Actual problems of modern medicine最新文献

{"title":"Role of pathogenic and mentally pathogenic microflora, which are localized in the orotopharynx in the ethiopathogenesis of secondary osteoarthrosis","authors":"Oleksiy Golub, T. Liadova, Olga Volobueva, Viacheslav Chernusky, M. Popov, H. Letiaho, K. Pavlikova","doi":"10.26565/2617-409x-2023-12-03","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-03","url":null,"abstract":"ABSTRACT. Much attention is paid to the problem of secondary osteoarthritis caused by various microorganisms and fungi of the genus S. albicans, associated with their significant growth and prevalence throughout the world among the population of various age groups, high temporary and permanent disability. At the same time, the problem of immunopathology in the pathogenesis of secondary osteoarthritis is being actively studied. The developed immunopathological process induced by pathogenic and opportunistic microflora in articular cartilage and synovial membrane is the main factor in the degenerative destruction of articular cartilage. Goal. to determine the role of pathogenic and opportunistic microflora localized in the oropharynx in the etiopathogenesis of secondary osteoarthritis. Research materials and methods. 65 patients aged from 19 to 45 years, who were undergoing inpatient treatment at Artz Klinic, Kharkiv, were examined for secondary osteoarthritis of the knee joint. The diagnosis was established according to the International Classification of Diseases of the 10th revision (ICD-10) - M18.1. Patients with a history of a high frequency of accompanying pathologies of the oropharynx were selected for the study: chronic tonsillitis - 48 (73.8%), tonsillitis - 32 (49.2%), pharyngitis - 34 (52.3%), sinusitis - 13 (20) %), otitis – 9 (13.8%) the etiology of which is determined by gram-positive and gram-negative microorganisms. All patients underwent microbiological examination of throat swabs, and 24 patients underwent microbiological examination of synovial fluid, which was taken for examination before intra-articular therapy. The obtained data were statistically processed by calculating the arithmetic mean and its error. The results. Presented modern ideas about secondary osteoarthritis caused by etiologically significant macroflora persisting in the oropharynx and as a result of organotropy due to the inclusion in its structure of mimicking antigens of articular cartilage play a leading role in the degradation of articular cartilage and articular bag, transferring the pathological process to an autoimmune basis. This approach makes it possible to develop early immunodiagnostics, prognosis of the disease, and immunocorrective therapy. Conclusions. Pathogenic and conditionally pathogenic microflora persisting in the oropharynx is characterized by organotropy (community of lipopolysaccharides and glycoproids), is identical to the cell-tissue structures of articular cartilage and synovial membrane in the causative agent and modulates the immune response through mimicking antigens.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"11 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139221509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Options of the course of post-COVID syndrome depending on age, gender, comorbidity and severity of the course of COVID-19","authors":"Liliia Todoriko, O. Shevchenko, O.Ya. Pidverbetskyi, Yana Toderika","doi":"10.26565/2617-409x-2023-12-02","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-02","url":null,"abstract":"ABSTRACT. Among residents of Chernivtsi region, the main characteristics, frequency and peculiarities of the occurrence of long-term symptomatic and post-COVID-19 syndrome have not been sufficiently elucidated. The goal of the study was set: to evaluate the options for the course of the post-covid syndrome depending on age, gender, comorbidity and severity of the course of COVID-19. Material and methods. The following research methods were used: electronic questionnaire, epidemiological, clinical and anamnestic, analytical and statistical methods. The study included 214 adult patients who were infected with the SARS-CoV-2 virus (the diagnosis was confirmed by PCR) and who suffered from COVID- 19 of varying degrees of severity and were randomized into two groups: the 1st group (main) included – 112 people (ratio of men/women - 56.4 % (n = 63): 47.5 % (n = 49)), comparative (102 people) – patients with a mild and moderate course of COVID-19 who were consulted and were treated on an outpatient basis (male/female ratio – 45.5 % (n = 46): 54.5 % (n = 56)). Statistical processing of the data obtained during the research was carried out using the IBM SPSS Statistics v26.0 program. Results. It was found that among inpatients there was a significantly significant number of patients older than 60 years old (p < 0.001), whereas among outpatients there were significantly more patients aged 18-29, which indicates a connection between the age of the respondents and the need for inpatient treatment presence of COVID-19. In the main group, the following symptoms occurred more frequently (p < 0.05): cough OR = 2.023 [CI 1.105-3.703], fever OR = 6.916 [CI 2.061-23.204], difficulty breathing (dyspnea) OR = 4.421 [2.230 -8.764]. In the comparison group, the following prevailed: loss of smell OR = 0.147 [CI 0.077-0.281], fatigue OR = 0.456 [CI 0.226-0.920], increased temperature OR=2.023 [2.061- 23.204]. With a higher frequency, such diseases as: coronary heart disease (OR = 33.088 [CI 9.444-115.930]), arterial hypertension (OR = 13.641 [CI 6.547-28.422]), diabetes (OR = 4.755 [CI 1.915-11.803]), heart failure (OR = 18.504 [CI 8.200-41.752]), obesity (OR = 4.828 [CI 2.433-9.581]). Conclusions. 1. Among the patients who received inpatient treatment, the vast majority were people over 40 years old, younger men (from 40 years old) were more likely than women (over 60). 2. In persons with a severe course of COVID-19, the frequency of symptoms of shortness of breath, cough, difficulty breathing, chest pain is more likely to be registered, and in outpatients - loss of smell and fatigue. 3. With a greater frequency, such diseases as: coronary heart disease (37.5 %), arterial hypertension (57.4 %), diabetes (21.3 %), heart failure (54,1 %), obesity (41.1 %). Smoking and alcohol abuse did not show significant reliable differences. 4. The combination of 3 pathologies (hypertension, heart failure, obesity) was most common - in 11 people (10 %).","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"253 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139222387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of immunohistochemical markers in recurrence of endometrial hyperplasia without atypia in women of reproductive age after treatment with progestins","authors":"D. Khaskhachikh, V. Potapov, Olesandra Poslavska, I. Garagulia","doi":"10.26565/2617-409x-2023-12-01","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-01","url":null,"abstract":"ABSTRACT. The high frequency of hyperplastic processes of the endometrium (EН), the lack of proper effectiveness of hormonal therapy, and the possibility of their malignancy place EH among the most relevant issues in modern medicine. The clinical significance of EH lies in the fact that they are one of the most common causes of uterine bleeding and hospitalization of women. It is known that along with hormonal disorders, other activators of proliferative activity, such as growth factors, proliferation and apoptosis markers, and extracellular matrix components, play a significant role in the development of EН. The study investigated the immunohistochemical markers in the endometrial tissue of reproductive-aged women with endometrial hyperplasia without atypia who were diagnosed with recurrent hyperplasia without atypia after 6 months of continuous therapy with a daily dose of 200 mg of progesterone. The following markers were selected for the study: PR, ER, p21, dcl-2, KI-67, eNOS, cycl-D1, BAX, b-catenin, E-cadgerin і Caspasa3, whose expression was examined by immunohistochemical methods before and after therapy. The control group consisted of women with secretory changes in the endometrium. The expression of receptors for PR, ER, p21, dcl-2, KI-67, eNOS, cycl-D1, BAX, b-catenin, E-cadgerin і Caspasa3 was studied primarily in women with non-neoplastic endometrial lesions (hyperplasia without atypia) and may be of greater significance in predicting the risk of progression and recurrence. Objective. The aim of the study was to determine changes in the expression of immunohistochemical markers in the endometrium in cases of hyperplasia without atypia before and after the use of progesterone therapy, and to identify the most predictive markers for therapy response. Results. The histological examination revealed significant changes in the endometrial biomarkers after therapy in women with no response to the treatment. The expression of receptors in the endometrium after therapy showed the following indicators: ER: a 20 % increase in glandular cells compared to baseline and a 63.3 % increase compared to the control group. In stromal cells, there was a 63.3% increase compared to baseline. PgR: An 85 % decrease compared to baseline. An 85 % decrease compared to the control group. p21: A 114 % increase in glandular cells compared to baseline and a 5% increase in stromal cells. Overall, there was a 29.3 % increase in expression compared to the control group. bcl-2: An 80 % decrease compared to baseline in glandular cells and a 90 % decrease compared to baseline in stromal cells. Ki-67: A 114 % increase compared to baseline in glandular cells and an expression more than 67% higher than the control group. eNOS: A 69 % increase compared to baseline in glandular cells and an 85% increase compared to baseline in stromal cells. Cyclin D1: A 15% increase compared to baseline in both glandular and stromal cells. BAX: A 10 % increase compared to baseline in both gl","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"92 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139215755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical guidelines of ukrainian hair research society. diagnosis and treatment of alopecia areata","authors":"I. Serbina, Kuzma Кhobzei, Tetyana Lіadova, O.І. Litus, S.V. Vozianova, Yuriy Andrashko, Svitlana Galnykina, Tetiana Sviatenko, Igor Svistunov, O. Syzon, I.V. Kadyhrob, Y. Ovcharenko","doi":"10.26565/2617-409x-2023-12-06","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-06","url":null,"abstract":"ABSTRACT. Alopecia areata is an immune-mediated disease resulting from the interaction of genetic factors and exogenous triggers, leading to the activation of the Janus Kinases - Signal Transducer and Activator of Transcription signaling pathway, the formation of non-specific autoimmune inflammation and disruption of immune tolerance of hair follicles. Alopecia areata has an unpredictable course with a non-scarring type of hair loss, it can affect the hair part of the head and/or hair in other areas, it can be manifested by damage to the nail plates. The psychotraumatic impact of this disease can be compared to the consequences of life-threatening or disabling diseases. For this reason, the degree of negative impact of alopecia areata on the quality of life may not correlate with the objective condition of patients, which is often not taken into account in the diagnosis and treatment of the disease. Despite the variety of treatment options available, achieving effective and safe disease control is not always straightforward. Treating patients with alopecia areata and comorbid conditions can be particularly challenging and may require close collaboration between specialists from various fields. For these and other reasons, there is significant dissatisfaction among patients regarding alopecia areata and its treatment. The systematic organization, unification, and adaptation of modern knowledge about alopecia areata have led to the creation of two algorithms: a diagnostic algorithm and a therapeutic algorithm. These algorithms provide a differentiated approach to patient management, with age, disease severity, clinical form, disease activity stage, comorbid pathology, prognostic factors, and patient quality of life taken into account. Agents with immunosuppressive action belong to the main group of drugs in the treatment of alopecia areata, according to the antigenic concept of the pathogenesis of the disease. Ongoing work is being done to update treatment protocols to include JAK inhibitors and other preparations, taking into based on new developments and the expanding pharmaceutical market.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"227 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139227141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New approaches to the correction of immune disorders in adenomyosis","authors":"M. Scherbina, Lilya Potapova, I. Scherbina, Olga Mertsalova, A. Chekhunova","doi":"10.26565/2617-409x-2023-12-05","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-05","url":null,"abstract":"ABSTRACT. A large number of studies have been devoted to the study of the problem of genital endometriosis, however, the etiology and mechanisms of the disease remain unresolved. Adenomyosis affects about 10% of women of reproductive age, occurs in 30% of women with pelvic pain syndrome and up to 50% of patients with female infertility. Numerous theories of the origin of endometriosis cannot explain the key points in the development of the disease, namely the penetration of the basal layer of the endometrium into the adjacent myometrium. This makes it difficult to choose an adequate treatment strategy for patients with adenomyosis. Treatment of adenomyosis is one of the most difficult issues in modern gynecology, one of the promising approaches in increasing the effectiveness of treatment of patients with adenomyosis is immunocorrective therapy. The aim of the work was to increase the effectiveness of treatment of adenomyosis patients by improving the diagnostic and prognostic tactics of patient management based on the study of pathogenetic aspects. Materials and methods. 115 patients of reproductive age were included in the study. The effectiveness of complex compared to traditional treatment was evaluated. Clinical and laboratory, instrumental and immunological indicators were evaluated in dynamics. Research results and their discussion. Taking into account the peculiarities of pathogenetic mechanisms, which indicate a violation of the cellular and macrophage links of immunity, cytokine imbalance, which contribute to the development of the disease and its persistence, we have developed a comprehensive approach to increasing the effectiveness of the treatment of patients with adenomyosis, which aims to reduce the pro-inflammatory immunological potential. Against the background of the comprehensive treatment, the activity of autoimmune reactions is reduced, the indicators of phagocytic and oxygen activity of neutrophils and monocytes are normalized, cytokine imbalance is reduced - the level of production of pro-inflammatory cytokines and VEGF is normalized. Conclusions. Based on the results of the work, the approaches to the treatment of adenomyosis patients were optimized, the feasibility of using corrective drugs in complex therapy was substantiated.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"188 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139225009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of drugs of protocol therapy on the production of pro-inflammatory cytokines of t-lymphocytes of children with bronchial asthma","authors":"T. Liadova, Olga Volobueva, Viacheslav Chernusky, M. Popov, H. Letiaho, K. Pavlikova","doi":"10.26565/2617-409x-2023-12-04","DOIUrl":"https://doi.org/10.26565/2617-409x-2023-12-04","url":null,"abstract":"ABSTRACT. At the current stage of solving the problem in the pathogenesis of atopic BA in moderate-severe and severe course of the disease, the leading role is played by pro-inflammatory cytokines of T-lymphocytes and factors of the late phase of allergic inflammation. Goal. To determine the effect of the drugs of the therapy protocol recommended by GINA (2021) and the Ministry of Health of Ukraine No. 2856 on the production of pro-inflammatory cytokines in children with AD. Materials and methods. The study was conducted in 106 patients with BA and 20 healthy children aged 5 to 14 years in the period of disease remission before and after therapy. The impact of the protocol therapy scheme on the production of pro-inflammatory cytokines and their antibody control in children with different degrees of severity of the course of the disease was evaluated. The results. In asthma in children with a mild persistent course, protocol therapy reduces the release of mediators of the early phase of the allergic disease and the partial production of pro-inflammatory cytokines, which leads to clinical remission of the disease. With a moderately severe persistent course of AD, the influence of protocol therapy drugs reduce the level of production of pro-inflammatory cytokines to weakly positive values, which indicates incomplete control of therapy and unstable clinical remission. In severe persistent AD, protocol therapy partially reduces the production of pro-inflammatory cytokines, but does not affect the late phase of allergic inflammation and the autoimmune component of the pathogenesis of the disease. Conclusions. The recommended GINA protocol therapy (2021) eliminates the early phase and does not affect the late phase of allergic inflammation and the autoimmune component. This requires the development of additional therapy for moderate and severe asthma in children.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"22 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139216899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organization of medical care provision for cancer patients (according to the survey of oncologists)","authors":"V. Zub, A. Kotuza","doi":"10.26565/2617-409x-2022-10-02","DOIUrl":"https://doi.org/10.26565/2617-409x-2022-10-02","url":null,"abstract":"ABSTRACT. The fight against oncological diseases remains one of the priority areas of the health care system of Ukraine. However, the development of medical science, the introduction of innovations in oncology practice, the COVID-19 pandemic and the conditions of wartime necessitate the need to review and improve the process of organizing the provision of oncological care to the population of Ukraine. Aim. The aim of the study is to research the opinion of practicing oncologists regarding certain aspects of the organization of medical care for cancer patients.9 Materials and methods. In the period of August-September 2022, an expert survey of 111 oncologists of the highest and the first qualification categories was conducted. The survey was carried out in 10 regions of Ukraine, which made it possible to cover all regional zones of Ukraine (northern, southern, western, northeastern and central regions of Ukraine). The findings were processed using statistical methods, structural and logical analysis and a systemic approach. Results. Most of the interviewed oncologists are guided in their work by the current standards of diagnosis and treatment of cancer patients on the basis of evidence-based medicine, however, about half of them note the need to review and make changes to it, while the international standards need adaptation to the possibilities of providing oncological care in Ukraine, according to the interviewees. A large number of oncologists need to organize internships, which, in their opinion, should improve the quality of medical services, and also suggest improving and expanding measures aimed at primary prevention and early diagnosis of oncological diseases. Conclusions. The data of the conducted research will contribute to the improvement of the quality of oncological medical care, revision of the standards of diagnosis and treatment of oncological diseases. The findings will be used to develop and work out a model for the optimization of the oncology care system for the population of Ukraine.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133958942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of bacterial vaginosis in the development of inflammatory diseases of the female genital organs and the formation of disorders of the placental complex in the early stages of pregnancy","authors":"A. Hoshovska","doi":"10.26565/2617-409x-2022-10-01","DOIUrl":"https://doi.org/10.26565/2617-409x-2022-10-01","url":null,"abstract":"ABSTRACT. This paper presents some features of microbiocenosis of the vulva and vagina in pregnant women against the background of inflammatory diseases of the female genital organs and the role of bacterial vaginosis in the development of primary placental dysfunction during the formation of the placental complex. Goal. To determine the species composition of the microflora of vaginal contents in pregnant women by means of bacterioscopic, bacteriological research methods, polymerase chain reaction, pH-metry of vaginal discharge. Materials and methods. We used bacterioscopic, bacteriological, ultrasound research methods, polymerase chain reaction, and pH-metry of vaginal secretions. Studies of uteroplacental blood circulation were carried out on the ultrasonic diagnostic device \"SonoAce 8000 Life\". According to the set goal, a study was conducted on 87 women at 6-7 and 12-14 weeks of gestation. The main group consisted of 47 women with signs of bacterial vaginosis, the control group consisted of 40 practically healthy women. The results. In the women of the main group, the growth of contamination of the mucous membrane of the vulva and vagina with vaginal gardnerella is characteristic - 53.9%. To diagnose the formation of primary placental dysfunction, a dopplerometric study of blood flow indicators in uterine arteries revealed a significant increase in vascular resistance indices in 34 (46.7%) (p>0.05) pregnant women of the main observation group. Conclusions. The revealed features of the microbiocenosis of the genital tract in pregnant women in the early stages of guttation of patients with inflammatory diseases of the female genital organs indicate that the leading role in the development of inflammatory diseases of the female genital organs is played by the violation of the ecosystem of the vagina. These diagnostic criteria will make it possible to detect the insufficiency of the placental bed, to diagnose primary placental dysfunction at the preclinical stage (at 8-12 weeks of pregnancy).","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129808571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic value of left ventricular global longitudinal strain in patients with hypertrophic cardiomyopathy","authors":"V. Tseluyko, Olena Butko, K. Kinoshenko","doi":"10.26565/2617-409x-2022-10-05","DOIUrl":"https://doi.org/10.26565/2617-409x-2022-10-05","url":null,"abstract":"ABSTRACT. Hypertrophic cardiomyopathy (HCM) is one of the widespread genetically determined diseases of the myocardium, which is accompanied by the development of diastolic and, subsequently, systolic dysfunction of the myocardium. The aim of our study was to evaluate the clinical and instrumental features of patients with hypertrophic cardiomyopathy with impaired left ventricular global longitudinal strain (GLS) and its prognostic value for the development of cardiovascular events in the Ukrainian population of patients with hypertrophic cardiomyopathy. Materials and methods. The data of 35 patients with hypertrophic cardiomyopathy who underwent a comprehensive clinical and instrumental examination with determination of the absolute global longitudinal strain on speckle-tracking echocardiography were retrospectively analyzed. The patients were divided into two groups: Group I (GLS< 14.5) and Group II (GLS≥ 14.5). Results. A decrease in global longitudinal strain was associated with a longer disease duration (8 (5-11) vs 3 (2-5) years, p=0.003), increasing of complaints on irregularity of heart beat (66.7% vs 23.5%, p= 0.018) and weakness (61.1% vs 23.5%, p=0.04), increased systolic blood pressure (SBP) (130 (120-140) vs 110 (100-120) mm Hg, p= 0.009), the absence of patients without signs of heart failure (0 vs 29.4%, p=0.019), an increase in IVRT (106.19±28.62 vs 84.57±27.54 ms, p=0.044) and a greater number of ventricular extrasystoles (17 (4-69) vs 2 (0.5-3), p=0.014). According to the Kaplan-Meier analysis of survival in relation to fatal and non-fatal cardiovascular events or their combination with hospitalization for heart failure, they had significantly worse survival rates (Log-Rank, p=0.016 and p=0.003). Conclusions. Hypertrophic cardiomyopathy patients with poor global longitudinal strain scores were characterized by worse clinical and instrumental data and an unfavorable cardiovascular prognosis.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125840444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ghrelin as a biomarker of non-motor symptoms and sleep disorders at Parkinson's disease","authors":"K. Tarianyk, N. Lytvynenko, Halyna Silenko, Olena Palenka","doi":"10.26565/2617-409x-2022-10-04","DOIUrl":"https://doi.org/10.26565/2617-409x-2022-10-04","url":null,"abstract":"ABSTRACT. Among the movement disorders characterized by Parkinson's disease, an equally important component is non-motor symptoms. To date, the neurophysiological basis of development and potential biomarkers of the disease remain insufficiently studied. The purpose of our study is to analyze the possibility of using the level of ghrelin in blood plasma as a biomarker of non-motor symptoms and sleep disturbances in Parkinson's disease depending on circadian rhythms. We examined 64 patients with Parkinson's disease registered at the Center for Parkinson's Disease and Other Neurodegenerative Diseases, Department of Nervous Diseases, Poltava State Medical University, and 30 patients without signs of neurodegenerative disease. The diagnosis was established according to the criteria of the World Brain Bank of Great Britain. Non-motor manifestations were studied according to the results of the non-motor symptom assessment scale, the severity of sleep disorders was assessed according to the sleep scale at Parkinson's disease. Results. In the course of the study, a decrease in the level of ghrelin in the blood plasma and the connection of the ghrelin content with sleep and digestive system disorders in patients with Parkinson's disease were established. patients, which is consistent with other studies. Ghrelin stimulates motility and emptying of the stomach, as well as motility of the small and large intestines. This indicates the probable role of ghrelin in the pathophysiology of diseases of the digestive system at Parkinson's disease. Conclusions. The level of plasma ghrelin in patients with Parkinson's disease and its diurnal fluctuations can be considered as a potential biomarker of non-motor symptoms and their fluctuations due to its links with sleep disorders and circadian rhythm.","PeriodicalId":372609,"journal":{"name":"Actual problems of modern medicine","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115514813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}