Influence of zinc and magnesium substitution on ion release from Bioglass 45S5 at physiological and acidic pH

Q1 Materials Science

Biomedical Glasses Pub Date : 2015-09-14 DOI:10.1515/bglass-2015-0009

M. Blochberger, L. Hupa, D. Brauer

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引用次数: 32

Abstract

Abstract Ion release of Mg- and Zn-substituted Bioglass 45S5 (46.1 SiO2-2.6 P2O5-26.9 CaO-24.3Na2O; mol%; with 0, 25, 50, 75 or 100% of calcium replaced bymagnesium/zinc) was investigated at pH 7.4 (Tris buffer) and pH 4 (acetic acid/sodium acetate buffer) in static and dynamic dissolution experiments. Despite Mg2+ and Zn2+ having the same charge and comparable ionic radii, they influenced the dissolution behaviour in very different ways. In Tris, Mgsubstituted glasses showed similar ion release as 45S5, while Zn-substituted glasses showed negligible ion release. At low pH, however, release behaviour was similar, with all glasses releasing large percentages of ions within a few minutes. Precipitation of crystalline phases also varied, as Mg- and Zn-substitution inhibited apatite formation, and Zn-substitution resulted in formation of zinc phosphate phases at low pH. These results are relevant for glasses used in aluminium-free glass ionomer bone cements, as they show that Zn/Mg-substituted glasses release ions similarly fast as glasses containing no Zn/Mg, suggesting that these ions are no prerequisite for ionomer glasses. Zn-substituted glasses may potentially be used as controlled-release materials, which release antibacterial zinc ions when needed only, i.e. at low pH conditions (e.g. bacterial infection), but not at normal physiological pH conditions.

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生理和酸性pH下锌和镁取代对45S5生物玻璃离子释放的影响

镁和锌取代生物玻璃45S5 (46.1 SiO2-2.6 P2O5-26.9 CaO-24.3Na2O)的离子释放摩尔%;分别在pH 7.4 (Tris缓冲液)和pH 4(醋酸/醋酸钠缓冲液)条件下进行静态和动态溶解实验，分别为0、25、50、75%和100%钙(镁/锌)。尽管Mg2+和Zn2+具有相同的电荷和相似的离子半径，但它们以非常不同的方式影响溶解行为。在Tris中，mg取代玻璃的离子释放与45S5相似，而zn取代玻璃的离子释放可以忽略不计。然而，在低pH下，释放行为是相似的，所有的玻璃在几分钟内释放出大量的离子。结晶相的析出也有所不同，因为Mg-和Zn-取代抑制了磷灰石的形成，而Zn-取代导致在低ph下形成磷酸锌相。这些结果与用于无铝玻璃离聚体骨水泥的玻璃有关，因为它们表明，Zn/Mg取代的玻璃释放离子的速度与不含Zn/Mg的玻璃相似，这表明这些离子不是离子玻璃的先决条件。锌取代玻璃可能潜在地用作控释材料，仅在需要时才释放抗菌锌离子，即在低pH条件下(例如细菌感染)，而不是在正常的生理pH条件下。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomedical Glasses Materials Science-Surfaces, Coatings and Films

自引率

0.00%

发文量

审稿时长

17 weeks

期刊介绍： Biomedical Glasses is an international Open Access-only journal covering the field of glasses for biomedical applications. The scope of the journal covers the science and technology of glasses and glass-based materials intended for applications in medicine and dentistry. It includes: Chemistry, physics, structure, design and characterization of biomedical glasses Surface science and interactions of biomedical glasses with aqueous and biological media Modeling structure and reactivity of biomedical glasses and their interfaces Biocompatibility of biomedical glasses Processing of biomedical glasses to achieve specific forms and functionality Biomedical glass coatings and composites In vitro and in vivo evaluation of biomedical glasses Glasses and glass-ceramics in engineered regeneration of tissues and organs Glass-based devices for medical and dental applications Application of glasses and glass-ceramics in healthcare.