Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine最新文献

{"title":"Correlation Analysis of Direct LDL Measurement and Calculated LDL Methods in Lipid Profile Assessment: A Comprehensive Study.","authors":"M Rasheed Khan, K Durga Sowmithri, Arafeen Shazia, Mohammad Nawaz, P K Raksha Khaveyya, B Parkavi","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>Assessing LDL cholesterol is pivotal for cardiovascular risk evaluation. While direct LDL measurement is accurate, calculated LDL methods offer practicality and cost-effectiveness. This study aims to evaluate the correlation between direct LDL measurement and various calculated LDL methods, shedding light on their clinical utility.</p><p><strong>Methods: </strong>A retrospective analysis of lipid profiles from 1075 patients was conducted, encompassing direct LDL measurement and calculation of LDL using nine different methods. Statistical analyses, including correlation coefficients and scatter plots, were employed to assess the agreement between direct LDL and calculated LDL methods.</p><p><strong>Results: </strong>Surprisingly, all calculated LDL methods exhibited a robust correlation with direct LDL measurement across the study cohort. The Friedewald equation, as well as modified equations demonstrated particularly robust correlations. These findings indicate the reliability of calculated LDL methods in estimating LDL cholesterol levels.</p><p><strong>Discussion: </strong>The significant correlation observed between direct LDL measurement and calculated LDL methods underscores the clinical utility of the latter. While direct LDL measurement remains the gold standard, calculated LDL methods offer practical advantages, particularly in resource-limited settings.</p><p><strong>Conclusion: </strong>In conclusion, this study highlights the excellent correlation between direct LDL measurement and calculated LDL methods in lipid profile assessment. Clinicians can leverage calculated LDL methods as reliable alternatives for LDL cholesterol estimation, facilitating efficient cardiovascular risk evaluation in routine clinical practice. Further research may explore the optimal use of calculated LDL methods in specific patient populations, enhancing their clinical applicability and utility.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"244-264"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospectively diagnosed familial hypocalciuric hypercalcaemia following total parathyroidectomy in an asymptomatic patient.","authors":"Rucita Severaj","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Familial hypocalciuric hypercalcemia (FHH) is a rare, benign condition that shares characteristics with primary hyperparathyroidism (PHPT), a more sinister condition that requires surgical intervention. This case report demonstrates misdiagnosis of FHH and highlights important learning points to prevent this in the future.</p><p><strong>Case presentation: </strong>Hypercalcaemia was incidentally discovered in a 21-year-old patient who had no symptoms of hypercalcaemia and no significant family history. Clinical examination was normal. Biochemical investigations revealed hypercalcaemia of 2.84mmol/L (2.15 - 2.50mmol/L) and hypophosphataemia of 0.71mmol/L (0.78 - 1.42mmol/L). Parathyroid hormone (PTH) concentration was mildly and inappropriately elevated (10.3pmol/L [2.0 - 8.5pmol/L]) triggering a suspicion of PTH-mediated hypercalcaemia. Parathyroid scintigraphy reported an ill-defined area of focal uptake above the left thyroid lobe. Fractional excretion of calcium estimations on 24hour urine collections were borderline (0.01) for FHH on multiple occasions however, further investigations to exclude FHH were not performed before a diagnosis of primary hyperparathyroidism was made, and a total parathyroidectomy performed. Several months post-operatively, the patient still demonstrated persistent hypercalcaemia. Her siblings had since been diagnosed with FHH. The patient was then retrospectively diagnosed with FHH. Genetic testing for FHH is not available in South Africa which limited the opportunity to confirm the diagnosis.</p><p><strong>Conclusions: </strong>This case report provides a classical presentation of the rare, benign disorder of FHH. It highlights the negative outcomes that may result from misdiagnosis of this condition as PHPT. Biochemical investigations play an integral role in differentiating these conditions. Effective clinician-laboratory communication is crucial for optimal patient outcomes.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"329-332"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726324/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vitamin D Controversies in the Laboratory Medicine: A Review of Clinical Guidelines and Recommendations.","authors":"María Monsalud Arrebola, Xavier Filella, María Dolores Albaladejo-Oton, Nuria Giménez, María Gemma Serrano-Olmedo, Rafael José García-Martínez, Elena Bonet-Estruch, María Santamaría-González, Diana Pérez-Torrella, Daniel Morell-García, Juan Antonio Allué-Palacín, María Ángels Ruiz-Mínguez, Miguel Ángel Castaño-López","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A narrative review of the main guidelines and recommendations published from 2011 up to date about the status of vitamin D deficiency has been carried out. The objective of this review is to discuss the origin of the controversy about the status of this entity, as well as the evolution of the methodological aspects and clinical situations that require vitamin D screening. The results obtained indicate that the criteria defining vitamin D status, according to two studies published in 2011, the Institute of Medicine (IOM) recommendations and the Endocrine Society (ES) guidelines, regardless the affected population. Concerning the methodology used, progress has been made thanks to the Vitamin D Standardization Program (VDSP), although the most recent results from the external Vitamin D External Quality Program Assessment Scheme (DEQAS) indicate that there is still a significant bias among the different immunoassays available. In relation to the criteria for screening, an agreement is observed in the most recent publications.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"223-243"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726334/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolopment of Recommendations for Standardized Reporting of Protein Electrophoresis in Pakistan.","authors":"Sibtain Ahmed, Ayra Siddiqui, Aysha Habib Khan, Lena Jafri, Hafsa Majid, Ghazanfar Abbas, Alina Abdul Rehman, Muhammad D Khan, Muhammad Q A Khan, Sahar Iqbal, Samia Khan, Rizwana Kausar, Imran Siddiqui","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Introduction: </strong>The standardization of reporting in clinical laboratories, particularly regarding Serum Protein Electrophoresis (SPEP) and Urine Protein Electrophoresis (UPEP), is crucial for effective communication of findings to clinicians and optimal patient management. However, in countries like Pakistan with limited healthcare resources and a prevalent self-payment model, challenges arise in achieving standardized reporting practices. This manuscript addresses the need for standardized guidelines for protein electrophoresis reporting in Pakistan, aiming to enhance laboratory practices and patient care.</p><p><strong>Methods: </strong>This study was conducted at the Aga Khan University Hospital (AKUH), Pakistan. A team consisting of five Consultant Chemical Pathologists and two senior technologists, led by the Section Head of Chemical Pathology at AKU, used a Modified Delphi Methodology to achieve consensus on the developed framework. Consensus was defined as agreement by at least six out of the seven experts (85.71%). The source guideline for this process was the Recommendations for Standardized Reporting of Protein Electrophoresis from Australia and New Zealand.</p><p><strong>Results: </strong>Consultant Chemical Pathologists reviewed the original and modified recommendations, resulting in a framework of ten sub-sections and 65 recommendations. Through a series of four meetings, including a diverse team of experts, the recommendations were systematically critiqued and reviewed. After detailed deliberations, 54 recommendations were finalized by consensus. The final document was further reviewed by CCBP staff and additional consultants from different institutions in Pakistan to ensure unbiased and comprehensive expert input.</p><p><strong>Discussion: </strong>The developed guidelines offer a framework for consistent and comprehensive reporting of PEP results, addressing variations in practices among clinical laboratories in Pakistan. Key modifications to the recommendations reflect a pragmatic approach to navigating resource constraints, ensuring that laboratory reports remain informative and actionable for clinicians. By prioritizing clinical relevance and practicality, the guidelines aim to enhance diagnostic accuracy and facilitate appropriate clinical management decisions.</p><p><strong>Conclusion: </strong>The standardized reporting guidelines for SPEP and UPEP represent a significant milestone in optimizing laboratory practices and improving patient care in Pakistan. Moving forward, continued monitoring and adaptation of the guidelines will be essential to ensure their sustained relevance and effectiveness in meeting the evolving needs of the healthcare system. Embracing a commitment to excellence in laboratory practices holds promise for advancing healthcare quality and accessibility in low-resource settings globally.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"314-323"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous reference intervals for plasma cystatin C and creatinine in Vietnamese children.","authors":"Mai Thi Chi Tran, Dung Lan Dao, Ha Thi Ngoc Bui, Tze Ping Loh","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Serum (plasma) creatinine and cystatin C are widely used in pediatric clinical practice to assess glomerular filtration rate. Both markers have limitations due to the low index of individuality, which affects the clinical sensitivity of population-based reference intervals, especially when wide age ranges are considered. This study aimed to establish age-related reference intervals for plasma cystatin C and creatinine in Vietnamese children.</p><p><strong>Methods: </strong>A total of 454 children, equally divided between boys and girls, aged from 1 day to 18 years, were recruited from the outpatient clinic of Vietnam National Children's Hospital. None of the participants had kidney or infectious diseases. Plasma samples were analyzed for cystatin C and creatinine using standard clinical chemistry methods. Using the the Lambda-Mu-Sigma method, we derived centile charts showing dynamic changes in these biomarkers.</p><p><strong>Results: </strong>In this cohort, plasma creatinine levels were high at birth, declined to their lowest point between ages of 2 and 3 years, and then gradually increased until adulthood. Plasma cystatin C levels were also elevated at birth, decreased to a steady state around age of 2 year, and remained stable until age of 10 years. From ages 10 to 14 years, cystatin C levels slightly increased, followed by a decrease from ages 15 to 18 years.</p><p><strong>Conclusions: </strong>Accurate assessment of glomerular filtration in children requires reliable laboratory tests and age-specific reference intervals. Providing serum (plasma) cystatin C and creatinine reference intervals with appropriate age partitions is crucial for improving the clinical sensitivity for detecting renal dysfunction, especially during the first few years of life.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"300-313"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MicroRNA Significance in Cancer: An Updated Review on Diagnostic, Prognostic, and Therapeutic Perspectives.","authors":"Vijay Singh, Aniruddha Sen, Sapna Saini, Shailendra Dwivedi, Ruchika Agrawal, Akash Bansal, Shashank Shekhar","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The article provides a thorough and up-to-date analysis of the role that microRNAs (miRNAs) within the realm of cancer therapy, paying specific attention to their diagnostic, prognostic as well as therapeutic capabilities. The miRNAs (small non-coding RNAs) are the current major genes that regulate gene expression. They are a key factor in the genesis of cancer. They are oncogenes, or tumor suppressors that play key functions in the signaling pathway that contribute to the development of cancer. This article focuses on the double importance of microRNAs for cancer oncogenesis. This includes both their ability to inhibit cancer suppressor genes and the stimulation of cancer-causing oncogenes. MicroRNAs have been identified for a long time as biomarkers to help in diagnosing cancer and have distinct signatures specific to different kinds of cancer. There are many detection strategies including RT-qPCR, Next Generation Sequencing (NGS) as well as Microarray Analysis that have been evaluated to prove their effectiveness in aiding the non-invasive diagnosis of cancer. The paper provides an overview of the importance of miRNAs to prognosis, highlighting their ability to forecast tumor progression as well as outcomes for cancer patients. In addition, their therapeutic value remains a subject of research. Research is being conducted in order to investigate miRNA-targeting therapy including antisense oligonucleotides, or small molecules inhibitors as possible treatment options for cancer. These methods could favor more specific and individualized approaches than the current techniques. The article also focuses on the current challenges and future prospects linked to miRNA research and demonstrates the complex biological functions they play as well as clinical applications that require investigation. The review is the source of information for researchers, clinicians and scientists who are interested in advancing studies into cancer research as well as personalized treatments.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"265-284"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Patient-Generated Health Data from Mobile Devices into Electronic Health Records: Best Practice Recommendations by the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM).","authors":"James H Nichols, Ramy Samir Assad, Juergen Becker, Pradeep K Dabla, Alistair Gammie, Bernard Gouget, Michael Heydlauf, Evgenija Homsak, Irena Korita, Kazuhiko Kotani, Ebru Saatçi, Sanja Stankovic, Zihni Onur Uygun, Laila AbdelWareth","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>An increasing number of wearable medical devices are being used for personal monitoring and professional health care purposes. These mobile health devices collect a variety of biometric and health data but do not routinely connect to a patient's electronic health record (EHR) or electronic medical record (EMR) for access by a patient's health care team.</p><p><strong>Methods: </strong>The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM) developed consensus recommendations for consideration when interfacing mobile health devices to an EHR/EMR.</p><p><strong>Results: </strong>IFCC C-MHBLM recommendations cover personalized monitoring and privacy concerns, data security, quality assurance of data transfer, and incorporation of alert triggers to warn users of important health conditions.</p><p><strong>Conclusions: </strong>Considerations for interface ease-of-use, display of patient data in the EHR/EMR, and needs-based training programs for healthcare staff to understand the critical requirements, proper use, and integration of mobile health devices with EHR/EMRs are provided. Cooperation between healthcare providers, device manufacturers, and software developers is also recommended to drive future innovation in mobile health device technology development.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"324-328"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Light After Armageddon: Enhancing Cardiovascular Care through Emerging Technologies and Patient-Centric Approaches.","authors":"Damien Gruson, Chiara Peranio, Sergio Bernardini, Aistė Štaraitė, Mikki Koo, Mike Coyle, Bryan Shannon, David Luu, Ed Harding, Tuğba Kemaloğlu Öz","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 4","pages":"212-215"},"PeriodicalIF":0.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11726328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142984985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative Analysis of HbA1c Estimation Using Immunoturbidimetry and High-Pressure Liquid Chromatography Methods in Non-Dialysis Chronic Kidney Disease Patients.","authors":"Chanchal Dhingra, Namrata Rao, Shefali Singh, Anumesh K Pathak, Vandana Tiwari, Manish R Kulshrestha, Juhi Verma","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Chronic kidney disease (CKD) concomitant with diabetes mellitus (DM), anemia and uremia. Thus, monitoring HbA1c levels presents a complex clinical challenge.</p><p><strong>Methods: </strong>This analytical cross-sectional study was conducted from May 2022 to April 2023 at Dr. Ram Manohar Lohia Institute of Medical Sciences, Lucknow. We compared HbA1c values obtained by the turbidimetric inhibition immunoassay (TINIA) and high-pressure liquid chromatography (HPLC) methods among non-dialysis CKD patients (n=127).</p><p><strong>Results: </strong>HbA1c was not detectable among 27 patients by TINIA but measurable with HPLC, all being's anemic. The remaining 100 patients, it was detectable by both the methods. Among these 100 patients, linear regression analysis showed a very strong positive correlation between TINIA-HbA1c and HPLC-HbA1c (R2=0.861; p<0.0001). The agreement between methods was substantial (Cohen's kappa 0.657; p<0.0001). However, HbA1c levels were detected significantly higher with HPLC (Median 7.9, IQR 2.7) than that of TINIA (Median 7.0, IQR 2.9;p=0.025) in diabetics while the difference was not significant in non-diabetic group with both HPLC (Median 5.4,IQR 0.8) and TINIA (Median 5.1,IQR 1.1). Carbamylated Hb (CHb; as detected by HPLC as a side product) was correlated to both HbA1c by HPLC (r=0.299;p=0.007) and TINIA (r=0.336;p=0.006) as well as to serum urea levels (r=0.439;p<0.0001).</p><p><strong>Conclusion: </strong>HPLC estimates all HbA1c patients in our study group while TINIA failed to do so in around 21.26% cases. The very low hemoglobin levels and high carbamylated hemoglobin were apparent as two most common causes. Also, the values with TINIA are significantly lower in comparison to HPLC among diabetics with CKD.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 3","pages":"195-205"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536278/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Approach to Include the Cost of Consumables in Biochemistry Analyzer Procurement on the Reagent Rental Model Alleviates Hidden Expenses.","authors":"Manish Raj Kulshrestha, Vandana Tiwari, Shivani Singh, Anumesh K Pathak","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Clinical biochemistry analyzers are essential for diagnosing and monitoring various diseases and conditions. However, the procurement of these analyzers is often based on the initial purchase cost, which does not reflect the total cost of ownership.</p><p><strong>Methods: </strong>We applied a novel approach to include all hidden costs to run parameters (consumables and accessories) on a cost-per-reportable test (CPRT) basis. Fixed expenses like water purification plant, HIS connectivity, and electricity backup were assumed to be included in the cost per test itself, while the calibration cost was distributed uniformly in the calculation of CPRT itself. This CPRT was taken to compare the financial results of different bids.</p><p><strong>Results: </strong>The cost per reportable test received after applying our novel approach in maintenance-free reagent rental basis bid was 47.4% lower than the previous cost per test for the purchased equipment.</p><p><strong>Conclusion: </strong>This substantial decrease in cost with our novel approach reduced laboratory expenses possible with accurate comparison among analyzers with uniform specifications after eliminating the hidden expenses.</p>","PeriodicalId":37192,"journal":{"name":"Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine","volume":"35 3","pages":"182-188"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11536279/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142591914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}