支气管哮喘患儿脑血管功能不全发展中的自身免疫成分

Chernusky Viacheslav, Popov Mykola, Letyago Hanna, Govalenkova Olha, Tolmacheva Svitlana, O. Olena
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摘要

支气管哮喘(BA)仍然是我们这个时代最严重的疾病之一。一些研究表明,这种疾病在许多情况下,特别是在终止妊娠的威胁下,母亲的急性和慢性疾病,伴随着胎儿缺氧,起源于产前和产后。一般来说,考虑到大脑细胞组织组织和脑血管血液供应的特殊性,长时间的缺氧损伤会增加下丘脑-间脑结构和大脑皮层的活动。现有的呼吸系统疾病导致大脑结构、情绪领域和自主调节的血液动力学和代谢紊乱。然而,儿童时期的这一问题需要进一步研究。目的是研究自身免疫过程在BA患儿脑血管功能不全发病机制中的作用。材料和方法。我们检查了121例5至15岁哮喘患者的加重期。为了研究自身免疫成分在AD患儿脑血管功能不全发展中的作用及其与支气管肺系统自身免疫过程的关系,我们采用了一种定量测定脑血管和脑地形结构脂多糖抗原(LA)自身抗体以及同源LA支气管和肺组织自身抗体的方法。研究结果表明,脑血流动力学障碍的最初迹象已经记录在轻度疾病的患者中,并根据BA的严重程度而加重。结论。最典型的变化是中小血管张力增高和脑静脉循环受损。我们还发现,大脑血管和细胞组织结构中针对脂多糖抗原的自身抗体水平与气管、支气管和肺组织中针对脂多糖抗原的自身抗体水平升高相关,反映了儿童AD的严重程度。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Autoimune component in the development of celebrovascular insufficiency in children with bronchial asthma
Bronchial asthma (BA) remains one of the most serious diseases of our time. A number of studies have shown that this disease in a number of cases, especially with the threat of termination of pregnancy, acute and chronic diseases of mothers, accompanied by fetal hypoxia, originates in the ante- and postnatal period. In general, taking into account the peculiarities of the cellular tissue organization of the brain and cerebrovascular blood supply, prolonged hypoxic lesions increase the activity of the hypothalamic-diencephalic structures and the cerebral cortex. The existing respiratory disorders lead to hemodynamic and metabolic disorders of cerebral structures, emotional sphere and autonomic regulation. However, this issue in childhood requires further study. The aim is to study autoimmune processes in the pathogenesis of cerebrovascular insufficiency in children with BA. Materials and methods. We examined 121 patients with asthma aged 5 to 15 years in the period of exacerbation. To study the role of the autoimmune component in the development of cerebrovascular insufficiency and its relationship with the autoimmune process in the bronchopulmonary system in AD in children, we used a method for the quantitative determination of autoantibodies to lipopolysaccharide antigens (LA) of cerebral vessels and topographic structures of the brain, as well as to homologous LA bronchi and lung tissue. The results of the studies have shown that the first signs of cerebral hemodynamic disturbance are recorded already in patients with mild disease and are aggravated depending on the severity of BA. Conclusions. The most characteristic changes are an increase in the tone of small and medium vessels and impaired cerebral venous circulation. It was also found that the levels of autoantibodies to lipopolysaccharide antigens of cerebral vessels and cellular tissue structures of the brain correlate with an increase in the level of autoantibodies to lipopolysaccharide antigens of the trachea, bronchi and lung tissue and reflect the severity of AD in children.
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