Transgender Health最新文献

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Gender-Affirmation Surgery Training in United States Academic Plastic Surgery Residency Programs 美国整形外科住院医师学术项目中的性别确认手术培训
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-14 DOI: 10.1089/trgh.2022.0206
Michael Ha, L. Ngaage, Emily R. Finkelstein, Caroline Simon, Nicholas Hricz, Kevin Y. Zhu, Joshua Yoon, Fan Liang, Jens Berli, Yvonne Rasko
{"title":"Gender-Affirmation Surgery Training in United States Academic Plastic Surgery Residency Programs","authors":"Michael Ha, L. Ngaage, Emily R. Finkelstein, Caroline Simon, Nicholas Hricz, Kevin Y. Zhu, Joshua Yoon, Fan Liang, Jens Berli, Yvonne Rasko","doi":"10.1089/trgh.2022.0206","DOIUrl":"https://doi.org/10.1089/trgh.2022.0206","url":null,"abstract":"","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138975507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Health Service Utilization and Its Associations with Depression and Sexual Risk Behaviors Among Transgender Women in Shanghai, China. 上海跨性别女性卫生服务利用与抑郁和性危险行为的关系
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0009
Liying Wang, Rachel Harris, Jane M Simoni, Qing Yue, Jie Fu, Huang Zheng, Zhen Ning, Casey D Xavier Hall, Paul A Burns, Frank Y Wong
{"title":"Health Service Utilization and Its Associations with Depression and Sexual Risk Behaviors Among Transgender Women in Shanghai, China.","authors":"Liying Wang, Rachel Harris, Jane M Simoni, Qing Yue, Jie Fu, Huang Zheng, Zhen Ning, Casey D Xavier Hall, Paul A Burns, Frank Y Wong","doi":"10.1089/trgh.2021.0009","DOIUrl":"10.1089/trgh.2021.0009","url":null,"abstract":"<p><strong>Purpose: </strong>Given the limited research on health care utilization among transgender women in China, we described the use of primary health care and gender-affirming health care, and the associations between utilization of gender-affirming health care and depression and sexual risk behaviors.</p><p><strong>Methods: </strong>We conducted a cross-sectional survey in 2017 among a purposive sample of transgender women in Shanghai, China (<i>N</i>=199). We examined correlates of health care utilization and its association with depression and sexual risk behaviors with Chi-square (<i>χ</i><sup>2</sup>), Fisher's exact tests, and analysis of variance.</p><p><strong>Results: </strong>The majority of the sample (78.5%) only had physician appointments when having an illness, while about one-fifth of the sample had physician appointments for yearly checkups. Nineteen out of 199 participants (9.5%) received gender-affirming surgery, among which only five used hormone therapy prescribed by a doctor (26.3%). Receiving some form of gender-affirming surgery was associated with higher depression scores [Welch's <i>F</i><sub>(2, 12.22)</sub>=4.16, <i>p</i>=0.04], engagement in sex work (<i>p</i>=0.001), having 7 or more male sexual partners in the last 30 days (<i>p</i>=0.003), lifetime unprotected sex with a man (<i>p</i>=0.050), and unprotected sex with a main partner (<i>p</i>=0.043). Compared with transgender women who received both breast augmentation and vulvo-vaginoplasty (mean=5.86), those who received breast augmentation only (mean=12.33) scored higher on depression (<i>p</i>=0.04).</p><p><strong>Conclusions: </strong>Access to gender-affirming health care is low among transgender women in this study. The utilization of gender-affirming surgery is associated with depression and sexual risk behaviors. Findings suggest China should establish national guidelines on transgender-related health care and set up more clinics to provide consultation and services for the transgender population in China.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42761331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beliefs and Intentions of Anesthesia Physicians Toward Providing Culturally Competent Care to Transgender Patients. 麻醉医师为跨性别患者提供文化上合格的护理的信念和意图
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2022.0041
Erin Blanchard, Retta Evans, Hussein Abdullatif, Michelle Brown, Tekuila Carter, Jenna LaChenaye
{"title":"Beliefs and Intentions of Anesthesia Physicians Toward Providing Culturally Competent Care to Transgender Patients.","authors":"Erin Blanchard, Retta Evans, Hussein Abdullatif, Michelle Brown, Tekuila Carter, Jenna LaChenaye","doi":"10.1089/trgh.2022.0041","DOIUrl":"10.1089/trgh.2022.0041","url":null,"abstract":"<p><strong>Purpose: </strong>Anesthesiologists have limited relationships with their patients before delivering care and have little time for patient interactions. Yet, they should possess the knowledge and skills to treat all patients in an equitable, culturally competent manner, including transgender patients. The study's purpose was to determine behavioral factors influencing culturally competent care by anesthesia physicians with transgender patients.</p><p><strong>Methods: </strong>A two-phase design was utilized in 2020 to examine the attitudes, subjective norms, and perceived behavioral control of anesthesia physicians, both in training and practicing independently. Phase 1 allowed exploration of themes related to facilitators and barriers of the provision of culturally competent care to transgender patients. Phase 2 involved the creation and deployment of a 51-question survey informed by phase 1 to 100 anesthesia physicians at a single academic medical center in the southeastern United States.</p><p><strong>Results: </strong>Thematic analysis was performed on results from the phase 1 elicitation survey, which informed the creation of the survey for phase 2. One hundred phase 2 surveys were distributed, with a 70% response rate. Analyses were conducted to determine the largest influence of intent to interact with transgender patients in a culturally competent manner, as well as to establish the reliability of the tool.</p><p><strong>Conclusion: </strong>Attitude followed by subjective norms were positive influencers of intent, while lack of knowledge was a negative influencer. Strengthening attitudes and subjective norms, while implementing programs to increase knowledge, competence, and humility, would be goals for future studies and actions toward improving healthcare of transgender individuals.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732157/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46649212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Medical Educators' Perceptions and Experiences of Transgender Curriculum in Barbados. 巴巴多斯医学教育工作者对跨性别课程的看法和经验
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2022.0027
Natalie Greaves, Maisha K Emmanuel, Arianne Harvey, Heather Harewood, Jill Gromer, Md Anwarul Azim Majumder, Michael H Campbell
{"title":"Medical Educators' Perceptions and Experiences of Transgender Curriculum in Barbados.","authors":"Natalie Greaves, Maisha K Emmanuel, Arianne Harvey, Heather Harewood, Jill Gromer, Md Anwarul Azim Majumder, Michael H Campbell","doi":"10.1089/trgh.2022.0027","DOIUrl":"10.1089/trgh.2022.0027","url":null,"abstract":"<p><strong>Purpose: </strong>This study explored medical educators' understanding of the term transgender and their attitudes and perspectives regarding (1) health system responsiveness to transgender needs and (2) transgender curriculum in medical education.</p><p><strong>Methods: </strong>The study employed purposive sampling of medical educators responsible for design and delivery of curriculum. Fifteen of 18 eligible educators participated in Zoom focus groups (FG1 <i>n</i>=7, FG2 <i>n</i>=8). FGs averaged 93 min and were recorded, transcribed verbatim, and analyzed using a qualitative interpretivist methodology with deductive and inductive coding assisted by NVivo 12 Pro software.</p><p><strong>Results: </strong>Educators were knowledgeable about the term transgender and the physical and psychosocial needs of transgender people. Participants viewed transgender care as a significant emerging health area. However, infrequent personal or clinical contact, coupled with constraints in human and other resources, resulted in the perception that transgender content as a stand-alone component of curriculum is difficult to justify. Participants articulated a need for broad-based diversity content, including disabilities, primarily at the undergraduate level. Educators saw transgender health as relevant for undergraduate-level psychiatry and postgraduate medical specializations. Analysis and discussion framed participant perspectives in the context of stigma, discrimination, and medicolegal and health systems that impede access to health care for transgender people.</p><p><strong>Conclusion: </strong>Participants demonstrated knowledge of transgender and transgender health care needs. Areas for improvements in health care responsiveness were identified, particularly related to structural stigma and discrimination. Although participants expressed interest in including transgender health in the curriculum, this would require pragmatic optimization of teaching resources.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45805057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mental Health of Transmasculine Adults Receiving Gender-Affirming Hormone Therapy in Thailand. 泰国接受性别确认激素治疗的跨男性成人的心理健康
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0160
Napon Pliensak, Ammarin Suwan, Krasean Panyakhamlerd, Thanapob Bumphenkiatikul, Sorawit Wainipitapong
{"title":"Mental Health of Transmasculine Adults Receiving Gender-Affirming Hormone Therapy in Thailand.","authors":"Napon Pliensak, Ammarin Suwan, Krasean Panyakhamlerd, Thanapob Bumphenkiatikul, Sorawit Wainipitapong","doi":"10.1089/trgh.2021.0160","DOIUrl":"10.1089/trgh.2021.0160","url":null,"abstract":"<p><strong>Purpose: </strong>Many studies have shown conflicting results regarding mental health among transmasculine adults or transgender men (TM). This study aimed to identify the prevalence of depression among Thai TM receiving gender-affirming hormone therapy (GAHT).</p><p><strong>Methods: </strong>All TM, over 18 years of age, who received GAHT for at least three consecutive months were invited to complete a self-report questionnaire that covered participants' demographic and clinical data. Mental health, including depression, anxiety, and quality of life (QoL), was assessed. We reported the prevalence of mental illnesses and examined the correlations between mental health scores and other associated data.</p><p><strong>Results: </strong>A total of 84 TM were included in the analysis. Major depression and generalized anxiety disorder were detected in 14.3% and 3.6%, respectively. Depression severity was negatively associated with age and QoL. Depression and anxiety severity were found to be positively associated.</p><p><strong>Conclusions: </strong>Compared with the general Thai population, the prevalence of mental health problems among Thai TM receiving GAHT was higher. Age of maturity may be a potential mental health protective factor, and assessment in younger individuals may benefit mental health.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10777821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46222306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Mediating Role of Avoidant and Facilitative Coping on the Relation Between Discrimination and Alcohol Use Among Transgender and Gender-Diverse Individuals. 回避应对和促进应对在跨性别和性别多元个体歧视与酒精使用关系中的中介作用
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0173
Louis Lindley, Loren Bauerband
{"title":"The Mediating Role of Avoidant and Facilitative Coping on the Relation Between Discrimination and Alcohol Use Among Transgender and Gender-Diverse Individuals.","authors":"Louis Lindley, Loren Bauerband","doi":"10.1089/trgh.2021.0173","DOIUrl":"10.1089/trgh.2021.0173","url":null,"abstract":"<p><strong>Purpose: </strong>The motivational model of alcohol use indicates that there is a relation between chronic stress and alcohol use, and that this relation is mediated by substance use to cope. However, this model has not been applied to the experiences of transgender and gender-diverse (TGD) individuals. In response, this study investigated whether facilitative (e.g., active and interpersonal coping) and avoidant (e.g., cognitive avoidance and substance use to cope) coping mediate the relation between discrimination and alcohol use.</p><p><strong>Methods: </strong>Participants include 496 TGD individuals (97 trans women, 126 trans men, and 273 nonbinary), 18-68 years of age (mean=32.09 and standard deviation=12.47), who completed a survey about health behaviors and stress. An exploratory factor analysis and confirmatory factor analysis of the Brief Coping Orientation to Problems Experienced (COPE) were conducted to determine the coping patterns of TGD individuals and multiple mediation analyses were conducted to examine whether distinct coping strategies mediated the relation between discrimination and alcohol use.</p><p><strong>Results: </strong>Both facilitative and avoidant coping strategies were significantly related to discrimination; however, only active coping and substance use to cope were related to alcohol use. Mediation results showed that substance use to cope (i.e., an avoidant coping strategy) was the only significant mediator. Descriptive results showed nonsignificant differences between TGD gender identities regarding levels of alcohol use and engagement with coping strategies.</p><p><strong>Conclusion: </strong>The results indicate a clear need for interventions to reduce utilization of avoidant coping strategies among TGD individuals.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45847674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Assessing Knowledge of, Experience with, and Willingness to Prescribe Hormone Therapy to Transgender Individuals with HIV: A National Survey of HIV Practitioners. 评估艾滋病毒跨性别患者激素治疗的知识、经验和意愿:对艾滋病毒从业者的全国调查
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0187
Sophie M Cannon, Laramie R Smith, Donna M Jacobsen, Michelle T Valderama, Jordan Silva, Jill Blumenthal
{"title":"Assessing Knowledge of, Experience with, and Willingness to Prescribe Hormone Therapy to Transgender Individuals with HIV: A National Survey of HIV Practitioners.","authors":"Sophie M Cannon, Laramie R Smith, Donna M Jacobsen, Michelle T Valderama, Jordan Silva, Jill Blumenthal","doi":"10.1089/trgh.2021.0187","DOIUrl":"10.1089/trgh.2021.0187","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to determine if human immunodeficiency virus (HIV) practitioners offer gender-affirming hormone therapy (GAHT) to their transgender patients living with HIV, as previous studies have shown that these patients are more likely to be virally suppressed and retained in care.</p><p><strong>Methods: </strong>We conducted an online survey sent to 2570 HIV practitioners who attended an International Antiviral Society-USA event between 2017 and 2019. We also assessed demographics, transgender care training, comfort, prescribing practices, and knowledge.</p><p><strong>Results: </strong>Respondents (<i>N</i>=385) were mainly primary care (49%) and infectious disease (ID)/HIV (42%) practitioners. Fifty-seven percent prescribed GAHT to transgender people living with HIV, but only 7% received formal training. Thirty-five percent were ID/HIV, 60% were primary care, and 5% were other specialty practitioners. Most felt that it would be beneficial to have formal education in GAHT practices during training (83%). There were statistically significant differences in GAHT education, experiences, knowledge, and interest in future training and prescribing by health care specialty. Commonly cited barriers to providing therapy included lack of training (33%), lack of transgender people living with HIV in practice (18%), and lack of qualified mental health professionals (15%).</p><p><strong>Conclusion: </strong>This survey is the first to assess GAHT practices among HIV practitioners from across the United States. The majority of those surveyed prescribe GAHT to their transgender patients living with HIV. Although most felt comfortable doing so, few had formal training and knowledge scores were low. We advocate for the integration of GAHT education into formal training programs and offer resources for those who wish to pursue education.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41458460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Testosterone Pellet Use in Transgender Men. 睾酮颗粒在变性男性中的应用
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0205
Kwan Cheng, Aren Skolnick
{"title":"Testosterone Pellet Use in Transgender Men.","authors":"Kwan Cheng, Aren Skolnick","doi":"10.1089/trgh.2021.0205","DOIUrl":"10.1089/trgh.2021.0205","url":null,"abstract":"<p><strong>Purpose: </strong>We assessed the efficacy and short-term adverse effects of testosterone pellet use in transgender men to broaden therapeutic options.</p><p><strong>Methods: </strong>We conducted a retrospective study of 30 transgender men who started testosterone pellets between 2018 and 2020.</p><p><strong>Results: </strong>Testosterone pellets were started at dosages 675-825 mg per cycle and dose was adjusted according to testosterone levels obtained 1 to 6 months post-testosterone pellet insertion. Pharmacokinetics of testosterone pellet in transgender men was similar to those in cisgender men. Total testosterone levels reached a peak in 1 month and remained in the therapeutic range for ∼4 months in the range of 300-800 ng/dL. After switching over to testosterone pellets, 100% of patients continued to achieve amenorrhea and deepening of their voice. Most of the patients noticed increased hair growth in androgen-dependent regions (96.3%) and improved libido (70%). Adverse events were notable for a rate of polycythemia that was unexpectedly high at 46.67%. Pellet extrusion was found in 13.33% of patients. There was a low rate of pellet site hematoma (6.67%) and cellulitis (3.33%). No thromboembolic or cardiovascular events occurred in any of the patients.</p><p><strong>Conclusion: </strong>This study reveals that testosterone pellets are a reasonable alternative to other testosterone modalities in transgender men but would use caution in patients with a history of polycythemia or higher risk for thromboembolic events.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43595034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Spectrum, Procedural Feasibility, and the Value of a Surgeon's Opinion in Varying Gender-Affirming Surgeries. 频谱,程序的可行性,和外科医生的意见在不同的性别确认手术的价值
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2021.0214
Natalia Whitney, Alireza Hamidian Jahromi
{"title":"Spectrum, Procedural Feasibility, and the Value of a Surgeon's Opinion in Varying Gender-Affirming Surgeries.","authors":"Natalia Whitney, Alireza Hamidian Jahromi","doi":"10.1089/trgh.2021.0214","DOIUrl":"10.1089/trgh.2021.0214","url":null,"abstract":"<p><p>The understanding of gender has expanded contributing to gaps in gender-affirming care. Traditional gender-affirming surgeries focus on binary results, diminishing room for affirmation of other identities. Surgeons are faced with the challenge of deciding whether a variation of gender-affirming surgery can be safely performed per request. The ethical question of when a surgeon may say yes or no to these varying requests comes after the consideration of premorbid conditions, body habitus, age, social and family support, individuals' goals, and risk assessment. Preoperative evaluations must take into account surgical experience, barriers to care, increased risk profile, and the surgeon's personal biases.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732170/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43878296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sublingual Estradiol Offers No Apparent Advantage Over Combined Oral Estradiol and Cyproterone Acetate for Gender-Affirming Hormone Therapy of Treatment-Naive Trans Women: Results of a Prospective Pilot Study. 舌下雌二醇与联合口服雌二醇和醋酸环丙孕酮对未接受治疗的变性女性进行性别确认激素治疗相比没有明显优势:一项前瞻性试点研究的结果
IF 2 4区 医学
Transgender Health Pub Date : 2023-12-13 eCollection Date: 2023-12-01 DOI: 10.1089/trgh.2023.0022
Iris Yaish, Guy Gindis, Yona Greenman, Yaffa Moshe, Mira Arbiv, Assaf Buch, Yael Sofer, Gabi Shefer, Karen Tordjman
{"title":"Sublingual Estradiol Offers No Apparent Advantage Over Combined Oral Estradiol and Cyproterone Acetate for Gender-Affirming Hormone Therapy of Treatment-Naive Trans Women: Results of a Prospective Pilot Study.","authors":"Iris Yaish, Guy Gindis, Yona Greenman, Yaffa Moshe, Mira Arbiv, Assaf Buch, Yael Sofer, Gabi Shefer, Karen Tordjman","doi":"10.1089/trgh.2023.0022","DOIUrl":"10.1089/trgh.2023.0022","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic gender-affirming hormone therapy (GAHT) with sublingual estradiol (SLE) has not been studied. We aimed to compare GAHT with SLE only, to combined oral (CO) estradiol and cyproterone acetate, in treatment-naive trans women.</p><p><strong>Methods: </strong>Twenty-two trans women enrolled into either the CO arm or the SLE-only arm (0.5 mg four times daily) in this 6-month prospective study. Anthropometric and laboratory variables were collected at baseline and 3 and 6 months. At the study beginning and end, body composition was measured by dual-energy X-ray absorptiometry and bioelectrical impedance, and gender dysphoria, sexual desire, and function were assessed by validated questionnaires.</p><p><strong>Results: </strong>Subjects in the SLE were older, 26.3±5.8 years versus 20.1±2.3 years, <i>p</i>=0.006. All anthropometric, body composition, and laboratory variables were identical at baseline. Although dysphoria appeared greater, and sexual function lower at baseline in the CO group, this canceled out after age adjustment. Both treatments induced similar biochemical and hormonal changes. Creatinine, hemoglobin and cholesterol decreased significantly, while testosterone was suppressed to the same level in both groups: 3.22 [1.47-5.0] nmol/L in the SLE group and 2.41 [0.55-8.5] nmol/L in the CO, <i>p</i>=0.65. Significant changes in body composition toward a more feminine body were noted in both groups. Dysphoria did not significantly improve in either group, while sexual desire and function decreased at six months in both, <i>p</i><0.001.</p><p><strong>Conclusions: </strong>Both treatments achieved similar clinical changes. At this stage, SLE, which repeatedly induces alarming excursions of serum estradiol throughout the day, appears to offer no advantage over the CO approach.</p>","PeriodicalId":37265,"journal":{"name":"Transgender Health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10732161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47051795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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