The role of bacterial vaginosis in the development of inflammatory diseases of the female genital organs and the formation of disorders of the placental complex in the early stages of pregnancy

ABSTRACT. This paper presents some features of microbiocenosis of the vulva and vagina in pregnant women against the background of inflammatory diseases of the female genital organs and the role of bacterial vaginosis in the development of primary placental dysfunction during the formation of the placental complex. Goal. To determine the species composition of the microflora of vaginal contents in pregnant women by means of bacterioscopic, bacteriological research methods, polymerase chain reaction, pH-metry of vaginal discharge. Materials and methods. We used bacterioscopic, bacteriological, ultrasound research methods, polymerase chain reaction, and pH-metry of vaginal secretions. Studies of uteroplacental blood circulation were carried out on the ultrasonic diagnostic device "SonoAce 8000 Life". According to the set goal, a study was conducted on 87 women at 6-7 and 12-14 weeks of gestation. The main group consisted of 47 women with signs of bacterial vaginosis, the control group consisted of 40 practically healthy women. The results. In the women of the main group, the growth of contamination of the mucous membrane of the vulva and vagina with vaginal gardnerella is characteristic - 53.9%. To diagnose the formation of primary placental dysfunction, a dopplerometric study of blood flow indicators in uterine arteries revealed a significant increase in vascular resistance indices in 34 (46.7%) (p>0.05) pregnant women of the main observation group. Conclusions. The revealed features of the microbiocenosis of the genital tract in pregnant women in the early stages of guttation of patients with inflammatory diseases of the female genital organs indicate that the leading role in the development of inflammatory diseases of the female genital organs is played by the violation of the ecosystem of the vagina. These diagnostic criteria will make it possible to detect the insufficiency of the placental bed, to diagnose primary placental dysfunction at the preclinical stage (at 8-12 weeks of pregnancy).