilot study evaluates acute and sub-chronic safety and efficacy of imageable zinc-silicate (Zn-Si) glass microspheres in a swine renal artery embolization (RAE) model. Eight swine were divided into two cohorts. Clinical determinants of embolization effectiveness, including imageability, deliverability and temporal/ spatial distribution of microspheres in target tissues were assessed. Subsequently, cohort I and II were used to evaluate the acute and subchronic host response against the Zn-Si microspheres versus a clinical control. The developed microspheres provide for direct intraprocedural feedback using standard diagnostic imaging techniques. Fluoroscopy correlated with ex-vivo high-resolution radiography, CT and micro-CT, demonstrating high imageability, excellent spatial distribution and packing of the Zn- Si microspheres. At follow-up, infarction of the embolized kidneys was noted without any major adverse tissue reaction. Mild recanalization was observed microscopically for both experimental and control microspheres. Zn-Si microspheres permit the definition of spatial distribution in a target tissue, consequently permitting the optimization, personalization and improvement of TAE techniques.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67220812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications 含锌生物活性眼镜用于骨再生，牙科和骨科应用

Biomedical Glasses Pub Date : 2015-07-29 DOI: 10.1515/bglass-2015-0006

P. Balasubramanian, L. Strobel, U. Kneser, A. Boccaccini

{"title":"Zinc-containing bioactive glasses for bone regeneration, dental and orthopedic applications","authors":"P. Balasubramanian, L. Strobel, U. Kneser, A. Boccaccini","doi":"10.1515/bglass-2015-0006","DOIUrl":"https://doi.org/10.1515/bglass-2015-0006","url":null,"abstract":"Abstract Zinc is a vital and beneficial trace element found in the human body. Though found in small proportions, zinc performs a variety of functions in relation to the immune system, cell division, fertility and the body growth and maintenance. In particular, zinc is proven to be a necessary element for the formation, mineralization, development and maintenance of healthy bones. Considering this attractive attributes of zinc, recent research has widely focused on using zinc along with silicate-based bioactive glasses for bone tissue engineering applications. This paper reviews relevant literature discussing the significance of zinc in the human body, along with its ability to enhance antibacterial effects, bioactivity and distinct physical, structural and mechanical properties of bioactive glasses. In this context, even if the present analysis is not meant to be exhaustive and only representative studies are discussed, literature results confirm that it is essential to understand the properties of zinc-containing bioactive glasses with respect to their in vitro biological behavior, possible cytotoxic effects and degradation characteristics to be able to effectively apply these glasses in bone regeneration strategies. Topics attracting increasing research efforts in this field are elaborated in detail in this review, including a summary of the structural, physical, biological and mechanical properties of zinc-containing bioactive glasses. This paper also presents an overview of the various applications in which zinc-containing bioactive glasses are considered for use as bone tissue scaffolds, bone filling granules, bioactive coatings and bone cements, and advances and remaining challenges are highlighted.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 65

Bioactivity of toothpaste containing bioactive glass in remineralizing media: effect of fluoride release from the enzymatic cleavage of monofluorophosphate. 含生物活性玻璃牙膏在再矿化介质中的生物活性:单氟磷酸盐酶解释放氟的影响。

Biomedical Glasses Pub Date : 2015-07-21 DOI: 10.1515/bglass-2015-0005

Anthony L. B. Maçon, Esther Valliant, J. Earl, Julian R. Jones

{"title":"Bioactivity of toothpaste containing bioactive glass in remineralizing media: effect of fluoride release from the enzymatic cleavage of monofluorophosphate.","authors":"Anthony L. B. Maçon, Esther Valliant, J. Earl, Julian R. Jones","doi":"10.1515/bglass-2015-0005","DOIUrl":"https://doi.org/10.1515/bglass-2015-0005","url":null,"abstract":"Abstract Objectives. The aim was to introduce a new methodology to characterize toothpaste containing bioactive glass and to evaluate the effect of release of fluoride ions, by cleaving monofluorophosphate (MFP), on the mineral forming ability of Sensodyne Repair & Protect (SRP). which contains NovaMinTM (bioactive glass, 45S5 composition). Methods. SRP, NovaMin particles, and placebo paste (PLA) which did not contain NovaMin, were immersed into a remineralization media (RS), which mimics the ionic strength of human saliva, for 3 days with different concentrations of alkaline phosphatase (ALP): 0, 25 and 75 U.L−1. Ion concentration profiles and pH were monitored by ICPOES and F− ion selective electrode. Remaining solids were collected by freeze-drying and their surfaces analysed. Results. Hydroxyapatite (HA) formed on the surface of BG alone (after 1 h) and in toothpaste (after 2 h), whereas PLA did not induce any precipitation. ALP cleaved MFP at different rates depending on the enzyme concentration. Increasing the concentration of ALP from 0 and 75 U.L−1 reduced the time of HA formation from 2 h to 24 h. However, the presence of fluoride induced the precipitation of fluorapatite. No evidence of fluorite (CaF2) was observed. The apatite formation ability of toothpaste can be assessed using the presented method.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Core/Clad Phosphate Glass Fibres Containing Iron and/or Titanium 含铁和/或钛的芯/包层磷酸盐玻璃纤维

Biomedical Glasses Pub Date : 2015-07-20 DOI: 10.1515/bglass-2015-0004

I. Ahmed, S. Shaharuddin, N. Sharmin, D. Furniss, C. Rudd

{"title":"Core/Clad Phosphate Glass Fibres Containing Iron and/or Titanium","authors":"I. Ahmed, S. Shaharuddin, N. Sharmin, D. Furniss, C. Rudd","doi":"10.1515/bglass-2015-0004","DOIUrl":"https://doi.org/10.1515/bglass-2015-0004","url":null,"abstract":"Abstract Phosphate glasses are novel amorphous biomaterials due to their fully resorbable characteristics, with controllable degradation profiles. In this study, phosphate glasses containing titanium and/or iron were identified to exhibit sufficiently matched thermal properties (glass transition temperature, thermal expansion coefficient and viscosity) which enabled successful co-extrusion of glass billets to form a core/clad preform. The cladding composition for the core/clad preforms were also reversed. Fe clad and Ti clad fibres were successfully drawn with an average diameter of between 30~50 μm. The average cladding annular thickness was estimated to be less than 2 μm. Annealed core/clad fibres were degraded in PBS for a period of 27 days. The strength of the Fe clad fibres appeared to increase from 303 ± 73 MPa to 386 ± 45 MPa after nearly 2 weeks in the dissolution medium (phosphate buffered solution) before decreasing by day 27. The strength of the Ti clad fibres revealed an increase from 236 ± 53 MPa to 295 ± 61 MPa when compared at week 3. The tensile modulus measured for both core/clad fibres ranged between 51 GPa to 60 GPa. During the dissolution study, Fe clad fibres showed a peeling mechanism compared to the Ti clad fibres.","PeriodicalId":37354,"journal":{"name":"Biomedical Glasses","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2015-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/bglass-2015-0004","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67221044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 12