{"title":"Bilateral Ovarian Cystadenoma in a Dog: Morphological and Histopathological Features.","authors":"Zahra Nozari, Samin Khodaverdian, Asghar Mogheiseh, Nasrollah Ahmadi, Shiva Amanollahi","doi":"10.1155/crve/8710723","DOIUrl":"https://doi.org/10.1155/crve/8710723","url":null,"abstract":"<p><p>Normal and abnormal cystic structures around the ovaries need to be evaluated based on the history, clinical signs, diagnostic imaging and paraclinical methods. An intact spitz nulliparous female, 9 years old, was referred with a normal estrous cycle and health history. During the ultrasound examination, bilateral cystic structures were observed around the ovaries just caudal to the kidneys. The left-side cystic masses were larger than the right-side and no abdominal free fluid observed. Based on the cystic structures and the age of the dog, an ovariohysterectomy was performed and histopathological samples were prepared for evaluation. Histopathological evaluation revealed multicystadenoma tumors originating from the subepithelial structures of the ovaries. No clinical signs of hormonal activity of cystic tumors were observed. They may affect transportation of oocytes from the ovary to the oviduct due to their physical structures in the ovulation space and infundibulum of the oviduct.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"8710723"},"PeriodicalIF":0.0,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13490829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148799046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A Luque Castro, N D Sargison, A Morrison, D J Bartley, M Abbas, A I Macrae, F R Murdoch, R F Kelly
{"title":"Investigating the Epidemiology of <i>Haemonchus contortus</i>, Using Traditional Faecal Diagnostics Supported by Deep-Amplicon Sequencing, in an Outbreak of Haemonchosis in a Scottish Pedigree Sheep Flock.","authors":"A Luque Castro, N D Sargison, A Morrison, D J Bartley, M Abbas, A I Macrae, F R Murdoch, R F Kelly","doi":"10.1155/crve/5558878","DOIUrl":"10.1155/crve/5558878","url":null,"abstract":"<p><p>This case report describes an investigation of an outbreak of haemonchosis in a Scottish pedigree sheep flock. The case occurred in a small lowland flock of pedigree Spotted Dutch sheep (<i>n</i> = 16) grazing pasture previously grazed by alpacas and horses. In 2024, despite routine anthelmintic treatments, clinical signs in the sheep led to suspicions and subsequent confirmation of acute haemonchosis. As part of clinical investigations, traditional faecal parasitology was combined with species identification using peanut agglutinin staining of GIN eggs and ITS-2 deep-amplicon genomic sequencing of first-stage larvae. Using these techniques, <i>Haemonchus contortus</i> was identified as the predominant GIN, and FAMACHA scoring was used to assess the level of anaemia for targeted selective treatment of affected animals. Additionally, ITS-2 deep-amplicon genomic sequencing described the GIN species profile of different animal management groups to further understand <i>H. contortus</i> epidemiology and inform control practices against future outbreaks. This case highlights the benefits of combining traditional faecal egg count diagnostics with GIN species identification techniques to better understand <i>H. contortus</i> epidemiology, thereby promoting sustainable control practices against haemonchosis.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"5558878"},"PeriodicalIF":0.0,"publicationDate":"2026-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13444728/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148686108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mohammad Reza Foroughi-Gilvaee, Nadi Maazi, Negin Raazi, Ahad Muhammadnejad
{"title":"Synchronous Multiple Primary Tumors in a Dog: A Case Report.","authors":"Mohammad Reza Foroughi-Gilvaee, Nadi Maazi, Negin Raazi, Ahad Muhammadnejad","doi":"10.1155/crve/3637175","DOIUrl":"10.1155/crve/3637175","url":null,"abstract":"<p><p>Multiple primary tumors (MPTs) are rare in dogs and challenging to diagnose when distinct lesions coexist. A 9-year-old mixed-breed female presented with mammary and cutaneous masses. Imaging revealed no pulmonary metastasis but metallic foreign bodies. Histopathology identified a low-grade intraductal carcinoma (HER2-negative), melanosis with borderline proliferative features in an inguinal lymph node, and benign acrochordons. Immunohistochemistry confirmed S100 positivity and elevated Ki-67 in the melanocytic component, suggesting melanocytic lesion with borderline proliferative features. Treatment included bilateral mastectomy, lymph node excision, and chemotherapy. Post-treatment bloodwork showed mild cytopenias and biochemical changes consistent with hepatocellular stress. No recurrence or metastasis occurred within 6 months. This case highlights the role of multimodal diagnostics in distinguishing MPTs from metastasis and guiding therapy in complex geriatric oncology cases.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"3637175"},"PeriodicalIF":0.0,"publicationDate":"2026-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13435256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148674302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Maya Weinberg, Dominika Kňazovická, Rianne Pelgrims, İlayda Taşkaya, Pera Sinkovec, Luis Víquez-R, Kendra Phelps, Allyson Walsh, Lucy A Weinert, Alex J Dumbrell, Paul A Racey, Tigga Kingston, Julie Teresa Shapiro
{"title":"Case Report of Unusual Mortality of Egyptian Fruit Bat (<i>Rousettus aegyptiacus</i>) in northern Cyprus.","authors":"Maya Weinberg, Dominika Kňazovická, Rianne Pelgrims, İlayda Taşkaya, Pera Sinkovec, Luis Víquez-R, Kendra Phelps, Allyson Walsh, Lucy A Weinert, Alex J Dumbrell, Paul A Racey, Tigga Kingston, Julie Teresa Shapiro","doi":"10.1155/crve/9140169","DOIUrl":"10.1155/crve/9140169","url":null,"abstract":"<p><p>We report an unusual mortality event affecting the isolated Egyptian fruit bat (<i>Rousettus aegyptiacus</i>) population in northern Cyprus, combining clinical admissions, microbiological findings, and roost surveys to assess magnitude and potential drivers. From January to June 2025, the Cyprus Wildlife Research Institute (CWRI) Wildlife Hospital received an unprecedented surge in admissions with 12 individuals (compared with a total of 16 admissions from 2017 to 2024), with high acute mortality: most bats arrived moribund and died within 12-24 h. Clinical records noted localized purulent lesions and abscesses in 58% of cases. Bacteriological culture and PCR assays recovered <i>Staphylococcus aureus</i> from abscesses and skin swab samples in multiple individuals; isolates exhibited susceptibility to tested antibiotics. Necropsy sampling confirmed viable <i>S. aureus</i> in several specimens despite prolonged storage. Concurrent targeted surveys of 10 known roosts in Feb-Mar 2026 documented marked declines at multiple historical sites, including reductions from hundreds to single-digit counts at formerly large colonies and the complete absence of bats at multiple roosts. No clear evidence of recent human disturbance, extreme weather anomalies, or reduced food availability was found; shotgun cartridges from historical hunting were present, but no direct anthropogenic cause was apparent. Although <i>S. aureus</i> infections-seasonally concentrated in winter-are consistent with observed lesions and may have contributed to morbidity and mortality, causality for the population-level declines remains unknown, and other factors (toxins, unassessed pathogens, and multifactor stressors) cannot be excluded. Given the genetic isolation and conservation significance of the Cyprus Egyptian fruit bat population, these findings are concerning. We recommend urgent, coordinated longitudinal population monitoring, expanded pathogen surveillance including whole-genome sequencing of <i>S. aureus</i> isolates, toxicological screening, and development of a species recovery plan incorporating emergency response, habitat protection, and public outreach.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"9140169"},"PeriodicalIF":0.0,"publicationDate":"2026-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13426321/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148654524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Surgical Intervention and Treatment of a Mammary Adenocarcinoma in the Sugar Glider (<i>Petaurus breviceps</i>): A Double Case Report.","authors":"Taryn Peña, Zoë Tormollen","doi":"10.1155/crve/6684002","DOIUrl":"10.1155/crve/6684002","url":null,"abstract":"<p><p>A 6-year-old, intact female sugar glider (<i>Petaurus breviceps</i>) presented for evaluation after experiencing progressive weight loss and lethargy. Sedated examination revealed a firm, 7-mm wide marsupium mass, and surgery was pursued after cytology results suggested epithelial malignancy. The patient's entire marsupium was surgically excised, and biopsy of the associated tumor revealed a primary mammary adenocarcinoma without vascular infiltration. Preoperative and postoperative antibiotics and meloxicam were used to decrease inflammation and infection following the procedure. At the 6- and 12-month recheck examinations, the initial patient was well-muscled and energetic with no signs of neoplastic recurrence. Case 1 had confirmed disease-free survival at 12 months. A second 6-year-old, intact female sugar glider presented for surgical consultation following the fine-needle aspiration of a bilobular marsupium mass. Analogous surgical protocols were implemented with the second patient. Subsequent biopsy revealed neoplastic epithelial cells consistent with a mammary adenocarcinoma. No local recurrence or disease progression has been reported for the second patient following the operation. Case 2 had owner-reported well-being at 11 months without clinical re-examination. To the authors' knowledge, these cases represent the first reported survival beyond 11 months following surgical treatment of mammary adenocarcinoma in <i>P. breviceps</i>, though long-term recurrence risk remains unknown.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"6684002"},"PeriodicalIF":0.0,"publicationDate":"2026-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13379947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148498087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Lara Vilela Soares, Yury Carantino Costa Andrade, Maria Eduarda Raffaini de Oliveira Cunha, Alessandra Aparecida Medeiros Ronchi, Vanessa Martins Fayad Milken, Sofia Borin-Crivellenti, Leandro Z Crivellenti
{"title":"Cyclosporine as a Novel Therapeutic Option for Eosinophilic Cystitis in a Paraplegic Dog.","authors":"Lara Vilela Soares, Yury Carantino Costa Andrade, Maria Eduarda Raffaini de Oliveira Cunha, Alessandra Aparecida Medeiros Ronchi, Vanessa Martins Fayad Milken, Sofia Borin-Crivellenti, Leandro Z Crivellenti","doi":"10.1155/crve/7317611","DOIUrl":"10.1155/crve/7317611","url":null,"abstract":"<p><p>Eosinophilic cystitis is characterized by eosinophilic infiltration and proliferation within the layers of the bladder wall. Its etiology remains unclear, and there is no established consensus regarding treatment in either human or veterinary medicine. A 4-year-old female dog developed paraplegia after a car accident, with a spinal cord injury in the lumbar region diagnosed by radiography. Five months after the trauma, the animal began to present with hematuria and recurrent episodes of urinary tract infection, with an unsatisfactory response to conventional therapies with bladder emptying management and antibiotics for 1 year. Bladder wall biopsy revealed findings consistent with eosinophilic cystitis. Due to the persistence of clinical signs, cyclosporine treatment was initiated, alongside previous surgery and antibiotics, resulting in significant clinical improvement, normalization of bladder ultrasonographic findings, and no observed adverse effects during the treatment period. The medication was continued for 6 months, followed by a gradual tapering. Six months after discontinuation, the animal remained asymptomatic. This case highlights the potential use of cyclosporine in the treatment of eosinophilic cystitis and supports the hypothesis that spinal cord injury may represent a possible risk factor for EC in dogs. It also emphasizes the importance of including EC in the differential diagnosis of bladder wall thickening. This report has some limitations, including the evaluation of a single patient, the use of concurrent therapies, and the absence of serum cyclosporine level monitoring.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"7317611"},"PeriodicalIF":0.0,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13358354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Edenilson Doná Frigerio, Samira das Mercês Saboia Bezerra, Luísa Husz Toledo, Bruna Rodrigues Ferreira Sengue, Maria Eduarda Roselli Silvério, Igor Luiz Salardani Senhorello, Alexandre Lima de Andrade, Daniela Bernadete Rozza, Gisele Fabrino Machado
{"title":"Invasive Squamous Cell Carcinoma of the Larynx in a Dog.","authors":"Edenilson Doná Frigerio, Samira das Mercês Saboia Bezerra, Luísa Husz Toledo, Bruna Rodrigues Ferreira Sengue, Maria Eduarda Roselli Silvério, Igor Luiz Salardani Senhorello, Alexandre Lima de Andrade, Daniela Bernadete Rozza, Gisele Fabrino Machado","doi":"10.1155/crve/5935429","DOIUrl":"10.1155/crve/5935429","url":null,"abstract":"<p><p>Squamous cell carcinoma (SCC) is a malignant epithelial neoplasm commonly affecting the skin and oral cavity of dogs, whereas laryngeal involvement is considered rare. Neoplasms arising in the larynx may cause severe upper airway obstruction and present diagnostic and therapeutic challenges due to the anatomical and functional constraints of this region. An 11-year-old neutered male mixed-breed dog was evaluated for a one-month history of progressive upper airway obstruction characterized by dyspnea, tachypnea, and dysphagia. Clinical examination revealed a solitary mass protruding into the laryngeal lumen in the arytenoid region. Surgical excision was performed, and intraoperative frozen section evaluation indicated compromised surgical margins. Definitive histopathology confirmed an invasive SCC. Adjunct electrochemotherapy was applied following identification of compromised surgical margins, and the dog showed favorable short-term clinical recovery following surgery. No evidence of recurrence or metastasis was observed during a three-month follow-up period. This case highlights the clinical relevance of laryngeal SCC in dogs and emphasizes the importance of thorough clinical examination and early detection, as well as the integration of clinical evaluation, histopathology, and intraoperative margin assessment in the management of upper airway neoplasms. The combined use of surgical excision, frozen section analysis, and adjunct electrochemotherapy may be considered a potential therapeutic approach in anatomically constrained regions where complete tumor removal is limited.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"5935429"},"PeriodicalIF":0.0,"publicationDate":"2026-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13352134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A Case Report of Proximal Radioulnar Osteosarcoma in a Great Dane Dog.","authors":"Prakash Adhikari, Abishek Khanal, Dinesh Kumar Singh, Binita Kunwar, Ayushma Aryal","doi":"10.1155/crve/7060510","DOIUrl":"10.1155/crve/7060510","url":null,"abstract":"<p><p>Osteosarcoma is the most common primary malignant bone tumor in dogs, characterized by aggressive local invasion and early metastatic potential, most frequently affecting the appendicular skeleton of large and giant breeds. This report describes a rare case of proximal radioulnar osteosarcoma in a 3.5-year-old intact male Great Dane that presented with progressive left forelimb lameness, swelling distal to the elbow, and weight loss. Radiographic examination revealed an aggressive mixed lytic-proliferative lesion involving the proximal radius and ulna, with distinct margins and no radiographic evidence of pulmonary metastasis. A definitive diagnosis of proximal radioulnar osteosarcoma was established by histopathological examination following forelimb amputation with scapulectomy. The dog underwent surgery and showed good postoperative recovery, with no evidence of recurrence during a 6-month follow-up period. Adjuvant chemotherapy was recommended to prevent metastasis, but the owner's financial constraints did not allow for this treatment. This case highlights the importance of early recognition, comprehensive diagnostic evaluation, and timely surgical intervention in managing canine osteosarcoma, particularly at uncommon anatomical sites.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"7060510"},"PeriodicalIF":0.0,"publicationDate":"2026-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13347832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148425084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M Dhunputh, M Petibon, A Avé, B Castro, S Besançon, P Verwaerde, V Saponaro
{"title":"Transient Myocardial Thickening in an 11-Year-Old Cat Infected With Feline Infectious Peritonitis and Treated With GS-441524.","authors":"M Dhunputh, M Petibon, A Avé, B Castro, S Besançon, P Verwaerde, V Saponaro","doi":"10.1155/crve/8562619","DOIUrl":"10.1155/crve/8562619","url":null,"abstract":"<p><p>This case report provides a thorough description of the clinical assessment and management of an extremely rare case of transient myocardial thickening associated with feline infectious peritonitis (FIP) and highlights the overlap of clinical signs secondary to FIP or congestive heart failure. An 11-year-old male Norwegian cat was presented with a 3-week history of weakness, dysorexia, tachypnea, dyspnea, and weight loss. Thoracic point-of-care ultrasound (POCUS) revealed severe bilateral pleural effusion without cardiac chamber enlargement. Blood work including serum protein electrophoresis (demonstrating polyclonal gammopathy) was suggestive of FIP. Analyses of pleural effusion consisted of real-time PCR being positive for FCoV nucleic acids with a high viral load and slightly equivocal increased NT-proBNP. Together with the noncardiogenic nature of the effusion, these findings were consistent with a diagnosis of FIP. Three days after the presentation, the cat exhibited progressive dyspnea secondary to newly collected pleural effusion with markedly increased NT-proBNP. At that time, echocardiography revealed left ventricular wall thickening and left atrial enlargement, thus suggesting hypertrophic cardiomyopathy or myocarditis with left-sided congestive heart failure. Cardiac troponin I concentration was increased. Nine days after admission, the patient was discharged on cardiac therapy and nucleoside analog GS-441524. Fifteen days after initiation of GS treatment, echocardiography showed a decrease in left ventricular wall thickness. No long-term complications or recurrences of FIP or myocardial hypertrophy were observed at the 1.5-, 4-, and 18-month follow-ups, with normalization of cardiac troponin I concentration and echocardiographic variables, thus supporting the hypothesis of FIP-related transient myocardial thickening. To the authors' knowledge, this is one of the rare reports of transient myocardial thickening in the FIP setting, following GS-441524 treatment. Cardiac POCUS and NT-proBNP dosage in pleural effusion should systematically be performed in order to unmask congestive heart failure.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"8562619"},"PeriodicalIF":0.0,"publicationDate":"2026-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13334134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148438388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Corneal Lesions Associated With Feline Herpesvirus-1 Modified Live Vaccine Strain F2 in Two Cats.","authors":"Yasuharu Suga, Seiya Maehara, Akihiko Saito, Yasunari Kitamura, Rikio Kirisawa","doi":"10.1155/crve/8387185","DOIUrl":"10.1155/crve/8387185","url":null,"abstract":"<p><p>Feline herpesvirus-1 (FHV-1) modified live vaccine (MLV) is designated as a core vaccine for cats. As reported here, two 2-month-old domestic short hair cats (Cat 1 and Cat 2; the two were littermates) initially presented with sneezing, nasal and ocular discharge, and ocular discomfort (Day 0), which had persisted since their vaccination. At 1.5 months of age, both cats were vaccinated with a vaccine containing the FHV-1 MLV strain F2 at another clinic. A few days later, they developed sneezing and ocular discharge almost simultaneously. Ten days after vaccination, they were diagnosed with allergic conjunctivitis and administered corticosteroid eye drops for 7 days. On Day 0, both cats presented with dendritic ulcers in one eye and a superficial corneal ulcer in the other eye. Treatment with oral antiherpesvirus medication and hyaluronic acid eye drops was initiated. A genomic analysis of FHV-1 strains isolated on Day 0 and of specimens obtained on Day 3 for real-time PCR suggested that both cats were infected with the same strain as the F2 strain and that there was no mixed infection with the field strain. Real-time PCR was performed to identify ocular surface pathogens other than FHV-1, and feline calicivirus (FCV) was detected in specimens collected from the superficial corneal ulcers of both cats on Day 3. On Day 6, dendritic ulcers in both cats healed. On Day 15, superficial corneal ulcers in both cats developed corneal crystalline deposits and deep neovascularization. In the eyes with superficial corneal ulcers in both cats, symblepharon subsequently developed in Cat 1, and eosinophilic keratitis subsequently developed in Cat 2. In conclusion, findings suggested that corneal ulcers caused by the F2 strain may be associated with the development of specific corneal lesions in cats that were young, that had a coinfection with FCV, and that were administered corticosteroids.</p>","PeriodicalId":37339,"journal":{"name":"Case Reports in Veterinary Medicine","volume":"2026 ","pages":"8387185"},"PeriodicalIF":0.0,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13275551/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148296619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}