Preparation and Characterization of Low Temperature Heat-Treated 45S5 Bioactive Glass-Ceramic Analogues

Q1 Materials Science

Biomedical Glasses Pub Date : 2015-09-07 DOI:10.1515/bglass-2015-0008

K. Xie, Lei Zhang, Xianyan Yang, Xiao-qiang Wang, Guojing Yang, Licheng Zhang, H. Shao, Yong He, Jianzhong Fu, Z. Gou

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引用次数: 24

Abstract

Abstract The 45S5 Bioglassr and its sintered bioactive glass-ceramic (BGC) have been widely investigated as bone implants, mainly for its ability to bond to hard tissues. However, high temperature treatment is not enough to improve its poor mechanical properties, but compromise its biologically relevant performances. The innovative BGC compositions based on the thermally treated 45S5 Bioglassr were developed by decreasing the P2O5 quantity and adding B2O3 (0-6%) into the Na2O–2CaO–3SiO2- based bioactive glasses (BG). The thermally treated BGCs were fully characterized from the microstructural and mechanical points of view and compared to each other. Their bioactivity and bio-dissolutionwere established by means of in vitro soaking tests. The new B2O3-added 45S5 BG analogues, named NCS-xB, can be transformed to crystalline phase (Na2Ca2Si3O9)-based BGCs of high compactness and bioactivity at a relatively low temperature heat treatment (≤ 900ºC), since their bioactivity is preserved. Our experimental results suggest that the new 45S5 BGC analogues with optimized composition exhibit improved micro- structural and mechanical properties, and are beneficial for making specific products such as porous scaffolds or composites for bone defect repair.

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低温热处理45S5生物活性玻璃陶瓷类似物的制备与表征

45S5生物玻璃及其烧结生物活性玻璃陶瓷(BGC)作为骨植入物被广泛研究，主要是由于其与硬组织的结合能力。然而，高温处理不仅不能改善其较差的力学性能，还会损害其生物学相关性能。通过减少P2O5的用量，在Na2O-2CaO-3SiO2基生物活性玻璃(BG)中加入B2O3(0-6%)，开发了基于热处理45S5生物玻璃的新型生物活性玻璃(BGC)。从显微组织和力学角度对热处理后的BGCs进行了全面表征，并进行了比较。采用体外浸渍法测定其生物活性和生物溶出度。新的添加b2o3的45S5 BG类似物，命名为NCS-xB，可以在相对较低的温度热处理(≤900℃)下转化为具有高致密性和生物活性的晶体相(Na2Ca2Si3O9)基bgc，因为它们的生物活性得到了保留。实验结果表明，优化后的45S5 BGC类似物具有较好的微观结构和力学性能，有利于制备多孔骨缺损修复材料或复合材料。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.