Actual problems of modern medicine最新文献

{"title":"The morphological specifics of the stromal and parenchymal liver components of 6-12-months old children from hiv-mono-infected mothers","authors":"","doi":"10.26565/2617-409x-2021-7-06","DOIUrl":"https://doi.org/10.26565/2617-409x-2021-7-06","url":null,"abstract":"To determine the morphological specifics of the stromal and parenchymal liver components of 6-12-months old children from HIV-mono-infected mothers. Materials and methods. The morphometric investigation included 87 liver tissue biopsies of 6-12-months old dead children from HIV-mono-infected mothers. All morphometric parameters of the parenchymal and stromal liver components were calculated using the Avtandilov`s microscopic morphometric grid, which was consisted of 100 equidistant points. It was inserted into the microscope`s ocular tube with a total × 200 microscope magnification. The number of points that were found on the corresponding types of parenchymal and stromal liver components was calculated. In every case, it was selected 10 random microscopic areas and then all data were obtained, calculated and presented as percentages. Results. Morphometric parameters of hepatocytes: mononuclear hepatocytes – 90.2±7.6 % [control – 93.5±7.1], two-nuclear hepatocytes – 9.8±1.2 % [control – 6.5±1.2], TMHC (two-/mononuclear hepatocytes coefficient) – 0.10±0.02 [control – 0.06±0.01], hepatocytes with fat vacuoles – 19.6±2.1 % [control – 0.5±0.2]. Parenchymal and stromal liver components: parenchyma – 56.1±3.3 % [control – 74.2±4.3], stroma (including blood vessels and bile ducts) – 43.9±3.7 % [control – 25.8±2.6], SPI (stroma/parenchyma index) – 0.78±0.02 [control – 0.34±0.01]. Morphometric parameters of all of the liver components: hepatocytes – 56.1±3.3 % [control – 74.2±4.3], portal tracts – 26.4±2.1 % [control – 3.1±0.6], central veins – 8.1±1.2 % [control – 9.3±1.4], sinusoids – 7.3±1.2 % [control – 10.5±1.3], bile ducts – 2.1±0.1 % [control – 2.9±0.2]. Expression level parameters: fibronectin – 73.2±4.2 % [control – 17.3±2.5], collagen type I – 15.9±1.2 % [control – 9.7±1.9], collagen type III – 20.1±2.6 % [control – 10.1±0.9], collagen type IV – 7.3±0.2 % [control – 5.9±0.2]. Conclusions. It was established, that in the liver of 6-12-months old children from HIV-mono-infected mothers, the parenchymal component of the liver showed the signs of its significant reduction, increase of regenerative activity of hepatocytes, and fatty degeneration of hepatocytes with a certain sign of reactive steatohepatitis. Also, it was established, that the stromal component of the liver of children from HIV-infected mothers showed the signs of its progressive proliferation and collagenization due to increased production and accumulation of fibronectin, type I, type III collagens in the stroma of portal tracts and newly formed septa, and the signs of hepatic sinusoid capillarization due to type IV collagen accumulation in the space of Disse of the hepatic sinusoids.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129914656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of factors causing appearance of food hypersensitivity in young children in Lviv oblast","authors":"","doi":"10.26565/2617-409x-2021-7-05","DOIUrl":"https://doi.org/10.26565/2617-409x-2021-7-05","url":null,"abstract":"Food hypersensitivity in young children is a topical issue, since it encompasses a wide range of clinical symptoms and requires a personified approach in diagnostic, therapeutic and preventive measures. A progressive increase in different forms of food hypersensitivity is associated with many factors, particularly malnutrition and harmful ecological conditions. Epigenetic and genetic factors, which potentially can be related to food hypersensitivity and allergy, are being thoroughly studied. In this complex situation, the detection of risk factors for disease development is important for offering patients proper recommendations on diet, living conditions and lifestyle. Aim of the research: to perform analysis of factors, which cause appearance of food hypersensitivity in young children in Lviv oblast. Materials and methods. A study of the number of children with food intolerance was conducted using a specially compiled questionnaire. Thus, 4500 questionnaires were distributed in pre-school and medical establishments to question parents. The questionnaire had 34 questions that were grouped into four parts: general information and detailed information in parts A, B, and C. The general information part of the questionnaire included questions about the region where the child lived, passport data of the child (age, gender) and presence of serious disease (either past or present). Part A had questions about serious diseases that a child had suffered; part B asked about the child’s genealogical and medical history and presence of harmful habits in the family; part C had questions about the environment and living conditions of the child, as well as nutrition and its relation to the development of clinical symptoms of disease. Results. Analysis of 3214 questionnaires was conducted, which enabled to obtain information from parents on anamnesis and living conditions of young children. Values of 56 factors were analyzed, calculating correlation coefficients with a formation of food hypersensitivity for each of them. Statistical analysis allowed distinguishing 15 signs among these factors, which significantly correlated with the formation of food hypersensitivity in young children. Conclusions. The investigation enabled not only to detect factors that affect formation of food hypersensitivity in young children, but also to suggest a mathematical model of individual calculation of risk factors for this pathology. Data of conducted mathematical analysis can be used for elaboration of a complex of prophylaxis measures on development of food hypersensitivity in young children in Lviv oblast.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124069275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aloplasty of oncisional ventral hernias of using nanomodified polypropilene mesh","authors":"","doi":"10.26565/2617-409x-2019-3-09","DOIUrl":"https://doi.org/10.26565/2617-409x-2019-3-09","url":null,"abstract":"Aloplasty of incisional ventral hernia (IVH), method of placement and fixation nanomodified polypropylene mesh retro muscular, buth this is accompanied by a fairly high freguency of postoperative complications from the postoperative wound.\u0000\u0000In our view, the use of a nanomodified polypropylene mesh modified by carbon nanotubes and an antiseptic of polyhexamethlene guanidme chloride in combination with the method of placement and fixation retro muscular the results of operative treatment of IVH.\u0000\u0000Aim – to improve the results of operative treatment of incisional ventral hernias in combination with the method of placement and fixation retro muscular nanomodified polypropylene mesh.\u0000\u0000Materials and methods. The analysis of operative treatment of 148 patients with IVH of has been performed. Depending on the type of mesh used during surgical treatment, patients were divided into 2 groups. In 74 (50%) of Group I patients, method of placement and fixation nanomodified polypropylene mesh retro muscular. In the 2nd group, 74 (50%) patients method of placement and fixation retro muscular of a classic polypropylene mesh.\u0000\u0000Results and discussion. Statistically significant results were obtained in patients of Group I compared to Group II: seroma was in 24 (32.4±1.2%) in Group II compared to 5 (6.8±0.5%) in Group I (p<0.05), respectively, the suppuration of the postoperative wound – 7 (9.5±0.5%) to 1 (1.4±0.2%) (p<0.05). The terms of stay of patients of group II on inpatient treatment – 12,1±2,3 days group II – 7,1±1,1 days.\u0000\u0000Long-term results: ligature fistulas of the anterior abdominal wall were detected in 5 (7.7±0.5%) patients of group II, in patients of group I of the ligature fistulas were not detected (p<0.05), meshoma – in 3 (4.6±0.3%) of patients in group II, in group I there was no stir (p>0.05). Chronic pain in the abdominal wall in 6 – 8 months after surgery was observed in 5 (7.7±0.6)% patients in group II and in 1 (1.5±0.2%) group I (p>0.05), recurrences of hernia were found in 6 (9.2±0.6%) patients of group II, in group I – in 1 (1.5±0.2)% (p<0.05).\u0000\u0000Conclusion. Operative treatment of IVH method of placement and fixation nanomodified polypropylene mesh retro muscular is more effective compared with the use of the classical polypropylene mesh, namely, reducing the freguency of seroma from 32.4±1.2% in the II group of patients to 6.8±0.5% in group I, respectively, suppurations of postoperative wounds – from 9.5±0.5% to 1.4±0.2%, inflammatory infiltrates – from 12.2±0.6% to 1.4±0.2%, ligaturial fistulas of the anterior abdominal wall – from 7.7±0.5% to 0%, meshoma – from 4.6±0.3% to 0%, chronic postoperative pain – from 7.7±0.6% to 1.5±0.2%, recurrence of hernia–from 9.2±0.6% to 1.5±0.2%.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129138603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spectrum and prevalence of genetic pathology among children and adolescents of the northern districts of kharkiv region","authors":"Yana Hryshchenko","doi":"10.26565/2617-409x-2019-3-03","DOIUrl":"https://doi.org/10.26565/2617-409x-2019-3-03","url":null,"abstract":"The spectrum and prevalence of genetic pathology among the population of a certain region are determined by the founder effect and microevolution factors and, therefore, are not always comparable in different countries. The study of these indicators is an important trend of modern human genetics. The purpose of the research was to study genetic and epidemiological characteristics of the pediatric population of two northern districts of the Kharkiv region, Ukraine: Bogodukhiv and Vovchansk.\u0000\u0000Total number of children aged 0–17 was 6896 in Bogodukhiv district, and 7891 in Vovchansk district on 01/01/2016. The medical records of 307 patients were analyzed in healthcare facilities of both districts and the city of Kharkiv. The subject of the study was the cases of single-gene and chromosomal diseases.\u0000\u0000The burden of genetic disorders among children and adolescents was 0.30% in both districts. The prevalence of single-gene diseases in these districts was 0.24% in Bogodukhiv district and 0.25% in Vovchansk district. There were 9 and 12 single-gene disorders with different modes of inheritance, respectively. Only two of them were common in the districts: congenital hypothyroidism and sensorineural hearing loss. The incidence of the latter is 1:985 in Bogodukhiv district and 1:1578 in Vovchansk district. Chromosomal pathology was detected in 0.06% of the patients in Bogodukhiv district and 0.05% in Vovchansk district. Down syndrome was the only nosological form of chromosomal disorders in both districts.\u0000\u0000For other five areas of Kharkiv region, the prevalence of genetic pathology ranges from 0.36% in Izyum district to 0.47% in Balakliia and Blyzniuky as have been previously reported.\u0000\u0000The incidence of single-gene disorders is 0.27% in Izyum and 0.39% in Blyzniuky, while the incidence of chromosomal disorders varies from 0.07% in Zmiiv to 0.13% in Krasnohrad.\u0000\u0000Thus, the spectrum and prevalence of single-gene and chromosomal pathology in Bogodukhiv and Vovchansk districts correspond to those in other districts of Kharkiv region and most European countries.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"44 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115268950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Some of the biochemical indicators peculiar to the liver`s functional activity in patients with acute epiglottitis","authors":"","doi":"10.26565/2617-409x-2019-3-07","DOIUrl":"https://doi.org/10.26565/2617-409x-2019-3-07","url":null,"abstract":"This paper has studied the liver`s functional activity in acute epiglottitis (AE) using such biochemical indicators as: Weltmann test, the activity of asparagine transferase and alanine transferase, thymol test, and alkaline phosphatase. The pathological process, which involves the epiglottis, aryepiglottic folds and surrounding tissues, changes the main clinical and biochemical blood and urine values in patients with acute epiglottitis. 86 patients with epiglottitis aged 20 to 81 years old stayed at the CCH No. 30 in of Kharkiv (clinical site of the ENT-department of Kharkiv Medical Academy of Postgraduate Education) were the subject of our study. It has been found that almost all patients with AE have elevated values even a month after recovery. De Ritis ratio, in particular AST/ALT ratio should be paid special attention. Even after 30 days of recovery, De Ritis ratio remained high, 32.25% higher if compared to healthy people.\u0000\u0000The Weltmann test was increased by 12.8%, being associated with an increased percentage content of α1- and α2-globulins in the serum; the test tends to increase in the case of acute inflammatory conditions. The highest activity of LF was determined in patients with abscessed form. After 30 days of the occurrence of the disease, the activity of LF remained increased by 84.3% (infiltrative form) and by 52.9% in the case of abscessed form. An increased LF activity in the blood is a sing of damaged hepatocytes under conditions of endogenous intoxication. There was found a disorder of protein-forming and enzyme-forming functions of the liver (according to the liver tests) in patients with acute epiglottitis that requires a long-term therapy with the use of medications aimed at stabilizing the structure and function of the liver.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"62 11","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131721537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent drug addiction in the family: causes of occurrence and prevention","authors":"V.M. Podolian","doi":"10.26565/2617-409x-2021-7-11","DOIUrl":"https://doi.org/10.26565/2617-409x-2021-7-11","url":null,"abstract":"Adolescent addiction is a serious social problem, considering the significant danger posed by drugs to the health of the younger generation and the social situation at large. Much of the family's lack of attention to the problems of the younger generation has led to the emergence of adolescent drug addiction and the spread of this phenomenon in modern society. The relevance of the study is conditioned by the alarming rate of spread of adolescent drug addiction in society and the decline in the average age of adolescents who have tried drugs for the first time. Purpose: to identify the root causes of adolescent drug addiction in families and to create methods to prevent this phenomenon. Material and methods: The main method of research is the method of analysis, which was used to comprehensively address the issue of adolescent drug addiction in the family, in particular the causes and consequences of this phenomenon. With the help of quantitative-analytical and logical research methods, the factors that motivate young people to use drugs, despite the obvious threat to their health and life, were comprehensively considered and described. Results: Authors identify the main factors that push modern adolescents to start using drugs, the role of the family in such a phenomenon, the types of relations within families where adolescent addiction develops. The types of family relations and the nature of intra-family relations, in which adolescent drug use begins, are revealed. The paper describes the proposed measures to prevent adolescent drug addiction, which should be used to stop the spread of this phenomenon in society. The applied value of this study is to determine the causes of adolescent drug addiction in the family and to develop measures to prevent the occurrence of this phenomenon and its further spread in society. Conclusions: Adolescent drug addiction is a serious social problem, the roots of which should be sought in each particular family where the adolescent who started taking drugs was born and raised. The causes of drug addiction in modern families are due to a significant amount of social and psychological factors. The issue of adolescent drug addiction in the family should be considered comprehensively, with reference to the place and role of the family in society. In addition, the involvement of adolescents in sports displaces drugs and contributes to their complete elimination from life. By identifying the main social and psychological aspects that motivate modern adolescents to use drugs, it is possible to create conditions to prevent a situation in society in which drug use by Ukrainian adolescents, in general, would be possible.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131846501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Оveruse injuries in musicians. part i: etiopathogenesis, diagnostics","authors":"Оглядова Стаття","doi":"10.26565/2617-409x-2020-5-06","DOIUrl":"https://doi.org/10.26565/2617-409x-2020-5-06","url":null,"abstract":"Overuse injuries are encountered by 50-85 % of instrumental musicians and manifest themselves in tendovaginitis, bursitis and tunnel syndromes, leading to long-term temporary loss of ability to work (and in severe cases, to permanent disability). For Ukraine, the problem is of particular relevance for several reasons: first, there have been no studies of the professional diseases of musicians in the country in the last decade; second, there are a very large number of music schools in the country, but none of them teaches future musicians how to prevent occupational diseases; thirdly, there are no specialized medical centres for the treatment of professional pathology of musicians. The aim of the research was to analyze the latest achievements in diagnosing, treating and preventing stress injuries in musicians. The analysis was performed by studies published in 2016-2020 in journals indexed in the Scopus, WoS, Medline and PubMed scientific databases. It has been established that the etiopathogenesis of overuse injuries in musicians is associated with a whole complex of primary and secondary factors. The non-physiological performing technique is of greatest importance: the inability to evenly distribute the load on the muscles involved in performing practice, as well as the non-ergonomic posture. Excessive playing duration is no less harmful: more than three hours of continuous practice every day. Serious aggravating factors are: impairment of range of joint movement (hyper- or hypomobility), weak physical strength of the muscles of the shoulder girdle and spine, a small hand with short fingers (for pianists and string players), and low awareness of instrumental musicians (both students and teachers) in the prevention of occupational diseases, due to the imperfection of the music education system.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128755184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Features of the clinical course of cardiovascular pathology on the background of thyrotoxicosis","authors":"","doi":"10.26565/2617-409x-2019-3-10","DOIUrl":"https://doi.org/10.26565/2617-409x-2019-3-10","url":null,"abstract":"Relevance of the topicofthyroid diseases is duetothein crease in their number in the world and in Ukraine inparticular over the past 5 years, as well as the fact that the total frequency of various forms of thyroid pathology, even outside the zones of endemic goiter, is about 20% of the total morbidity. \u0000\u0000On the example of a clinical case, the question of diagnostics, management tactics and features of the clinical course of cardiovascular pathology on the background of thyrotoxicosis in the absence of adequate therapy for a long time are considered.\u0000\u0000Thyrotoxicosis leads to the occurrence of early complications of the cardiovascular system, which determine the further prognosis of the patient’s quality of life. The heart effects of Thyrotoxicosisare most dangerous for the elderly, and they (the heart effects of Thyrotoxicosis) often dominate the clinical picture in them (the elderly).\u0000\u0000Difficulties in their diagnosis are due, among other things, to the frequent absence of ophthalmopathy. When atrial fibrillation develops, the presence of cardiac symptoms may increase, indicating an accelerated development of heart failure.\u0000\u0000Therefore, the management of patients with cardiovascular disease on the background of thyrotoxicosis has its own peculiarities, which should be taken into account during treatment.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121772730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Мorphological research in practice student scientific experiment","authors":"","doi":"10.26565/2617-409x-2020-5-09","DOIUrl":"https://doi.org/10.26565/2617-409x-2020-5-09","url":null,"abstract":"The article describes the activities of the student scientific society of V. N. Karazin Kharkiv National University, which includes an anatomical scientific group working at the Department of Human Anatomy of the Medical Faculty, as well as the purpose and objectives of student science in the study of program disciplines of higher education knowledge of the future profession of a morphologist. Describes the research activities of the department, conducting basic research in the field of scientific topics in human anatomy, morphology, surgery, ophthalmology, immunology, clinical pharmacology. The article aims to acquaint with the problems of biopsy diagnostics in a modern clinic and the possibilities of pathological anatomical laboratories in the introduction of new research methods in the practice of physicians, which include morphological studies of biopsy diagnostic, surgical material using histological, histochemical, immunohistochemical, molecular biological, electron micrometric and other methods. The article shows the progress of medical technologies, which emphasize the importance of visual examinations of previously inaccessible parts of the body, emphasizes the fateful role of a pathomorphologist, who must work with drugs of impeccable quality and be absolutely sure of the reliability of the result each histochemical reaction. The article analyzes the sections of clinical disciplines in the specialty of diagnostician, which allow the pathologist to morphologically assess the narrow and complex sections of pathological anatomical diagnosis, which introduces students to the basics of pathological and anatomical services and types of morphological research in the clinic. The main purpose of the student scientific society is emphasized, which is to foster a creative approach to research, as well as to promote the development and promotion of medical science among students.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130410717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma","authors":"Chernusky Viacheslav, Popov Mykola, Letyago Hanna, Govalenkova Olha, Tolmacheva Svitlana, O. Olena","doi":"10.26565/2617-409x-2021-7-08","DOIUrl":"https://doi.org/10.26565/2617-409x-2021-7-08","url":null,"abstract":"Bronchial asthma (BA) remains one of the most serious diseases of our time. A number of studies have shown that this disease in a number of cases, especially with the threat of termination of pregnancy, acute and chronic diseases of mothers, accompanied by fetal hypoxia, originates in the ante- and postnatal period. In general, taking into account the peculiarities of the cellular tissue organization of the brain and cerebrovascular blood supply, prolonged hypoxic lesions increase the activity of the hypothalamic-diencephalic structures and the cerebral cortex. The existing respiratory disorders lead to hemodynamic and metabolic disorders of cerebral structures, emotional sphere and autonomic regulation. However, this issue in childhood requires further study. The aim is to study autoimmune processes in the pathogenesis of cerebrovascular insufficiency in children with BA. Materials and methods. We examined 121 patients with asthma aged 5 to 15 years in the period of exacerbation. To study the role of the autoimmune component in the development of cerebrovascular insufficiency and its relationship with the autoimmune process in the bronchopulmonary system in AD in children, we used a method for the quantitative determination of autoantibodies to lipopolysaccharide antigens (LA) of cerebral vessels and topographic structures of the brain, as well as to homologous LA bronchi and lung tissue. The results of the studies have shown that the first signs of cerebral hemodynamic disturbance are recorded already in patients with mild disease and are aggravated depending on the severity of BA. Conclusions. The most characteristic changes are an increase in the tone of small and medium vessels and impaired cerebral venous circulation. It was also found that the levels of autoantibodies to lipopolysaccharide antigens of cerebral vessels and cellular tissue structures of the brain correlate with an increase in the level of autoantibodies to lipopolysaccharide antigens of the trachea, bronchi and lung tissue and reflect the severity of AD in children.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"209 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133177832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}